Food frontiers最新文献_第8页

Baicalin attenuates vascular inflammation and endothelial dysfunction in diabetes 黄芩苷可减轻糖尿病患者的血管炎症和内皮功能障碍

IF 7.4

Food frontiers Pub Date : 2024-09-15 DOI: 10.1002/fft2.483

Lingchao Miao, Yifan Yang, Jinming Dai, Mei Bai, Yuehan Wang, Haiying Cui, Lin Lin, Metab Alharbi, Wai San Cheang

{"title":"Baicalin attenuates vascular inflammation and endothelial dysfunction in diabetes","authors":"Lingchao Miao, Yifan Yang, Jinming Dai, Mei Bai, Yuehan Wang, Haiying Cui, Lin Lin, Metab Alharbi, Wai San Cheang","doi":"10.1002/fft2.483","DOIUrl":"https://doi.org/10.1002/fft2.483","url":null,"abstract":"Baicalin is a natural flavonoid shown to attenuate inflammation, tumor, and cardiovascular diseases. However, its effect on endothelial function in diabetes remains unclear and was investigated in current study. A high-fat diet (60% kcal fat diet) was used to feed male C57BL/6 mice for 14 weeks to build a diet-induced obese (DIO) diabetic mouse model. Baicalin (50 and 100 mg/kg/day) or vehicle was applied to DIO mice by oral gavage in the last 4 weeks. Separated mouse aortic rings were induced by high glucose and primary rat aortic endothelial cells (RAECs) were stimulated by advanced glycation end products (AGEs), and cotreated with or without varying doses of baicalin and 5′AMP-activated protein kinase (AMPK) inhibitor Compound C. Forty-eight-hour exposure to high glucose impaired acetylcholine-induced endothelium-dependent relaxations in mouse aortas and produced excessive levels of reactive oxygen species (ROS). Similar phenomenon was observed in aortas from DIO mice. Baicalin treatment could alleviate these damage through preventing expression and translocation of nuclear factor (NF)-κB p65 pathway, accomplished with decreased expressions of vascular cell adhesion molecule 1 (VCAM-1) and intracellular adhesion molecule 1 (ICAM-1) as well as proinflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). These improvements were AMPK-dependent as Compound C abolished the effects. Similar beneficial effects of baicalin and inhibitory effects of Compound C were observed in AGEs (200 µg/mL, 24 h)-induced RAECs. To conclude, baicalin protects against vascular inflammation and endothelial dysfunction associated with diabetes through suppression on inflammation and oxidative stress via activating AMPK.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2756-2765"},"PeriodicalIF":7.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota dysbiosis and oxidative damage in high-fat diet-induced impairment of spermatogenesis: Role of protocatechuic acid intervention 高脂饮食引起的精子发生障碍中的肠道微生物群失调和氧化损伤：原儿茶酸干预的作用

IF 7.4

Food frontiers Pub Date : 2024-09-15 DOI: 10.1002/fft2.484

Ruizhi Hu, Xizi Yang, Long Wang, Dingding Su, Ziyu He, Jiaxing Li, Jiatai Gong, Wentao Zhang, Siqi Ma, Mingkun Shi, Jing Lv, Qianjin Zhang, De-Xing Hou, Hongfu Zhang, Jianhua He, Yulong Yin, Jun Wang, Shusong Wu

{"title":"Gut microbiota dysbiosis and oxidative damage in high-fat diet-induced impairment of spermatogenesis: Role of protocatechuic acid intervention","authors":"Ruizhi Hu, Xizi Yang, Long Wang, Dingding Su, Ziyu He, Jiaxing Li, Jiatai Gong, Wentao Zhang, Siqi Ma, Mingkun Shi, Jing Lv, Qianjin Zhang, De-Xing Hou, Hongfu Zhang, Jianhua He, Yulong Yin, Jun Wang, Shusong Wu","doi":"10.1002/fft2.484","DOIUrl":"https://doi.org/10.1002/fft2.484","url":null,"abstract":"In the realm of experimental and epidemiological research, the impact of endotoxemia caused by obesity on male fertility is widely acknowledged. However, the existing body of evidence lacks rigorous studies to substantiate this notion. To address this gap, we have selected protocatechuic acid (PCA) as a potential inhibitor of endotoxemia induced by obesity. This selection is further supported by our utilization of a male model of C57BL/6J mice induced by a high-fat diet (HFD) and the fecal microbiota transplantation assay. Our findings reveal a negative correlation between semen quality and endotoxin levels in the mice model induced by an HFD. Furthermore, intervention with PCA resulted in the restoration of testicular morphology, sperm traits, and function. The transplantation of PCA did not exhibit restorative effects on semen quality, but it did effectively prevent obesity-induced intestinal leakage and endotoxemia. By directly enhancing antioxidant capacity, PCA successfully reversed the fertility reduction caused by obesity. These findings offer substantiation that endotoxemia does not play a significant role in the diminished fertility observed in obese males and propose that the inclusion of dietary antioxidant supplementation can potentially restore male fertility.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2566-2578"},"PeriodicalIF":7.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are mesopelagic organisms nutritious food? Impact on metabolism, availability of nutrients, and contaminants from dietary intervention in C57BL/6J mice model 中层生物是营养食品吗？在 C57BL/6J 小鼠模型中进行饮食干预对新陈代谢、营养物质供应和污染物的影响

IF 7.4

Food frontiers Pub Date : 2024-09-13 DOI: 10.1002/fft2.480

Atabak M. Azad, Lene Secher Myrmel, Martin Wiech, Ole Jakob Nøstbakken, Even Fjære, Anne-Katrine Lundebye, Quang Tri Ho, Lise Madsen

{"title":"Are mesopelagic organisms nutritious food? Impact on metabolism, availability of nutrients, and contaminants from dietary intervention in C57BL/6J mice model","authors":"Atabak M. Azad, Lene Secher Myrmel, Martin Wiech, Ole Jakob Nøstbakken, Even Fjære, Anne-Katrine Lundebye, Quang Tri Ho, Lise Madsen","doi":"10.1002/fft2.480","DOIUrl":"https://doi.org/10.1002/fft2.480","url":null,"abstract":"Mesopelagic species are unexplored novel low-trophic sources of essential micronutrients and may contribute to combat malnutrition. In this study, common mesopelagic species from the North Sea including Northern krill (Meganyctiphanes norvegica), glacier lanternfish (Benthosema glaciale), and Muller's pearlside (Maurolicus muelleri) were supplemented in mice feed using a Western diet recipe. The metabolic outcomes were subsequently compared to those of ordinary seafood. Consumption of mesopelagic species induced a large variation in weight gain, in the following order: lanternfish (7.1 g) > krill (14.4 g) > control (19.7 g) > pearlside (22.6 g). The lanternfish-supplemented diet containing wax esters reduced weight gain and obesity and improved insulin sensitivity. The wax esters from the lanternfish-supplemented diet were efficiently absorbed, with more than 92% of the fatty alcohols being assimilated. The inclusion of lanternfish and pearlside led to improvements in the fatty acid (FA) composition in the mouse liver, evidenced by increased levels of essential long-chain polyunsaturated FAs and an increased n-3/n-6 ratio (0.7 to 1.45 vs. 0.46 in control group). Notably, no adverse effects were found in mice fed pearlside and lanternfish, although an elevated level of fluoride in femur bone was observed in mice fed a diet supplemented with krill followed by reduced sperm concentration and sperm motility. Collectively, our findings underscore the diverse array of metabolic and physiological effects induced by the consumption of mesopelagic species. Furthermore, these species can be considered as good sources of n-3 FAs and essential vitamins, suggesting their potential value to human nutrition.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2737-2755"},"PeriodicalIF":7.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanidin-3-O-glucoside magic: Unveiling the power to inhibit cholesterol absorption via the intestinal farnesoid X receptor–bile acids pathway with Lactobacillus Marvel 花青素-3-O-葡萄糖苷的魔力：揭示乳酸杆菌通过肠道法尼瑟类 X 受体-胆汁酸途径抑制胆固醇吸收的能力

IF 7.4

Food frontiers Pub Date : 2024-09-13 DOI: 10.1002/fft2.482

Sihang Wang, Bin Li, Hui Tan, Xiyun Sun, Jinlong Tian, Shuying Li, Yongping Xu, Yuanyuan Bian, Yuehua Wang

{"title":"Cyanidin-3-O-glucoside magic: Unveiling the power to inhibit cholesterol absorption via the intestinal farnesoid X receptor–bile acids pathway with Lactobacillus Marvel","authors":"Sihang Wang, Bin Li, Hui Tan, Xiyun Sun, Jinlong Tian, Shuying Li, Yongping Xu, Yuanyuan Bian, Yuehua Wang","doi":"10.1002/fft2.482","DOIUrl":"https://doi.org/10.1002/fft2.482","url":null,"abstract":"Cyanidin-3-O-glucoside (C3G), an abundant and widely utilized anthocyanin monomer, has been shown to significantly inhibit cholesterol absorption. Building on our previous research demonstrating the role of Lactobacillus as a specific intestinal microflora associated with C3G-mediated cholesterol absorption inhibition, the present study aimed to evaluate the inhibitory effects of C3G on high-fat diet–induced cholesterol absorption. Results indicate that C3G significantly reduced total cholesterol and triglyceride levels while suppressing red grease formation in Caco-2 cells. In vivo, C3G ameliorated blood lipid levels and mitigated small intestinal damage, as evidenced by restored villus length and basal thickness. Additionally, C3G upregulated intestinal farnesoid X receptor (FXR) mRNA expression and inhibited the expression of key cholesterol absorption proteins, Niemann-Pick C1-Like 1 and acetyl-CoA acetyltransferase 2. Furthermore, C3G increased short-chain fatty acid content and activated ileal bile acid-binding protein expression. C3G also inhibited intestinal bile acid (BA) reabsorption, promoted fecal BA excretion, and obstructed cholesterol emulsification. Moreover, C3G modulated gut microbiota abundance and diversity, increasing the abundance of Akkermansia, Bifidobacterium, Coprococcus, Ruminococcus, and Butyricicoccus. In conclusion, our findings suggest that C3G inhibits cholesterol absorption by reshaping intestinal flora composition and regulating the FXR-BAs axis. This study provides a theoretical foundation for the use of C3G as a raw material for inhibiting cholesterol absorption.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2721-2736"},"PeriodicalIF":7.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The reverse genetic as a potential of virus-induced gene silencing in tomato biology 反向遗传是番茄生物学中病毒诱导基因沉默的潜力所在

IF 7.4

Food frontiers Pub Date : 2024-09-10 DOI: 10.1002/fft2.455

Qiong Tang, Sishan Wei, Zexun Chen, Xiaodong Zheng, Pengcheng Tu, Fei Tao

{"title":"The reverse genetic as a potential of virus-induced gene silencing in tomato biology","authors":"Qiong Tang, Sishan Wei, Zexun Chen, Xiaodong Zheng, Pengcheng Tu, Fei Tao","doi":"10.1002/fft2.455","DOIUrl":"https://doi.org/10.1002/fft2.455","url":null,"abstract":"In the realm of plant genomics, virus-induced gene silencing (VIGS) technology emerges as a potent tool, employing a reverse genetic strategy to elucidate plant gene functions. Recognized for its simplicity, cost-effectiveness, and broad applicability, VIGS facilitates the exploration of novel genes in vegetable crops and unveils mechanisms underlying disease resistance and stress response. Moreover, it offers vital support for crop enhancement and molecular breeding. In the context of tomato biology, VIGS holds promise for transformative advancements, spanning from genomics and variety improvement to molecular breeding. This review comprehensively analyzes the pivotal breakthroughs achieved in tomato physiology through global applications of VIGS and explores its strengths and limitations. Future prospects suggest VIGS's pivotal role in reshaping tomato biology, modulating secondary metabolism, and bolstering stress resilience. By delineating diverse applications of VIGS technology, this review fosters innovation in tomato research, opening new vistas for its utilization in plant gene functional analysis.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2498-2514"},"PeriodicalIF":7.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quinic acid as an inhibitor of α-glucosidase activity, nonenzymatic glycosylation, and glucose transport in Caco-2 cells 奎宁酸是 Caco-2 细胞中 α-葡萄糖苷酶活性、非酶糖基化和葡萄糖转运的抑制剂

IF 7.4

Food frontiers Pub Date : 2024-09-10 DOI: 10.1002/fft2.486

Ziyi Han, Leyu Wang, Panjie Sun, Mengxin Huang, Fei Yu, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li

{"title":"Quinic acid as an inhibitor of α-glucosidase activity, nonenzymatic glycosylation, and glucose transport in Caco-2 cells","authors":"Ziyi Han, Leyu Wang, Panjie Sun, Mengxin Huang, Fei Yu, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li","doi":"10.1002/fft2.486","DOIUrl":"https://doi.org/10.1002/fft2.486","url":null,"abstract":"Hyperglycemia and diabetes are common metabolic disorders. It is considered a safe and effective strategy to screen active ingredients from food and herbs for controlling blood sugar levels. Quinic acid (QA) is a natural polyphenolic acid with various health-promoting properties. In this study, QA was found to exhibit a potent inhibitory effect on α-glucosidase activity, with a half maximal inhibitory concentration (IC50) of 5.46 mM. This inhibitory property surpassed that of three common organic acids including gallic acid, malic acid, and citric acid. A combination of 25% acarbose (0.5 mM) and 75% QA (5 mM) (v/v) exhibited synergistic inhibition of α-glucosidase activity. Enzyme kinetics, fluorescence spectra, and molecular docking analyses indicated that QA acted as an uncompetitive inhibitor of α-glucosidase, with hydrogen bonds playing a key role in the intermolecular interactions. Moreover, QA was found to effectively inhibit three major nonenzymatic glycation products including advanced glycosylation end products (AGEs), fructosamine, and α-dicarbonyl in a dose-dependent manner, outperforming the positive control aminoguanidine (AG) within the tested concentration range. Utilizing a Caco-2 cell model, QA demonstrated the ability to inhibit the transmembrane absorption of glucose. This study highlighted QA as a promising food functional factor that had been overlooked in the past, offering potential benefits in improving hyperglycemia, diabetes, and associated complications through the inhibition of α-glucosidase, nonenzymatic glycosylation, and glucose uptake.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2545-2555"},"PeriodicalIF":7.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota-directed dietary factors enhance exercise performance in mice 肠道微生物群指导的饮食因素可提高小鼠的运动能力

IF 7.4

Food frontiers Pub Date : 2024-09-09 DOI: 10.1002/fft2.460

Hongchao Wang, Huimin Yan, Jinlin Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu

{"title":"Gut microbiota-directed dietary factors enhance exercise performance in mice","authors":"Hongchao Wang, Huimin Yan, Jinlin Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu","doi":"10.1002/fft2.460","DOIUrl":"https://doi.org/10.1002/fft2.460","url":null,"abstract":"This study investigated the effect of dietary interventions targeting gut microbiota on exercise performance in mice. Analysis of the gut microbiota of individuals with varying levels of physical activity revealed enrichment of Eubacterium rectale and Faecalibacterium prausnitzii in the active population. Through in vitro fecal fermentation experiments, dietary factor combinations that promote the abundance of these bacteria were identified. Dietary interventions, including E. rectale supplementation, FAG combination (gavage of Fructus Arctii extract, Agaricus blazei Murrill polysaccharides, and galactooligosaccharides mixture), and CFG combination (gavage of curcumin, Fructus Arctii extract, and galactooligosaccharides mixture), significantly improved mouse exercise performance, increased glycogen accumulation, regulated serum biochemical parameters, and increased short-chain fatty acid and fatty acid amide levels in feces. Metagenomic sequencing revealed alterations in the composition of the gut microbiota. Fecal metabolome analysis highlighted changes in metabolites related to lipids, organic acids, nucleic acids, and carbohydrates. These findings suggest that E. rectale and dietary interventions positively affect exercise performance by modulating the gut microbiota and associated metabolites.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2705-2720"},"PeriodicalIF":7.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the impact of climate on mackerel (Scomber japonicus) quality during vehicle transportation: A transportation modeling approach 评估车辆运输过程中气候对鲭鱼（Scomber japonicus）质量的影响：运输建模方法

IF 7.4

Food frontiers Pub Date : 2024-09-08 DOI: 10.1002/fft2.468

Seul-Ki Park, Su-Jeong Lee, Sung-Hwan Eom, Kyung Tae Kim, Young-Sun Lee, Eun-Song Kim, Sung Bum Son, Won Je Jang, Kee-Jai Park, Eun-Woo Lee

{"title":"Assessing the impact of climate on mackerel (Scomber japonicus) quality during vehicle transportation: A transportation modeling approach","authors":"Seul-Ki Park, Su-Jeong Lee, Sung-Hwan Eom, Kyung Tae Kim, Young-Sun Lee, Eun-Song Kim, Sung Bum Son, Won Je Jang, Kee-Jai Park, Eun-Woo Lee","doi":"10.1002/fft2.468","DOIUrl":"https://doi.org/10.1002/fft2.468","url":null,"abstract":"This study investigates the impact of environmental factors on the quality changes of mackerel (Scomber japonicus), a globally significant fish species valued for its high nutritional content, especially its unsaturated fatty acids and proteins. In South Korea, marine products like mackerel undergo auction, sorting, packaging, and transportation. Assessing the fish freshness and quality during these processes, before it reaches consumers, is crucial. This research aimed to track the changes in mackerel quality indicators after the auction and correlate them with the environmental factors affecting transportation. Using a transportation model established for both summer and winter, mackerel samples were categorized by their weight (200 and 300 g). Results show poorer quality indicators in summer compared to winter, particularly in the 200 g group. Microbiological indicators such as the total viable count (0.923) and total coliforms (0.958) were most strongly correlated with the season, whereas the lipid oxidation indicators acid value (0.627) and peroxide value (0.536) were moderately correlated with the season. Interestingly, the wider standard deviation distribution observed in summer suggests that individual mackerel characteristics may influence the degree of quality changes. These findings offer insights into mackerel quality fluctuations during auction and transportation, aiding in future efforts to maintain seafood quality amidst climate change.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2533-2544"},"PeriodicalIF":7.4,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical insights into the immunomodulatory effects of food-derived peptides 食品肽免疫调节作用的临床启示

IF 7.4

Food frontiers Pub Date : 2024-09-08 DOI: 10.1002/fft2.481

Kangkai Chen, Dongwei Ma, Xin Yang, Ping Liu, Jin Wang, Wang Liao

引用次数: 0

Effect of varying dietary fatty acid patterns on early-life food allergy in rats 不同膳食脂肪酸模式对大鼠早期食物过敏的影响

IF 7.4

Food frontiers Pub Date : 2024-09-05 DOI: 10.1002/fft2.446

Manman Liu, Cheng Chen, Junjuan Wang, Shiwen Han, Sufang Duan, Fang Li, Ignatius Man-Yau Szeto, Yali Liu, Huilian Che, Changqi Liu

{"title":"Effect of varying dietary fatty acid patterns on early-life food allergy in rats","authors":"Manman Liu, Cheng Chen, Junjuan Wang, Shiwen Han, Sufang Duan, Fang Li, Ignatius Man-Yau Szeto, Yali Liu, Huilian Che, Changqi Liu","doi":"10.1002/fft2.446","DOIUrl":"https://doi.org/10.1002/fft2.446","url":null,"abstract":"The prevalence of food allergies is increasing worldwide, affecting approximately 8% of children. Food allergies that develop early in life can persist throughout an individual's life. Dietary patterns, particularly those involving fatty acids (FAs), play an important role in the regulation of immune cells, thereby affecting the development of food allergies. Aimed to investigate the effects of different FA patterns on food allergies, this study established a sensitised infant rat model and fed it with feeds containing different types of FAs. We then assessed the clinical allergy symptoms, immune balance, and gut microbiota. Our animal allergy model revealed that diets rich in specific FAs exerted different regulatory effects on food allergies. Notably, n-3 long-chain polyunsaturated FAs exhibited the strongest inhibitory effect on food allergies, accompanied by a reduction in allergy symptoms, lower serum antibody levels, and modulation of T cell differentiation. By contrast, high levels of medium-chain FAs promoted the occurrence and progression of food allergies. In addition, various dietary FA patterns have varying impacts on the gut microbiota, influencing overall diversity, microbial composition, and function. N-3 long-chain polyunsaturated FAs may be associated with a significant increase in the copy number of 15-cis-phytoene synthase in the intestinal flora. These findings suggest that dietary intake of different FAs during early life can affect an individual's susceptibility to food allergies by shaping the gut microbiota, which may offer a novel therapeutic approach for the treatment of food allergies.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2691-2704"},"PeriodicalIF":7.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0