Advances In Anatomic Pathology最新文献_第3页

An Update on Soft Tissue Tumors of the Paratesticular Region. 睾丸旁区软组织肿瘤研究进展。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-07-01 DOI: 10.1097/PAP.0000000000000546

Benjamin L Coiner, William J Anderson

引用次数: 0

Part 1: The Role of the Surgical Pathologist in the Recognition of Hereditary Tumor Syndromes. 第一部分：外科病理学家在遗传性肿瘤综合征识别中的作用。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-07-01 Epub Date: 2026-07-27 DOI: 10.1097/PAP.0000000000000542

Vania Nosé, Abbas Agaimy, Zubair Baloch, Gladell P Paner

引用次数: 0

From Familial Clustering to a Dedicated Classification: The Historical Recognition of Hereditary Tumor Syndromes in the WHO Classification of Tumors. 从家族聚类到专门分类：WHO肿瘤分类中对遗传性肿瘤综合征的历史认识。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1097/PAP.0000000000000544

Sule Canberk, Vania Nosé

{"title":"From Familial Clustering to a Dedicated Classification: The Historical Recognition of Hereditary Tumor Syndromes in the WHO Classification of Tumors.","authors":"Sule Canberk, Vania Nosé","doi":"10.1097/PAP.0000000000000544","DOIUrl":"10.1097/PAP.0000000000000544","url":null,"abstract":"Background: Familial cancer aggregation has been recognized for more than 150 years. For much of that period, hereditary tumor predisposition was incorporated into tumor classification in a fragmented, organ-specific manner. Across successive editions, the WHO classification of tumours moved from morphology-based histologic typing toward an integrated classification that includes molecular pathology, inherited predisposition and, in the fifth edition, a dedicated framework for genetic tumour syndromes.Scope: This review traces the historical development of genetic tumor syndrome recognition, from 19th-century familial cancer pedigrees and mid-20th-century clinical syndrome delineation to the molecular definition of classic predisposition syndromes. It also examines how these entities were gradually incorporated into the WHO Blue Book editions. Particular emphasis is placed on the transition from organ-based coverage to a pathway-based classification organized around major cellular mechanisms, molecular pathways, clinical syndromes, and affected genes or genomic loci.Conclusions: The dedicated WHO framework for genetic tumour syndromes represents an important classificatory shift. It recognizes that constitutional and mosaic cancer predisposition cannot be adequately represented by organ-specific tumor taxonomy alone. For pathologists, this framework reinforces the diagnostic importance of tumor morphology, immunohistochemistry, and molecular findings as sentinel indicators of possible genetic predisposition. It also provides a standardized structure for comparing established syndromes, incorporating emerging entities and supporting clinical genetics, surveillance, family counseling, and epidemiological ascertainment.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"231-244"},"PeriodicalIF":2.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DICER1 Syndrome and Tumor Pathology: An Updated Review for Diagnostic Practice. DICER1综合征和肿瘤病理：诊断实践的最新回顾。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-06-10 DOI: 10.1097/PAP.0000000000000540

Maria C Riascos, Vania Nosé

引用次数: 0

Pixelomics: The Omics-Style Interrogation of Whole Slide Images for Precision Pathology. 像素组学：用于精确病理的整张幻灯片图像的组学式询问。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2026-04-23 DOI: 10.1097/PAP.0000000000000535

Ehsan Ullah, Anil V Parwani

引用次数: 0

Advances in Precision Diagnostics: The Emerging Role of Digital Pathology and Artificial Intelligence. 精确诊断的进展：数字病理学和人工智能的新兴作用。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2026-05-07 DOI: 10.1097/PAP.0000000000000538

Anil V Parwani, Mahul B Amin

引用次数: 0

Advances in Digital Cytopathology and Artificial Intelligence Applications. 数字细胞病理学与人工智能应用研究进展。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2026-04-27 DOI: 10.1097/PAP.0000000000000529

Swati Satturwar, Anil V Parwani, Zaibo Li

{"title":"Advances in Digital Cytopathology and Artificial Intelligence Applications.","authors":"Swati Satturwar, Anil V Parwani, Zaibo Li","doi":"10.1097/PAP.0000000000000529","DOIUrl":"10.1097/PAP.0000000000000529","url":null,"abstract":"Cytopathology is the first field of pathology in which artificial intelligence (AI) models were successfully developed and commercialized for routine clinical screening of cervical cytology, a practice that has been in place for the past 2 to 3 decades. However, the development and deployment of AI applications for nongynecologic cytology has just begun. The variety of cytology specimen types and preparations with associated unique characteristics presents technical challenges for the complete digitization of the cytology workflow. Despite of these challenges, a few institutions have adopted a complete digital cytology workflow. Technical advancement in digital cytopathology have replaced conventional rapid onsite evaluation by a variety of virtual telecytology systems. Novel digital diagnostic solutions for cytology are evolving. Among these, Hologic Genius is the only one approved by the Food and Drug Administration (FDA) for routine clinical screening of cervical cytology in the United States. The recommendations for AI validation and best-practice guidelines for digital cytopathology are currently being developed. Prospect of technical and AI advances in digital cytopathology include automation of sample preparation, ROSE using telecytology, automation of screening of gynecologic and nongynecologic cytology specimens, automated quantitation of biomarkers, quality control, and beyond. This review article uncovers recent advances in digital cytopathology and discusses potential use cases of AI applications for routine cytopathology practice in this modern era of digital cytopathology.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"190-200"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ex Vivo Digital Microscopy Techniques in Surgical Pathology. 离体数字显微技术在外科病理学。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2026-03-04 DOI: 10.1097/PAP.0000000000000530

Savitri Krishnamurthy

{"title":"Ex Vivo Digital Microscopy Techniques in Surgical Pathology.","authors":"Savitri Krishnamurthy","doi":"10.1097/PAP.0000000000000530","DOIUrl":"10.1097/PAP.0000000000000530","url":null,"abstract":"Ex vivo digital microscopy uses light in the visible and adjacent spectra to obtain digital images of tissues. They are optical imaging techniques that allow the acquisition of digital images of tissues with minimal or no tissue preparation and are currently available for evaluation of fresh and/or fixed tissues. This review will provide an overview of the different types of ex vivo digital microscopy techniques, including confocal microscopy (CM), optical coherence tomography (OCT), stimulated Raman Spectroscopy (SRS), light sheet microscopy (LSM), microscopy with ultraviolet excitation (MUSE), structured illumination microscopy (SIM), and nonlinear microscopy (NLM). Except for OCT and SRS, all the other tissue imaging techniques require labeling of tissues with fluorescent dyes to obtain digital images. An advantage of several of these techniques, including fluorescence CM, SRS, LSM, MUSE, SIM, and NLM, is that they can produce hematoxylin and eosin-like images. The promising potential of ex vivo digital microscopy techniques in surgical pathology practice is supported by several retrospective and limited prospective studies. Applications of ex vivo digital microscopy techniques include real-time evaluation of fresh tissue at the bedside in clinics and radiology suites, as well as intraoperatively in pathology laboratories. These techniques have great potential for incorporation into standard-of-care surgical pathology practice.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"181-189"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Generative AI for Anatomic Pathology-A Review of Current Applications to Envisage the Future Direction. 解剖病理学的多模态生成人工智能-展望未来方向的当前应用综述。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2025-04-29 DOI: 10.1097/PAP.0000000000000498

Ehsan Ullah, Mirza Mansoor Baig, Asim Waqas, Ghulam Rasool, Rajendra Singh, Ashwinikumar Shandilya, Hamid GholamHossieni, Anil V Parwani

{"title":"Multimodal Generative AI for Anatomic Pathology-A Review of Current Applications to Envisage the Future Direction.","authors":"Ehsan Ullah, Mirza Mansoor Baig, Asim Waqas, Ghulam Rasool, Rajendra Singh, Ashwinikumar Shandilya, Hamid GholamHossieni, Anil V Parwani","doi":"10.1097/PAP.0000000000000498","DOIUrl":"10.1097/PAP.0000000000000498","url":null,"abstract":"This review focuses on the purported applications of multimodal Gen-AI models for anatomic pathology image analysis and interpretation to predict future directions. A scoping review was conducted to explore the applications of multimodal Gen-AI models in advancing histopathology image analysis. A comprehensive search was conducted using electronic databases for relevant articles published within the past year (July 1, 2023 to June 30, 2024). The selected articles were critically analyzed to identify and summarize the applications of multimodal Gen-AI in anatomic pathology image analysis. Multimodal Gen AI models reported in the literature claim moderate to high accuracy on tasks including image classification, segmentation, and text-to-image retrieval. This review demonstrates the potential of multimodal Gen AI models for useful applications in pathology, including assisting with diagnoses, generating data for education and research, and detection of molecular features from anatomic pathology images. These models use data from a few academic institutions thus they require validation on diverse real-world data. There is an urgent need to build consensus models for optimal model performance through multicenter collaboration using a federated learning approach and the use of carefully curated synthetic anatomic pathology data. These models also need to achieve reliability, generalizability and meet the standards required for clinical use. Despite the rigorous need for evaluation and the need to address genuine concerns, multimodal GenAI models present a promising perspective for the advancement and scalability of anatomic pathology.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"206-216"},"PeriodicalIF":2.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates on Digital Pathology and Artificial Intelligence for Clinical Applications in Surgical Pathology. 数字病理学和人工智能在外科病理学临床应用中的最新进展。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2026-04-23 DOI: 10.1097/PAP.0000000000000536

Ehsan Ullah, Krutika Mishra, Anil V Parwani

引用次数: 0