Advances In Anatomic Pathology最新文献_第10页

Follicular Neoplasm of Thyroid Revisited: Current Differential Diagnosis and the Impact of Molecular Testing. 甲状腺滤泡性肿瘤:当前的鉴别诊断和分子检测的影响。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000368

N Paul Ohori, Michiya Nishino

{"title":"Follicular Neoplasm of Thyroid Revisited: Current Differential Diagnosis and the Impact of Molecular Testing.","authors":"N Paul Ohori, Michiya Nishino","doi":"10.1097/PAP.0000000000000368","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000368","url":null,"abstract":"The diagnosis of \"follicular neoplasm\" (FN) in thyroid cytopathology has a long history that originated not long after the practice of fine-needle aspiration (FNA) of thyroid nodules. From the outset, this interpretive category was intended to convey a set of differential diagnoses rather than a precise diagnosis, as key diagnostic features, such as capsular and vascular invasion, were not detectable on cytology preparations. Cytologic-histologic correlation studies over the past several decades have shown that FN interpretation can be applied to the spectrum of nonneoplastic tumors to carcinomas. Most tumors classified as FN include follicular adenoma, follicular carcinoma, noninvasive follicular thyroid tumor with papillary-like nuclear features, and follicular variant of papillary thyroid carcinoma. Less common entities that may be classified as FN on FNA include hyalinizing trabecular tumor (HTT), poorly differentiated thyroid carcinoma, medullary carcinoma, and nonthyroidal lesions such as parathyroid tissue, paraganglioma, and metastatic tumors. Advances in our ability to detect characteristic molecular alterations (eg, GLIS gene rearrangements for hyalinizing trabecular tumor) in FNA samples may assist in the identification of some of these entities. In this review, we summarize the pathophysiology, history, and evolution of the terminology and the current differential diagnosis according to the recently published 2022 World Health Organization classification, molecular testing, and management of nodules classified as FN.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Advances in Thyroid Pathology: High Grade Follicular Cell-derived Thyroid Carcinoma and Anaplastic Thyroid Carcinoma. 甲状腺病理学进展:高级别滤泡细胞衍生的甲状腺癌和间变性甲状腺癌。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000380

Bin Xu, Ronald A Ghossein

{"title":"Advances in Thyroid Pathology: High Grade Follicular Cell-derived Thyroid Carcinoma and Anaplastic Thyroid Carcinoma.","authors":"Bin Xu, Ronald A Ghossein","doi":"10.1097/PAP.0000000000000380","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000380","url":null,"abstract":"In the upcoming World Health Organization fifth edition classification of endocrine tumors, there were several major changes related to high grade follicular-derived thyroid carcinoma (HGFCTC) and anaplastic thyroid carcinoma (ATC) based on emerging evidence about the diagnostic criteria clinical behavior, prognostic factors, and molecular signatures of these tumors. In this review, we aim to summarize the major evolutions of HGFCTC and ATC. HGFCTC is a nonanaplastic carcinoma with high grade features (High mitotic count, tumor necrosis). It is subdivided into poorly differentiated thyroid carcinoma diagnosed using the Turin proposal and differentiated high grade thyroid carcinoma. The latter is defined by the presence of the cytoarchitectutal features of well-differentiated thyroid carcinoma (eg, papillae) but harbors elevated mitotic activity and/or tumor necrosis. Poorly differentiated thyroid carcinoma is predominantly RAS -driven and associated with RAI avidity and high propensity for distant metastasis, whereas differentiated high grade thyroid carcinoma is mostly BRAFV600E -driven. ATC may show a wide range of histologic features. Carcinoma of pure squamous phenotype is associated with a high frequency of BRAF V600E mutations and is now considered as a subtype of ATC. There is a stepwise molecular progression from well-differentiated carcinoma to HGFCTC to ATC manifested by 1) early and persistent driver alteration in the MAPK pathway, particularly BRAF V600E and RAS mutations, and 2) gain of secondary aggressive molecular signatures (such as TERT promoter and TP53 mutations) when tumors progress from well-differentiated to high grade to anaplastic carcinoma.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10341535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Advances in Adrenal and Extra-adrenal Paraganglioma: Practical Synopsis for Pathologists. 肾上腺和肾上腺外副神经节瘤的研究进展:病理学家实用指南。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000365

Carl Christofer Juhlin, Ozgur Mete

{"title":"Advances in Adrenal and Extra-adrenal Paraganglioma: Practical Synopsis for Pathologists.","authors":"Carl Christofer Juhlin, Ozgur Mete","doi":"10.1097/PAP.0000000000000365","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000365","url":null,"abstract":"Adrenal paraganglioma (or \"pheochromocytoma\") and extra-adrenal paraganglioma, collectively abbreviated PPGL, are rare but spectacular nonepithelial neuroendocrine neoplasms. These are the most inheritable neoplasia of all, with a metastatic potential in a varying degree. As of such, these lesions demand careful histologic, immunohistochemical, and genetic characterization to provide the clinical team with a detailed report taking into account the anticipated prognosis and risk of syndromic/inherited disease. While no histologic algorithm, immunohistochemical biomarker, or molecular aberration single-handedly can identify potentially lethal cases upfront, the combined analysis of various risk parameters may stratify PPGL patients more stringently than previously. Moreover, the novel 2022 WHO Classification of Endocrine and Neuroendocrine Tumors also brings some new concepts into play, not least the reclassification of special neuroendocrine neoplasms (cauda equina neuroendocrine tumor and composite gangliocytoma/neuroma-neuroendocrine tumor) previously thought to belong to the spectrum of PPGL. This review focuses on updated key diagnostic and prognostic concepts that will aid when facing this rather enigmatic tumor entity in clinical practice.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10335140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

An Overview of Pituitary Neuroendocrine Tumors (PitNET) and Algorithmic Approach to Diagnosis. 垂体神经内分泌肿瘤(PitNET)及其诊断算法综述。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000367

Maria A Gubbiotti, Zubair Baloch

引用次数: 1

Histopathologic Features of Adrenal Cortical Carcinoma. 肾上腺皮质癌的组织病理学特征。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000363

Alessandro Gambella, Marco Volante, Mauro Papotti

{"title":"Histopathologic Features of Adrenal Cortical Carcinoma.","authors":"Alessandro Gambella, Marco Volante, Mauro Papotti","doi":"10.1097/PAP.0000000000000363","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000363","url":null,"abstract":"Adrenal cortical carcinoma (ACC) is a rare and aggressive malignancy that poses challenging issues regarding the diagnostic workup. Indeed, no presurgical technique or clinical parameters can reliably distinguish between adrenal cortical adenomas, which are more frequent and have a favorable outcome, and ACC, and the final diagnosis largely relies on histopathologic analysis of the surgical specimen. However, even the pathologic assessment of malignancy in an adrenal cortical lesion is not straightforward and requires a combined evaluation of multiple histopathologic features. Starting from the Weiss score, which was developed in 1984, several histopathologic scoring systems have been designed to tackle the difficulties of ACC diagnosis. Dealing with specific histopathologic variants (eg, Liss-Weiss-Bisceglia scoring system for oncocytic ACC) or patient characteristics (eg, Wieneke index in the pediatric setting), these scores remarkably improved the diagnostic workup of ACC and its subtypes. Nevertheless, cases with misleading features or discordant correlations between pathologic findings and clinical behavior still occur. Owing to multicentric collaborative studies integrating morphologic features with ancillary immunohistochemical markers and molecular analysis, ACC has eventually emerged as a multifaceted, heterogenous malignancy, and, while innovative and promising approaches are currently being tested, the future clinical management of patients with ACC will mainly rely on personalized medicine and target-therapy protocols. At the dawn of the new Fifth World Health Organization classification of endocrine tumors, this review will tackle ACC from the pathologist's perspective, thus focusing on the main available diagnostic, prognostic, and predictive tissue-tethered features and biomarkers and providing relevant clinical and molecular correlates.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10340988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Classic, the Trendy, and the Refashioned: A Primer for Pathologists on What Is New in Familial Endocrine Tumor Syndromes. 经典，潮流，和改造:什么是新的家族性内分泌肿瘤综合征病理学家入门。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000370

Emad Ababneh, Vania Nosé

{"title":"The Classic, the Trendy, and the Refashioned: A Primer for Pathologists on What Is New in Familial Endocrine Tumor Syndromes.","authors":"Emad Ababneh, Vania Nosé","doi":"10.1097/PAP.0000000000000370","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000370","url":null,"abstract":"Familial endocrine tumor syndromes are continuously expanding owing to the growing role of genetic testing in routine clinical practice. Pathologists are usually the first on the clinical team to encounter these syndromes at their initial presentation; thus, recognizing them is becoming more pivotal in routine pathology practice to help in properly planning management and further family testing. Our increasing knowledge about them is reflected in the newer syndromes included in the new World Health Organization classification and in the evolving discovery of new endocrine tumors and new familial associations. In many of these syndromes, the clinical features and co-occurrence of multiple neoplasia are the only clues (multiple endocrine neoplasia syndromes). In other syndromes, specific morphologic findings (pituitary blastoma and DICER1 syndrome, cribriform morular thyroid carcinoma, and AFP syndrome) and available ancillary studies (SDHB in SDH-deficient tumor syndromes) can aid pathologists. The aim of this review is to provide a primer on recent updates on familial endocrine tumor syndromes and related tumors, focusing on recent classification changes or tumor syndromes where a clearer role for pathologists is at play.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10328779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Special Issue on Neuroendocrine Tumors: Updates on Classification Systems, Streamlining Diagnosis, and Emphasis on Molecular Signatures in Neuroendocrine Neoplasms. 神经内分泌肿瘤特刊:更新分类系统，简化诊断，并强调神经内分泌肿瘤的分子特征。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000381

Maria A Gubbiotti, Kathleen T Montone, Zubair Baloch

引用次数: 0

Advances and Updates in Parathyroid Pathology. 甲状旁腺病理学的最新进展。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2023-01-01 DOI: 10.1097/PAP.0000000000000379

Hamza N Gokozan, Theresa Scognamiglio

{"title":"Advances and Updates in Parathyroid Pathology.","authors":"Hamza N Gokozan, Theresa Scognamiglio","doi":"10.1097/PAP.0000000000000379","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000379","url":null,"abstract":"Hyperparathyroidism is a common endocrine disorder characterized by elevated levels of parathyroid hormone and hypercalcemia and is divided into 3 types: primary, secondary, and tertiary. Distinction between these types is accomplished by correlation of clinical, radiologic, and laboratory findings with pathologic features. Primary hyperparathyroidism occurs sporadically in 85% of cases with the remaining cases associated with multiple familial syndromes. The pathologic manifestations of primary hyperparathyroidism include parathyroid adenoma, parathyroid hyperplasia, and parathyroid carcinoma. Recent advances in the understanding of the pathogenesis of parathyroid disease has helped to refine the diagnosis and classification of parathyroid lesions. The identification of multiple clonal proliferations in traditional multiglandular parathyroid hyperplasia has led to the adoption by the World Health Organization (WHO) of the alternate term of primary hyperparathyroidism-related multiglandular parathyroid disease. Additional nomenclature changes include the adoption of the term atypical parathyroid tumor in lieu of atypical parathyroid adenoma to reflect the uncertain malignant potential of these neoplasms. Clinical and morphologic features characteristic of familial disease have been described that can help the practicing pathologist identify underlying familial disease and provide appropriate management. Use of ancillary immunohistochemistry and molecular studies can be helpful in classifying parathyroid neoplasms. Parafibromin has proven useful as a diagnostic and prognostic marker in atypical parathyroid tumors and parathyroid carcinomas. This review provides an update on the diagnosis and classification of parathyroid lesions considering the recent advances in the understanding of the molecular and clinical features of parathyroid disease and highlights the use of ancillary studies (immunohistochemical, and molecular) to refine the diagnosis of parathyroid lesions.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10703891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Focal Active Brunner Gland Lobulitis: Ignored or Yet Undetected Sign of Crohn Duodenitis? 局灶性活动性布鲁纳腺小叶炎：被忽视还是未被发现的克罗恩十二指肠炎征兆？

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2022-12-22 DOI: 10.1097/PAP.0000000000000392

Badr AbdullGaffar, Huda Quarishi

引用次数: 0

Small Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates. 肺神经内分泌肿瘤的小活检和细胞学：分类、免疫组织化学、分子图谱和世界卫生组织更新的简要概述。

IF 6.7 2区医学

Advances In Anatomic Pathology Pub Date : 2022-11-01 Epub Date: 2022-09-02 DOI: 10.1097/PAP.0000000000000360

Simon Sung, Jonas J Heymann, Michelle Garlin Politis, Marina K Baine, Natasha Rekhtman, Anjali Saqi

引用次数: 1