Food frontiers最新文献_第8页

Scutellarein Alleviates Ulcerative Colitis by Reshaping Gut Microbiota and Regulating the PRMT1-Mediated Th17/Treg Balance 灯盏花苷通过重塑肠道菌群和调节prmt1介导的Th17/Treg平衡来缓解溃疡性结肠炎

IF 6.9

Food frontiers Pub Date : 2026-05-28 DOI: 10.1002/fft2.70301

Yefan Zhou, Xinyu Xu, Huan Fang, Xue Wang, Jiaqi Hua, Linping Lu, Dongxu Li, Yangyang Wen, Jieqiong Yao, Fang Liu, Jing He, Fucheng He, Mingxia Zhou

{"title":"Scutellarein Alleviates Ulcerative Colitis by Reshaping Gut Microbiota and Regulating the PRMT1-Mediated Th17/Treg Balance","authors":"Yefan Zhou, Xinyu Xu, Huan Fang, Xue Wang, Jiaqi Hua, Linping Lu, Dongxu Li, Yangyang Wen, Jieqiong Yao, Fang Liu, Jing He, Fucheng He, Mingxia Zhou","doi":"10.1002/fft2.70301","DOIUrl":"https://doi.org/10.1002/fft2.70301","url":null,"abstract":"Ulcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa with an increasing global burden and limited therapeutic efficacy. Scutellarein (Scu), a bioactive flavonoid found in various edible plants of Lamiaceae and Verbenaceae, has been shown to possess anti-inflammatory and antioxidant activities. Herein, we systematically evaluated the effectiveness of scutellarein in the treatment of UC and identified its direct target and underlying inflammation suppression mechanism. Integrated 16S rRNA sequencing and untargeted metabolomics showed that scutellarein preserves gut microbial and metabolic homeostasis and enhances intestinal barrier integrity via enrichment of D-(-)-quinic acid (DQ). Limited proteolysis mass spectrometry (Lip-MS) identified protein arginine methyltransferase 1 (PRMT1) as a bona fide target of scutellarein. Mechanistic investigations further uncovered that scutellarein directly binds to the Y128 residue of PRMT1, which in turn inhibits STAT3 asymmetric dimethylation and phosphorylation. This cascade collectively downregulates RORγt expression, restrains Th17 differentiation, and ultimately restores the Th17/Treg cell equilibrium. Overall, scutellarein exerts dual protective effects in UC by reinforcing epithelial barrier function through microbiota-metabolite regulation and suppressing mucosal inflammation via the PRMT1/STAT3/RORγt axis. Our findings not only elucidate a novel multicomponent mechanism for a natural product but also nominate PRMT1 as a compelling new therapeutic target for UC.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 4","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148098292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soybean-Derived Exosome-Like Nanovesicles Regulate Lipid Metabolism via Mitochondrial Biogenesis and UCP1/PGC-1α Mediated Thermogenesis 大豆衍生的外泌体样纳米囊泡通过线粒体生物发生和UCP1/PGC-1α介导的产热调节脂质代谢

IF 6.9

Food frontiers Pub Date : 2026-05-28 DOI: 10.1002/fft2.70300

Zhenzhu Zhu, Luyuan Ni, Mingwei Gao, Qian Yang, Changli Zhang, Qin Liu

{"title":"Soybean-Derived Exosome-Like Nanovesicles Regulate Lipid Metabolism via Mitochondrial Biogenesis and UCP1/PGC-1α Mediated Thermogenesis","authors":"Zhenzhu Zhu, Luyuan Ni, Mingwei Gao, Qian Yang, Changli Zhang, Qin Liu","doi":"10.1002/fft2.70300","DOIUrl":"https://doi.org/10.1002/fft2.70300","url":null,"abstract":"Obesity has become an important public health concern in modern society. Plant-derived exosome-like nanovesicles are emerging as candidates for obesity intervention. The lipid-lowering effect of soybean-derived exosome-like nanovesicles (SELNs) remains unknown. The aim is to explore the effect of SELNs on the lipid metabolism and its anti-obesity mechanism. SELNs were isolated and characterized. Proteomic analysis showed that among the 1% top-ranking proteins in SELNs, 173 proteins were predicted to be involved in the lipid metabolism. SELNs were stable in the stomach acid environment and ruptured in the intestinal fluid. SELNs boosted mitochondrial function and inhibited lipid droplet formation in sodium palmitate-induced high-fat Caenorhabditis elegans and palmitate-induced HepG2 cells. The triglyceride content of differentiated 3T3-L1 adipocytes was decreased when the dosage of SELNs increased. The key proteins/genes related to lipid metabolism of 3T3-L1 adipocytes after SELNs pretreatment were analyzed by western blot and polymerase chain reaction. The data showed that SELNs significantly upregulated the uncoupling protein 1 (UCP-1)-mediated thermogenesis pathway, as well as lipolysis and fatty acid β-oxidation at 1 × 1010 particles/mL. SELNs also promoted the mitochondrial biogenesis of adipocytes. In addition, protein cargos in SELNs play a vital role in inhibiting the lipid accumulation in adipocytes, not lipids or RNAs. These findings indicate that protein cargos in SELNs have the potential to regulate lipid metabolism, reduce lipid deposition, and improve the mitochondrial function of adipocytes. This study will provide a fundamental theory of SELNs for obesity intervention.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 4","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148098294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 6.9

Food frontiers Pub Date : 2026-05-25

引用次数: 0

IF 6.9

Food frontiers Pub Date : 2026-05-25

引用次数: 0

Obacunone Targets Serine–Threonine Kinase Receptor–Associated Protein to Promote the Formation of the TGF‐β/Smad7 Complex and Ameliorates Bleomycin‐Induced Pulmonary Fibrosis 欧诺酮靶向丝氨酸-苏氨酸激酶受体相关蛋白促进TGF - β/Smad7复合物的形成并改善博来霉素诱导的肺纤维化

Food frontiers Pub Date : 2026-05-01 DOI: 10.1002/fft2.70298

Yonghu Chen, H Y Chen, Guangxi Li, Ning Li, Xuezheng Li, Zhe Jiang

{"title":"Obacunone Targets Serine–Threonine Kinase Receptor–Associated Protein to Promote the Formation of the TGF‐β/Smad7 Complex and Ameliorates Bleomycin‐Induced Pulmonary Fibrosis","authors":"Yonghu Chen, H Y Chen, Guangxi Li, Ning Li, Xuezheng Li, Zhe Jiang","doi":"10.1002/fft2.70298","DOIUrl":"https://doi.org/10.1002/fft2.70298","url":null,"abstract":"ABSTRACT Pulmonary fibrosis (PF) is a complex and fatal interstitial lung disease in which the TGF‐β/Smad signaling pathway plays a pivotal role in fibrotic progression. However, strategies for precise modulation of this pathway remain limited. In this study, a bleomycin (BLM)‐induced mouse model of PF and TGF‐β‐stimulated MLE‐12 or primary lung fibroblast models were used to investigate the antifibrotic effects and underlying mechanisms of obacunone (OB). OB markedly attenuated PF progression, reduced collagen deposition and hydroxyproline (HYP) levels, and inhibited wound healing and migration capacities of TGF‐β‐stimulated MLE‐12 cells and fibroblasts. Surface plasmon resonance (SPR), cellular thermal shift assay (CETSA), molecular docking, and molecular dynamics simulations identified a direct binding interaction between OB and serine–threonine kinase receptor–associated protein (STRAP). Furthermore, co‐immunoprecipitation (Co‐IP) and immunofluorescence analyses confirmed that OB promoted the formation of the STRAP–TGF‐βR II/Smad7 complex, thereby suppressing activation of the TGF‐β/Smad2/3 pathway. Collectively, this study is the first to demonstrate that OB ameliorates PF by targeting STRAP to modulate the TGF‐β/Smad2/3 signaling cascade, providing new evidence for the antifibrotic mechanism of OB and supporting STRAP as a potential therapeutic target for PF intervention.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 6.9

Food frontiers Pub Date : 2026-04-24

引用次数: 0

IF 6.9

Food frontiers Pub Date : 2026-04-24

引用次数: 0

Rosa roxburghii-Derived Exosome-Like Nanovesicles Alleviate Ulcerative Colitis Based on Th17/Treg Immune Balance and Gut Microbiota Modulation 刺梨衍生的外泌体样纳米囊泡缓解溃疡性结肠炎基于Th17/Treg免疫平衡和肠道菌群调节

IF 6.9

Food frontiers Pub Date : 2026-04-24 DOI: 10.1002/fft2.70284

Yuanyuan Wang, Yan Zeng, Guoying Liu, Hai Zou, Jie Wang, Jun Zhang, Ketao Jin, Zhangfeng Zhong, Xiaozhou Mou

{"title":"Rosa roxburghii-Derived Exosome-Like Nanovesicles Alleviate Ulcerative Colitis Based on Th17/Treg Immune Balance and Gut Microbiota Modulation","authors":"Yuanyuan Wang, Yan Zeng, Guoying Liu, Hai Zou, Jie Wang, Jun Zhang, Ketao Jin, Zhangfeng Zhong, Xiaozhou Mou","doi":"10.1002/fft2.70284","DOIUrl":"10.1002/fft2.70284","url":null,"abstract":"Plant-derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of intercellular communication, as they can deliver bioactive payloads to target cells. As a traditional functional food, Rosa roxburghii-derived exosome-like nanovesicles (RNVs) have not been fully characterized in colitis pathogenesis. This study investigated the efficacy of RNVs in a murine colitis model via dextran sulfate sodium (DSS) salt exposure. RNVs have a nanoscale size (< 200 nm hydrodynamic diameter) and favorable colloidal stability. In vitro experiments using primary human macrophages demonstrated the superior biocompatibility of RNVs. RNV pre-administration alleviated pathological features in murine DSS-colitis, which was confirmed by in vivo experiments. This study provides solid evidence that RNVs ameliorate DSS-induced colitis in murine models through multipronged mechanisms: (i) reconstitution of gut microbiota composition; (ii) elevating levels of short-chain fatty acids; (iii) modulating inflammatory mediators and antioxidant factors and restoring intestinal barrier integrity via tight junction regulation; and (iv) rebalancing of Th17/Treg immune responses. In conclusion, this study reveals the essential pathways responsible for the anti-inflammatory/antioxidant actions of PDVs and demonstrates their translational potential as novel nanovesicle-based carriers for functional foods.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organophosphate Insecticide Half-Lives in Foods Fermented With Lactic Acid Bacteria 乳酸菌发酵食品中有机磷杀虫剂的半衰期

IF 6.9

Food frontiers Pub Date : 2026-04-24 DOI: 10.1002/fft2.70285

Julia Steenkamp, Graham Hepworth, Kate Howell

{"title":"Organophosphate Insecticide Half-Lives in Foods Fermented With Lactic Acid Bacteria","authors":"Julia Steenkamp, Graham Hepworth, Kate Howell","doi":"10.1002/fft2.70285","DOIUrl":"https://doi.org/10.1002/fft2.70285","url":null,"abstract":"There is a growing concern that chronic, low-level exposure to organophosphate insecticides, through residues in food, is a threat to human health. Evidence is emerging that fermentation with lactic acid bacteria may be an effective way of reducing these residues. The aim of this review is to synthesize the evidence on organophosphate insecticide degradation during lactic acid fermentation, analyze the effect on organophosphate insecticide half-lives, and explore the factors that impact degradation. A systematic literature search identified 14 eligible studies, which were screened for Risk of Bias (RoB) using the RoBDMAT tool. Collated results showed that organophosphate insecticides degraded over time, and this was irrespective of inoculation with lactic acid bacteria. However, of 249 experiments involving controlled fermentation, 232 demonstrated that fermentation with lactic acid bacteria could speed up insecticide degradation, beyond the rate of inherent degradation in the food matrix, leading to shorter half-lives. Species of lactic acid bacteria that demonstrated strong potential for organophosphate insecticide degradation were Lactiplantibacillus plantarum subsp. plantarum, Lactobacillus delbrueckii subsp. bulgaricus, and Levilactobacillus brevis. While the findings are promising, the small evidence base and study variability highlight the need for further research. The results of this review may help to inform more reliable organophosphate exposure assessments for the population as well as provide novel insights for both consumers and food manufacturers, expanding the market potential for fermented foods.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 6.9

Food frontiers Pub Date : 2026-04-20

引用次数: 0