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IgG4-related Sclerosing Disease of the Gallbladder: Incidental Malignancy Mimicker Associated With Cholelithiasis? IgG4相关胆囊硬化症：与胆石症相关的偶发恶性肿瘤模仿者？
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1097/PAP.0000000000000453
Domenika Ortiz Requena, Julio Poveda, Oliver G McDonald, Nemencio Ronquillo, Monica Garcia-Buitrago, Elizabeth A Montgomery
{"title":"IgG4-related Sclerosing Disease of the Gallbladder: Incidental Malignancy Mimicker Associated With Cholelithiasis?","authors":"Domenika Ortiz Requena, Julio Poveda, Oliver G McDonald, Nemencio Ronquillo, Monica Garcia-Buitrago, Elizabeth A Montgomery","doi":"10.1097/PAP.0000000000000453","DOIUrl":"10.1097/PAP.0000000000000453","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"251-255"},"PeriodicalIF":5.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Involvement of Skin and Soft Tissue by Erdheim-Chester Disease. Arkadi M. Rywlin 国际病理学幻灯片研讨会精选病例：埃尔德海姆-切斯特病累及皮肤和软组织。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-07-01 Epub Date: 2024-01-05 DOI: 10.1097/PAP.0000000000000429
David I Suster, Shira Ronen, Saul Suster
{"title":"Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Involvement of Skin and Soft Tissue by Erdheim-Chester Disease.","authors":"David I Suster, Shira Ronen, Saul Suster","doi":"10.1097/PAP.0000000000000429","DOIUrl":"10.1097/PAP.0000000000000429","url":null,"abstract":"<p><p>Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis that preferentially involves long bones but can affect a variety of other organs. Initial presentation with extraskeletal involvement is not unusual and is most commonly observed in the central nervous system, heart, retroperitoneum, lungs, and skin. Initial presentation of the disease as a subcutaneous soft tissue mass is exceedingly rare and may pose difficulties for diagnosis. We describe a case of Erdheim-Chester disease that initially presented as a cutaneous and subcutaneous soft tissue mass in the right posterior shoulder of a 52-year-old man.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"271-274"},"PeriodicalIF":5.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Cord-Stromal Tumors of the Ovary: An Update and Review. Part I - Pure Ovarian Stromal Tumors. 卵巢性索间质瘤：最新进展与回顾。第一部分--纯卵巢间质瘤。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-07-01 Epub Date: 2024-02-19 DOI: 10.1097/PAP.0000000000000435
Kyle M Devins, Robert H Young, Esther Oliva
{"title":"Sex Cord-Stromal Tumors of the Ovary: An Update and Review. Part I - Pure Ovarian Stromal Tumors.","authors":"Kyle M Devins, Robert H Young, Esther Oliva","doi":"10.1097/PAP.0000000000000435","DOIUrl":"10.1097/PAP.0000000000000435","url":null,"abstract":"<p><p>In two separate reviews, we review the time-honored but still frequently challenging features of ovarian sex cord-stromal tumors, and also emphasize new developments including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part on the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr Robert E. Scully. In part I, we present the major clinical, pathologic, and genomic features of the pure ovarian stromal tumors including comments on differential diagnosis and briefly note significant historical contributions. In part II we will discuss pure sex cord and sex cord-stromal tumors.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"215-230"},"PeriodicalIF":6.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Cord-Stromal Tumors of the Ovary: An Update and Review. Part II - Pure Sex Cord and Sex Cord-Stromal Tumors. 卵巢性索间质瘤：最新进展与回顾。第二部分--纯性脐带和性脐带间质瘤。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-07-01 Epub Date: 2024-02-29 DOI: 10.1097/PAP.0000000000000436
Kyle M Devins, Robert H Young, Esther Oliva
{"title":"Sex Cord-Stromal Tumors of the Ovary: An Update and Review. Part II - Pure Sex Cord and Sex Cord-Stromal Tumors.","authors":"Kyle M Devins, Robert H Young, Esther Oliva","doi":"10.1097/PAP.0000000000000436","DOIUrl":"10.1097/PAP.0000000000000436","url":null,"abstract":"<p><p>We review the time honored but still frequently challenging features of ovarian sex cord-stromal tumors and also emphasize new developments, including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part to the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr. Robert E. Scully. In part I, we reviewed the pure ovarian stromal tumors. Now, in part II, we present the major clinical, pathologic, and genomic features of pure sex cord and sex cord-stromal tumors.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"231-250"},"PeriodicalIF":6.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Social Media Paradox: Unravelling the Impact of Digital Networks on Pathology. 社交媒体悖论：揭示数字网络对病理学的影响。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-06-03 DOI: 10.1097/PAP.0000000000000455
Archit Goel, Gargi Kapatia, Amber Parwaiz, Shruti Gupta
{"title":"The Social Media Paradox: Unravelling the Impact of Digital Networks on Pathology.","authors":"Archit Goel, Gargi Kapatia, Amber Parwaiz, Shruti Gupta","doi":"10.1097/PAP.0000000000000455","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000455","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The International System for Reporting Serous Fluid Cytopathology: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies. 国际浆液细胞病理学报告系统：诊断测试准确性研究的系统回顾和元分析》。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-05-02 DOI: 10.1097/pap.0000000000000454
Fatima E Jamal, Johannes A Vey, Tanja Proctor, Angela Ishak, Fernando C Schmitt, Ilias P Nikas
{"title":"The International System for Reporting Serous Fluid Cytopathology: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies.","authors":"Fatima E Jamal, Johannes A Vey, Tanja Proctor, Angela Ishak, Fernando C Schmitt, Ilias P Nikas","doi":"10.1097/pap.0000000000000454","DOIUrl":"https://doi.org/10.1097/pap.0000000000000454","url":null,"abstract":"This is the first systematic review and meta-analysis of The International System (TIS) for reporting serous fluid cytopathology. Our aims were to present the pooled malignancy rate of each TIS reporting category and the diagnostic accuracy of cytology using this system. Database search using a predefined strategy was followed by study selection, data extraction, study quality assessment, and statistical analysis. Data derived from 16 eligible studies were pooled. The pooled rates of malignancy were as follows: 27% (95% CI; 16%-41%) for \"nondiagnostic\" (ND), 11% (95% CI; 7%-18%) for negative for malignancy\" (NFM), 49% (95% CI; 37%-61%) for \"atypia of undetermined significance\" (AUS), 90% (95% CI; 81%-95%) for \"suspicious for malignancy\" (SFM), and 100% (95% CI; 98%-100%) for \"positive for malignancy\" (MAL). Studies performed exclusively in cancer hospitals showed higher pooled malignancy rates, compared with academic and community hospitals serving the general population, in the ND [40% (95% CI; 21%-62%) vs. 22% (95% CI; 11%-39%)], NFM [20% (95% CI; 13%-30%) vs. 9% (95% CI; 5%-17%)], and AUS categories [55% (95% CI; 47%-63%) vs. 46% (95% CI; 31%-62%)]. Notably, the difference was significant in the NFM category (P=0.04). When both SFM and MAL cytology interpretations were considered as malignant outcomes, the pooled sensitivity and specificity were 68.74% (95% CI; 59.90%-76.39%) and 98.81% (95% CI; 98.18%-99.22%), respectively. In addition, the diagnostic odds ratio (DOR) was found to be 170.7 (95% CI; 96.2-303.3). Despite its strengths, our study also had some limitations. Therefore, future large-scale longitudinal studies could strengthen the findings of this review.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"60 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Subtypes of Bladder Cancer: Component Signatures and Potential Value in Clinical Decision-making. 膀胱癌的分子亚型：膀胱癌分子亚型：成分特征和临床决策的潜在价值。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-05-01 Epub Date: 2024-01-18 DOI: 10.1097/PAP.0000000000000430
Joshua Warrick
{"title":"Molecular Subtypes of Bladder Cancer: Component Signatures and Potential Value in Clinical Decision-making.","authors":"Joshua Warrick","doi":"10.1097/PAP.0000000000000430","DOIUrl":"10.1097/PAP.0000000000000430","url":null,"abstract":"<p><p>Bladder cancer may be classified into \"molecular subtypes\" based on gene expression. These are associated with treatment response and patient outcomes. The gene expression signatures that define these subtypes are diverse, including signatures of epithelial differentiation, stromal involvement, cell cycle activity, and immune cell infiltration. Multiple different systems are described. While earlier studies considered molecular subtypes to be intrinsic properties of cancer, recent data have shown molecular subtypes change as tumors progress and evolve, and often differ between histologically distinct regions of a tumor. The data also indicate that some signatures that define molecular subtypes may be treated as independent continuous variables, rather than categorical subtypes, and these individual signatures may be more clinically informative. This review describes molecular subtypes of urothelial carcinoma, including histologic subtypes and tumors with divergent differentiation, and explores potential future uses in patient management.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"178-187"},"PeriodicalIF":6.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates on Urinary Bladder Tumors With Neuroendocrine Features. 具有神经内分泌特征的膀胱肿瘤的最新进展。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-05-01 Epub Date: 2024-03-25 DOI: 10.1097/PAP.0000000000000433
Dilara Akbulut, Hikmat Al-Ahmadie
{"title":"Updates on Urinary Bladder Tumors With Neuroendocrine Features.","authors":"Dilara Akbulut, Hikmat Al-Ahmadie","doi":"10.1097/PAP.0000000000000433","DOIUrl":"10.1097/PAP.0000000000000433","url":null,"abstract":"<p><p>The most common neuroendocrine tumor in the urinary bladder is small cell carcinoma, which can be pure or mixed with components of urothelial or other histologic subtypes. Large cell neuroendocrine carcinoma of the bladder is rare and remains ill-defined but is increasingly recognized. Well-differentiated neuroendocrine tumor and paraganglioma can arise in the bladder but are very rare in this location. Recent advances in molecular characterization allowed for better classification and may offer improved stratification of these tumors.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"169-177"},"PeriodicalIF":5.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel and Emerging Concepts in Genitourinary Tumors Empowered in the Multidisciplinary and Molecular Era. 多学科和分子时代赋予泌尿生殖系统肿瘤的新概念。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI: 10.1097/PAP.0000000000000442
Gladell P Paner
{"title":"Novel and Emerging Concepts in Genitourinary Tumors Empowered in the Multidisciplinary and Molecular Era.","authors":"Gladell P Paner","doi":"10.1097/PAP.0000000000000442","DOIUrl":"10.1097/PAP.0000000000000442","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"145-146"},"PeriodicalIF":6.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Diagnostic Reporting for Prostatic Adenocarcinoma: Morphologic Aspects, Molecular Correlates, and Management Perspectives. 前列腺腺癌的当代诊断报告：形态学方面、分子相关性和管理视角。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-05-01 Epub Date: 2024-03-25 DOI: 10.1097/PAP.0000000000000444
Selvaraj Muthusamy, Steven Christopher Smith
{"title":"Contemporary Diagnostic Reporting for Prostatic Adenocarcinoma: Morphologic Aspects, Molecular Correlates, and Management Perspectives.","authors":"Selvaraj Muthusamy, Steven Christopher Smith","doi":"10.1097/PAP.0000000000000444","DOIUrl":"10.1097/PAP.0000000000000444","url":null,"abstract":"<p><p>The diagnosis and reporting of prostatic adenocarcinoma have evolved from the classic framework promulgated by Dr Donald Gleason in the 1960s into a complex and nuanced system of grading and reporting that nonetheless retains the essence of his remarkable observations. The criteria for the \"Gleason patterns\" originally proposed have been continually refined by consensuses in the field, and Gleason scores have been stratified into a patient-friendly set of prognostically validated and widely adopted Grade Groups. One product of this successful grading approach has been the opportunity for pathologists to report diagnoses that signal carefully personalized management, placing the surgical pathologist's interpretation at the center of patient care. At one end of the continuum of disease aggressiveness, personalized diagnostic care means to sub-stratify patients with more indolent disease for active surveillance, while at the other end of the continuum, reporting histologic markers signaling aggression allows sub-stratification of clinically significant disease. Whether contemporary reporting parameters represent deeper nuances of more established ones (eg, new criteria and/or quantitation of Gleason patterns 4 and 5) or represent additional features reported alongside grade (intraductal carcinoma, cribriform patterns of carcinoma), assessment and grading have become more complex and demanding. Herein, we explore these newer reporting parameters, highlighting the state of knowledge regarding morphologic, molecular, and management aspects. Emphasis is made on the increasing value and stakes of histopathologists' interpretations and reporting into current clinical risk stratification and treatment guidelines.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"188-201"},"PeriodicalIF":6.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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