卵巢黏液性肿瘤的诊断与风险分层：侵袭模式、免疫组化和分子诊断。

IF 5.1 2区医学 Q1 PATHOLOGY

Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI:10.1097/PAP.0000000000000473

Martin Köbel, Carlos Parra-Herran, Kylie Gorringe

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引用次数: 0

摘要

卵巢黏液瘤有多种亚分类。最近的研究强调了观察者间再现性的问题。本综述将重点关注一些新进展，包括可能有助于提高临床重要阈值的观察者间再现性的标准和辅助检查。这些问题包括：关于畸胎瘤相关卵巢粘液性肿瘤的单独术语的建议、TP53 免疫组化在区分拥挤型粘液性边界瘤和扩张型粘液性癌中的作用以及浸润模式的分配，浸润模式最近已被证实是重要的预后因素，即使在低分期粘液性卵巢癌中也是如此。

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Diagnosis and Risk Stratification of Ovarian Mucinous Neoplasms: Pattern of Invasion, Immunohistochemistry, and Molecular Diagnostics.

Ovarian mucinous tumors are subclassified in multiple categories. Recent studies have highlighted issues in interobserver reproducibility. This review will focus on some new developments including criteria and ancillary tests that may help to improve interobserver reproducibility at clinically important thresholds. These issues include proposals for a separate terminology of teratoma-associated ovarian mucinous neoplasms, the role of TP53 immunohistochemistry in distinction of crowded mucinous borderline tumors and expansile mucinous carcinomas as well as the assignment of the infiltrative pattern of invasion, which recently has been validated as important prognostic factor even in low stage mucinous ovarian carcinoma.

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来源期刊

Advances In Anatomic Pathology 医学-病理学

CiteScore

10.30

自引率

3.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Anatomic Pathology provides targeted coverage of the key developments in anatomic and surgical pathology. It covers subjects ranging from basic morphology to the most advanced molecular biology techniques. The journal selects and efficiently communicates the most important information from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology.