Advances In Anatomic Pathology最新文献_第5页

Gastrointestinal Stromal Tumors: Variants and Some Pitfalls That They Create. 胃肠道间质瘤：变异及其带来的一些陷阱。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1097/PAP.0000000000000463

Ammoura Ibrahim, Elizabeth A Montgomery

{"title":"Gastrointestinal Stromal Tumors: Variants and Some Pitfalls That They Create.","authors":"Ammoura Ibrahim, Elizabeth A Montgomery","doi":"10.1097/PAP.0000000000000463","DOIUrl":"10.1097/PAP.0000000000000463","url":null,"abstract":"The diagnosis of gastrointestinal stromal tumors (GISTs) is generally straightforward using a combination of histologic evaluation and pertinent immunohistochemical staining with CD117/kit and DOG-1 (discovered on GIST) antibodies. However, this tumor can be challenging in cases with an unusual morphology, in limited biopsies, for those in uncommon sites, post-treatment, and when other neoplasms express CD117/kit and DOG-1, thereby mimicking GIST. Finding epithelioid GISTs in the stomach in younger patients should prompt testing for succinate dehydrogenase (SHD)-deficiency using immunohistochemical staining for subunit B (SDHB). However, SDH-deficient GISTs can also arise in older patients, or as part of the Carney triad or Carney-Stratakis syndrome. GISTs with PDGFRA mutations can also prove difficult if they lack kit expression. It is also important to consider morphologic and immunophenotypic changes associated with treatment, including the potential absence of kit expression, particularly in GISTs that have metastasized. Therefore, obtaining clinical information regarding prior therapy with a tyrosine kinase inhibitor (TKI) is crucial.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"31 6","pages":"354-363"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laryngectomy Margin Assessment: A Little Help From a Template. 喉切除术边缘评估：模板的一点帮助。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-10-31 DOI: 10.1097/PAP.0000000000000471

Daniel J Zaccarini, Lester D R Thompson

引用次数: 0

Molecularly Defined Thoracic Neoplasms. 分子定义的胸部肿瘤。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-19 DOI: 10.1097/PAP.0000000000000439

Anja C Roden

{"title":"Molecularly Defined Thoracic Neoplasms.","authors":"Anja C Roden","doi":"10.1097/PAP.0000000000000439","DOIUrl":"10.1097/PAP.0000000000000439","url":null,"abstract":"Molecularly defined neoplasms are increasingly recognized, given the broader application and performance of molecular studies. These studies allow us to better characterize these neoplasms and learn about their pathogenesis. In the thorax, molecularly defined neoplasms include tumors such as NUT carcinoma, SMARCA4-deficient undifferentiated tumor (DUT), primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms. Overall, these tumors are rare but are now more often recognized given more widely available immunostains such as NUT (NUT carcinoma), BRG1 (SMARCA4-DUT), and INI-1 (SMARCB1-deficient neoplasm). Furthermore, cytogenetic studies for EWSR1 to support a hyalinizing clear cell carcinoma or primary pulmonary myxoid sarcoma are, in general, easily accessible. This enables pathologists to recognize and diagnose these tumors. The diagnosis of these tumors is important for clinical management and treatment. For instance, clinical trials are available for patients with NUT carcinoma, SMARCA4-DUT, and SMACRB1-deficient neoplasms. Herein, our current knowledge of clinical, morphologic, immunophenotypic, and molecular features of NUT carcinomas, SMARCA4-DUT, primary pulmonary myxoid sarcomas, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms will be reviewed.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"303-317"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence and Lung Pathology. 人工智能与肺部病理学

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-23 DOI: 10.1097/PAP.0000000000000448

Emanuel Caranfil, Kris Lami, Wataru Uegami, Junya Fukuoka

引用次数: 0

Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls. 肺腺癌侵袭的形态学特征：诊断陷阱。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-13 DOI: 10.1097/PAP.0000000000000451

Erik Thunnissen, Masayuki Noguchi, Sabina Berezowska, Mauro Giulio Papotti, Federica Filipello, Yuko Minami, Hans Blaauwgeers

引用次数: 0

From Morphology to Molecules: Advances in the Distinction of Multiple Primary Lung Cancers From Intrapulmonary Metastases in Non-Small Cell Lung Cancer. 从形态到分子：非小细胞肺癌多原发肺癌与肺内转移瘤的鉴别进展。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI: 10.1097/PAP.0000000000000449

Gheorghe-Emilian Olteanu, Izidor Kern, Lipika Kalson, Luka Brcic

{"title":"From Morphology to Molecules: Advances in the Distinction of Multiple Primary Lung Cancers From Intrapulmonary Metastases in Non-Small Cell Lung Cancer.","authors":"Gheorghe-Emilian Olteanu, Izidor Kern, Lipika Kalson, Luka Brcic","doi":"10.1097/PAP.0000000000000449","DOIUrl":"10.1097/PAP.0000000000000449","url":null,"abstract":"The increasing incidence of multiple lung nodules underscores the need for precise differentiation between multiple primary lung cancers (MPLCs) and intrapulmonary metastases (IPMs). This distinction impacts patient prognosis and treatment strategies. The prevalence of multiple lung nodules, ranging from 19.7% to 55.5%, highlights the clinical significance of this challenge. Historically, the role of histopathology, particularly comprehensive histology assessment (CHA), has been pivotal in differentiating MPLCs and IPMs. However, CHA has significant limitations, resulting in a constant search for a better way to distinguish those lesions. The best strategy for delineating MPLCs from IPMs is a multidisciplinary approach combining clinical data, radiology, histology, and molecular methods. Histology provides architectural and cellular characteristics, radiology contributes anatomic context and lesion characterization, and molecular methods reveal molecular features critical for accurate differentiation. Incorporating clinical data further enhances diagnostic precision. This review presents current knowledge and current approaches to multiple lung tumors. It is clear that even with a combination of pathology, radiology, and molecular data, definitive classification of multifocal lung tumors is not always possible.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"318-323"},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Thoracic Pathology. 胸部病理学的挑战。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1097/PAP.0000000000000456

Sanja Dacic, Luka Brcic

引用次数: 0

Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations. 原发性免疫缺陷单基因病相关极早发炎症性肠病的临床病理特征：聚焦IFIH1突变的胃肠道组织学特征。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2024-08-14 DOI: 10.1097/PAP.0000000000000457

Luisa Santoro, Federica Grillo, Maria D'Armiento, Anna Maria Buccoliero, Michele Rocco, Jacopo Ferro, Alessandro Vanoli, Barbara Cafferata, Maria Cristina Macciomei, Claudia Mescoli, Mara Cananzi, Rita Alaggio, Matteo Fassan, Luca Mastracci, Paola Francalanci, Paola Parente

{"title":"Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations.","authors":"Luisa Santoro, Federica Grillo, Maria D'Armiento, Anna Maria Buccoliero, Michele Rocco, Jacopo Ferro, Alessandro Vanoli, Barbara Cafferata, Maria Cristina Macciomei, Claudia Mescoli, Mara Cananzi, Rita Alaggio, Matteo Fassan, Luca Mastracci, Paola Francalanci, Paola Parente","doi":"10.1097/PAP.0000000000000457","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000457","url":null,"abstract":"Very early onset inflammatory bowel disease (VEO-IBD) is a clinical term referring to IBD-like symptomatology arising in children younger than 6 years. VEO-IBD may be due to polygenic etiology in \"pure\" IBD (Crohn disease-CD and ulcerative colitis-UC), or it may be caused by primary immunodeficiency underlined by monogenic disease. Primary immunodeficiency monogenic diseases have a Mendelian inheritance and affect the immune system with multiorgan morbidity and possible effects on the gastrointestinal system. Primary Immunodeficiency monogenic diseases differ from \"pure\" IBD as the latter primarily affect the gastrointestinal tract with mitigated extraintestinal symptomatology. Since their first description, primary immunodeficiency monogenic diseases, although rare, have been the subject of increasing interest due to their dramatic phenotype, difficulty in reaching a timely diagnosis, and specific therapeutic approach. In this paper, we present a brief review of primary immunodeficiency monogenic diseases, focusing on to their clinicopathologic features as well as delving, in greater detail, into monogenic diseases caused by IFIH1 mutations. The clinicopathologic features of 4 patients with IFIH1, a gene involved in interferon pathway deficiency, will be described using a histologic pattern of damage approach confirming the need to avoid the histologic diagnosis of VEO-IBD in children younger than 6 years.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

#PathX: #PathTwitter's Transformation and a Discussion on Different Social Media Platforms Used by Pathologists in 2024. #PathX: #PathTwitter的转型以及2024年病理学家使用的不同社交媒体平台的讨论。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2024-07-01 Epub Date: 2023-12-04 DOI: 10.1097/PAP.0000000000000424

Casey P Schukow, Lavisha S Punjabi, Fadi W Abdul-Karim

引用次数: 0

Modernizing Forensic Pathology Education on TikTok: Lessons Learned on this "Social Media Frontier". TikTok 上的法医病理学教育现代化：在 "社交媒体前沿 "吸取的经验教训。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2024-07-01 Epub Date: 2024-02-05 DOI: 10.1097/PAP.0000000000000437

Casey P Schukow, Meredith K Herman, Julia Kochanowski, Patrick A Hansma

引用次数: 0