Advances In Anatomic Pathology最新文献

Other Primary Epithelial Neoplasms of the Liver.

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-09 DOI: 10.1097/PAP.0000000000000494

Wai Szeto, Rifat Mannan

{"title":"Other Primary Epithelial Neoplasms of the Liver.","authors":"Wai Szeto, Rifat Mannan","doi":"10.1097/PAP.0000000000000494","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000494","url":null,"abstract":"Primary liver carcinoma (PLC) is the sixth most common malignancy worldwide and the third leading cause of cancer-related mortalities. Hepatocellular carcinoma (HCC) is the most prevalent form of PLC, followed by intrahepatic cholangiocarcinoma (iCCA). In addition, there is a group of rarer PLCs that do not fit neatly into the HCC or iCCA categories. This review explores this heterogeneous group, including combined hepatocellular-cholangiocarcinoma (cHCC-CCA), intermediate cell carcinoma (ICC), mixed hepatocellular-neuroendocrine carcinoma, and undifferentiated primary liver carcinoma. cHCC-CCA is a rare subtype of PLC, characterized by both hepatocytic and cholangiocytic differentiation within the same tumor. The latest WHO classification (2019, fifth edition) redefined cHCC-CCA by eliminating the \"stem cell subtypes\" and emphasized that diagnosis should primarily rely on morphologic features, supported by immunohistochemical staining to better define subtypes. Intermediate cell carcinoma is a subtype of cHCC-CCA and is comprised of monomorphic tumor cells that exhibit characteristics intermediate between hepatocytes and cholangiocytes, with immunohistochemical expression of hepatocytic and cholangiocytic markers within the same cell. Another rare entity, combined HCC and neuroendocrine carcinoma (NEC), contains an admixture of HCC and NEC components within the same tumor. Undifferentiated primary liver carcinoma, on the other hand, lacks definitive lineage differentiation beyond an epithelial phenotype. These heterogeneous PLCs pose diagnostic challenges owing to their mixed/unusual histologic features and overlapping immunohistochemical markers. They tend to have poor prognoses, highlighting the critical importance of accurate and timely diagnosis.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preneoplastic and Neoplastic Biliary Diseases.

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-07 DOI: 10.1097/PAP.0000000000000497

Tom Z Liang, Shefali Chopra

{"title":"Preneoplastic and Neoplastic Biliary Diseases.","authors":"Tom Z Liang, Shefali Chopra","doi":"10.1097/PAP.0000000000000497","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000497","url":null,"abstract":"Preneoplastic and neoplastic biliary disease comprises biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasms, mucinous cystic neoplasms (MCNs), and cholangiocarcinoma and their variants. Correct recognition of these entities can be challenging, especially on small/needle biopsies, but is required to plan therapy and guide transplant in the setting of cirrhosis. Salient histologic features of these entities, along with ancillary use of immunostains and key molecular findings aiding in diagnosis, are discussed. Type 2 intraductal papillary neoplasm of the bile ducts is typically associated with an invasive malignancy and lack unique molecular features associated with the Type 1 intraductal papillary neoplasm, thus they are called \"papillary cholangiocarcinoma\" by some authors. Some of the cholangiocarcinoma variants, like enteroblastic and mucoepidermoid, are under-recognized and can pose diagnostic challenges. The tubulocystic and cholangioblastic variants are relatively recently described but are being increasingly recognized. The cholangioblastic variant has a novel NIBPL-NACC1 fusion described in the more recent larger series reported, making it a somewhat unique variant of cholangiocarcinoma. Nomenclature of the cholangioblastic variant is in evolution as is the link between adenofibroma and the tubulocystic variant. Correct recognition of these variant subtypes would aid in long-term studies to better determine the prognosis in these subtypes.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemangioblastoma-like Clear Cell Stromal Tumor of the Lung: A Comprehensive Review With Insights From a Case.

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-07 DOI: 10.1097/PAP.0000000000000482

Jian Zeng, Peng Lushan, Qin Jing, Wei Du

引用次数: 0

Hepatoblastoma: Comprehensive Review With Recent Updates.

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-03 DOI: 10.1097/PAP.0000000000000495

Jingjing Jiao, Romil Saxena, Raffaella Morotti

{"title":"Hepatoblastoma: Comprehensive Review With Recent Updates.","authors":"Jingjing Jiao, Romil Saxena, Raffaella Morotti","doi":"10.1097/PAP.0000000000000495","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000495","url":null,"abstract":"Hepatoblastoma (HB), the most common primary malignant liver tumor of childhood, demonstrates remarkable histologic heterogeneity and can be classified into epithelial or mixed epithelial-mesenchymal subtypes. This review summarizes updates in histologic classification, molecular signatures, staging, and risk stratification of HB. The Children's Hepatic tumors International Collaboration represents an international effort to standardize the study of rare pediatric liver tumors; emphasis continues to remain on improving risk stratification by a combination of clinical, histologic, and molecular features to tailor treatment in a bid to reduce toxicity while maintaining or improving efficacy. Pure fetal HB is cured by complete resection without the need for adjuvant chemotherapy. Malignant rhabdoid tumors have been parsed out from small cell undifferentiated HBs by negative INI-1 staining on immunohistochemistry; these tumors require a distinct and more aggressive chemotherapeutic regimen. The significance of recently characterized \"blastema\" component in HB remains to be elucidated. Hepatocellular neoplasm, not otherwise specified, is a provisional diagnostic category for tumors exhibiting either intermediate or a combination of both HB and hepatocellular carcinoma histologic features. The Children's Hepatic tumors International Collaboration risk stratification algorithm includes age as an important discriminator of risk, in addition to AFP, metastasis, and PreTreatment EXTent of disease stage and its annotations.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Approach to the Bone Marrow Workup and Diagnosis of Eosinophilia and Mast Cell Disorders.

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-27 DOI: 10.1097/PAP.0000000000000486

Kaaren K Reichard, Tracy I George, Daniel A Arber

{"title":"An Approach to the Bone Marrow Workup and Diagnosis of Eosinophilia and Mast Cell Disorders.","authors":"Kaaren K Reichard, Tracy I George, Daniel A Arber","doi":"10.1097/PAP.0000000000000486","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000486","url":null,"abstract":"The approach to eosinophilia and mast cell disorders in the bone marrow is diverse and depends on multiple factors including access to ancillary testing, resources to support testing, type of practice setting (eg, community, remote, tertiary care center or specialized referral center for these disorders) and whether there are options for clinical trial enrollment. That said, while there are some basic principles to the workup that we can all likely agree upon, individual practice habits will need to be tailored to suit an individual setting. As such, the approach presented in this manuscript is meant to serve as a practical guide and not as dogma per se. Importantly, an in-depth discussion of individual diseases and International Consensus Classification diagnostic criteria will not be covered, as the main focus of this article is the approach to these disorders. The reader is referred to a comprehensive discussion of these diseases and diagnostic criteria in several excellent articles. While there are clear areas of overlap between eosinophilia and mast cell conditions (eg, systemic mastocytosis associated with eosinophilia, myeloid neoplasm with eosinophilia, and tyrosine kinase rearrangements), it is the authors' opinion that it is perhaps easier to navigate these entities separately (eg, eosinophilia as one broad topic and mast cell conditions as another) and to recognize the settings in which overlap may exist and what testing might be considered. Eosinophilia and mast cell conditions will be discussed separately supplemented by generous use of figures and tables to highlight key points.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Primer on Bluesky (and PathSky) for Pathologists, Trainees, and Medical Students.

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-24 DOI: 10.1097/PAP.0000000000000491

Casey P Schukow, Lavisha S Punjabi, Emma Khan

引用次数: 0

Bone Matrix-forming Tumors. 骨基质形成肿瘤

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1097/PAP.0000000000000476

Julio A Diaz-Perez, Andrew E Rosenberg

引用次数: 0

Cartilage Forming Tumors of the Skeleton. 骨骼软骨形成肿瘤。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1097/PAP.0000000000000475

Julio A Diaz-Perez, Andrew E Rosenberg

引用次数: 0

Giant Cell-Rich Tumors of the Skeleton. 富含巨细胞的骨骼肿瘤

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI: 10.1097/PAP.0000000000000477

Julio A Diaz-Perez, Andrew E Rosenberg

引用次数: 0

Mesenchymal Tumors of the Tubular Gastrointestinal Tract (Non-GIST): The GI Pathologist's Approach. 管状胃肠道间质瘤（非 GIST）：消化道病理学家的方法》。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1097/PAP.0000000000000469

Bence P Kővári, Gregory Y Lauwers

{"title":"Mesenchymal Tumors of the Tubular Gastrointestinal Tract (Non-GIST): The GI Pathologist's Approach.","authors":"Bence P Kővári, Gregory Y Lauwers","doi":"10.1097/PAP.0000000000000469","DOIUrl":"10.1097/PAP.0000000000000469","url":null,"abstract":"Mesenchymal neoplasms of the gastrointestinal tract are rare compared with epithelial lesions. However, over the past few decades, the increasing volume of gastrointestinal endoscopy has expedited the recognition of several novel entities with varying clinical significance. Its spectrum extends from reactive changes and benign neoplasms to highly aggressive sarcomas. At the malignant end of the spectrum, the importance of correctly diagnosing these tumors is underscored by the specific therapeutic implications available for some tumor types (eg, tyrosine kinase inhibitors for gastrointestinal stromal tumors) that allow personalized treatments. Benign lesions frequently surface among routine polypectomy specimens, sometimes offering diagnostic challenges. However, precise classification is the only way to avoid prognostic uncertainty and overtreatment, and to recognize possible syndromic associations. Hereby, we offer a pragmatic review of the topic from the gastrointestinal pathologist's perspective, who, although more accustomed to epithelial neoplasms, can use an algorithmic approach to diagnose mesenchymal entities successfully.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"110-131"},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0