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Controversial and Evolving Issues in Gynecologic Pathology. 妇科病理学中的争议和演变问题。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-10-14 DOI: 10.1097/PAP.0000000000000467
W Glenn McCluggage, Carlos Parra-Herran
{"title":"Controversial and Evolving Issues in Gynecologic Pathology.","authors":"W Glenn McCluggage, Carlos Parra-Herran","doi":"10.1097/PAP.0000000000000467","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000467","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Typing of Vulvar Squamous Cell Carcinoma: Why it is Important? 外阴鳞状细胞癌的分型：为什么很重要？
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-25 DOI: 10.1097/PAP.0000000000000466
Mona Alfaraidi, C Blake Gilks, Lynn Hoang
{"title":"Typing of Vulvar Squamous Cell Carcinoma: Why it is Important?","authors":"Mona Alfaraidi, C Blake Gilks, Lynn Hoang","doi":"10.1097/PAP.0000000000000466","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000466","url":null,"abstract":"<p><p>The classification of vulvar squamous cell carcinoma (VSCC), as in endometrial cancer, has shifted from the histology-based descriptors toward molecular-based identifiers. Recently, it has been reported that there are 3 genetically distinct and clinically significant subtypes of VSCC: HPV-associated VSCC, HPV-independent/p53 wild-type VSCC, and HPV-independent/p53-mutated VSCC. Each group has different prognostic implications as well as response to treatment, thus reinforcing the need for this 3-tier molecular classification. This molecular subtyping can easily be done on vulvar biopsies using p16 and p53 immunohistochemistry stains to further improve risk prediction and individualized treatment decisions, leading to better patient outcomes.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Predictive and Prognostic Biomarkers in Lower Female Genital Tract Pathology: PD-L1, MMR, HER2, p16, p53, and Beyond. 预测性和预后性生物标志物在女性下生殖道病理学中的作用：PD-L1、MMR、HER2、p16、p53 及其他。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-16 DOI: 10.1097/PAP.0000000000000458
Anne M Mills, Andre Pinto
{"title":"The Role of Predictive and Prognostic Biomarkers in Lower Female Genital Tract Pathology: PD-L1, MMR, HER2, p16, p53, and Beyond.","authors":"Anne M Mills, Andre Pinto","doi":"10.1097/PAP.0000000000000458","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000458","url":null,"abstract":"<p><p>Biomarkers play a crucial role in the diagnosis, treatment planning, and prognosis of premalignant and malignant lesions and are increasingly used in neoplasia of the lower female genital tract (LFGT) including the cervix, vagina, and vulva. This review will discuss key biomarkers routinely used in LFGT pathology, including programmed cell death ligand 1 (PD-L1), mismatch repair (MMR), and tumor mutational burden (TMB) testing, which are FDA-approved companion diagnostics for anti-PD-1 checkpoint inhibitors. Recent developments in HER2 testing as a marker for anti-HER2 therapies, and prognostic biomarkers such as p53 in HPV-independent vulvar intraepithelial lesions and carcinomas, are also reviewed.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STK11 Adnexal Tumor: Exploring the Association With Peutz-Jeghers Syndrome and its Distinction From Morphologic Mimickers. STK11 附件肿瘤：探索与 Peutz-Jeghers 综合征的关联及其与形态学模仿者的区别
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-03 DOI: 10.1097/PAP.0000000000000460
Jennifer A Bennett, Esther Oliva
{"title":"STK11 Adnexal Tumor: Exploring the Association With Peutz-Jeghers Syndrome and its Distinction From Morphologic Mimickers.","authors":"Jennifer A Bennett, Esther Oliva","doi":"10.1097/PAP.0000000000000460","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000460","url":null,"abstract":"<p><p>STK11 adnexal tumor is a novel malignant neoplasm of uncertain histogenesis frequently arising in a para-adnexal location and associated with Peutz-Jeghers syndrome in ∼50% of patients. Its broad morphologic spectrum and nonspecific immunohistochemical profile has resulted in misclassification in the past as a variety of other neoplasms including those of wolffian, sex cord-stromal, mesothelial, and epithelial derivation. This review focuses on the spectrum of adnexal neoplasms that may develop in Peutz-Jeghers syndrome, with particular emphasis on STK11 adnexal tumor and its differential diagnosis.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecularly Defined Thoracic Neoplasms. 分子定义的胸部肿瘤。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-19 DOI: 10.1097/PAP.0000000000000439
Anja C Roden
{"title":"Molecularly Defined Thoracic Neoplasms.","authors":"Anja C Roden","doi":"10.1097/PAP.0000000000000439","DOIUrl":"10.1097/PAP.0000000000000439","url":null,"abstract":"<p><p>Molecularly defined neoplasms are increasingly recognized, given the broader application and performance of molecular studies. These studies allow us to better characterize these neoplasms and learn about their pathogenesis. In the thorax, molecularly defined neoplasms include tumors such as NUT carcinoma, SMARCA4-deficient undifferentiated tumor (DUT), primary pulmonary myxoid sarcoma with EWSR1::CREB1 fusion, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms. Overall, these tumors are rare but are now more often recognized given more widely available immunostains such as NUT (NUT carcinoma), BRG1 (SMARCA4-DUT), and INI-1 (SMARCB1-deficient neoplasm). Furthermore, cytogenetic studies for EWSR1 to support a hyalinizing clear cell carcinoma or primary pulmonary myxoid sarcoma are, in general, easily accessible. This enables pathologists to recognize and diagnose these tumors. The diagnosis of these tumors is important for clinical management and treatment. For instance, clinical trials are available for patients with NUT carcinoma, SMARCA4-DUT, and SMACRB1-deficient neoplasms. Herein, our current knowledge of clinical, morphologic, immunophenotypic, and molecular features of NUT carcinomas, SMARCA4-DUT, primary pulmonary myxoid sarcomas, hyalinizing clear cell carcinoma, and SMARCB1-deficient neoplasms will be reviewed.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence and Lung Pathology. 人工智能与肺部病理学
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-23 DOI: 10.1097/PAP.0000000000000448
Emanuel Caranfil, Kris Lami, Wataru Uegami, Junya Fukuoka
{"title":"Artificial Intelligence and Lung Pathology.","authors":"Emanuel Caranfil, Kris Lami, Wataru Uegami, Junya Fukuoka","doi":"10.1097/PAP.0000000000000448","DOIUrl":"10.1097/PAP.0000000000000448","url":null,"abstract":"<p><p>This manuscript provides a comprehensive overview of the application of artificial intelligence (AI) in lung pathology, particularly in the diagnosis of lung cancer. It discusses various AI models designed to support pathologists and clinicians. AI models supporting pathologists are to standardize diagnosis, score PD-L1 status, supporting tumor cellularity count, and indicating explainability for pathologic judgements. Several models predict outcomes beyond pathologic diagnosis and predict clinical outcomes like patients' survival and molecular alterations. The manuscript emphasizes the potential of AI to enhance accuracy and efficiency in pathology, while also addressing the challenges and future directions for integrating AI into clinical practice.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls. 肺腺癌侵袭的形态学特征：诊断陷阱。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-13 DOI: 10.1097/PAP.0000000000000451
Erik Thunnissen, Masayuki Noguchi, Sabina Berezowska, Mauro Giulio Papotti, Federica Filipello, Yuko Minami, Hans Blaauwgeers
{"title":"Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls.","authors":"Erik Thunnissen, Masayuki Noguchi, Sabina Berezowska, Mauro Giulio Papotti, Federica Filipello, Yuko Minami, Hans Blaauwgeers","doi":"10.1097/PAP.0000000000000451","DOIUrl":"10.1097/PAP.0000000000000451","url":null,"abstract":"<p><p>Reproducibility of pulmonary invasive adenocarcinoma diagnosis is poor when applying the World Health Organization (WHO) classification. In this article, we aimed first to explain by 3-dimensional morphology why simple pattern recognition induces pitfalls for the assessment of invasion as applied in the current WHO classification of pulmonary adenocarcinomas. The underlying iatrogenic-induced morphologic alterations in collapsed adenocarcinoma in situ overlap with criteria for invasive adenocarcinoma. Pitfalls in seemingly acinar and papillary carcinoma are addressed with additional cytokeratin 7 and elastin stains. In addition, we provide more stringent criteria for a better reproducible and likely generalizable classification.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Morphology to Molecules: Advances in the Distinction of Multiple Primary Lung Cancers From Intrapulmonary Metastases in Non-Small Cell Lung Cancer. 从形态到分子：非小细胞肺癌多原发肺癌与肺内转移瘤的鉴别进展。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI: 10.1097/PAP.0000000000000449
Gheorghe-Emilian Olteanu, Izidor Kern, Lipika Kalson, Luka Brcic
{"title":"From Morphology to Molecules: Advances in the Distinction of Multiple Primary Lung Cancers From Intrapulmonary Metastases in Non-Small Cell Lung Cancer.","authors":"Gheorghe-Emilian Olteanu, Izidor Kern, Lipika Kalson, Luka Brcic","doi":"10.1097/PAP.0000000000000449","DOIUrl":"10.1097/PAP.0000000000000449","url":null,"abstract":"<p><p>The increasing incidence of multiple lung nodules underscores the need for precise differentiation between multiple primary lung cancers (MPLCs) and intrapulmonary metastases (IPMs). This distinction impacts patient prognosis and treatment strategies. The prevalence of multiple lung nodules, ranging from 19.7% to 55.5%, highlights the clinical significance of this challenge. Historically, the role of histopathology, particularly comprehensive histology assessment (CHA), has been pivotal in differentiating MPLCs and IPMs. However, CHA has significant limitations, resulting in a constant search for a better way to distinguish those lesions. The best strategy for delineating MPLCs from IPMs is a multidisciplinary approach combining clinical data, radiology, histology, and molecular methods. Histology provides architectural and cellular characteristics, radiology contributes anatomic context and lesion characterization, and molecular methods reveal molecular features critical for accurate differentiation. Incorporating clinical data further enhances diagnostic precision. This review presents current knowledge and current approaches to multiple lung tumors. It is clear that even with a combination of pathology, radiology, and molecular data, definitive classification of multifocal lung tumors is not always possible.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in Thoracic Pathology. 胸部病理学的挑战。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1097/PAP.0000000000000456
Sanja Dacic, Luka Brcic
{"title":"Challenges in Thoracic Pathology.","authors":"Sanja Dacic, Luka Brcic","doi":"10.1097/PAP.0000000000000456","DOIUrl":"10.1097/PAP.0000000000000456","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations. 原发性免疫缺陷单基因病相关极早发炎症性肠病的临床病理特征：聚焦IFIH1突变的胃肠道组织学特征。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-08-14 DOI: 10.1097/PAP.0000000000000457
Luisa Santoro, Federica Grillo, Maria D'Armiento, Anna Maria Buccoliero, Michele Rocco, Jacopo Ferro, Alessandro Vanoli, Barbara Cafferata, Maria Cristina Macciomei, Claudia Mescoli, Mara Cananzi, Rita Alaggio, Matteo Fassan, Luca Mastracci, Paola Francalanci, Paola Parente
{"title":"Clinicopathologic Features of Primary Immunodeficiency Monogenic Disease-related Very Early Onset Inflammatory Bowel Disease: Focus on Gastrointestinal Histologic Features in IFIH1 Mutations.","authors":"Luisa Santoro, Federica Grillo, Maria D'Armiento, Anna Maria Buccoliero, Michele Rocco, Jacopo Ferro, Alessandro Vanoli, Barbara Cafferata, Maria Cristina Macciomei, Claudia Mescoli, Mara Cananzi, Rita Alaggio, Matteo Fassan, Luca Mastracci, Paola Francalanci, Paola Parente","doi":"10.1097/PAP.0000000000000457","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000457","url":null,"abstract":"<p><p>Very early onset inflammatory bowel disease (VEO-IBD) is a clinical term referring to IBD-like symptomatology arising in children younger than 6 years. VEO-IBD may be due to polygenic etiology in \"pure\" IBD (Crohn disease-CD and ulcerative colitis-UC), or it may be caused by primary immunodeficiency underlined by monogenic disease. Primary immunodeficiency monogenic diseases have a Mendelian inheritance and affect the immune system with multiorgan morbidity and possible effects on the gastrointestinal system. Primary Immunodeficiency monogenic diseases differ from \"pure\" IBD as the latter primarily affect the gastrointestinal tract with mitigated extraintestinal symptomatology. Since their first description, primary immunodeficiency monogenic diseases, although rare, have been the subject of increasing interest due to their dramatic phenotype, difficulty in reaching a timely diagnosis, and specific therapeutic approach. In this paper, we present a brief review of primary immunodeficiency monogenic diseases, focusing on to their clinicopathologic features as well as delving, in greater detail, into monogenic diseases caused by IFIH1 mutations. The clinicopathologic features of 4 patients with IFIH1, a gene involved in interferon pathway deficiency, will be described using a histologic pattern of damage approach confirming the need to avoid the histologic diagnosis of VEO-IBD in children younger than 6 years.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":5.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141974802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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