Advances In Anatomic Pathology最新文献_第2页

Modern Approach to Nodal T-Cell Lymphomas. 淋巴结t细胞淋巴瘤的现代治疗方法。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1097/PAP.0000000000000492

Sarah L Ondrejka, Laurence de Leval

{"title":"Modern Approach to Nodal T-Cell Lymphomas.","authors":"Sarah L Ondrejka, Laurence de Leval","doi":"10.1097/PAP.0000000000000492","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000492","url":null,"abstract":"In recent decades, there have been many meaningful contributions to the pathology literature with respect to T-cell lymphoma pathogenesis and biology and improved diagnostics. We know more about disease classification, clinical characteristics, immunophenotype, and genetics than ever before, and yet diagnosis of nodal T-cell lymphomas continues to be a challenging exercise. Complicating interpretation are the many non-neoplastic mimickers of peripheral T-cell lymphoma including drug effects, viruses, autoimmune, and idiopathic conditions, that must be considered when faced with an abnormal lymph node biopsy. The number of immunohistochemical stains required to make a diagnosis of T-cell lymphoma is not standardized and may be exhaustive, requiring judicious use of tissue sections. Clonality studies may contribute to the diagnosis, though questions remain about test modality, when to exercise interpretive caution, and what to do if a clone cannot be demonstrated. Use of next generation sequencing in the diagnosis of nodal T-cell lymphomas is increasing, but how the data can be practically applied to diagnosis is still under examination. The goal of this paper is to consider nodal T-cell lymphoma diagnosis and classification in a modern context, using a question-and-answer format to capture the interest of the reader and address common pathology consultation queries.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"32 3","pages":"220-238"},"PeriodicalIF":5.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Generative AI for Anatomic Pathology-A Review of Current Applications to Envisage the Future Direction. 解剖病理学的多模态生成人工智能-展望未来方向的当前应用综述。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-29 DOI: 10.1097/PAP.0000000000000498

Ehsan Ullah, Mirza Mansoor Baig, Asim Waqas, Ghulam Rasool, Rajendra Singh, Ashwinikumar Shandilya, Hamid GholamHossieni, Anil V Parwani

{"title":"Multimodal Generative AI for Anatomic Pathology-A Review of Current Applications to Envisage the Future Direction.","authors":"Ehsan Ullah, Mirza Mansoor Baig, Asim Waqas, Ghulam Rasool, Rajendra Singh, Ashwinikumar Shandilya, Hamid GholamHossieni, Anil V Parwani","doi":"10.1097/PAP.0000000000000498","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000498","url":null,"abstract":"This review focuses on the purported applications of multimodal Gen-AI models for anatomic pathology image analysis and interpretation to predict future directions. A scoping review was conducted to explore the applications of multimodal Gen-AI models in advancing histopathology image analysis. A comprehensive search was conducted using electronic databases for relevant articles published within the past year (July 1, 2023 to June 30, 2024). The selected articles were critically analyzed to identify and summarize the applications of multimodal Gen-AI in anatomic pathology image analysis. Multimodal Gen AI models reported in the literature claim moderate to high accuracy on tasks including image classification, segmentation, and text-to-image retrieval. This review demonstrates the potential of multimodal Gen AI models for useful applications in pathology, including assisting with diagnoses, generating data for education and research, and detection of molecular features from anatomic pathology images. These models use data from a few academic institutions thus they require validation on diverse real-world data. There is an urgent need to build consensus models for optimal model performance through multicenter collaboration using a federated learning approach and the use of carefully curated synthetic anatomic pathology data. These models also need to achieve reliability, generalizability and meet the standards required for clinical use. Despite the rigorous need for evaluation and the need to address genuine concerns, multimodal GenAI models present a promising perspective for the advancement and scalability of anatomic pathology.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Hepatocellular Carcinoma: Molecular Insights, Histologic Subtypes, and Differential Diagnosis. 肝细胞癌的研究进展：分子观察、组织学亚型和鉴别诊断。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-25 DOI: 10.1097/PAP.0000000000000501

Wei Zheng, Yulin Haw, Hanlin L Wang

{"title":"Advances in Hepatocellular Carcinoma: Molecular Insights, Histologic Subtypes, and Differential Diagnosis.","authors":"Wei Zheng, Yulin Haw, Hanlin L Wang","doi":"10.1097/PAP.0000000000000501","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000501","url":null,"abstract":"Significant advancements over the past 2 decades have reshaped our understanding and diagnostic capabilities for hepatocellular carcinoma (HCC). These advancements span molecular insights into key driver gene mutations and chromosomal aberrations, refined recognition of distinct histologic subtypes, improved differentiation from precursor and benign hepatic lesions, and enhanced strategies for interpreting challenging biopsy samples. The discovery of driver mutations such as TERT promoter, CTNNB1, and TP53, along with chromosomal alterations, has provided essential tools for identifying malignancy and understanding tumor behavior. Concurrently, the recognition of distinct morphomolecular HCC subtypes has underscored the importance of integrating histologic and molecular findings for accurate diagnosis and prognostic assessment. In addition, differentiating HCC from dysplastic nodule and hepatocellular adenoma remains a diagnostic challenge, often requiring a combination of morphologic, immunohistochemical, and molecular approaches. Moreover, the interpretation of biopsy samples from borderline hepatocellular neoplasms highlights the limitations of conventional pathology alone and the need for comprehensive diagnostic strategies. This review aims to provide an updated overview of these interconnected aspects, emphasizing their collective role in advancing the precision diagnosis of HCC.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathology of Autoimmune Hepatitis: An Update. 自身免疫性肝炎的组织病理学研究进展

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-21 DOI: 10.1097/PAP.0000000000000500

Despoina Myoteri, Stratigoula Sakellariou, Dina G Tiniakos

{"title":"Histopathology of Autoimmune Hepatitis: An Update.","authors":"Despoina Myoteri, Stratigoula Sakellariou, Dina G Tiniakos","doi":"10.1097/PAP.0000000000000500","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000500","url":null,"abstract":"Autoimmune hepatitis (AIH) is a rare immune-mediated chronic liver disease that is diagnosed based on a combination of biochemical, immunologic, and histologic features and the exclusion of other causes of liver disease. According to the new consensus criteria of the International Autoimmune Hepatitis Pathology Group (IAIHPG), the likely histologic features include a chronic hepatitis pattern of injury with a lymphoplasmacytic portal infiltrate, interface activity, and portal-based fibrosis. More than mild lobular hepatitis with any of the above features can also be diagnosed as likely AIH in the absence of features of another liver disease. Centrilobular injury with prominent hepatocellular necrosis and mononuclear inflammation may represent an acute-onset disease and indicate possible AIH in the absence of concurrent liver disease. Kupffer cell hyaline bodies and portal lymphocyte apoptosis are significantly associated with AIH, whereas emperipolesis and hepatocellular rosette formation are nonspecific features indicative of disease severity. Liver histology is an integral part of the clinical diagnostic scoring system and is required to confirm or support AIH diagnosis. Substitution of the histologic component of the simplified AIH scoring system with the consensus IAIHPG criteria has been proposed to optimize clinical diagnosis. This review explores the significant role of histopathology in AIH by analyzing its main features and current histologic diagnostic criteria, different AIH presentations, differential diagnosis, assessment of concurrent liver disease, and identification of AIH variants with primary cholangiopathy.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Other Primary Epithelial Neoplasms of the Liver. 肝脏的其他原发性上皮肿瘤。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-09 DOI: 10.1097/PAP.0000000000000494

Wai Szeto, Rifat Mannan

{"title":"Other Primary Epithelial Neoplasms of the Liver.","authors":"Wai Szeto, Rifat Mannan","doi":"10.1097/PAP.0000000000000494","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000494","url":null,"abstract":"Primary liver carcinoma (PLC) is the sixth most common malignancy worldwide and the third leading cause of cancer-related mortalities. Hepatocellular carcinoma (HCC) is the most prevalent form of PLC, followed by intrahepatic cholangiocarcinoma (iCCA). In addition, there is a group of rarer PLCs that do not fit neatly into the HCC or iCCA categories. This review explores this heterogeneous group, including combined hepatocellular-cholangiocarcinoma (cHCC-CCA), intermediate cell carcinoma (ICC), mixed hepatocellular-neuroendocrine carcinoma, and undifferentiated primary liver carcinoma. cHCC-CCA is a rare subtype of PLC, characterized by both hepatocytic and cholangiocytic differentiation within the same tumor. The latest WHO classification (2019, fifth edition) redefined cHCC-CCA by eliminating the \"stem cell subtypes\" and emphasized that diagnosis should primarily rely on morphologic features, supported by immunohistochemical staining to better define subtypes. Intermediate cell carcinoma is a subtype of cHCC-CCA and is comprised of monomorphic tumor cells that exhibit characteristics intermediate between hepatocytes and cholangiocytes, with immunohistochemical expression of hepatocytic and cholangiocytic markers within the same cell. Another rare entity, combined HCC and neuroendocrine carcinoma (NEC), contains an admixture of HCC and NEC components within the same tumor. Undifferentiated primary liver carcinoma, on the other hand, lacks definitive lineage differentiation beyond an epithelial phenotype. These heterogeneous PLCs pose diagnostic challenges owing to their mixed/unusual histologic features and overlapping immunohistochemical markers. They tend to have poor prognoses, highlighting the critical importance of accurate and timely diagnosis.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preneoplastic and Neoplastic Biliary Diseases. 肿瘤前和肿瘤性胆道疾病。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-07 DOI: 10.1097/PAP.0000000000000497

Tom Z Liang, Shefali Chopra

{"title":"Preneoplastic and Neoplastic Biliary Diseases.","authors":"Tom Z Liang, Shefali Chopra","doi":"10.1097/PAP.0000000000000497","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000497","url":null,"abstract":"Preneoplastic and neoplastic biliary disease comprises biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasms, mucinous cystic neoplasms (MCNs), and cholangiocarcinoma and their variants. Correct recognition of these entities can be challenging, especially on small/needle biopsies, but is required to plan therapy and guide transplant in the setting of cirrhosis. Salient histologic features of these entities, along with ancillary use of immunostains and key molecular findings aiding in diagnosis, are discussed. Type 2 intraductal papillary neoplasm of the bile ducts is typically associated with an invasive malignancy and lack unique molecular features associated with the Type 1 intraductal papillary neoplasm, thus they are called \"papillary cholangiocarcinoma\" by some authors. Some of the cholangiocarcinoma variants, like enteroblastic and mucoepidermoid, are under-recognized and can pose diagnostic challenges. The tubulocystic and cholangioblastic variants are relatively recently described but are being increasingly recognized. The cholangioblastic variant has a novel NIBPL-NACC1 fusion described in the more recent larger series reported, making it a somewhat unique variant of cholangiocarcinoma. Nomenclature of the cholangioblastic variant is in evolution as is the link between adenofibroma and the tubulocystic variant. Correct recognition of these variant subtypes would aid in long-term studies to better determine the prognosis in these subtypes.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemangioblastoma-like Clear Cell Stromal Tumor of the Lung: A Comprehensive Review With Insights From a Case. 肺血管母细胞瘤样透明细胞间质瘤：从一个病例的全面回顾。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-07 DOI: 10.1097/PAP.0000000000000482

Jian Zeng, Peng Lushan, Qin Jing, Wei Du

引用次数: 0

Hepatoblastoma: Comprehensive Review With Recent Updates. 肝母细胞瘤：综合综述与最新进展。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-04-03 DOI: 10.1097/PAP.0000000000000495

Jingjing Jiao, Romil Saxena, Raffaella Morotti

{"title":"Hepatoblastoma: Comprehensive Review With Recent Updates.","authors":"Jingjing Jiao, Romil Saxena, Raffaella Morotti","doi":"10.1097/PAP.0000000000000495","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000495","url":null,"abstract":"Hepatoblastoma (HB), the most common primary malignant liver tumor of childhood, demonstrates remarkable histologic heterogeneity and can be classified into epithelial or mixed epithelial-mesenchymal subtypes. This review summarizes updates in histologic classification, molecular signatures, staging, and risk stratification of HB. The Children's Hepatic tumors International Collaboration represents an international effort to standardize the study of rare pediatric liver tumors; emphasis continues to remain on improving risk stratification by a combination of clinical, histologic, and molecular features to tailor treatment in a bid to reduce toxicity while maintaining or improving efficacy. Pure fetal HB is cured by complete resection without the need for adjuvant chemotherapy. Malignant rhabdoid tumors have been parsed out from small cell undifferentiated HBs by negative INI-1 staining on immunohistochemistry; these tumors require a distinct and more aggressive chemotherapeutic regimen. The significance of recently characterized \"blastema\" component in HB remains to be elucidated. Hepatocellular neoplasm, not otherwise specified, is a provisional diagnostic category for tumors exhibiting either intermediate or a combination of both HB and hepatocellular carcinoma histologic features. The Children's Hepatic tumors International Collaboration risk stratification algorithm includes age as an important discriminator of risk, in addition to AFP, metastasis, and PreTreatment EXTent of disease stage and its annotations.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Primer on Bluesky (and PathSky) for Pathologists, Trainees, and Medical Students. 对蓝天（和PathSky）的入门病理学家，实习生，和医学生。

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-24 DOI: 10.1097/PAP.0000000000000491

Casey P Schukow, Lavisha S Punjabi, Emma Khan

引用次数: 0

Bone Matrix-forming Tumors. 骨基质形成肿瘤

IF 5.1 2区医学

Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1097/PAP.0000000000000476

Julio A Diaz-Perez, Andrew E Rosenberg

引用次数: 0