STK11 附件肿瘤：探索与 Peutz-Jeghers 综合征的关联及其与形态学模仿者的区别

IF 5.1 2区医学 Q1 PATHOLOGY

Advances In Anatomic Pathology Pub Date : 2025-01-01 Epub Date: 2024-09-03 DOI:10.1097/PAP.0000000000000460

Jennifer A Bennett, Esther Oliva

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引用次数: 0

摘要

STK11 附件肿瘤是一种组织发生机制不确定的新型恶性肿瘤，常发生于附件旁，50% 的患者伴有 Peutz-Jeghers 综合征。其广泛的形态谱和非特异性免疫组化特征导致其在过去被误诊为其他多种肿瘤，包括沃尔夫性肿瘤、性索间质肿瘤、间皮瘤和上皮性肿瘤。本综述将重点讨论可能发生于 Peutz-Jeghers 综合征的附件肿瘤，尤其是 STK11 附件肿瘤及其鉴别诊断。

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STK11 Adnexal Tumor: Exploring the Association With Peutz-Jeghers Syndrome and its Distinction From Morphologic Mimickers.

STK11 adnexal tumor is a novel malignant neoplasm of uncertain histogenesis frequently arising in a para-adnexal location and associated with Peutz-Jeghers syndrome in ∼50% of patients. Its broad morphologic spectrum and nonspecific immunohistochemical profile has resulted in misclassification in the past as a variety of other neoplasms including those of wolffian, sex cord-stromal, mesothelial, and epithelial derivation. This review focuses on the spectrum of adnexal neoplasms that may develop in Peutz-Jeghers syndrome, with particular emphasis on STK11 adnexal tumor and its differential diagnosis.

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来源期刊

Advances In Anatomic Pathology 医学-病理学

CiteScore

10.30

自引率

3.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Anatomic Pathology provides targeted coverage of the key developments in anatomic and surgical pathology. It covers subjects ranging from basic morphology to the most advanced molecular biology techniques. The journal selects and efficiently communicates the most important information from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology.