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Advances In Anatomic Pathology最新文献

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Future Practices of Breast Pathology Using Digital and Computational Pathology. 使用数字和计算病理学的乳腺病理学的未来实践。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-09-22 DOI: 10.1097/PAP.0000000000000414
Matthew G Hanna, Edi Brogi
{"title":"Future Practices of Breast Pathology Using Digital and Computational Pathology.","authors":"Matthew G Hanna,&nbsp;Edi Brogi","doi":"10.1097/PAP.0000000000000414","DOIUrl":"10.1097/PAP.0000000000000414","url":null,"abstract":"<p><p>Pathology clinical practice has evolved by adopting technological advancements initially regarded as potentially disruptive, such as electron microscopy, immunohistochemistry, and genomic sequencing. Breast pathology has a critical role as a medical domain, where the patient's pathology diagnosis has significant implications for prognostication and treatment of diseases. The advent of digital and computational pathology has brought about significant advancements in the field, offering new possibilities for enhancing diagnostic accuracy and improving patient care. Digital slide scanning enables to conversion of glass slides into high-fidelity digital images, supporting the review of cases in a digital workflow. Digitization offers the capability to render specimen diagnoses, digital archival of patient specimens, collaboration, and telepathology. Integration of image analysis and machine learning-based systems layered atop the high-resolution digital images offers novel workflows to assist breast pathologists in their clinical, educational, and research endeavors. Decision support tools may improve the detection and classification of breast lesions and the quantification of immunohistochemical studies. Computational biomarkers may help to contribute to patient management or outcomes. Furthermore, using digital and computational pathology may increase standardization and quality assurance, especially in areas with high interobserver variability. This review explores the current landscape and possible future applications of digital and computational techniques in the field of breast pathology.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Novel Immunohistochemical Markers for Special Types of Breast Carcinoma. 新型免疫组织化学标记物在特殊类型乳腺癌中的作用。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.1097/PAP.0000000000000415
Anne Grabenstetter, Timothy M D'Alfonso
{"title":"The Role of Novel Immunohistochemical Markers for Special Types of Breast Carcinoma.","authors":"Anne Grabenstetter,&nbsp;Timothy M D'Alfonso","doi":"10.1097/PAP.0000000000000415","DOIUrl":"10.1097/PAP.0000000000000415","url":null,"abstract":"<p><p>Some histologic special types of breast carcinoma harbor specific recurrent genetic alterations that are not seen in other types of breast carcinoma (no special type), namely adenoid cystic carcinoma, secretory carcinoma, and tall cell carcinoma with reversed polarity. These tumors have unique morphologic features, are triple-negative, that is, do not express hormone receptors or HER2, and are generally associated with a favorable prognosis. Adenoid cystic carcinoma, like its counterpart in other organs, shows a MYB-NFIB fusion gene that is the result of a recurrent t(6;9)(q22-23;p23-24) translocation. Other MYB alterations have been described that result in overexpression of MYB . Secretory carcinoma is characterized by an ETV6-NTRK3 gene fusion that is the result of recurrent (12;15);(p13;q25) translocation, which is also seen in mammary analog secretory carcinoma of the salivary gland. Tall cell carcinoma with reversed polarity shows IDH2 p.Arg172 hotspot mutations. Immunohistochemical antibodies have emerged that identify the underlying genetic alterations in these tumors and serve as useful diagnostic tools. This review will provide an update on the molecular features and diagnostic immunohistochemical markers that have become increasingly popular to aid in diagnosing these uncommon triple-negative breast tumors.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring New Frontiers in the Role of Breast Pathologists in Breast Cancer. 探索乳腺病理学家在乳腺癌症中作用的新前沿。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.1097/PAP.0000000000000417
Shahla Masood
{"title":"Exploring New Frontiers in the Role of Breast Pathologists in Breast Cancer.","authors":"Shahla Masood","doi":"10.1097/PAP.0000000000000417","DOIUrl":"10.1097/PAP.0000000000000417","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41111312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRPS1, a New Promising Marker for Assessment of Distant Metastatic Breast Cancer. TRPS1，一种用于评估癌症远处转移的新的有前景的标记物。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-08-18 DOI: 10.1097/PAP.0000000000000409
Patrick J McIntire, Lauren A Duckworth, John Van Arnam, Hala Abdelwahab, Sandra J Shin
{"title":"TRPS1, a New Promising Marker for Assessment of Distant Metastatic Breast Cancer.","authors":"Patrick J McIntire,&nbsp;Lauren A Duckworth,&nbsp;John Van Arnam,&nbsp;Hala Abdelwahab,&nbsp;Sandra J Shin","doi":"10.1097/PAP.0000000000000409","DOIUrl":"10.1097/PAP.0000000000000409","url":null,"abstract":"This article reviewed the identification of breast cancer in the distant metastatic setting through traditional immunohistochemical markers, such as mammaglobin and GATA3, compared with the novel immunohistochemical stain, Trichorhinophalangeal syndrome-1 (TRPS1). We review previous studies evaluating TRPS1 staining, which were conducted using cytology specimens, as well as our recently conducted study evaluating this stain using surgical tissue samples, both from primary and distant metastatic invasive breast carcinoma. In summary, although no immunohistochemical stain is 100% specific or sensitive, in the metastatic setting where tissue available for ancillary studies is limited, TRPS1 was a reliable and even a standalone marker for breast origin, particularly in cases of triple-negative breast cancer.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10012267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Significance of Recognition of Human Epidermal Growth Factor 2 Low in Breast Cancer Therapy. 识别人表皮生长因子2低在癌症治疗中的意义。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-08-10 DOI: 10.1097/PAP.0000000000000408
Gary Tozbikian
{"title":"The Significance of Recognition of Human Epidermal Growth Factor 2 Low in Breast Cancer Therapy.","authors":"Gary Tozbikian","doi":"10.1097/PAP.0000000000000408","DOIUrl":"10.1097/PAP.0000000000000408","url":null,"abstract":"<p><p>In response to recent clinical trials that demonstrate the clinical benefit of antibody-drug conjugate drug therapy in breast cancer (BC) with human epidermal growth factor 2 (HER2) immunohistochemical scores of 1+ or 2+ and negative in situ hybridization results, a new concept of \"HER2-low BC\" has emerged to describe this newly relevant therapeutic category of BC. Clinical recognition of HER2-low BC has caused a paradigm shift in the therapeutic landscape and management of patients with BC and resulted in rapid changes in clinical practice guidelines. In addition the American Society of Clinical Oncology-College of American Pathologists (ASCO-CAP) recently updated their HER2 Guidelines Recommendations to specifically address HER2-low BC. A literature search in PubMed of peer-reviewed articles, regulatory communications, and relevant practice guidelines pertaining to HER2-low BC was conducted. In this review, we have summarized current published knowledge regarding the clinicopathologic and molecular features, diagnostic criteria, and most current guideline recommendations regarding HER2-low BC, and also highlight ongoing practical and diagnostic challenges when identifying HER2-low BC in routine clinical practice.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nipple Lesions of the Breast: An Update on Morphologic Features, Immunohistochemical Findings and Differential Diagnosis. 乳腺乳头病变：形态学特征、免疫组织化学表现和鉴别诊断的最新进展。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-09-26 DOI: 10.1097/PAP.0000000000000413
Edi Brogi, Cristian Scatena
{"title":"Nipple Lesions of the Breast: An Update on Morphologic Features, Immunohistochemical Findings and Differential Diagnosis.","authors":"Edi Brogi,&nbsp;Cristian Scatena","doi":"10.1097/PAP.0000000000000413","DOIUrl":"10.1097/PAP.0000000000000413","url":null,"abstract":"<p><p>Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells. Invasive breast cancer may also arise primarily in the nipple. Most of these conditions present as a palpable mass and/or skin changes with or without nipple discharge. Due to the delicate location and often relatively small size of nipple lesions, biopsy specimens are often superficial and fragmented, and the interpretation is challenging. Knowledge of the morphologic and immunophenotypic features of nipple lesions is essential in making the correct diagnosis. Information on the molecular alterations underpinning nipple neoplasms is currently very limited.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41105294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Genetic Landscape of Fibroepithelial Lesions of the Breast. 乳腺纤维上皮病变的遗传景观。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-11-01 Epub Date: 2023-08-04 DOI: 10.1097/PAP.0000000000000407
Farnaz Dadmanesh, Xiaomo Li, Matthew Leong, Horacio Maluf, Bonnie Balzer
{"title":"The Genetic Landscape of Fibroepithelial Lesions of the Breast.","authors":"Farnaz Dadmanesh,&nbsp;Xiaomo Li,&nbsp;Matthew Leong,&nbsp;Horacio Maluf,&nbsp;Bonnie Balzer","doi":"10.1097/PAP.0000000000000407","DOIUrl":"10.1097/PAP.0000000000000407","url":null,"abstract":"<p><p>Fibroepithelial lesions of the breast encompass a broad spectrum of lesions from fibroadenomas and their variants to phyllodes tumors, including their clinical range of benign, borderline, and malignant. Classification of this spectrum of neoplasms has historically and currently been based purely on morphology, although the nomenclature has shifted over the years largely due to the significant histologic overlap that exists primarily within the cellular fibroadenomas to borderline malignant phyllodes tumor categories. A review of the current diagnostic challenge, proposed ancillary studied and their value in prognostic significance, is provided. This article highlights the most recent molecular and genetic findings as well as the limitations of the studies, in the context of practical and available applications for the diagnostician and managerial implications for the clinician.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9934576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Review of the Newest World Health Organization (WHO) Cytopathology Reporting Systems. 最新的世界卫生组织(WHO)细胞病理学报告系统的综合审查。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-07-06 DOI: 10.1097/PAP.0000000000000404
Jitendra Singh Nigam, Jyotsna Naresh Bharti, Ashutosh Rath, Immanuel Pradeep
{"title":"A Comprehensive Review of the Newest World Health Organization (WHO) Cytopathology Reporting Systems.","authors":"Jitendra Singh Nigam,&nbsp;Jyotsna Naresh Bharti,&nbsp;Ashutosh Rath,&nbsp;Immanuel Pradeep","doi":"10.1097/PAP.0000000000000404","DOIUrl":"https://doi.org/10.1097/PAP.0000000000000404","url":null,"abstract":"<p><p>World Health Organization cytopathology reporting system systems have proposed for the pancreatobiliary tract, lung, lymph node, and soft tissue aligned with the updates in the World Health Organization classification of Tumor series. Among them, the pancreatobiliary tract and lung specimen reporting system have been published recently and are now a 7-tier and 5-tier category system, respectively, without any subcategorization. World Health Organization reporting systems also encourage the application of ancillary diagnostic tests like cell block preparation, immunocytochemistry, and rapid on-site evaluation for better categorization of specimens and further management, especially in indeterminate (atypical and suspicious for malignancy) and malignant cytology categories. In this brief review, we aim to provide a brief outline of both the systems and their clinical risk-based management strategies.</p>","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9775962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesothelioma: A Tumor of Ubiquitous Distribution. 间皮瘤：一种普遍分布的肿瘤。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-07-01 Epub Date: 2022-12-12 DOI: 10.1097/PAP.0000000000000388
Cesar A Moran
{"title":"Mesothelioma: A Tumor of Ubiquitous Distribution.","authors":"Cesar A Moran","doi":"10.1097/PAP.0000000000000388","DOIUrl":"10.1097/PAP.0000000000000388","url":null,"abstract":"","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Mesothelioma of Tunica Vaginalis Testis: Update for 2022. 阴道-睾丸恶性间皮瘤：2022年更新。
IF 6.7 2区 医学
Advances In Anatomic Pathology Pub Date : 2023-07-01 Epub Date: 2022-09-21 DOI: 10.1097/PAP.0000000000000371
Kenneth A Iczkowski
{"title":"Malignant Mesothelioma of Tunica Vaginalis Testis: Update for 2022.","authors":"Kenneth A Iczkowski","doi":"10.1097/PAP.0000000000000371","DOIUrl":"10.1097/PAP.0000000000000371","url":null,"abstract":"Malignant mesothelioma of the testicular tunics is rare. About one third of cases are metastatic and carry a poor prognosis. This paper reviews the epidemiology, clinicopathologic features, treatment, and outcome of this entity.","PeriodicalId":7305,"journal":{"name":"Advances In Anatomic Pathology","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9596345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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