Drug-induced Liver Injury: Pathology Patterns and Common Culprits.

IF 2.6 2区 医学 Q1 PATHOLOGY
Paige H Parrack, Lei Zhao
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引用次数: 0

Abstract

Drug-induced liver injury (DILI) has an incredible range of morphologic presentations, from acute extensive necrosis to resolving injury with ceroid-laden macrophages. The diversity in presentation on biopsy is diagnostically challenging, but DILI is becoming more widely recognized, especially with the aid of resources like LiverTox. Some medications, such as acetaminophen, have well-established patterns of injury. However, newer medications, such as immune checkpoint inhibitors, are continually being developed, and our understanding of their effects on the liver are evolving. In this chapter, we will focus on the DILI patterns and frequently encountered DILI culprits. Ultimately, DILI is a diagnosis of exclusion, and close clinical correlation is essential when navigating the differential.

药物性肝损伤:病理模式和常见罪魁祸首。
药物性肝损伤(DILI)具有令人难以置信的形态表现,从急性广泛坏死到由含ceroid的巨噬细胞解决损伤。活检表现的多样性在诊断上具有挑战性,但DILI正在得到越来越广泛的认可,特别是在LiverTox等资源的帮助下。一些药物,如对乙酰氨基酚,有明确的损伤模式。然而,新的药物,如免疫检查点抑制剂,正在不断开发,我们对它们对肝脏影响的理解也在不断发展。在本章中,我们将重点讨论DILI模式和经常遇到的DILI罪魁祸首。最终,DILI是一种排除性诊断,在鉴别诊断时,密切的临床相关性是必不可少的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.30
自引率
3.00%
发文量
88
审稿时长
>12 weeks
期刊介绍: Advances in Anatomic Pathology provides targeted coverage of the key developments in anatomic and surgical pathology. It covers subjects ranging from basic morphology to the most advanced molecular biology techniques. The journal selects and efficiently communicates the most important information from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology.
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