Frontiers in network physiology最新文献

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Inter-muscular networks of synchronous muscle fiber activation. 同步肌纤维激活的肌间网络。
Frontiers in network physiology Pub Date : 2022-11-14 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.1059793
Sergi Garcia-Retortillo, Plamen Ch Ivanov
{"title":"Inter-muscular networks of synchronous muscle fiber activation.","authors":"Sergi Garcia-Retortillo,&nbsp;Plamen Ch Ivanov","doi":"10.3389/fnetp.2022.1059793","DOIUrl":"10.3389/fnetp.2022.1059793","url":null,"abstract":"<p><p>Skeletal muscles continuously coordinate to facilitate a wide range of movements. Muscle fiber composition and timing of activation account for distinct muscle functions and dynamics necessary to fine tune muscle coordination and generate movements. Here we address the fundamental question of how distinct muscle fiber types dynamically synchronize and integrate as a network across muscles with different functions. We uncover that physiological states are characterized by unique inter-muscular network of muscle fiber cross-frequency interactions with hierarchical organization of distinct sub-networks and modules, and a stratification profile of links strength specific for each state. We establish how this network reorganizes with transition from rest to exercise and fatigue-a complex process where network modules follow distinct phase-space trajectories reflecting their functional role in movements and adaptation to fatigue. This opens a new area of research, Network Physiology of Exercise, leading to novel network-based biomarkers of health, fitness and clinical conditions.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9125261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
On the scaling properties of oscillatory modes with balanced energy. 关于具有平衡能量的振荡模式的缩放特性。
Frontiers in network physiology Pub Date : 2022-11-08 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.974373
Dobromir G Dotov
{"title":"On the scaling properties of oscillatory modes with balanced energy.","authors":"Dobromir G Dotov","doi":"10.3389/fnetp.2022.974373","DOIUrl":"10.3389/fnetp.2022.974373","url":null,"abstract":"<p><p>Animal bodies maintain themselves with the help of networks of physiological processes operating over a wide range of timescales. Many physiological signals are characterized by 1/<i>f</i> scaling where the amplitude is inversely proportional to frequency, presumably reflecting the multi-scale nature of the underlying network. Although there are many general theories of such scaling, it is less clear how they are grounded on the specific constraints faced by biological systems. To help understand the nature of this phenomenon, we propose to pay attention not only to the geometry of scaling processes but also to their energy. The first key assumption is that physiological action modes constitute thermodynamic work cycles. This is formalized in terms of a theoretically defined oscillator with dissipation and energy-pumping terms. The second assumption is that the energy levels of the physiological action modes are balanced on average to enable flexible switching among them. These ideas were addressed with a modelling study. An ensemble of dissipative oscillators exhibited inverse scaling of amplitude and frequency when the individual oscillators' energies are held equal. Furthermore, such ensembles behaved like the Weierstrass function and reproduced the scaling phenomenon. Finally, the question is raised whether this kind of constraint applies both to broadband aperiodic signals and periodic, narrow-band oscillations such as those found in electrical cortical activity.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9500047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphometric similarity networks discriminate patients with lumbar disc herniation from healthy controls and predict pain intensity. 形态计量学相似性网络可区分腰椎间盘突出症患者和健康对照组,并预测疼痛强度。
Frontiers in network physiology Pub Date : 2022-10-25 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.992662
Lili Yang, Andrew D Vigotsky, Binbin Wu, Bangli Shen, Zhihan Yan, A Vania Apkarian, Lejian Huang
{"title":"Morphometric similarity networks discriminate patients with lumbar disc herniation from healthy controls and predict pain intensity.","authors":"Lili Yang, Andrew D Vigotsky, Binbin Wu, Bangli Shen, Zhihan Yan, A Vania Apkarian, Lejian Huang","doi":"10.3389/fnetp.2022.992662","DOIUrl":"10.3389/fnetp.2022.992662","url":null,"abstract":"<p><p>We used a recently advanced technique, morphometric similarity (MS), in a large sample of lumbar disc herniation patients with chronic pain (LDH-CP) to examine morphometric features derived from multimodal MRI data. To do so, we evenly allocated 136 LDH-CPs to exploratory and validation groups with matched healthy controls (HC), randomly chosen from the pool of 157 HCs. We developed three MS-based models to discriminate LDH-CPs from HCs and to predict the pain intensity of LDH-CPs. In addition, we created analogous models using resting state functional connectivity (FC) to perform the above discrimination and prediction of pain, in addition to comparing the performance of FC- and MS-based models and investigating if an ensemble model, combining morphometric features and resting-state signals, could improve performance. We conclude that 1) MS-based models were able to discriminate LDH-CPs from HCs and the MS networks (MSN) model performed best; 2) MSN was able to predict the pain intensity of LDH-CPs; 3) FC networks constructed were able to discriminate LDH-CPs from HCs, but they could not predict pain intensity; and 4) the ensemble model neither improved discrimination nor pain prediction performance. Generally, MSN is sensitive enough to uncover brain morphology alterations associated with chronic pain and provides novel insights regarding the neuropathology of chronic pain.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9129611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global and non-Global slow oscillations differentiate in their depth profiles. 全球和非全球缓慢振荡在深度剖面上有所不同。
Frontiers in network physiology Pub Date : 2022-10-24 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.947618
Sang-Cheol Seok, Elizabeth McDevitt, Sara C Mednick, Paola Malerba
{"title":"Global and non-Global slow oscillations differentiate in their depth profiles.","authors":"Sang-Cheol Seok, Elizabeth McDevitt, Sara C Mednick, Paola Malerba","doi":"10.3389/fnetp.2022.947618","DOIUrl":"10.3389/fnetp.2022.947618","url":null,"abstract":"<p><p>Sleep slow oscillations (SOs, 0.5-1.5 Hz) are thought to organize activity across cortical and subcortical structures, leading to selective synaptic changes that mediate consolidation of recent memories. Currently, the specific mechanism that allows for this selectively coherent activation across brain regions is not understood. Our previous research has shown that SOs can be classified on the scalp as Global, Local or Frontal, where Global SOs are found in most electrodes within a short time delay and gate long-range information flow during NREM sleep. The functional significance of space-time profiles of SOs hinges on testing if these differential SOs scalp profiles are mirrored by differential depth structure of SOs in the brain. In this study, we built an analytical framework to allow for the characterization of SO depth profiles in space-time across cortical and sub-cortical regions. To test if the two SO types could be differentiated in their cortical-subcortical activity, we trained 30 machine learning classification algorithms to distinguish Global and non-Global SOs within each individual, and repeated this analysis for light (Stage 2, S2) and deep (slow wave sleep, SWS) NREM stages separately. Multiple algorithms reached high performance across all participants, in particular algorithms based on k-nearest neighbors classification principles. Univariate feature ranking and selection showed that the most differentiating features for Global vs. non-Global SOs appeared around the trough of the SO, and in regions including cortex, thalamus, caudate nucleus, and brainstem. Results also indicated that differentiation during S2 required an extended network of current from cortical-subcortical regions, including all regions found in SWS and other basal ganglia regions, and amygdala and hippocampus, suggesting a potential functional differentiation in the role of Global SOs in S2 vs. SWS. We interpret our results as supporting the potential functional difference of Global and non-Global SOs in sleep dynamics.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes. 不同 E/I 平衡机制下共振神经元网络同步的异质机制
Frontiers in network physiology Pub Date : 2022-09-30 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.975951
Jiaxing Wu, Sara J Aton, Victoria Booth, Michal Zochowski
{"title":"Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes.","authors":"Jiaxing Wu, Sara J Aton, Victoria Booth, Michal Zochowski","doi":"10.3389/fnetp.2022.975951","DOIUrl":"10.3389/fnetp.2022.975951","url":null,"abstract":"<p><p>Rhythmic synchronization of neuronal firing patterns is a widely present phenomenon in the brain-one that seems to be essential for many cognitive processes. A variety of mechanisms contribute to generation and synchronization of network oscillations, ranging from intrinsic cellular excitability to network mediated effects. However, it is unclear how these mechanisms interact together. Here, using computational modeling of excitatory-inhibitory neural networks, we show that different synchronization mechanisms dominate network dynamics at different levels of excitation and inhibition (i.e. E/I levels) as synaptic strength is systematically varied. Our results show that with low synaptic strength networks are sensitive to external oscillatory drive as a synchronizing mechanism-a hallmark of resonance. In contrast, in a strongly-connected regime, synchronization is driven by network effects via the direct interaction between excitation and inhibition, and spontaneous oscillations and cross-frequency coupling emerge. Unexpectedly, we find that while excitation dominates network synchrony at low excitatory coupling strengths, inhibition dominates at high excitatory coupling strengths. Together, our results provide novel insights into the oscillatory modulation of firing patterns in different excitation/inhibition regimes.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long- and short-term fluctuations compared for several organ systems across sleep stages. 比较多个器官系统在不同睡眠阶段的长期和短期波动。
Frontiers in network physiology Pub Date : 2022-09-09 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.937130
Johannes Zschocke, Ronny P Bartsch, Martin Glos, Thomas Penzel, Rafael Mikolajczyk, Jan W Kantelhardt
{"title":"Long- and short-term fluctuations compared for several organ systems across sleep stages.","authors":"Johannes Zschocke, Ronny P Bartsch, Martin Glos, Thomas Penzel, Rafael Mikolajczyk, Jan W Kantelhardt","doi":"10.3389/fnetp.2022.937130","DOIUrl":"10.3389/fnetp.2022.937130","url":null,"abstract":"<p><p>Some details of cardiovascular and cardio-respiratory regulation and their changes during different sleep stages remain still unknown. In this paper we compared the fluctuations of heart rate, pulse rate, respiration frequency, and pulse transit times as well as EEG alpha-band power on time scales from 6 to 200 s during different sleep stages in order to better understand regulatory pathways. The five considered time series were derived from ECG, photoplethysmogram, nasal air flow, and central electrode EEG measurements from full-night polysomnography recordings of 246 subjects with suspected sleep disorders. We applied detrended fluctuation analysis, distinguishing between short-term (6-16 s) and long-term (50-200 s) correlations, i.e., scaling behavior characterized by the fluctuation exponents <i>α</i> <sub>1</sub> and <i>α</i> <sub>2</sub> related with parasympathetic and sympathetic control, respectively. While heart rate (and pulse rate) are characterized by sex and age-dependent short-term correlations, their long-term correlations exhibit the well-known sleep stage dependence: weak long-term correlations during non-REM sleep and pronounced long-term correlations during REM sleep and wakefulness. In contrast, pulse transit times, which are believed to be mainly affected by blood pressure and arterial stiffness, do not show differences between short-term and long-term exponents. This is in constrast to previous results for blood pressure time series, where <i>α</i> <sub>1</sub> was much larger than <i>α</i> <sub>2</sub>, and therefore questions a very close relation between pulse transit times and blood pressure values. Nevertheless, very similar sleep-stage dependent differences are observed for the long-term fluctuation exponent <i>α</i> <sub>2</sub> in all considered signals including EEG alpha-band power. In conclusion, we found that the observed fluctuation exponents are very robust and hardly modified by body mass index, alcohol consumption, smoking, or sleep disorders. The long-term fluctuations of all observed systems seem to be modulated by patterns following sleep stages generated in the brain and thus regulated in a similar manner, while short-term regulations differ between the organ systems. Deviations from the reported dependence in any of the signals should be indicative of problems in the function of the particular organ system or its control mechanisms.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9500043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics. 将生理学与平均场动力学联系起来的机械性神经质量模型的发展。
Frontiers in network physiology Pub Date : 2022-09-01 DOI: 10.3389/fnetp.2022.911090
Richa Tripathi, Bruce J Gluckman
{"title":"Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics.","authors":"Richa Tripathi,&nbsp;Bruce J Gluckman","doi":"10.3389/fnetp.2022.911090","DOIUrl":"https://doi.org/10.3389/fnetp.2022.911090","url":null,"abstract":"<p><p>Brain rhythms emerge from the mean-field activity of networks of neurons. There have been many efforts to build mathematical and computational embodiments in the form of discrete cell-group activities-termed neural masses-to understand in particular the origins of evoked potentials, intrinsic patterns of activities such as theta, regulation of sleep, Parkinson's disease related dynamics, and mimic seizure dynamics. As originally utilized, standard neural masses convert input through a sigmoidal function to a firing rate, and firing rate through a synaptic alpha function to other masses. Here we define a process to build mechanistic neural masses (mNMs) as mean-field models of microscopic membrane-type (Hodgkin Huxley type) models of different neuron types that duplicate the stability, firing rate, and associated bifurcations as function of relevant slow variables - such as extracellular potassium - and synaptic current; and whose output is both firing rate and impact on the slow variables - such as transmembrane potassium flux. Small networks composed of just excitatory and inhibitory mNMs demonstrate expected dynamical states including firing, runaway excitation and depolarization block, and these transitions change in biologically observed ways with changes in extracellular potassium and excitatory-inhibitory balance.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9127926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Modelling the perception of music in brain network dynamics. 用大脑网络动力学模拟音乐感知。
Frontiers in network physiology Pub Date : 2022-08-29 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.910920
Jakub Sawicki, Lenz Hartmann, Rolf Bader, Eckehard Schöll
{"title":"Modelling the perception of music in brain network dynamics.","authors":"Jakub Sawicki, Lenz Hartmann, Rolf Bader, Eckehard Schöll","doi":"10.3389/fnetp.2022.910920","DOIUrl":"10.3389/fnetp.2022.910920","url":null,"abstract":"<p><p>We analyze the influence of music in a network of FitzHugh-Nagumo oscillators with empirical structural connectivity measured in healthy human subjects. We report an increase of coherence between the global dynamics in our network and the input signal induced by a specific music song. We show that the level of coherence depends crucially on the frequency band. We compare our results with experimental data, which also describe global neural synchronization between different brain regions in the gamma-band range in a time-dependent manner correlated with musical large-scale form, showing increased synchronization just before transitions between different parts in a musical piece (musical high-level events). The results also suggest a separation in musical form-related brain synchronization between high brain frequencies, associated with neocortical activity, and low frequencies in the range of dance movements, associated with interactivity between cortical and subcortical regions.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9484203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Adaptive networks in functional modeling of physiological systems. 社论:生理系统功能建模中的自适应网络。
Frontiers in network physiology Pub Date : 2022-08-25 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.996784
Eckehard Schöll, Jakub Sawicki, Rico Berner, Plamen Ch Ivanov
{"title":"Editorial: Adaptive networks in functional modeling of physiological systems.","authors":"Eckehard Schöll, Jakub Sawicki, Rico Berner, Plamen Ch Ivanov","doi":"10.3389/fnetp.2022.996784","DOIUrl":"10.3389/fnetp.2022.996784","url":null,"abstract":"","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9125267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Models and Tools can Contribute to a Better Understanding of Brain Activity? 哪些模型和工具有助于更好地了解大脑活动?
Frontiers in network physiology Pub Date : 2022-07-18 eCollection Date: 2022-01-01 DOI: 10.3389/fnetp.2022.907995
Marc Goodfellow, Ralph G Andrzejak, Cristina Masoller, Klaus Lehnertz
{"title":"What Models and Tools can Contribute to a Better Understanding of Brain Activity?","authors":"Marc Goodfellow, Ralph G Andrzejak, Cristina Masoller, Klaus Lehnertz","doi":"10.3389/fnetp.2022.907995","DOIUrl":"10.3389/fnetp.2022.907995","url":null,"abstract":"<p><p>Despite impressive scientific advances in understanding the structure and function of the human brain, big challenges remain. A deep understanding of healthy and aberrant brain activity at a wide range of temporal and spatial scales is needed. Here we discuss, from an interdisciplinary network perspective, the advancements in physical and mathematical modeling as well as in data analysis techniques that, in our opinion, have potential to further advance our understanding of brain structure and function.</p>","PeriodicalId":73092,"journal":{"name":"Frontiers in network physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9125265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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