Food frontiers最新文献

Correction to “The Algal Polysaccharide Ulvan Suppresses Growth of Hepatoma Cells”

IF 7.4

Food frontiers Pub Date : 2024-12-31 DOI: 10.1002/fft2.540

引用次数: 0

RS4 Type Resistant Starch Improves Type 2 Diabetes Mellitus in Mice by Interacting With Lactobacillus johnsonii

IF 7.4

Food frontiers Pub Date : 2024-12-16 DOI: 10.1002/fft2.528

Tao Xu, Yongheng Zhong, Shengyang Ji, Hang Xiao, Jun Li, Kaimian Li, Peiwu Li, Baiyi Lu

{"title":"RS4 Type Resistant Starch Improves Type 2 Diabetes Mellitus in Mice by Interacting With Lactobacillus johnsonii","authors":"Tao Xu, Yongheng Zhong, Shengyang Ji, Hang Xiao, Jun Li, Kaimian Li, Peiwu Li, Baiyi Lu","doi":"10.1002/fft2.528","DOIUrl":"https://doi.org/10.1002/fft2.528","url":null,"abstract":"RS4-type resistant starches have been applied in food industry as thickeners or studied as functional foods for a long time. However, the influence and mechanism of RS4 on Type 2 diabetes mellitus (T2DM) have not been elucidated. In this study, sinapic acid starch ester (SASE) was chosen as a representative of functional RS4, and its anti-diabetic activity and underlying mechanism were investigated. Results showed that SASE administration lowered blood glucose and ameliorated insulin resistance of streptozotocin-induced diabetic mice via increasing serum butyrate level. Fecal microbiota transplantation confirmed the T2DM-improving activity of SASE modulated gut microbiota. 16S rRNA gene sequencing indicated that SASE selectively promoted the proliferation of butyrate-producing bacterium. In vitro co-culture of promoted gut bacterium with SASE revealed that Lactobacillus johnsonii was one of the key bacteria in the degradation of SASE. In conclusion, RS4 could selectively promote gut bacteria and increase short-chain fatty acid production to alleviate T2DM.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"268-281"},"PeriodicalIF":7.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-Based Meat Alternatives Intake and Its Association With Health Status Among Vegetarians of the UK Biobank Volunteer Population

IF 7.4

Food frontiers Pub Date : 2024-12-16 DOI: 10.1002/fft2.532

Hana F. Navratilova, Anthony D. Whetton, Nophar Geifman

{"title":"Plant-Based Meat Alternatives Intake and Its Association With Health Status Among Vegetarians of the UK Biobank Volunteer Population","authors":"Hana F. Navratilova, Anthony D. Whetton, Nophar Geifman","doi":"10.1002/fft2.532","DOIUrl":"https://doi.org/10.1002/fft2.532","url":null,"abstract":"Consumption of plant-based meat alternatives (PBMAs) within the vegetarian population is increasing. This study assessed the relationship between PBMA intake and health markers using the UK Biobank cohort. Participants were categorized into vegetarian PBMA consumers and vegetarian PBMA nonconsumers. Nonparametric statistical tests were used to evaluate differences in participants’ characteristics, food intake, and 30 blood biochemistry measures after assessing data distributions. Metabolomics (168 metabolites) and proteomics (2923 proteins) data were further examined to identify significant differences between the two participant groups. Relative risks (RRs) for 45 chronic diseases and mental conditions were calculated using Poisson regression. Sensitivity analysis accounted for sociodemographic factors, and the proportion of energy from ultra-processed food (UPF) intake was determined. No substantial differences in sodium, free sugar, total sugar, or saturated fatty acids intake between vegetarian PBMA consumers and nonconsumers were found. However, PBMA consumers exhibited higher blood pressure (130/79 and 129/78 mmHg for consumer and nonconsumer groups, respectively) and elevated C-reactive protein (CRP) levels (1.76 ± 3.12 and 1.57 ± 3.17 mg/L for consumer and nonconsumer groups, respectively). Metabolite and protein abundance analysis showed no notable differences. Pathway enrichment analysis suggested that PBMAs may influence immune reactions through cell signaling pathways. PBMA consumers had a 42% increased risk of depression (p = 0.03) and a 40% reduction in irritable bowel syndrome (IBS) risk (p = 0.02), compared to nonconsumers. In conclusion, while no clear health risks or benefits were associated with PBMA consumption in vegetarians, the higher risk of depression, elevated CRP, and lower apolipoprotein A levels in PBMA consumers suggest potential inflammatory concerns that warrant further investigation.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"590-598"},"PeriodicalIF":7.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Residue Behavior and Risk Assessment of Thiamethoxam With Its Metabolite From Tea Production to Consumption

IF 7.4

Food frontiers Pub Date : 2024-12-16 DOI: 10.1002/fft2.525

Xinru Wang, Huan Yu, Zihan Wang, Chengmin Zha, Fengjian Luo, Zongmao Chen, Li Zhou

{"title":"Dynamic Residue Behavior and Risk Assessment of Thiamethoxam With Its Metabolite From Tea Production to Consumption","authors":"Xinru Wang, Huan Yu, Zihan Wang, Chengmin Zha, Fengjian Luo, Zongmao Chen, Li Zhou","doi":"10.1002/fft2.525","DOIUrl":"https://doi.org/10.1002/fft2.525","url":null,"abstract":"The entire fate of the widely used insecticide thiamethoxam from field cultivation, manufacturing to brewing were studied. A method to simultaneously detect thiamethoxam and its two metabolites, clothianidin and CGA265307, was developed. The field trial indicated a half-life of thiamethoxam at 3.2 days on tea leaves, meanwhile, generation of clothianidin was observed with the maximum accumulation of 0.0152 mg/kg after 1 day of thiamethoxam application. The processing factors (PFs) during tea manufacturing ranged from 0.16 to 1.36 and 0.72 to 1.27 for thiamethoxam and clothianidin, respectively. Notably, PFs for thiamethoxam and clothianidin were higher during microwave deenzymed green tea manufacturing than pan deenzymed green tea and traditional black tea. Both thiamethoxam and clothianidin showed high infusion factors during tea brewing, whereas the risk quotient indicated an acceptable dietary risk of thiamethoxam with clothianidin through tea consumption. These findings could facilitate a more accurate assessment of safety risks and better protect the health of tea consumers.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"259-267"},"PeriodicalIF":7.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea)

IF 7.4

Food frontiers Pub Date : 2024-11-25 DOI: 10.1002/fft2.524

Jianchun Shao, Zhangqi Li, Haokun You, Dejuan Wang, Jiaonan Zhang, Lei Wang, Chao Zhao, Wei Zhao

{"title":"Soybean Glycinin Reduced Growth Performance and Antioxidant Capacity and Caused Intestinal Inflammation and Microbiome Changes in Large Yellow Croaker (Larimichthys crocea)","authors":"Jianchun Shao, Zhangqi Li, Haokun You, Dejuan Wang, Jiaonan Zhang, Lei Wang, Chao Zhao, Wei Zhao","doi":"10.1002/fft2.524","DOIUrl":"https://doi.org/10.1002/fft2.524","url":null,"abstract":"Glycinin, a major anti-nutrient in soybean meal, may trigger enteritis and oxidative stress in fish with overconsumption. However, its impact on intestinal inflammation and underlying signaling mechanisms in Larimichthys crocea remains unclear. The purpose of this study was to assess the effects of glycinin on growth, antioxidant function, inflammatory response, and gut microbiota. Four isonitrogenous and isolipidic experimental feeds were prepared, supplemented with 0%(G0), 3%(G3), 6%(G6), and 12%(G12) glycinin, respectively, and fed to juvenile L. crocea for 10 weeks. The findings indicated that dietary glycinin markedly decreased the growth, feed utilization, and survival rate of L. crocea. In addition, L. crocea fed with G6 and G12 diets showed lower trypsin activity compared with those fed with G0 and G3 diets. Similarly, fish fed with G6 and G12 diets showed higher malondialdehyde content and lower superoxide dismutase activity in the liver compared with those fed with G0 and G3 diets, suggesting that glycinin induced oxidative stress and led to the imbalance of the antioxidant system. Dietary glycinin significantly increased the mRNA expression levels of toll-like receptors in the gut. Moreover, dietary glycinin resulted in a heightened expression of both C-rel and p65 proteins, while also elevating the phosphorylation levels of JNK and ERK proteins, indicating that glycinin activated the MAPK/NF-κB signaling route. In addition, dietary glycinin increased the abundance of pathogenic bacteria in the gut, including Bacteroides and Streptococcus, and reduced the Bifidobacterium abundance. The findings suggested that L. crocea is highly sensitive to glycinin, and a 3% level can cause growth decline and enteritis.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"248-258"},"PeriodicalIF":7.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food Safety in Developing Countries: Common Foodborne and Waterborne Illnesses, Regulations, Organizational Structure, and Challenges of Food Safety in the Context of Nepal

IF 7.4

Food frontiers Pub Date : 2024-11-16 DOI: 10.1002/fft2.517

Deepak Subedi, Madhav Paudel, Sandesh Poudel, Niranjan Koirala

{"title":"Food Safety in Developing Countries: Common Foodborne and Waterborne Illnesses, Regulations, Organizational Structure, and Challenges of Food Safety in the Context of Nepal","authors":"Deepak Subedi, Madhav Paudel, Sandesh Poudel, Niranjan Koirala","doi":"10.1002/fft2.517","DOIUrl":"https://doi.org/10.1002/fft2.517","url":null,"abstract":"Food safety presents a global challenge, contributing to 600 million cases of foodborne diseases and 420,000 fatalities annually worldwide. In developing countries, such as Nepal, addressing food safety is particularly intricate and arduous because of the prevalent issues of food insecurity, poverty, illiteracy, and regulatory hurdles. The objectives of this comprehensive review are to evaluate the prevalent foodborne and waterborne illnesses, examine the existing regulations and institutional frameworks, and identify the challenges associated with food safety in Nepal. Additionally, this review aims to propose strategies to enhance food safety measures in the country. An electronic search was conducted using relevant keywords to include articles and literature pertinent to the topic. Common foodborne illnesses in Nepal include cholera, typhoid fever, hepatitis, worm infections, and poisoning from mushrooms, heavy metals, and pesticides. While existing rules, regulations, and government infrastructure exist, they often face limitations in effectively addressing these multifaceted challenges. Food safety in developing countries, such as Nepal, faces several challenges, including inadequate regulatory frameworks, limited surveillance and monitoring, rural–urban disparities, and high incidences of foodborne illness. Additional issues stem from weak law enforcement, poor food safety practices, limited infrastructure, informal sector challenges, cross-border trade, limited access to clean water, and the impacts of climate change. A multisectoral One Health approach involving collaboration among government agencies, food industry stakeholders, consumers, and civil society organizations is imperative to enhance food safety in developing countries such as Nepal.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"86-123"},"PeriodicalIF":7.4,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF-κB/MAPK Signaling Pathway via TGR5

IF 7.4

Food frontiers Pub Date : 2024-11-10 DOI: 10.1002/fft2.516

Zetian Wang, Wei Luo, Qing Wang, Chunzheng Liu, Yanshan Gong, Baitian Li, Xuejiao Zeng, Jiaqi Lin, Zehua Su, Xin Li, Yongze Yu, Zhongmin Liu, Ling Gao, Lijun Liao

{"title":"hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF-κB/MAPK Signaling Pathway via TGR5","authors":"Zetian Wang, Wei Luo, Qing Wang, Chunzheng Liu, Yanshan Gong, Baitian Li, Xuejiao Zeng, Jiaqi Lin, Zehua Su, Xin Li, Yongze Yu, Zhongmin Liu, Ling Gao, Lijun Liao","doi":"10.1002/fft2.516","DOIUrl":"https://doi.org/10.1002/fft2.516","url":null,"abstract":"The protective effects of human umbilical cord mesenchymal stem cells (hUCMSCs) on heart failure (HF)-induced intestinal injury have not been fully understood. Flow cytometry and immunofluorescence analysis revealed that hUCMSCs renewed themselves, grew, and transformed into various cell types. Meanwhile, hUCMSCs safeguarded against intestinal damage, regulated imbalances in the intestinal flora and bile acid metabolism, and enhanced the levels of hyodeoxycholic acid (HDCA) in pigs with HF. HDCA protected against HF-induced intestinal injury in mice through Takeda G protein–coupled receptor 5 (TGR5). Protein analysis showed that HDCA exerted protective effects on the intestines via the signal transducer and activator of transcription 3 (STAT3)/nuclear factor kappa B (NF-κB)/mitogen-activated protein kinase (MAPK) signaling pathway. Mouse experiments revealed that HDCA bound to TGR5 to inhibit MAPK and NF-κB signaling pathway activation, which relies on the STAT3 signaling pathway. Moreover, hUCMSCs protected against intestinal injury in the pig model of HF by suppressing the activation of the STAT3/NF-κB/MAPK signaling pathway via TGR5.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"575-589"},"PeriodicalIF":7.4,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity of Alternaria-derived toxins and their toxicodynamic and toxicokinetic characteristics in the food chain

IF 7.4

Food frontiers Pub Date : 2024-11-07 DOI: 10.1002/fft2.507

Sarfaraz Hussain, Aqleem Abbas, Maratab Ali, Israt Jahan, Muhammad Jabran, Muhammad Afaq Ahmed, Zienab F. R. Ahmed, Xinhua Zhang

{"title":"Diversity of Alternaria-derived toxins and their toxicodynamic and toxicokinetic characteristics in the food chain","authors":"Sarfaraz Hussain, Aqleem Abbas, Maratab Ali, Israt Jahan, Muhammad Jabran, Muhammad Afaq Ahmed, Zienab F. R. Ahmed, Xinhua Zhang","doi":"10.1002/fft2.507","DOIUrl":"https://doi.org/10.1002/fft2.507","url":null,"abstract":"The Alternaria genus comprises more than 250 fungal species among which pathogenic species cause diseases in economically important crops and contaminate food via secreted toxins. Among these host-specific toxins (HSTs) generally harm specific plants, while certain non-host-specific toxins (nHSTs) have significant mutagenic and cytotoxic effects on humans and other vertebrates. Alternaria spp. tend to accumulate mycotoxins in food and food products, causing spoilage in fields during harvesting, postharvest stages, and storage. Changing climatic conditions and large cultivation areas led to a rise in Alternaria mycotoxins, with vegetarians being more frequently exposed. There is limited information on the toxicity incidence, absorption, excretion, and distribution of these mycotoxins in farms and domesticated animals; therefore, further investigation is required. This review covers current studies on the toxic effects of Alternaria mycotoxins, including genotoxicity, teratogenicity, nephrotoxicity, cytotoxicity, DNA damage, carcinogenicity, and immunosuppressive role. The toxicokinetic properties of these mycotoxins were explored, based on both in vitro and in vivo investigations. Combined effects of Alternaria mycotoxins with other mycotoxins in food are not well studied and can vary widely, showing synergistic, additive, or antagonistic interactions based on the specific combinations involved. The data presented here could strengthen risk assessment for Alternaria mycotoxins by emphasizing the need to minimize contact between contaminated and uncontaminated food and establish appropriate measures to ensure food safety.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"185-217"},"PeriodicalIF":7.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Pullulan to Induce Disease Resistance Against Diaporthe nobilis in Postharvest Kiwifruit

IF 7.4

Food frontiers Pub Date : 2024-11-06 DOI: 10.1002/fft2.510

Shukun Yu, Huanhuan Li, Lihong Han, Junjie Wang, Xiaofeng Tang, Zhao-Jun Wei, Yongsheng Liu, Min Miao

{"title":"Application of Pullulan to Induce Disease Resistance Against Diaporthe nobilis in Postharvest Kiwifruit","authors":"Shukun Yu, Huanhuan Li, Lihong Han, Junjie Wang, Xiaofeng Tang, Zhao-Jun Wei, Yongsheng Liu, Min Miao","doi":"10.1002/fft2.510","DOIUrl":"https://doi.org/10.1002/fft2.510","url":null,"abstract":"Kiwifruit stands out as a globally favored fruit owing to its palatable flavor and nutritional benefits. However, it continues to ripen after harvest, and this trait makes it more susceptible to fungal infections. Diaporthe spp. has garnered attention for causing postharvest soft rot in kiwifruit; consequently, effective prevention and treatment strategies for soft rot are crucial for managing postharvest diseases in kiwifruit. We found that pullulan treatment greatly decreased both the incidence of disease and lesion diameter following Diaporthe nobilis inoculation in kiwifruit. Pullulan at the concentrations (1%, 3%, and 5%) markedly reduced the disease incidence of the soft rot in kiwifruit after 3 days of inoculation with D. nobilis by 19.16%, 31.66%, and 48.33%, respectively, and lesion diameter of 5% pullulan treated kiwifruit was 38.1% lower than that of the control 3 days after treatment. Importantly, pullulan treatment maintained and reduced the accumulation of superoxide anion (O2−), hydrogen peroxide (H2O2), and the peroxidation of membrane lipids; maintained high levels of ascorbic acid (AsA) and glutathione (GSH); and stimulated the buildup of total phenolic. Additionally, pullulan treatment markedly increased the activities of defense-related enzymes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), phenylalanine ammonialyase (PAL), chitinase (CHI), and β-1,3 glucanase (GLU). Furthermore, pullulan treatment was found to activate expressions of defense-related genes. Overall, our data confirm the application of pullulan treatment for controlling postharvest soft rot in kiwifruit, potentially offering a valuable strategy for enhancing the storage stability and shelf life of this economically significant fruit.","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"563-574"},"PeriodicalIF":7.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cover Image: Volume 5, Issue 6 封面图片：第 5 卷第 6 期

IF 7.4

Food frontiers Pub Date : 2024-11-06 DOI: 10.1002/fft2.521

引用次数: 0