Advances In Anatomic Pathology最新文献

Steatotic Liver Disease: Navigating Pathologic Features, Diagnostic Challenges, and Emerging Insights. 脂肪变性肝病：导航病理特征，诊断挑战和新兴见解。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-11-01 Epub Date: 2025-01-17 DOI: 10.1097/PAP.0000000000000483

Jingjing Jiao, Xuchen Zhang

引用次数: 0

Histopathology of Autoimmune Hepatitis: An Update. 自身免疫性肝炎的组织病理学研究进展

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-11-01 Epub Date: 2025-04-21 DOI: 10.1097/PAP.0000000000000500

Despoina Myoteri, Stratigoula Sakellariou, Dina G Tiniakos

{"title":"Histopathology of Autoimmune Hepatitis: An Update.","authors":"Despoina Myoteri, Stratigoula Sakellariou, Dina G Tiniakos","doi":"10.1097/PAP.0000000000000500","DOIUrl":"10.1097/PAP.0000000000000500","url":null,"abstract":"Autoimmune hepatitis (AIH) is a rare immune-mediated chronic liver disease that is diagnosed based on a combination of biochemical, immunologic, and histologic features and the exclusion of other causes of liver disease. According to the new consensus criteria of the International Autoimmune Hepatitis Pathology Group (IAIHPG), the likely histologic features include a chronic hepatitis pattern of injury with a lymphoplasmacytic portal infiltrate, interface activity, and portal-based fibrosis. More than mild lobular hepatitis with any of the above features can also be diagnosed as likely AIH in the absence of features of another liver disease. Centrilobular injury with prominent hepatocellular necrosis and mononuclear inflammation may represent an acute-onset disease and indicate possible AIH in the absence of concurrent liver disease. Kupffer cell hyaline bodies and portal lymphocyte apoptosis are significantly associated with AIH, whereas emperipolesis and hepatocellular rosette formation are nonspecific features indicative of disease severity. Liver histology is an integral part of the clinical diagnostic scoring system and is required to confirm or support AIH diagnosis. Substitution of the histologic component of the simplified AIH scoring system with the consensus IAIHPG criteria has been proposed to optimize clinical diagnosis. This review explores the significant role of histopathology in AIH by analyzing its main features and current histologic diagnostic criteria, different AIH presentations, differential diagnosis, assessment of concurrent liver disease, and identification of AIH variants with primary cholangiopathy.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"414-426"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Liver Diseases With Near-Normal Histology: A Review Focusing on Metabolic, Storage, and Inclusion Disorders. 组织学接近正常的罕见肝病：代谢、储存和包涵性疾病综述

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-11-01 Epub Date: 2025-02-17 DOI: 10.1097/PAP.0000000000000488

Xiaotang Du, Hanlin L Wang

{"title":"Rare Liver Diseases With Near-Normal Histology: A Review Focusing on Metabolic, Storage, and Inclusion Disorders.","authors":"Xiaotang Du, Hanlin L Wang","doi":"10.1097/PAP.0000000000000488","DOIUrl":"10.1097/PAP.0000000000000488","url":null,"abstract":"Despite the growing availability of noninvasive and faster diagnostic modalities, biopsy remains an important tool in the diagnosis and management of liver diseases. However, it is not uncommon that liver biopsies reveal normal or near normal histologic findings in patients with abnormal liver biochemistries, elevated autoantibodies, clinical findings suggestive of portal hypertension, systemic autoimmune or inflammatory diseases, hepatomegaly, cirrhosis by imaging, or other indications. These scenarios present significant diagnostic challenges and are rarely discussed in detail in the literature or textbooks. This article aims to provide a comprehensive review of a group of selected rare liver diseases, with a focus on metabolic, storage and inclusion disorders, that may exhibit a near-normal histology on biopsy. By recognizing subtle histologic features and correlating with clinical history, laboratory results and imaging findings, it is often possible to narrow down the differential diagnosis. In many cases, this integrative approach can yield a definitive diagnosis, allowing for tailored treatment and better patient outcomes.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"363-374"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Advances in Cholestatic Liver Diseases. 胆汁淤积性肝病的分子研究进展。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-11-01 Epub Date: 2025-06-16 DOI: 10.1097/PAP.0000000000000502

Raima Memon, Romil Saxena

{"title":"Molecular Advances in Cholestatic Liver Diseases.","authors":"Raima Memon, Romil Saxena","doi":"10.1097/PAP.0000000000000502","DOIUrl":"10.1097/PAP.0000000000000502","url":null,"abstract":"The list of genetically defined causes of cholestatic liver diseases continues to expand; it currently includes mutations affecting bile acid synthesis, basolateral and apical membrane transporters, bile duct development, canalicular tight junctions, and bile acid conjugation, among others. The most frequently identified mutations in large multi-institutional studies of cholestasis occur in JAG1, ATP8B1, ABCB11, ABCB4, SERPINA1 , and CFTR . Mutations in JAG1 , SERPINA1 , and CFTR cause Alagille syndrome, alpha-1 antitrypsin deficiency, and cystic fibrosis, respectively. Mutations in ATP8B1 , ABCB11 , and ABCB4 cause a spectrum of diseases that range from the episodic, nonprogressive benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy to the severe and rapidly progressive familial intrahepatic cholestasis. These cholestatic disorders present a wide range of symptoms and overlapping clinical features. However, in contemporary practice, diagnosis is often easily and rapidly established by clinically available comprehensive gene panels. In addition to diagnosis, these panels also aid in the discovery of novel genes or variants as potential causes of cholestasis. Genetic mutations may also be responsible for drug-induced cholestasis, as the liver plays a vital role in metabolism of drugs and xenobiotics. Uptake into hepatocytes and elimination into the bloodstream or bile of drugs and xenobiotics involve transporters across the basolateral and apical hepatocellular membranes, respectively. Therefore, mutations in any of the transporters lead to impaired metabolism and/or elimination of these substances. Furthermore, a large number of drugs and xenobiotics have a transcriptional or functional inhibitory effect on transporters such as BSEP and MDR3, setting the stage for the all-too-common drug-induced cholestasis.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"375-386"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced Liver Injury: Pathology Patterns and Common Culprits. 药物性肝损伤：病理模式和常见罪魁祸首。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-11-01 Epub Date: 2025-08-04 DOI: 10.1097/PAP.0000000000000506

Paige H Parrack, Lei Zhao

引用次数: 0

Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations. 原发性免疫缺陷单基因病相关极早发炎症性肠病的临床病理特征：聚焦IFIH1突变的胃肠道组织学特征。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-11-01 Epub Date: 2024-08-14 DOI: 10.1097/PAP.0000000000000457

Luisa Santoro, Federica Grillo, Maria D'Armiento, Anna Maria Buccoliero, Michele Rocco, Jacopo Ferro, Alessandro Vanoli, Barbara Cafferata, Maria Cristina Macciomei, Claudia Mescoli, Mara Cananzi, Rita Alaggio, Matteo Fassan, Luca Mastracci, Paola Francalanci, Paola Parente

{"title":"Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations.","authors":"Luisa Santoro, Federica Grillo, Maria D'Armiento, Anna Maria Buccoliero, Michele Rocco, Jacopo Ferro, Alessandro Vanoli, Barbara Cafferata, Maria Cristina Macciomei, Claudia Mescoli, Mara Cananzi, Rita Alaggio, Matteo Fassan, Luca Mastracci, Paola Francalanci, Paola Parente","doi":"10.1097/PAP.0000000000000457","DOIUrl":"10.1097/PAP.0000000000000457","url":null,"abstract":"Very early onset inflammatory bowel disease (VEO-IBD) is a clinical term referring to IBD-like symptomatology arising in children younger than 6 years. VEO-IBD may be due to polygenic etiology in \"pure\" IBD (Crohn disease-CD and ulcerative colitis-UC), or it may be caused by primary immunodeficiency underlined by monogenic disease. Primary immunodeficiency monogenic diseases have a Mendelian inheritance and affect the immune system with multiorgan morbidity and possible effects on the gastrointestinal system. Primary Immunodeficiency monogenic diseases differ from \"pure\" IBD as the latter primarily affect the gastrointestinal tract with mitigated extraintestinal symptomatology. Since their first description, primary immunodeficiency monogenic diseases, although rare, have been the subject of increasing interest due to their dramatic phenotype, difficulty in reaching a timely diagnosis, and specific therapeutic approach. In this paper, we present a brief review of primary immunodeficiency monogenic diseases, focusing on to their clinicopathologic features as well as delving, in greater detail, into monogenic diseases caused by IFIH1 mutations. The clinicopathologic features of 4 patients with IFIH1 , a gene involved in interferon pathway deficiency, will be described using a histologic pattern of damage approach confirming the need to avoid the histologic diagnosis of VEO-IBD in children younger than 6 years.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"427-435"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar Soft Part Sarcoma: An Updated Review. 肺泡软组织肉瘤：最新综述。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-10-16 DOI: 10.1097/PAP.0000000000000513

Pedram Argani, Cristina R Antonescu

引用次数: 0

Perivascular Cell Tumors (PEComas) of the Genitourinary Tract: A Summary. 泌尿生殖道血管周围细胞瘤（PEComas）：综述。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-09-24 DOI: 10.1097/PAP.0000000000000512

Susan K Potterveld, Pedram Argani, Ankur R Sangoi

引用次数: 0

A Primer on Bluesky (and PathSky) for Pathologists, Trainees, and Medical Students. 对蓝天（和PathSky）的入门病理学家，实习生，和医学生。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-09-01 Epub Date: 2025-03-24 DOI: 10.1097/PAP.0000000000000491

Casey P Schukow, Lavisha S Punjabi, Emma Khan

引用次数: 0

Hepatoblastoma: Comprehensive Review With Recent Updates. 肝母细胞瘤：综合综述与最新进展。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2025-09-01 Epub Date: 2025-04-03 DOI: 10.1097/PAP.0000000000000495

Jingjing Jiao, Romil Saxena, Raffaella Morotti

{"title":"Hepatoblastoma: Comprehensive Review With Recent Updates.","authors":"Jingjing Jiao, Romil Saxena, Raffaella Morotti","doi":"10.1097/PAP.0000000000000495","DOIUrl":"10.1097/PAP.0000000000000495","url":null,"abstract":"Hepatoblastoma (HB), the most common primary malignant liver tumor of childhood, demonstrates remarkable histologic heterogeneity and can be classified into epithelial or mixed epithelial-mesenchymal subtypes. This review summarizes updates in histologic classification, molecular signatures, staging, and risk stratification of HB. The Children's Hepatic tumors International Collaboration represents an international effort to standardize the study of rare pediatric liver tumors; emphasis continues to remain on improving risk stratification by a combination of clinical, histologic, and molecular features to tailor treatment in a bid to reduce toxicity while maintaining or improving efficacy. Pure fetal HB is cured by complete resection without the need for adjuvant chemotherapy. Malignant rhabdoid tumors have been parsed out from small cell undifferentiated HBs by negative INI-1 staining on immunohistochemistry; these tumors require a distinct and more aggressive chemotherapeutic regimen. The significance of recently characterized \"blastema\" component in HB remains to be elucidated. Hepatocellular neoplasm, not otherwise specified, is a provisional diagnostic category for tumors exhibiting either intermediate or a combination of both HB and hepatocellular carcinoma histologic features. The Children's Hepatic tumors International Collaboration risk stratification algorithm includes age as an important discriminator of risk, in addition to AFP, metastasis, and PreTreatment EXTent of disease stage and its annotations.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"309-316"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0