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Advances In Anatomic Pathology最新文献

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Mesenchymal Tumors of the Human Body: A Targeted Practical Review (Part II). 人体间充质肿瘤：有针对性的实践回顾（第二部分）。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI: 10.1097/PAP.0000000000000490
Andrew Rosenberg, Andre Pinto
{"title":"Mesenchymal Tumors of the Human Body: A Targeted Practical Review (Part II).","authors":"Andrew Rosenberg, Andre Pinto","doi":"10.1097/PAP.0000000000000490","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000490","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"32 2","pages":"109"},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Mesenchymal Tumors. 儿童间充质肿瘤。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1097/PAP.0000000000000480
Omar Aljuboori, Ali G Saad
{"title":"Pediatric Mesenchymal Tumors.","authors":"Omar Aljuboori, Ali G Saad","doi":"10.1097/PAP.0000000000000480","DOIUrl":"10.1097/PAP.0000000000000480","url":null,"abstract":"<p><p>Vascular, fibrous/myofibroblastic, and myogenic tumors account for the majority of mesenchymal tumors in children. These tumors often show significant overlap in morphology and immunophenotype posing diagnostic difficulties and, thus, their classification remains challenging. Recent advances in immunohistochemistry have proved helpful in identifying a specific line of differentiation in some tumors, but other tumors remain difficult to classify. Molecular investigations have provided an existing tool to better understand the pathogenesis of some of these tumors and, in some cases like the EWING family of tumors, expanded the classification resulting in the emergence of previously unknown tumors. Some of these tumors are currently diagnosed according to their underlying molecular abnormality, such as CIC -rearranged sarcoma, BCOR -rearranged sarcoma, etc. This review focuses on the common mesenchymal neoplasms of the pediatric population with emphasis on the salient histologic features, immunoprofile, and molecular characteristics. For practical purposes, the latter are summarized in Supplemental Table 1, Supplemental Digital Content 1, http://links.lww.com/PAP/A46 .</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"180-192"},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipomatous Neoplasms of Soft Tissue: A Contemporary Review. 软组织脂肪瘤：当代回顾。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI: 10.1097/PAP.0000000000000468
Kshitij Arora, Andrew E Rosenberg
{"title":"Lipomatous Neoplasms of Soft Tissue: A Contemporary Review.","authors":"Kshitij Arora, Andrew E Rosenberg","doi":"10.1097/PAP.0000000000000468","DOIUrl":"10.1097/PAP.0000000000000468","url":null,"abstract":"<p><p>This review summarizes the clinicopathologic features of various lipomatous tumors of soft tissue and addresses some recent conceptual issues relating to adipocytic neoplasms, such as atypical spindle cell/pleomorphic lipomatous tumor and myxoid pleomorphic liposarcoma, and provides an update on the molecular aspects of these tumors. Recent advances in cytogenetic characterization and classification of lipomatous tumors are reviewed, and the genetic importance of distinct chromosomal aberrations are briefly discussed.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"147-156"},"PeriodicalIF":5.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Liver Diseases With Near-Normal Histology: A Review Focusing on Metabolic, Storage, and Inclusion Disorders. 组织学接近正常的罕见肝病：代谢、储存和包涵性疾病综述
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-02-17 DOI: 10.1097/PAP.0000000000000488
Xiaotang Du, Hanlin L Wang
{"title":"Rare Liver Diseases With Near-Normal Histology: A Review Focusing on Metabolic, Storage, and Inclusion Disorders.","authors":"Xiaotang Du, Hanlin L Wang","doi":"10.1097/PAP.0000000000000488","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000488","url":null,"abstract":"<p><p>Despite the growing availability of noninvasive and faster diagnostic modalities, biopsy remains an important tool in the diagnosis and management of liver diseases. However, it is not uncommon that liver biopsies reveal normal or near normal histologic findings in patients with abnormal liver biochemistries, elevated autoantibodies, clinical findings suggestive of portal hypertension, systemic autoimmune or inflammatory diseases, hepatomegaly, cirrhosis by imaging, or other indications. These scenarios present significant diagnostic challenges and are rarely discussed in detail in the literature or textbooks. This article aims to provide a comprehensive review of a group of selected rare liver diseases, with a focus on metabolic, storage and inclusion disorders, that may exhibit a near-normal histology on biopsy. By recognizing subtle histologic features and correlating with clinical history, laboratory results and imaging findings, it is often possible to narrow down the differential diagnosis. In many cases, this integrative approach can yield a definitive diagnosis, allowing for tailored treatment and better patient outcomes.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Diagnostic Spectrum of Myelodysplastic Syndromes and Acute Myeloid Leukemia. 骨髓增生异常综合征和急性髓系白血病的诊断谱。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-02-03 DOI: 10.1097/PAP.0000000000000485
Daniel A Arber, Attilio Orazi
{"title":"The Diagnostic Spectrum of Myelodysplastic Syndromes and Acute Myeloid Leukemia.","authors":"Daniel A Arber, Attilio Orazi","doi":"10.1097/PAP.0000000000000485","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000485","url":null,"abstract":"<p><p>The International Consensus Classification (ICC) of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) expands on the work of prior classifications to refine the diagnostic criteria for MDS and AML and to identify specific genetic disease subtypes. This review summarizes the approach to the diagnosis of MDS and AML from the ICC perspective. For MDS, the significance of detecting mutations in SF3B1, usually associated with ring sideroblasts, as well as the poor prognosis of mutations of TP53 are now included. For AML, new genetic categories are included, and the classification now incorporates additional clinically significant gene mutations by recognizing AML with TP53 mutation and AML with mutations in genes associated with prior therapy or MDS. Finally, the new category of MDS/AML is introduced for adult patients without recurrent de novo genetic abnormalities with 10% to 19% peripheral blood or bone marrow blasts that allow for more treatment flexibility based on clinical findings. While the increase in genetic categories and changes in blast cell requirements can be confusing, a stepwise approach is provided to allow easy use of the classification.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steatotic Liver Disease: Navigating Pathologic Features, Diagnostic Challenges, and Emerging Insights. 脂肪变性肝病：导航病理特征，诊断挑战和新兴见解。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-17 DOI: 10.1097/PAP.0000000000000483
Jingjing Jiao, Xuchen Zhang
{"title":"Steatotic Liver Disease: Navigating Pathologic Features, Diagnostic Challenges, and Emerging Insights.","authors":"Jingjing Jiao, Xuchen Zhang","doi":"10.1097/PAP.0000000000000483","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000483","url":null,"abstract":"<p><p>Steatotic liver disease (SLD) is now used as an overarching category encompassing five subcategories: metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic and alcohol related/associated liver disease (MetALD), alcohol-related/associated liver disease (ALD), SLD with specific etiology, and cryptogenic SLD. This review summarizes foundational and recent advances in the histologic evaluation of SLD, including common pathologic features across all subcategories, distinctions associated with different etiologies, scoring and grading systems, and the evolution of digital pathology techniques for SLD assessment.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Typing of Vulvar Squamous Cell Carcinoma: Why it is Important? 外阴鳞状细胞癌的分型：为什么很重要？
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-09-25 DOI: 10.1097/PAP.0000000000000466
Mona Alfaraidi, C Blake Gilks, Lynn Hoang
{"title":"Typing of Vulvar Squamous Cell Carcinoma: Why it is Important?","authors":"Mona Alfaraidi, C Blake Gilks, Lynn Hoang","doi":"10.1097/PAP.0000000000000466","DOIUrl":"10.1097/PAP.0000000000000466","url":null,"abstract":"<p><p>The classification of vulvar squamous cell carcinoma (VSCC), as in endometrial cancer, has shifted from the histology-based descriptors toward molecular-based identifiers. Recently, it has been reported that there are 3 genetically distinct and clinically significant subtypes of VSCC: HPV-associated VSCC, HPV-independent/p53 wild-type VSCC, and HPV-independent/p53-mutated VSCC. Each group has different prognostic implications as well as response to treatment, thus reinforcing the need for this 3-tier molecular classification. This molecular subtyping can easily be done on vulvar biopsies using p16 and p53 immunohistochemistry stains to further improve risk prediction and individualized treatment decisions, leading to better patient outcomes.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"20-29"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Stratification of Miscellaneous Uterine Mesenchymal Neoplasms: The Role of Morphology, Immunohistochemistry, and Molecular Testing. 杂性子宫间质肿瘤的风险分层：形态学、免疫组织化学和分子检测的作用。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.1097/PAP.0000000000000479
Nicholas Ladwig, Baris Boyraz
{"title":"Risk Stratification of Miscellaneous Uterine Mesenchymal Neoplasms: The Role of Morphology, Immunohistochemistry, and Molecular Testing.","authors":"Nicholas Ladwig, Baris Boyraz","doi":"10.1097/PAP.0000000000000479","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000479","url":null,"abstract":"<p><p>Uterine mesenchymal tumors are a diverse group of tumors that can display a broad range of morphologic, immunohistochemical, and molecular profiles and are associated with varied clinical behaviors. In recent years, they have increasingly been classified by their underlying molecular alterations, leading to a more precise separation of diagnostic entities. As their diagnostic criteria have been refined, so too have the features that can be used to predict clinical outcomes. This review includes a discussion of uterine inflammatory myofibroblastic tumors, perivascular epithelioid cell tumors (PEComa), and uterine tumors resembling ovarian sex cord tumors, with a focus on updates on their clinical behavior and tools for risk stratification to identify malignant tumors. In addition, we discuss the importance of using an integrated approach when classifying uterine mesenchymal tumors to improve diagnostic accuracy and guide clinical management.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"32 1","pages":"57-69"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Stratification of Uterine Smooth Muscle Tumors: The Role of Morphology, Immunohistochemistry, and Molecular Testing. 子宫平滑肌肿瘤的风险分层：形态学、免疫组织化学和分子检测的作用。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.1097/PAP.0000000000000478
Amir Momeni-Boroujeni, Marisa R Nucci, David B Chapel
{"title":"Risk Stratification of Uterine Smooth Muscle Tumors: The Role of Morphology, Immunohistochemistry, and Molecular Testing.","authors":"Amir Momeni-Boroujeni, Marisa R Nucci, David B Chapel","doi":"10.1097/PAP.0000000000000478","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000478","url":null,"abstract":"<p><p>Uterine smooth muscle neoplasms are a biologically and clinically heterogeneous group of tumors. Morphology is the cornerstone of pathologic diagnosis of these tumors, and most are readily classified as benign or malignant on the basis of routine histologic examination. However, rare subsets-including intravenous leiomyomatosis, benign metastasizing leiomyoma, and disseminated peritoneal leiomyomatosis-have a capacity for extrauterine spread despite benign cytomorphology. A further subset of uterine smooth muscle neoplasms, termed \"smooth muscle tumor of uncertain malignant potential (STUMP),\" are not readily classified as benign or malignant and carry an intermediate prognosis. STUMP is a protean category, whose precise definition is subject to disagreement among experts. The risk profiles of different STUMP morphotypes remain largely unresolved. Finally, multiple morphology-based systems for risk stratification of uterine leiomyosarcoma have been proposed, though none is widely adopted. Immunohistochemical and molecular prognostic markers for both STUMP and leiomyosarcoma remain in the early phases of adoption in routine diagnostic practice.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"32 1","pages":"44-56"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovarian Sex Cord-Stromal Neoplasms: An Overview of Molecular Events and How to Correlate Morphology With Molecular Findings. 卵巢性索间质肿瘤：分子事件概述以及如何将形态学与分子发现联系起来。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-11-04 DOI: 10.1097/PAP.0000000000000474
Joseph T Rabban, W Glenn McCluggage
{"title":"Ovarian Sex Cord-Stromal Neoplasms: An Overview of Molecular Events and How to Correlate Morphology With Molecular Findings.","authors":"Joseph T Rabban, W Glenn McCluggage","doi":"10.1097/PAP.0000000000000474","DOIUrl":"10.1097/PAP.0000000000000474","url":null,"abstract":"<p><p>Since the discovery in 2009 that missence pathogenic variants/mutations in FOXL2 are extremely common in ovarian adult granulosa cell tumours, the last 2 decades have witnessed significant developments in our understanding of the molecular events underlying the pathogenesis of other ovarian sex cord-stromal tumours (SCSTs). In this review, we cover the molecular events in ovarian SCSTs and provide practical guidance to the reporting pathologist as to how and when molecular testing may be useful in diagnosis. We stress the need to correlate the morphology and molecular since most of the molecular events are not entirely specific for a particular tumour type and our knowledge is continually evolving with the elucidation of \"new\" molecular events. We also discuss that in some tumours, molecular testing is helpful in triaging the patient for genetic referral and germline testing since some of the molecular events may be germline in nature.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"70-84"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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