Food frontiers最新文献

Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple-Negative Breast Cancer Through Canonical Wnt Signaling Garcinone C通过典型Wnt信号抑制乳腺癌干细胞并诱导凋亡

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70277

Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen

{"title":"Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple-Negative Breast Cancer Through Canonical Wnt Signaling","authors":"Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen","doi":"10.1002/fft2.70277","DOIUrl":"10.1002/fft2.70277","url":null,"abstract":"Natural phytochemicals derived from dietary sources have demonstrated promising anticancer potential with favorable safety profiles. Among them, Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), demonstrated superior antitumor activity compared to other derivatives in our preliminary screening. Here, we report the first comprehensive evaluation of the efficacy of Gar. C against triple-negative breast cancer (TNBC) using both in vitro and in vivo models. Gar. C significantly inhibited cell viability and stemness in TNBC cell lines (SUM159 and SUM149) in a dose-dependent manner, with IC50 values of 4.54 ± 0.13 µM and 5.97 ± 0.16 µM, respectively. Mechanistically, Gar. C induced mitochondrial-mediated apoptosis, as indicated by an increased Bax/Bcl-2 ratio and loss of mitochondrial membrane potential, and triggered G0/G1 cell cycle arrest via modulation of cyclin D1 and p21. Furthermore, Gar. C effectively suppressed cancer stemness, as evidenced by a reduced CD44+/CD24− population. RNA sequencing and Western blot analyses suggested that the inhibition of the Wnt/β-catenin signaling pathway was a key mechanism contributing to its dual effects on inducing apoptosis and suppressing stemness. Importantly, in a xenograft mouse model using SUM159 cells, Gar. C significantly inhibited tumor growth and metastasis. These findings highlight the potential of Gar. C as a promising natural compound for the prevention and treatment of TNBC.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Assessment to Optimization: A Comprehensive Review of the Mutton Quality Evaluation Index, Factors, and Improvement Strategies 从评价到优化：羊肉品质评价指标、影响因素及改进策略综述

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70273

Man-yu Liu, Yi-chen Jian, Fang Wang, Long-xian Zhang, Sen-yang Li, Shu-cheng Huang, Fu-chun Jian

{"title":"From Assessment to Optimization: A Comprehensive Review of the Mutton Quality Evaluation Index, Factors, and Improvement Strategies","authors":"Man-yu Liu, Yi-chen Jian, Fang Wang, Long-xian Zhang, Sen-yang Li, Shu-cheng Huang, Fu-chun Jian","doi":"10.1002/fft2.70273","DOIUrl":"https://doi.org/10.1002/fft2.70273","url":null,"abstract":"Meat, as an important source of animal protein, has attracted widespread attention in recent years because of its quality and safety issues. Therefore, it is particularly important to assess potential impact risks and identify improvement strategies. This review comprehensively discusses the main factors influencing the meat quality, including genetic and environment factors. Furthermore, this review focuses on the application of nutritional and feed-based strategies for improving the meat quality, including feed additives such as probiotics, prebiotics, plant extracts, antioxidants, and functional amino acids, which can markedly enhance the physicochemical properties, nutritional quality, and taste of meat by modulating the intestinal microecological balance, strengthening antioxidant defense mechanisms, and optimizing nutrient metabolism. These insights will help lay the foundation for promoting the high-quality development of the lamb industry and implementing the One Health concept.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple-Negative Breast Cancer Through Canonical Wnt Signaling Garcinone C通过典型Wnt信号抑制乳腺癌干细胞并诱导凋亡

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70277

Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen

{"title":"Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple-Negative Breast Cancer Through Canonical Wnt Signaling","authors":"Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen","doi":"10.1002/fft2.70277","DOIUrl":"https://doi.org/10.1002/fft2.70277","url":null,"abstract":"Natural phytochemicals derived from dietary sources have demonstrated promising anticancer potential with favorable safety profiles. Among them, Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), demonstrated superior antitumor activity compared to other derivatives in our preliminary screening. Here, we report the first comprehensive evaluation of the efficacy of Gar. C against triple-negative breast cancer (TNBC) using both in vitro and in vivo models. Gar. C significantly inhibited cell viability and stemness in TNBC cell lines (SUM159 and SUM149) in a dose-dependent manner, with IC50 values of 4.54 ± 0.13 µM and 5.97 ± 0.16 µM, respectively. Mechanistically, Gar. C induced mitochondrial-mediated apoptosis, as indicated by an increased Bax/Bcl-2 ratio and loss of mitochondrial membrane potential, and triggered G0/G1 cell cycle arrest via modulation of cyclin D1 and p21. Furthermore, Gar. C effectively suppressed cancer stemness, as evidenced by a reduced CD44+/CD24− population. RNA sequencing and Western blot analyses suggested that the inhibition of the Wnt/β-catenin signaling pathway was a key mechanism contributing to its dual effects on inducing apoptosis and suppressing stemness. Importantly, in a xenograft mouse model using SUM159 cells, Gar. C significantly inhibited tumor growth and metastasis. These findings highlight the potential of Gar. C as a promising natural compound for the prevention and treatment of TNBC.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Assessment to Optimization: A Comprehensive Review of the Mutton Quality Evaluation Index, Factors, and Improvement Strategies 从评价到优化：羊肉品质评价指标、影响因素及改进策略综述

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70273

Man-yu Liu, Yi-chen Jian, Fang Wang, Long-xian Zhang, Sen-yang Li, Shu-cheng Huang, Fu-chun Jian

{"title":"From Assessment to Optimization: A Comprehensive Review of the Mutton Quality Evaluation Index, Factors, and Improvement Strategies","authors":"Man-yu Liu, Yi-chen Jian, Fang Wang, Long-xian Zhang, Sen-yang Li, Shu-cheng Huang, Fu-chun Jian","doi":"10.1002/fft2.70273","DOIUrl":"10.1002/fft2.70273","url":null,"abstract":"Meat, as an important source of animal protein, has attracted widespread attention in recent years because of its quality and safety issues. Therefore, it is particularly important to assess potential impact risks and identify improvement strategies. This review comprehensively discusses the main factors influencing the meat quality, including genetic and environment factors. Furthermore, this review focuses on the application of nutritional and feed-based strategies for improving the meat quality, including feed additives such as probiotics, prebiotics, plant extracts, antioxidants, and functional amino acids, which can markedly enhance the physicochemical properties, nutritional quality, and taste of meat by modulating the intestinal microecological balance, strengthening antioxidant defense mechanisms, and optimizing nutrient metabolism. These insights will help lay the foundation for promoting the high-quality development of the lamb industry and implementing the One Health concept.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple-Negative Breast Cancer Through Canonical Wnt Signaling Garcinone C通过典型Wnt信号抑制乳腺癌干细胞并诱导凋亡

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70277

Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen

{"title":"Garcinone C Suppresses Cancer Stem Cells and Induces Apoptosis in Triple-Negative Breast Cancer Through Canonical Wnt Signaling","authors":"Danhong Zheng, Jiazi Chen, Yong Wang, Da Ma, Jing Chen","doi":"10.1002/fft2.70277","DOIUrl":"https://doi.org/10.1002/fft2.70277","url":null,"abstract":"Natural phytochemicals derived from dietary sources have demonstrated promising anticancer potential with favorable safety profiles. Among them, Garcinone C (Gar. C), a xanthone derived from mangosteen (Garcinia mangostana), demonstrated superior antitumor activity compared to other derivatives in our preliminary screening. Here, we report the first comprehensive evaluation of the efficacy of Gar. C against triple-negative breast cancer (TNBC) using both in vitro and in vivo models. Gar. C significantly inhibited cell viability and stemness in TNBC cell lines (SUM159 and SUM149) in a dose-dependent manner, with IC50 values of 4.54 ± 0.13 µM and 5.97 ± 0.16 µM, respectively. Mechanistically, Gar. C induced mitochondrial-mediated apoptosis, as indicated by an increased Bax/Bcl-2 ratio and loss of mitochondrial membrane potential, and triggered G0/G1 cell cycle arrest via modulation of cyclin D1 and p21. Furthermore, Gar. C effectively suppressed cancer stemness, as evidenced by a reduced CD44+/CD24− population. RNA sequencing and Western blot analyses suggested that the inhibition of the Wnt/β-catenin signaling pathway was a key mechanism contributing to its dual effects on inducing apoptosis and suppressing stemness. Importantly, in a xenograft mouse model using SUM159 cells, Gar. C significantly inhibited tumor growth and metastasis. These findings highlight the potential of Gar. C as a promising natural compound for the prevention and treatment of TNBC.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity? 天然产物作为肠道微生物群的调节剂：开发新的治疗肥胖的方法？

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70275

Hongchao Yuan, Yau-Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang

{"title":"Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity?","authors":"Hongchao Yuan, Yau-Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang","doi":"10.1002/fft2.70275","DOIUrl":"10.1002/fft2.70275","url":null,"abstract":"The global increase in obesity and related metabolic disorders calls for innovative treatment approaches that extend beyond traditional drug-based interventions. These conventional pharmacological methods are frequently associated with considerable adverse effects. This review synthesizes recent advances in understanding how natural products—including polyphenols, prebiotics, alkaloids, saponins, and polysaccharides—modulate gut microbiota to combat obesity. Key findings highlight that compounds like resveratrol, berberine, and Panax notoginseng saponins enhance beneficial microbial populations (e.g., Akkermansia and Bifidobacterium), promote short-chain fatty acid production, and restore intestinal barrier integrity, thereby ameliorating metabolic dysfunction. Clinical and preclinical studies demonstrate their potential to reduce adiposity, inflammation, and insulin resistance. However, challenges such as limited human trials, variability in gut microbiota composition, and standardization of natural products remain. This work advocates for further large-scale human studies to validate these findings, positioning natural products as promising, sustainable adjuvants in obesity management through microbiota-targeted therapies.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Assessment to Optimization: A Comprehensive Review of the Mutton Quality Evaluation Index, Factors, and Improvement Strategies 从评价到优化：羊肉品质评价指标、影响因素及改进策略综述

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70273

Man-yu Liu, Yi-chen Jian, Fang Wang, Long-xian Zhang, Sen-yang Li, Shu-cheng Huang, Fu-chun Jian

{"title":"From Assessment to Optimization: A Comprehensive Review of the Mutton Quality Evaluation Index, Factors, and Improvement Strategies","authors":"Man-yu Liu, Yi-chen Jian, Fang Wang, Long-xian Zhang, Sen-yang Li, Shu-cheng Huang, Fu-chun Jian","doi":"10.1002/fft2.70273","DOIUrl":"https://doi.org/10.1002/fft2.70273","url":null,"abstract":"Meat, as an important source of animal protein, has attracted widespread attention in recent years because of its quality and safety issues. Therefore, it is particularly important to assess potential impact risks and identify improvement strategies. This review comprehensively discusses the main factors influencing the meat quality, including genetic and environment factors. Furthermore, this review focuses on the application of nutritional and feed-based strategies for improving the meat quality, including feed additives such as probiotics, prebiotics, plant extracts, antioxidants, and functional amino acids, which can markedly enhance the physicochemical properties, nutritional quality, and taste of meat by modulating the intestinal microecological balance, strengthening antioxidant defense mechanisms, and optimizing nutrient metabolism. These insights will help lay the foundation for promoting the high-quality development of the lamb industry and implementing the One Health concept.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal Polysaccharides as Next-Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons 真菌多糖作为下一代生物活性物质：结构-活性图谱、作用方式和生物技术研究进展

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70238

Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian

{"title":"Fungal Polysaccharides as Next-Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons","authors":"Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian","doi":"10.1002/fft2.70238","DOIUrl":"https://doi.org/10.1002/fft2.70238","url":null,"abstract":"Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs. Findings show that monosaccharide composition (MC), molecular weight (Mw), glycosidic linkage patterns, and higher order conformations, particularly β-(1→3)/(1→6) triple-helical structures, are the primary determinants of bioactivity. Structure–activity evidence indicates that glucose-rich β-glucans enhance immunomodulation and antitumor responses, while mannose and rhamnose-enriched heteropolysaccharides contribute to hypoglycemic and antioxidant effects. Molecular studies further reveal that FPs regulate multiple signaling pathways, including TLR4/NF-κB, MAPK, PI3K/Akt, and Nrf2, thereby mediating immune activation, inflammation suppression, oxidative stress reduction, and metabolic homeostasis. Across biological activities, FPs demonstrate strong immunoregulatory, antitumor, antioxidant, hypoglycemic, hepatoprotective, and lipid-modulating effects, with growing evidence of microbiota-dependent mechanisms and synergy with conventional therapies. This review highlights that specific structural motifs and conformational attributes are directly linked to functional performance, providing a foundation for predictable structure–activity models. We conclude that FPs hold significant promise as next-generation functional ingredients, therapeutic adjuvants, and biomaterial platforms. However, their translation requires standardized analytical methods, deeper mechanistic studies, and well-designed clinical investigations.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity? 天然产物作为肠道微生物群的调节剂：开发新的治疗肥胖的方法？

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70275

Hongchao Yuan, Yau-Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang

{"title":"Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity?","authors":"Hongchao Yuan, Yau-Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang","doi":"10.1002/fft2.70275","DOIUrl":"https://doi.org/10.1002/fft2.70275","url":null,"abstract":"The global increase in obesity and related metabolic disorders calls for innovative treatment approaches that extend beyond traditional drug-based interventions. These conventional pharmacological methods are frequently associated with considerable adverse effects. This review synthesizes recent advances in understanding how natural products—including polyphenols, prebiotics, alkaloids, saponins, and polysaccharides—modulate gut microbiota to combat obesity. Key findings highlight that compounds like resveratrol, berberine, and Panax notoginseng saponins enhance beneficial microbial populations (e.g., Akkermansia and Bifidobacterium), promote short-chain fatty acid production, and restore intestinal barrier integrity, thereby ameliorating metabolic dysfunction. Clinical and preclinical studies demonstrate their potential to reduce adiposity, inflammation, and insulin resistance. However, challenges such as limited human trials, variability in gut microbiota composition, and standardization of natural products remain. This work advocates for further large-scale human studies to validate these findings, positioning natural products as promising, sustainable adjuvants in obesity management through microbiota-targeted therapies.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity? 天然产物作为肠道微生物群的调节剂：开发新的治疗肥胖的方法？

IF 6.9

Food frontiers Pub Date : 2026-04-10 DOI: 10.1002/fft2.70275

Hongchao Yuan, Yau-Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang

{"title":"Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity?","authors":"Hongchao Yuan, Yau-Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang","doi":"10.1002/fft2.70275","DOIUrl":"https://doi.org/10.1002/fft2.70275","url":null,"abstract":"The global increase in obesity and related metabolic disorders calls for innovative treatment approaches that extend beyond traditional drug-based interventions. These conventional pharmacological methods are frequently associated with considerable adverse effects. This review synthesizes recent advances in understanding how natural products—including polyphenols, prebiotics, alkaloids, saponins, and polysaccharides—modulate gut microbiota to combat obesity. Key findings highlight that compounds like resveratrol, berberine, and Panax notoginseng saponins enhance beneficial microbial populations (e.g., Akkermansia and Bifidobacterium), promote short-chain fatty acid production, and restore intestinal barrier integrity, thereby ameliorating metabolic dysfunction. Clinical and preclinical studies demonstrate their potential to reduce adiposity, inflammation, and insulin resistance. However, challenges such as limited human trials, variability in gut microbiota composition, and standardization of natural products remain. This work advocates for further large-scale human studies to validate these findings, positioning natural products as promising, sustainable adjuvants in obesity management through microbiota-targeted therapies.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"7 3","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://iadns.onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0