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Advances In Anatomic Pathology最新文献

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Precancerous Lesions of HPV-independent Vulvar Squamous Cell Carcinoma: Clinicopathologic Consideration of an Evolving Spectrum. 与 HPV 无关的外阴鳞状细胞癌的癌前病变：对不断演变的癌谱的临床病理学思考。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-11-04 DOI: 10.1097/PAP.0000000000000472
Jaclyn Watkins, Oluwole Fadare
{"title":"Precancerous Lesions of HPV-independent Vulvar Squamous Cell Carcinoma: Clinicopathologic Consideration of an Evolving Spectrum.","authors":"Jaclyn Watkins, Oluwole Fadare","doi":"10.1097/PAP.0000000000000472","DOIUrl":"10.1097/PAP.0000000000000472","url":null,"abstract":"<p><p>HPV-independent squamous cell carcinomas of the vulva comprise the majority of vulvar cancers, but their putative precancers represent only a small proportion of the vulvar squamous intraepithelial lesions that are encountered in routine practice. The precancerous lesions of HPV-independent vulvar squamous cell carcinoma encompass a spectrum of lesions that, collectively, may pose significant diagnostic challenges. Included in this spectrum are differentiated vulvar intraepithelial neoplasia [dVIN], the prototypical lesion of the group, which is characterized by a high propensity for progression, a relatively short duration to progression, frequent association with lichen sclerosus, and according to our review of the recent literature, TP53 /p53 aberration in 50% to 95% (mean 77.4%) of cases. Regarding the latter, some authors consider TP53 /p53 aberration to be a diagnostic requirement for dVIN, although this is controversial, as discussed further herein. Also included in the spectrum of lesions that are considered in this review are possibly related HPV-independent, p53-wild type lesions that have historically been reported as \"vulvar acanthosis with altered differentiation\" (VAAD), \"differentiated exophytic vulvar intraepithelial lesion\" (DEVIL), \"verruciform lichen simplex chronicus\" (vLSC), and which more recently, have collectively been described as \"verruciform acanthotic vulvar intraepithelial neoplasia (vaVIN)\" or \"vulvar aberrant maturation (VAM).\" In this review, we perform a comprehensive clinicopathologic review of putative precancerous lesions of HPV-independent squamous cell carcinomas of the vulva, with an emphasis on recent developments in terminology, practical diagnostic issues, biomarkers, and pathogenesis.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"4-19"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STK11 Adnexal Tumor: Exploring the Association With Peutz-Jeghers Syndrome and its Distinction From Morphologic Mimickers. STK11 附件肿瘤：探索与 Peutz-Jeghers 综合征的关联及其与形态学模仿者的区别
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-09-03 DOI: 10.1097/PAP.0000000000000460
Jennifer A Bennett, Esther Oliva
{"title":"STK11 Adnexal Tumor: Exploring the Association With Peutz-Jeghers Syndrome and its Distinction From Morphologic Mimickers.","authors":"Jennifer A Bennett, Esther Oliva","doi":"10.1097/PAP.0000000000000460","DOIUrl":"10.1097/PAP.0000000000000460","url":null,"abstract":"<p><p>STK11 adnexal tumor is a novel malignant neoplasm of uncertain histogenesis frequently arising in a para-adnexal location and associated with Peutz-Jeghers syndrome in ∼50% of patients. Its broad morphologic spectrum and nonspecific immunohistochemical profile has resulted in misclassification in the past as a variety of other neoplasms including those of wolffian, sex cord-stromal, mesothelial, and epithelial derivation. This review focuses on the spectrum of adnexal neoplasms that may develop in Peutz-Jeghers syndrome, with particular emphasis on STK11 adnexal tumor and its differential diagnosis.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"98-108"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Predictive and Prognostic Biomarkers in Lower Female Genital Tract Pathology: PD-L1, MMR, HER2, p16, p53, and Beyond. 预测性和预后性生物标志物在女性下生殖道病理学中的作用：PD-L1、MMR、HER2、p16、p53 及其他。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-09-16 DOI: 10.1097/PAP.0000000000000458
Anne M Mills, Andre Pinto
{"title":"The Role of Predictive and Prognostic Biomarkers in Lower Female Genital Tract Pathology: PD-L1, MMR, HER2, p16, p53, and Beyond.","authors":"Anne M Mills, Andre Pinto","doi":"10.1097/PAP.0000000000000458","DOIUrl":"10.1097/PAP.0000000000000458","url":null,"abstract":"<p><p>Biomarkers play a crucial role in the diagnosis, treatment planning, and prognosis of premalignant and malignant lesions and are increasingly used in neoplasia of the lower female genital tract (LFGT) including the cervix, vagina, and vulva. This review will discuss key biomarkers routinely used in LFGT pathology, including programmed cell death ligand 1 (PD-L1), mismatch repair (MMR), and tumor mutational burden (TMB) testing, which are FDA-approved companion diagnostics for anti-PD-1 checkpoint inhibitors. Recent developments in HER2 testing as a marker for anti-HER2 therapies, and prognostic biomarkers such as p53 in HPV-independent vulvar intraepithelial lesions and carcinomas, are also reviewed.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"30-43"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversial and Evolving Issues in Gynecologic Pathology. 妇科病理学中的争议和演变问题。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-10-14 DOI: 10.1097/PAP.0000000000000467
W Glenn McCluggage, Carlos Parra-Herran
{"title":"Controversial and Evolving Issues in Gynecologic Pathology.","authors":"W Glenn McCluggage, Carlos Parra-Herran","doi":"10.1097/PAP.0000000000000467","DOIUrl":"10.1097/PAP.0000000000000467","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"1-3"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and Risk Stratification of Ovarian Mucinous Neoplasms: Pattern of Invasion, Immunohistochemistry, and Molecular Diagnostics. 卵巢黏液性肿瘤的诊断与风险分层：侵袭模式、免疫组化和分子诊断。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.1097/PAP.0000000000000473
Martin Köbel, Carlos Parra-Herran, Kylie Gorringe
{"title":"Diagnosis and Risk Stratification of Ovarian Mucinous Neoplasms: Pattern of Invasion, Immunohistochemistry, and Molecular Diagnostics.","authors":"Martin Köbel, Carlos Parra-Herran, Kylie Gorringe","doi":"10.1097/PAP.0000000000000473","DOIUrl":"10.1097/PAP.0000000000000473","url":null,"abstract":"<p><p>Ovarian mucinous tumors are subclassified in multiple categories. Recent studies have highlighted issues in interobserver reproducibility. This review will focus on some new developments including criteria and ancillary tests that may help to improve interobserver reproducibility at clinically important thresholds. These issues include proposals for a separate terminology of teratoma-associated ovarian mucinous neoplasms, the role of TP53 immunohistochemistry in distinction of crowded mucinous borderline tumors and expansile mucinous carcinomas as well as the assignment of the infiltrative pattern of invasion, which recently has been validated as important prognostic factor even in low stage mucinous ovarian carcinoma.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"85-97"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Tumors of the Skin: A Review. 皮肤间质瘤：综述。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI: 10.1097/PAP.0000000000000465
Katherine Drews-Elger, Erik A Williams
{"title":"Mesenchymal Tumors of the Skin: A Review.","authors":"Katherine Drews-Elger, Erik A Williams","doi":"10.1097/PAP.0000000000000465","DOIUrl":"10.1097/PAP.0000000000000465","url":null,"abstract":"<p><p>Mesenchymal tumors of the skin are rare and clinically heterogeneous, and can represent diagnostic challenge for pathologists. Most of these lesions have overlapping clinical and histological features, thus the understanding of architectural patterns, cytoplasmic and stromal features can facilitate proper diagnosis. Anatomic site may be an important factor in the differential diagnosis, as are patient's age and sex. Ancillary tests are often required and can be useful to rule out other entities. Molecular diagnostics is playing an increasingly important role in the diagnosis of soft tissue neoplasms. Here, we review clinical, histological, and molecular features of some of the most common of these uncommon entities including benign and malignant lesions.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"31 6","pages":"442-450"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Approach to Mesenchymal and Spindle Cell Tumors of the Breast. 乳腺间质细胞瘤和纺锤形细胞瘤的诊断方法。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI: 10.1097/PAP.0000000000000464
Marissa J White, Ashley Cimino-Mathews
{"title":"Diagnostic Approach to Mesenchymal and Spindle Cell Tumors of the Breast.","authors":"Marissa J White, Ashley Cimino-Mathews","doi":"10.1097/PAP.0000000000000464","DOIUrl":"10.1097/PAP.0000000000000464","url":null,"abstract":"<p><p>Mesenchymal and spindle cell tumors of the breast represent a broad and heterogeneous group of lesions that may be sampled on core needle biopsy or surgical excision. Mesenchymal lesions unique to the breast are those that derive from the specialized breast myofibroblast, such as mammary myofibroblastoma and pseudoangiomatous stromal hyperplasia. However, any mesenchymal lesion arising in extramammary soft tissue may also arise in the breast, including fibroblastic, peripheral nerve sheath, adipocytic, and vascular lesions. The spindle cell lesions pose the greatest diagnostic challenge, due to the significant radiographic, morphologic, and immunophenotypic overlap within the category of mesenchymal lesions and more broadly with other nonmesenchymal breast lesions. The distinction is particularly challenging on the limited material of breast core needle biopsies, and caution should be taken before definitively classifying a breast spindle cell lesion on core needle biopsy to avoid unnecessary treatment if misdiagnosed. Consideration of a wide differential diagnosis, adequate sampling of a resection specimen, use of a targeted immunopanel, and selective use of molecular assays are essential steps for accurate classification of mesenchymal lesions in the breast. This review covers the clinical, histologic, and immunophenotypic features of mesenchymal tumors of the breast, with a special emphasis on the differential diagnoses unique to the breast and challenges encountered on breast core needle biopsy.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":"31 6","pages":"411-428"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Tumors of the Head and Neck. 头颈部间质瘤。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.1097/PAP.0000000000000462
Karina Colossi Furlan, Bruce M Wenig
{"title":"Mesenchymal Tumors of the Head and Neck.","authors":"Karina Colossi Furlan, Bruce M Wenig","doi":"10.1097/PAP.0000000000000462","DOIUrl":"10.1097/PAP.0000000000000462","url":null,"abstract":"<p><p>The majority of neoplasms of the head and neck are of epithelial origin primarily including mucosal squamous cell neoplasms (papillomas; squamous cell carcinoma) as well as salivary gland neoplasms. However, the full spectrum of mesenchymal neoplasms (benign and malignant) typically arising in soft tissue sites may also develop in superficial layers of the upper aerodigestive tract. The diversity of mesenchymal neoplasms arising in the head and neck is beyond the scope of this article, and our focus will be on some of the more common and/or diagnostic problematic mesenchymal tumors occurring in the sinonasal tract, oral cavity/odontogenic, pharynx, larynx, and neck.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"364-379"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Tumors of the Human Body: A Targeted Practical Review. 人体间质肿瘤：有针对性的实用综述。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1097/PAP.0000000000000459
Andre Pinto, Andrew E Rosenberg
{"title":"Mesenchymal Tumors of the Human Body: A Targeted Practical Review.","authors":"Andre Pinto, Andrew E Rosenberg","doi":"10.1097/PAP.0000000000000459","DOIUrl":"10.1097/PAP.0000000000000459","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"353"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common Diagnostic Challenges in Genitourinary Mesenchymal Tumors: A Practical Approach. 泌尿生殖系统间质瘤的常见诊断难题：实用方法。
IF 5.1 2区 医学
Advances In Anatomic Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1097/PAP.0000000000000461
Jaylou M Velez Torres, Oleksandr N Kryvenko
{"title":"Common Diagnostic Challenges in Genitourinary Mesenchymal Tumors: A Practical Approach.","authors":"Jaylou M Velez Torres, Oleksandr N Kryvenko","doi":"10.1097/PAP.0000000000000461","DOIUrl":"10.1097/PAP.0000000000000461","url":null,"abstract":"<p><p>Mesenchymal neoplasms within the genitourinary tract include a wide spectrum of tumors, ranging from benign to malignant, and tumors of uncertain malignant potential. Except for stromal tumors of the prostate, which originate from the specific prostatic stroma, these neoplasms generally resemble their counterparts in other body sites. The rarity of these neoplasms and the limitation associated with small biopsy samples present unique diagnostic challenges for pathologists. Accurate diagnosis is paramount, as it significantly influences prognosis and guides management and treatment strategies. This review addresses common diagnostic scenarios, discusses key differential diagnoses, and sheds light on potential diagnostic pitfalls.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":" ","pages":"429-441"},"PeriodicalIF":5.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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