The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Glandular Lesions of the Urinary Bladder.

IF 2.6 2区 医学 Q1 PATHOLOGY
Gladell P Paner, Hikmat Al-Ahmadie, Nadine T Gaisa, Antonio Lopez-Beltran, Fiona Maclean, Toyonori Tsuzuki, Isabela Werneck da Cunha, Mahul B Amin, Jonathan Aning, Manju Aron, Daniel Athanazio, Richard M Bambury, Liang Cheng, Anuradha Gopalan, Christian Gulmann, Charles C Guo, Carole Harris, Gopa Iyer, Rafael E Jimenez, Masahiro Jinzaki, Eiji Kikuchi, Priti Lal, Kosuke Miyai, George J Netto, Chin-Chen Pan, Valeria Panebianco, Bas Wg van Rhijn, Arlene Siefker-Radtke, Steven C Smith, Tibor Szarvas, Sara E Wobker, Glen Kristiansen, Henning Reis
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Abstract

The Dublin ISUP Consensus Conference covered the proceedings on the best practice recommendations on nonurachal glandular lesions of the urinary bladder, bladder diverticular cancers, and molecular features of bladder and urachal glandular lesions. The conference proceedings on urachal neoplasms (except for their molecular features) are published elsewhere. The rationale for convening this conference was the lack of structured and consented pathologic recommendations in these rare lesions. Consensus by participants was reached on the following statements: (1) intestinal metaplasia with dysplasia is considered to be a precursor to primary bladder adenocarcinoma; (2) dysplasia arising from cystitis glandularis should be reported in terms of focality (focal or nonfocal) and grade (low or high); (3) the term "adenocarcinoma" should only be used for carcinomas showing pure (nonurothelial) morphology and should not be used interchangeably in urothelial carcinoma with "glandular differentiation" because of the pathobiological differences and management implications; (4) the different histologic subtypes of bladder adenocarcinoma should be specified in the report; (5) immunohistochemistry has an ancillary role in the work up of bladder adenocarcinoma versus gastrointestinal or Müllerian-type adenocarcinomas; (6) lymphovascular invasion should be included as a parameter when reporting bladder adenocarcinoma; (7) representative or targeted sampling will be sufficient for bladder diverticulum resection specimens; and (8) molecular analysis in genomic profiling should be performed only in advanced or metastatic bladder and urachal adenocarcinomas for targetable therapy. This report on glandular (nonurachal) lesions of the bladder from the Dublin ISUP consensus conference will serve as a best practice recommendation and as a guide for future research on these relatively rare lesions.

都柏林国际泌尿病理学会(ISUP)关于膀胱腺体病变病理最佳实践建议的共识会议。
都柏林ISUP共识会议涵盖了关于膀胱非尿管腺病变、膀胱憩室癌以及膀胱和尿管腺病变分子特征的最佳实践建议。关于泌尿道肿瘤的会议论文集(除其分子特征外)在其他地方发表。召开这次会议的理由是缺乏结构化和一致同意的病理建议在这些罕见的病变。与会者就以下陈述达成共识:(1)肠上皮化生伴不典型增生被认为是原发性膀胱腺癌的前兆;(2)腺性膀胱炎引起的发育不良应根据病灶(局灶性或非局灶性)和分级(低或高)进行报告;(3)“腺癌”一词应仅用于表现为纯粹(非尿路上皮)形态的癌,而不应在具有“腺分化”的尿路上皮癌中互换使用,因为其病理生物学差异和治疗意义;(4)报告中应明确膀胱腺癌的不同组织学亚型;(5)免疫组织化学在膀胱腺癌与胃肠道或勒氏腺癌相比的诊断中具有辅助作用;(6)报告膀胱腺癌时应将淋巴血管浸润作为一项参数;(7)膀胱憩室切除术标本的代表性或针对性取样就足够了;(8)只有在晚期或转移性膀胱和尿管腺癌中才能进行靶向治疗的分子分析。这份来自都柏林ISUP共识会议的关于膀胱腺(非尿路)病变的报告将作为最佳实践建议,并作为对这些相对罕见病变的未来研究的指南。
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来源期刊
CiteScore
10.30
自引率
3.00%
发文量
88
审稿时长
>12 weeks
期刊介绍: Advances in Anatomic Pathology provides targeted coverage of the key developments in anatomic and surgical pathology. It covers subjects ranging from basic morphology to the most advanced molecular biology techniques. The journal selects and efficiently communicates the most important information from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology.
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