Frontiers in network physiology最新文献

{"title":"Insomnia increases the risk for specific autoimmune diseases: a large-scale retrospective cohort study.","authors":"Sarah Stenger, Artem Vorobyev, Katja Bieber, Tanja Lange, Ralf J Ludwig, Jennifer E Hundt","doi":"10.3389/fnetp.2025.1499297","DOIUrl":"https://doi.org/10.3389/fnetp.2025.1499297","url":null,"abstract":"<p><strong>Objective: </strong>The global rise of autoimmune diseases presents a significant medical challenge, with inadequate treatment options, high morbidity risks, and escalating healthcare costs. While the underlying mechanisms of autoimmune disease development are not fully understood, both genetic predispositions and lifestyle factors, particularly sleep, play critical roles. Insomnia and circadian rhythm sleep disorders not only impair sleep but also disrupt multi-organ interactions by dysregulating sympathetic nervous system activity, altering immune responses, and influencing neuroendocrine function. These disruptions can contribute to immune system dysregulation, increasing the risk of autoimmune disease development.</p><p><strong>Methods: </strong>To assess the impact of impaired sleep on the risk of developing autoimmune diseases, a global population-based retrospective cohort study was conducted using electronic health records from the TriNetX US Global Collaborative Network, including 351,366 subjects in each propensity score matched group. Twenty autoimmune diseases were examined, and propensity score matching was employed to reduce bias. Three sensitivity analyses were conducted to test the robustness of the results.</p><p><strong>Results: </strong>The study identified significantly increased risks for several autoimmune diseases associated with impaired sleep, likely mediated by dysregulated neuroimmune and autonomic interactions. Specifically, cutaneous lupus erythematosus [hazard ratio (HR) = 2.119; confidence interval (CI) 1.674-2.682; p < 0.0001], rheumatoid arthritis (HR = 1.404; CI 1.313-1.501; p < 0.0001), Sjögren syndrome (HR = 1.84; CI 1.64-2.066; p < 0.0001), and autoimmune thyroiditis (HR = 1.348; CI 1.246-1.458; p < 0.0001) showed significantly increased risks. No diseases demonstrated reduced risks, and 4 out of 20 tested diseases did not show significant HR increases in any analysis.</p><p><strong>Conclusion: </strong>This study highlights the integral role of sleep in maintaining immune homeostasis through multi-organ interactions involving the autonomic nervous system, immune signalling pathways, and endocrine regulation. Disruptions in these systems due to chronic sleep impairment may predispose individuals to autoimmune diseases by altering inflammatory responses and immune tolerance. These findings underscore the necessity of recognizing and treating sleep disorders not only for general wellbeing but also as a potential strategy to mitigate the long-term risk of autoimmune disease development.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"5 ","pages":"1499297"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring the complexity of walking in the elderly and its impact on clinical measures around the risk of falls.","authors":"Samar Ezzina, Simon Pla, Didier Delignières","doi":"10.3389/fnetp.2025.1532700","DOIUrl":"https://doi.org/10.3389/fnetp.2025.1532700","url":null,"abstract":"<p><p><b>Introduction:</b> The hypothesis of the loss of complexity with aging and disease has received strong attention. Especially, the decrease of complexity of stride interval series in older people, during walking, was shown to correlate with falling propensity. However, recent experiments showed that a restoration of walking complexity in older people could occur through the prolonged experience of synchronized walking with a younger companion. This result was interpreted as the consequence of a complexity matching effect. <b>Experiment:</b> The aim of the present study was to analyze the link between the restoration of walking complexity in older people and clinical measures usually used in the context of rehabilitation or follow-up of older people. <b>Results:</b> We evidenced a link between restoring complexity, improving overall health and reducing fear of falling. In addition, we showed that 3 weeks of complexity matching training can have a positive effect on complexity up to 2 months post-protocol. Finally, we showed that the restoration of walking complexity obtained in the previous works is not guide-dependent.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"5 ","pages":"1532700"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information entropy dynamics, self-organization, and cybernetical neuroscience.","authors":"Alexander Fradkov","doi":"10.3389/fnetp.2025.1539166","DOIUrl":"https://doi.org/10.3389/fnetp.2025.1539166","url":null,"abstract":"<p><p>A version of the speed-gradient evolution models for systems obeying the maximum information entropy principle developed by H. Haken in his book of 1988 is proposed in this article. An explicit relation specifying system dynamics for general linear constraints is established. Two versions of the human brain entropy detailed balance-breaking model are proposed. In addition, the contours of a new scientific field called <i>cybernetical neuroscience</i> dedicated to the control of neural systems have been outlined.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"5 ","pages":"1539166"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PINNing cerebral blood flow: analysis of perfusion MRI in infants using physics-informed neural networks.","authors":"Christoforos Galazis, Ching-En Chiu, Tomoki Arichi, Anil A Bharath, Marta Varela","doi":"10.3389/fnetp.2025.1488349","DOIUrl":"https://doi.org/10.3389/fnetp.2025.1488349","url":null,"abstract":"<p><p>Arterial spin labelling (ASL) magnetic resonance imaging (MRI) enables cerebral perfusion measurement, which is crucial in detecting and managing neurological issues in infants born prematurely or after perinatal complications. However, cerebral blood flow (CBF) estimation in infants using ASL remains challenging due to the complex interplay of network physiology, involving dynamic interactions between cardiac output and cerebral perfusion, as well as issues with parameter uncertainty and data noise. We propose a new spatial uncertainty-based physics-informed neural network (PINN), SUPINN, to estimate CBF and other parameters from infant ASL data. SUPINN employs a multi-branch architecture to concurrently estimate regional and global model parameters across multiple voxels. It computes regional spatial uncertainties to weigh the signal. SUPINN can reliably estimate CBF (relative error <math><mrow><mo>-</mo> <mn>0.3</mn> <mo>±</mo> <mn>71.7</mn></mrow> </math> ), bolus arrival time (AT) <math><mrow><mo>(</mo> <mrow><mn>30.5</mn> <mo>±</mo> <mn>257.8</mn></mrow> <mo>)</mo></mrow> </math> , and blood longitudinal relaxation time <math><mrow><mo>(</mo> <mrow> <msub><mrow><mi>T</mi></mrow> <mrow><mn>1</mn> <mi>b</mi></mrow> </msub> </mrow> <mo>)</mo></mrow> </math> (-4.4 <math><mrow><mo>±</mo></mrow> </math> 28.9), surpassing parameter estimates performed using least squares or standard PINNs. Furthermore, SUPINN produces physiologically plausible spatially smooth CBF and AT maps. Our study demonstrates the successful modification of PINNs for accurate multi-parameter perfusion estimation from noisy and limited ASL data in infants. Frameworks like SUPINN have the potential to advance our understanding of the complex cardio-brain network physiology, aiding in the detection and management of diseases. Source code is provided at: https://github.com/cgalaz01/supinn.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"5 ","pages":"1488349"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining interictal intracranial EEG and fMRI to compute a dynamic resting-state index for surgical outcome validation.","authors":"Varina L Boerwinkle, Kristin M Gunnarsdottir, Bethany L Sussman, Sarah N Wyckoff, Emilio G Cediel, Belfin Robinson, William R Reuther, Aryan Kodali, Sridevi V Sarma","doi":"10.3389/fnetp.2024.1491967","DOIUrl":"10.3389/fnetp.2024.1491967","url":null,"abstract":"<p><strong>Introduction: </strong>Accurate localization of the seizure onset zone (SOZ) is critical for successful epilepsy surgery but remains challenging with current techniques. We developed a novel seizure onset network characterization tool that combines dynamic biomarkers of resting-state intracranial stereoelectroencephalography (rs-iEEG) and resting-state functional magnetic resonance imaging (rs-fMRI), vetted against surgical outcomes. This approach aims to reduce reliance on capturing seizures during invasive monitoring to pinpoint the SOZ.</p><p><strong>Methods: </strong>We computed the source-sink index (SSI) from rs-iEEG for all implanted regions and from rs-fMRI for regions identified as potential SOZs by noninvasive modalities. The SSI scores were evaluated in 17 pediatric drug-resistant epilepsy (DRE) patients (ages 3-15 years) by comparing outcomes classified as successful (Engel I or II) versus unsuccessful (Engel III or IV) at 1 year post-surgery.</p><p><strong>Results: </strong>Of 30 reviewed patients, 17 met the inclusion criteria. The combined dynamic index (im-DNM) integrating rs-iEEG and rs-fMRI significantly differentiated good (Engel I-II) from poor (Engel III-IV) surgical outcomes, outperforming the predictive accuracy of individual biomarkers from either modality alone.</p><p><strong>Conclusion: </strong>The combined dynamic network model demonstrated superior predictive performance than standalone rs-fMRI or rs-iEEG indices.</p><p><strong>Significance: </strong>By leveraging interictal data from two complementary modalities, this combined approach has the potential to improve epilepsy surgical outcomes, increase surgical candidacy, and reduce the duration of invasive monitoring.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"4 ","pages":"1491967"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musician's dystonia: a perspective on the strongest evidence towards new prevention and mitigation treatments.","authors":"Joy Grifoni, Valeria Crispiatico, Anna Castagna, Rosa Maria Converti, Marina Ramella, Angelo Quartarone, Teresa L'Abbate, Karolina Armonaite, Luca Paulon, Francescaroberta Panuccio, Franca Tecchio","doi":"10.3389/fnetp.2024.1508592","DOIUrl":"10.3389/fnetp.2024.1508592","url":null,"abstract":"<p><p>This perspective article addresses the critical and up-to-date problem of task-specific musician's dystonia (MD) from both theoretical and practical perspectives. Theoretically, MD is explored as a result of impaired sensorimotor interplay across different brain circuits, supported by the most frequently cited scientific evidence-each referenced dozens of times in Scopus. Practically, MD is a significant issue as it occurs over 60 times more frequently in musicians compared to other professions, underscoring the influence of individual training as well as environmental, social, and emotional factors. To address these challenges, we propose a novel application of the FeeSyCy principle (feedback-synchrony-plasticity), which emphasizes the pivotal role of feedback in guiding inter-neuronal synchronization and plasticity-the foundation of learning and memory. This model integrates with established literature to form a comprehensive framework for understanding MD as an impaired FeeSyCy-mediated relationship between the individual and their environment, ultimately leading to trauma. The proposed approach provides significant advantages by enabling the development of innovative therapeutic and preventive strategies. Specifically, it lays the groundwork for multimodal psycho-physical therapies aimed at restoring balance in the neural circuits affected by MD. These strategies include personalized psychotherapy combined with physical rehabilitation to address both the psychological and physiological dimensions of MD. This integration offers a practical and value-added solution to this pressing problem, with potential for broad applicability across similar conditions.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"4 ","pages":"1508592"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External low energy electromagnetic fields affect heart dynamics: surrogate for system synchronization, chaos control and cancer patient's health.","authors":"Frederico P Costa, Jack Tuszynski, Antonio F Iemma, Willian A Trevizan, Bertram Wiedenmann, Eckehard Schöll","doi":"10.3389/fnetp.2024.1525135","DOIUrl":"10.3389/fnetp.2024.1525135","url":null,"abstract":"<p><p>All cells in the human body, including cancer cells, possess specific electrical properties crucial for their functions. These properties are notably different between normal and cancerous cells. Cancer cells are characterized by autonomous oscillations and damped electromagnetic field (EMF) activation. Cancer reduces physiological variability, implying a systemic disconnection that desynchronizes bodily systems and their inherent random processes. The dynamics of heart rate, in this context, could reflect global physiological network instability in the sense of entrainment. Using a medical device that employs an active closed-loop system, such as administering specifically modulated EMF frequencies at targeted intervals and at low energies, we can evaluate the periodic oscillations of the heart. This procedure serves as a closed-loop control mechanism leading to a temporary alteration in plasma membrane ionic flow and the heart's periodic oscillation dynamics. The understanding of this phenomenon is supported by computer simulations of a mathematical model, which are validated by experimental data. Heart dynamics can be quantified using difference logistic equations, and it correlates with improved overall survival rates in cancer patients.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"4 ","pages":"1525135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The constrained-disorder principle defines the functions of systems in nature.","authors":"Yaron Ilan","doi":"10.3389/fnetp.2024.1361915","DOIUrl":"10.3389/fnetp.2024.1361915","url":null,"abstract":"<p><p>The Constrained Disorder Principle (CDP) defines all systems in nature by their degree of inherent variability. Per the CDP, the intrinsic variability is mandatory for their proper function and is dynamically changed based on pressures. The CDP defines the boundaries of inherent variability as a mechanism for continuous adaptation to internal and external perturbations, enabling survival and function under dynamic conditions. The laws of nature govern the world's natural phenomena and underlie the function of all systems. Nevertheless, the laws of physics do not entirely explain systems' functionality under pressure, which is essential for determining the correct operation of complex systems in nature. Variability and noise are two broad sources of inherent unpredictability in biology and technology. This paper explores how the CDP defines the function of systems and provides examples from various areas in nature where the CDP applies, including climate, genetic, biology, and human behavioral variabilities. According to the CDP, system malfunction results from inappropriate performance of the boundaries of inherent variability. The environment influences the physiological variability, and species interactions influence eco-evolutionary outcomes. The CDP defines human behavior as being driven by randomness and accounts for malfunctions and their corrections. The paper reviews variability-based CDP algorithms and CDP-based second-generation artificial intelligence systems and their potential for improving systems' prediction and efficiency by using variability.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"4 ","pages":"1361915"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body - a comprehensive review.","authors":"Frederico P Costa, Bertram Wiedenmann, Eckehard Schöll, Jack Tuszynski","doi":"10.3389/fnetp.2024.1483401","DOIUrl":"10.3389/fnetp.2024.1483401","url":null,"abstract":"<p><p>A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to possess characteristic electrical properties critical for physiological behavior, with major differences between normal and cancer cell counterparts. This opportunity can be explored as a novel treatment modality in Oncology. Cancer cells exhibit autonomous oscillations, deviating from normal rhythms. In this context, a shift from a static view of cellular processes is required for a better understanding of the dynamic connections between cellular metabolism, gene expression, cell signaling and membrane polarization as states in constant flux in realistic human models. In oncology, radiofrequency electromagnetic fields have produced sustained responses and improved quality of life in cancer patients with minimal side effects. This review aims to show how non-thermal systemic radiofrequency electromagnetic fields leads to promising therapeutic responses at cellular and tissue levels in humans, supporting this newly emerging cancer treatment modality with early favorable clinical experience specifically in advanced cancer.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"4 ","pages":"1483401"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant nocturnal wakefulness after sleep onset in metabolic dysfunction-associated steatotic liver disease.","authors":"Sofia Schaeffer, Andrijana Bogdanovic, Talitha Hildebrandt, Emilio Flint, Anne Geng, Sylvia Pecenko, Paul Lussier, Michael A Strumberger, Martin Meyer, Jakob Weber, Markus H Heim, Christian Cajochen, Christine Bernsmeier","doi":"10.3389/fnetp.2024.1458665","DOIUrl":"10.3389/fnetp.2024.1458665","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease with a multifactorial pathogenesis involving dietary, environmental, and genetic factors. Previous mouse models suggested that circadian misalignment may additionally influence its development as it influences metabolism in diverse organs including the liver. Further, data from sleep questionnaires proved sleep-wake disruption in patients with MASLD. We objectively assessed sleep-wake rhythms in patients with biopsy-proven MASLD (n = 35) and healthy controls (HC, n = 16) using actigraphy 24/7 for 4 weeks. With the aim to re-align sleep rhythms a single standardized sleep hygiene education session was performed after 2 weeks. Actigraphy data revealed that MASLD patients had more awakenings per night (MASLD vs. HC 8.5 vs. 5.5, <i>p</i> = 0.0036), longer wakefulness after sleep onset (MASLD vs. HC 45.4 min vs. 21.3 min, <i>p</i> = 0.0004), and decreased sleep efficiency (MASLD vs. HC 86.5% vs. 92.8%, <i>p</i> = 0.0008) compared with HC despite comparable sleep duration. Patients with MASLD self-reported shorter sleep duration (MASLD vs. HC 6 h vs. 6 h 45 min, <i>p</i> = 0.01) and prolonged sleep latency contributing to poorer sleep quality. Standardized sleep hygiene education did not produce significant changes in sleep parameters. Our findings indicate fragmented nocturnal sleep in patients with MASLD, characterized by increased wakefulness and reduced sleep efficiency, perceived subjectively as shortened sleep duration and delayed onset. A single sleep hygiene education session did not improve sleep parameters.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":"4 ","pages":"1458665"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}