Advances In Anatomic Pathology最新文献_第4页

Challenges and Barriers in Implementing AI for Clinical Applications in Anatomic Pathology. 人工智能在解剖病理学临床应用中的挑战和障碍。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-05-01 Epub Date: 2026-04-21 DOI: 10.1097/PAP.0000000000000537

Nickolas G Littlefield, Riyue Bao, Xia Rong, Ehsan Ullah, Anil V Parwani, Qiangqiang Gu

{"title":"Challenges and Barriers in Implementing AI for Clinical Applications in Anatomic Pathology.","authors":"Nickolas G Littlefield, Riyue Bao, Xia Rong, Ehsan Ullah, Anil V Parwani, Qiangqiang Gu","doi":"10.1097/PAP.0000000000000537","DOIUrl":"10.1097/PAP.0000000000000537","url":null,"abstract":"The transformation of anatomic pathology from microscope-based practice to digital and computational workflows has created unprecedented opportunities for artificial intelligence (AI)-driven diagnostics. Whole slide imaging systems, digital cytology, and enterprise pathology platforms now enable large-scale image analysis, quantitative tissue characterization, and integration with molecular and clinical data. In parallel, advances in machine and deep learning, and generative models have produced AI systems capable of tumor detection, grading, prognostication, biomarker assessment, and molecular inference directly from routine histologic and cytologic slides. Despite this rapid progress, translation of AI from research environments into routine clinical anatomic pathology remains limited. Barriers include data heterogeneity and limited generalizability, challenges in validation and regulatory compliance, infrastructure and interoperability constraints, workflow integration difficulties, and concerns regarding transparency, accountability, and professional trust. This review synthesizes current evidence on digital pathology and AI applications across surgical pathology and cytopathology, examines the technical, organizational, and regulatory factors that impede clinical adoption, and outlines practical recommendations for developing clinically deployable AI systems. Addressing these challenges through robust digital infrastructure, representative data sets, rigorous validation, and coordinated governance will be essential for realizing the full clinical potential of AI in anatomic pathology.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"174-180"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Round Cell Tumors of Soft Tissue and Skeleton in Children and Youth: A Narrative and TruSight-Based Illustrative Review of Diagnostic Cases. 儿童和青少年软组织和骨骼小圆细胞瘤：诊断病例的叙述和基于信任的说明性回顾。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-04-03 DOI: 10.1097/PAP.0000000000000532

Anita Nagy, Consolato M Sergi

{"title":"Small Round Cell Tumors of Soft Tissue and Skeleton in Children and Youth: A Narrative and TruSight-Based Illustrative Review of Diagnostic Cases.","authors":"Anita Nagy, Consolato M Sergi","doi":"10.1097/PAP.0000000000000532","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000532","url":null,"abstract":"Small round cell tumors (SRCT) affecting soft tissue and bone are a distinct category of malignancies. These lesions frequently exhibit similar clinical and radiologic features, may harbor overlapping histologic and immunophenotypic features, and generally have distinct prognostic outcomes. Therefore, in some instances, the diagnosis and accurate subclassification require molecular confirmation. We aimed to provide a comprehensive overview of the morphologic, immunohistochemical, and molecular features of SRCTs of soft tissue and bone in pediatric and young adult patients, with an emphasis on both commonly encountered tumors and rare, recently described entities, accompanied by illustrative material from our TruSight platform. The literature data were mined from the PubMed/Medline, Scopus, and Cochrane databases covering the period from January 1, 2014, to December 31, 2024, and the authors' personal experience with diagnostic cases at their institutions. We reviewed tumors that include sarcoma with EWSR1-non-ETS fusion, CIC-rearranged sarcoma, BCOR-rearranged sarcoma, Ewing sarcoma, alveolar rhabdomyosarcoma, desmoplastic small round cell tumor, high-grade/round cell myxoid liposarcoma, poorly differentiated synovial sarcoma, small-cell type osteosarcoma, mesenchymal chondrosarcoma, and extraskeletal myxoid chondrosarcoma. Immunohistochemistry plays a crucial role in interpreting a specific diagnosis or narrowing the differential diagnosis of SRCTs. Molecular genetic investigations are essential, particularly in cases exhibiting atypical or overlapping histologic and immunohistological features.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ductal Adenocarcinoma of the Prostate: Evolution and Current State. 前列腺导管腺癌：演变和现状。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1097/PAP.0000000000000522

Alessia Cimadamore, Carmine Franzese, Antonio Lopez-Beltran, Liang Cheng, Gladell P Paner, Rodolfo Montironi

引用次数: 0

Pheochromocytoma and Extra-Adrenal Paragangliomas: An Update in Diagnostics and Clinical Implications. 嗜铬细胞瘤和肾上腺外副神经节瘤：诊断和临床意义的最新进展。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1097/PAP.0000000000000528

Priscila Dias Goncalves, Peter M Sadow

{"title":"Pheochromocytoma and Extra-Adrenal Paragangliomas: An Update in Diagnostics and Clinical Implications.","authors":"Priscila Dias Goncalves, Peter M Sadow","doi":"10.1097/PAP.0000000000000528","DOIUrl":"10.1097/PAP.0000000000000528","url":null,"abstract":"Over the last 2 to 3 decades, we have seen incremental movement from the \"Rule of 10s\" for pheochromocytomas, particularly those regarding tumor bilaterality, malignancy, and patterns of inheritance. The biology and prevalence of these tumors have not changed, but there has been a great deal of progress in terms of our understanding of tumor genetics, variable modes of acquiring of both pheochromocytomas and paragangliomas (PPGL), and our approach to clinical management of these unpredictable neoplasias. Although these non-epithelial neuroendocrine tumors are rare, they are clinically significant due to their hormonal activity, association with hereditary syndromes, and biological potential. Their detection has increased in recent decades with improved biochemical testing and advanced imaging modalities, yet predicting clinical behavior continues to be a major challenge. Histologically, PPGL typically shows classic neuroendocrine architecture but may display morphologic diversity, occasionally mimicking other adrenal or paraganglionic tumors. Immunohistochemistry remains essential for diagnostic confirmation and as a surrogate for genetic alterations, offering valuable genotype-phenotype correlations. With increasing knowledge of tumor genetics, additional emphasis has been placed on histology-based risk-stratification for these lesions, particularly those prone to metastasis or multifocality, and the 2022 WHO endorses no individual risk-stratification system, as none seems to be of definitive merit over another. Instead, it promotes a comprehensive approach integrating morphologic, molecular, and clinical factors. Approximately 40% of PPGL harbor germline mutations, whereas somatic alterations account for additional subsets. Mutations in SDH x, VHL , RET , NF1 , and other susceptibility genes define molecular clusters with distinct signaling pathways and clinical behavior, underscoring the importance of multidisciplinary, lifelong management.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"129-139"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatic Tumor-Like Neoplasms Arising With Testicular Germ Cell Tumors: Distilling Evolving Understanding, Terminology, and Implications for the Practicing Surgical Pathologist. 睾丸生殖细胞肿瘤引起的躯体肿瘤样肿瘤：提炼不断发展的理解、术语和对实践外科病理学家的影响。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1097/PAP.0000000000000524

Sabina Desar, Daniel M Berney, Steven Christopher Smith

{"title":"Somatic Tumor-Like Neoplasms Arising With Testicular Germ Cell Tumors: Distilling Evolving Understanding, Terminology, and Implications for the Practicing Surgical Pathologist.","authors":"Sabina Desar, Daniel M Berney, Steven Christopher Smith","doi":"10.1097/PAP.0000000000000524","DOIUrl":"10.1097/PAP.0000000000000524","url":null,"abstract":"Tumors resembling conventional, somatic-type malignancies arise infrequently (<10%) in association with malignant, postpubertal-type testicular germ cell tumors, mainly at the metastatic sites (less frequently at primary), and often after treatment. Historically, the pathogenetic framework for these tumors, indeed their current classification and nomenclature under the WHO 5 th Edition, contemplated their arising from (malignant) postpubertal-type teratomatous components undergoing oncogenic changes homologous to conventional somatic malignancies of the relevant tissue lineages. Recent scholarship questions the specificity of their provenance to postpubertal-type teratoma, with strong evidence relating them also to postpubertal-type yolk sac tumor as well. In tandem, molecular studies support a close relationship to their associated postpubertal-type testicular germ cell tumor rather than identifying any of the known molecular drivers of the somatic-type malignancies they resemble. The histologic patterns observed include sarcoma-like tumors, carcinoma-like tumors, primitive-appearing embryonic-type neuroectodermal tumor, nephroblastoma-like tumors, neuroglial-like neoplasms, leukemia-like malignancies, and combined forms incorporating 2 or more of the foregoing. Although greater experience will be required to validate the changing conceptualization of their origin, from a management standpoint when seen at metastatic sites these somatic tumors-like neoplasms may be poorly responsive to cisplatin-based chemotherapy regimens whereas when seen in the primary site they behave favorably. Surgical resection, if feasible, may provide the best chance for sure at metastatic sites.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"68-80"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micropapillary Urothelial Carcinoma: A Review and Update. 微乳头状尿路上皮癌：综述与最新进展。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1097/PAP.0000000000000527

Merve Basar, Cansu Yol, Jie-Fu Chen, Hikmat Al-Ahmadie

引用次数: 0

Assessment of Adrenal Cortical Neoplasms for the GU Pathologist. GU病理学家对肾上腺皮质肿瘤的评估。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1097/PAP.0000000000000526

Rumeal D Whaley, Sounak Gupta, Lori A Erickson

引用次数: 0

Selected Reviews in Urologic Pathology. 泌尿病理学综述。

IF 2.6 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1097/PAP.0000000000000523

Samson W Fine, Cristina Magi-Galluzzi

引用次数: 0

TFE-Altered Renal Cell Carcinoma: A Contemporary Review With Practical Insights and Diagnostic Pearls for Surgical Pathologists. tfe改变的肾细胞癌：对外科病理学家的实用见解和诊断珍珠的当代回顾。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1097/PAP.0000000000000519

Christopher G Przybycin, Jane K Nguyen, Reza Alaghehbandan

引用次数: 0

Intraepithelial Penile Lesions. 阴茎上皮内病变。

IF 2.8 2区医学

Advances In Anatomic Pathology Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1097/PAP.0000000000000520

Hongzhi Xu, Jasreman Dhillon

{"title":"Intraepithelial Penile Lesions.","authors":"Hongzhi Xu, Jasreman Dhillon","doi":"10.1097/PAP.0000000000000520","DOIUrl":"10.1097/PAP.0000000000000520","url":null,"abstract":"Intraepithelial penile lesions encompass non-neoplastic and preneoplastic lesions. Non-neoplastic lesions comprise condyloma acuminatum, including giant condyloma acuminatum, also known as Buschke-Löwenstein tumor. It is usually the low-risk human papillomavirus (HPV) types 6 and 11 that are most prevalent in penile condylomas. However, high-risk HPV types can be detected along with low-risk types in a subset of patients. Penile intraepithelial neoplasia (PeIN) is a preneoplastic lesion that is either HPV-associated or HPV-independent. HPV-associated PeIN represents the majority of PeIN in regions where the incidence of penile cancer is lower, as in North America and Europe. HPV-associated PeIN is subdivided into basaloid, warty, and mixed subtypes and, less commonly, into pagetoid, clear-cell, and spindle-cell subtypes based on morphologic characteristics. HPV-associated PeIN is positive for immunohistochemical stain p16 and high-risk HPV in situ hybridization (ISH). Immunohistochemical stain p53 usually exhibits a wild-type staining pattern. HPV-independent PeIN/differentiated PeIN is more frequent in countries with a high incidence of penile cancer and an uncircumcised population. It is usually associated with predisposing factors like lichen sclerosus and chronic inflammatory conditions such as lichen planus, lichen simplex chronicus, and phimosis. The degree of atypia in differentiated PeIN ranges from subtle to full-thickness proliferation of markedly atypical pleomorphic cells. Many cases are associated with TP53 mutations and other alterations involving PIK3CA and HRAS. Recently, it has been proposed to further subclassify differentiated PeIN. Extramammary Paget disease (EMPD) can involve the skin of the penis and glans mucosa in elderly men. It is either primary or secondary, and when secondary, it can be associated with prostate or urothelial carcinoma. Lastly, rare case reports of primary penile melanoma in situ have been reported. The lesions can involve either the skin or mucosa, with the glans penis being the most commonly reported site.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"95-105"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0