Food frontiers最新文献

{"title":"hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF-κB/MAPK Signaling Pathway via TGR5","authors":"Zetian Wang,&nbsp;Wei Luo,&nbsp;Qing Wang,&nbsp;Chunzheng Liu,&nbsp;Yanshan Gong,&nbsp;Baitian Li,&nbsp;Xuejiao Zeng,&nbsp;Jiaqi Lin,&nbsp;Zehua Su,&nbsp;Xin Li,&nbsp;Yongze Yu,&nbsp;Zhongmin Liu,&nbsp;Ling Gao,&nbsp;Lijun Liao","doi":"10.1002/fft2.516","DOIUrl":"https://doi.org/10.1002/fft2.516","url":null,"abstract":"<p>The protective effects of human umbilical cord mesenchymal stem cells (hUCMSCs) on heart failure (HF)-induced intestinal injury have not been fully understood. Flow cytometry and immunofluorescence analysis revealed that hUCMSCs renewed themselves, grew, and transformed into various cell types. Meanwhile, hUCMSCs safeguarded against intestinal damage, regulated imbalances in the intestinal flora and bile acid metabolism, and enhanced the levels of hyodeoxycholic acid (HDCA) in pigs with HF. HDCA protected against HF-induced intestinal injury in mice through Takeda G protein–coupled receptor 5 (TGR5). Protein analysis showed that HDCA exerted protective effects on the intestines via the signal transducer and activator of transcription 3 (STAT3)/nuclear factor kappa B (NF-κB)/mitogen-activated protein kinase (MAPK) signaling pathway. Mouse experiments revealed that HDCA bound to TGR5 to inhibit MAPK and NF-κB signaling pathway activation, which relies on the STAT3 signaling pathway. Moreover, hUCMSCs protected against intestinal injury in the pig model of HF by suppressing the activation of the STAT3/NF-κB/MAPK signaling pathway via TGR5.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"575-589"},"PeriodicalIF":7.4,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of Alternaria-derived toxins and their toxicodynamic and toxicokinetic characteristics in the food chain","authors":"Sarfaraz Hussain,&nbsp;Aqleem Abbas,&nbsp;Maratab Ali,&nbsp;Israt Jahan,&nbsp;Muhammad Jabran,&nbsp;Muhammad Afaq Ahmed,&nbsp;Zienab F. R. Ahmed,&nbsp;Xinhua Zhang","doi":"10.1002/fft2.507","DOIUrl":"https://doi.org/10.1002/fft2.507","url":null,"abstract":"<p>The <i>Alternaria</i> genus comprises more than 250 fungal species among which pathogenic species cause diseases in economically important crops and contaminate food via secreted toxins. Among these host-specific toxins (HSTs) generally harm specific plants, while certain non-host-specific toxins (nHSTs) have significant mutagenic and cytotoxic effects on humans and other vertebrates. <i>Alternaria</i> spp. tend to accumulate mycotoxins in food and food products, causing spoilage in fields during harvesting, postharvest stages, and storage. Changing climatic conditions and large cultivation areas led to a rise in <i>Alternaria</i> mycotoxins, with vegetarians being more frequently exposed. There is limited information on the toxicity incidence, absorption, excretion, and distribution of these mycotoxins in farms and domesticated animals; therefore, further investigation is required. This review covers current studies on the toxic effects of <i>Alternaria</i> mycotoxins, including genotoxicity, teratogenicity, nephrotoxicity, cytotoxicity, DNA damage, carcinogenicity, and immunosuppressive role. The toxicokinetic properties of these mycotoxins were explored, based on both in vitro and in vivo investigations. Combined effects of <i>Alternaria</i> mycotoxins with other mycotoxins in food are not well studied and can vary widely, showing synergistic, additive, or antagonistic interactions based on the specific combinations involved. The data presented here could strengthen risk assessment for <i>Alternaria</i> mycotoxins by emphasizing the need to minimize contact between contaminated and uncontaminated food and establish appropriate measures to ensure food safety.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"185-217"},"PeriodicalIF":7.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Pullulan to Induce Disease Resistance Against Diaporthe nobilis in Postharvest Kiwifruit","authors":"Shukun Yu,&nbsp;Huanhuan Li,&nbsp;Lihong Han,&nbsp;Junjie Wang,&nbsp;Xiaofeng Tang,&nbsp;Zhao-Jun Wei,&nbsp;Yongsheng Liu,&nbsp;Min Miao","doi":"10.1002/fft2.510","DOIUrl":"https://doi.org/10.1002/fft2.510","url":null,"abstract":"<p>Kiwifruit stands out as a globally favored fruit owing to its palatable flavor and nutritional benefits. However, it continues to ripen after harvest, and this trait makes it more susceptible to fungal infections. <i>Diaporthe</i> spp. has garnered attention for causing postharvest soft rot in kiwifruit; consequently, effective prevention and treatment strategies for soft rot are crucial for managing postharvest diseases in kiwifruit. We found that pullulan treatment greatly decreased both the incidence of disease and lesion diameter following <i>Diaporthe nobilis</i> inoculation in kiwifruit. Pullulan at the concentrations (1%, 3%, and 5%) markedly reduced the disease incidence of the soft rot in kiwifruit after 3 days of inoculation with <i>D. nobilis</i> by 19.16%, 31.66%, and 48.33%, respectively, and lesion diameter of 5% pullulan treated kiwifruit was 38.1% lower than that of the control 3 days after treatment. Importantly, pullulan treatment maintained and reduced the accumulation of superoxide anion (O₂⁻), hydrogen peroxide (H₂O₂), and the peroxidation of membrane lipids; maintained high levels of ascorbic acid (AsA) and glutathione (GSH); and stimulated the buildup of total phenolic. Additionally, pullulan treatment markedly increased the activities of defense-related enzymes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), phenylalanine ammonialyase (PAL), chitinase (CHI), and β-1,3 glucanase (GLU). Furthermore, pullulan treatment was found to activate expressions of defense-related genes. Overall, our data confirm the application of pullulan treatment for controlling postharvest soft rot in kiwifruit, potentially offering a valuable strategy for enhancing the storage stability and shelf life of this economically significant fruit.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"563-574"},"PeriodicalIF":7.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Image: Volume 5, Issue 6","authors":"","doi":"10.1002/fft2.521","DOIUrl":"https://doi.org/10.1002/fft2.521","url":null,"abstract":"<p>The cover image is based on the Letter <i>Hyperspectral guidance for summer tea processing: Enhancing taste and aroma through short-term cycled heaping</i> by Hujing Cao et al., https://doi.org/10.1002/fft2.462.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":""},"PeriodicalIF":7.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142641334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medulla Tetrapanacis water extract ameliorates mastitis by suppressing bacterial internalization and inflammation via MAPKs signaling in vitro and in vivo","authors":"Carsten Tsun-Ka Kwok,&nbsp;Yuanhao Hu,&nbsp;Bun Tsoi,&nbsp;Fiona Wong,&nbsp;Pak-Ting Hau,&nbsp;Emily Wan-Ting Tam,&nbsp;Daniel Kam-Wah Mok,&nbsp;Yiu-Wa Kwan,&nbsp;George Pak-Heng Leung,&nbsp;Simon Ming-Yuen Lee,&nbsp;Jing-Jing Li,&nbsp;Franklin Wang-Ngai Chow,&nbsp;Sai-Wang Seto","doi":"10.1002/fft2.476","DOIUrl":"https://doi.org/10.1002/fft2.476","url":null,"abstract":"<p><i>Medulla Tetrapanacis</i> (MT) is a commonly used herbal ingredient in soup to promote lactation and management of mastitis among lactating mothers worldwide, particularly in Asian countries. However, scientific evidence to support its usage in the management of mastitis is limited. This study aimed to investigate the effects of MT water extract and its underlying mechanisms in <i>Staphylococcus aureus</i> (SA)–induced mastitis in human mammary epithelial cells (HuMEC) and lipopolysaccharide (LPS)–induced mastitis in lactating Sprague–Dawley (SD) rats. The anti-inflammatory and antibacterial effects of MT water extract were examined in SA-infected HuMEC by ELISA and plate counting, respectively. The effects of MT water extract on blood-milk barrier and the underlying mechanism of action of the MT water extract were also investigated by transendothelial electrical resistance assay and western blot. The effects and mechanisms of MT water extract on alleviating mastitis on SD rats were evaluated using LPS-induced mastitis rat model. Our results showed that MT water extract could suppress SA-induced mastitis by reducing SA internalization and growth, protecting blood-milk barrier integrity, and attenuating release of cytokines (interleukin 6 [IL-6] and tumor necrosis factor-alpha [TNF-α]) in HuEMC. Furthermore, the antibacterial effect might be related to the increase of antimicrobial peptides transcription, and the anti-inflammatory effect is at least partly mediated by inactivation of p38 and JNK signaling pathways. Finally, our in vivo results showed that MT water extract ameliorated LPS-induced mastitis in SD rats via suppressing inflammatory cytokine release (TNF-α, IL-6, and interleukin-1 beta), myeloperoxidase, and alleviating pathohistological damage by downregulation of JNK signaling pathway.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"500-515"},"PeriodicalIF":7.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation of Transport Phenomena for Microwave Freeze-Drying of Potato Slices Using Finite Element Analysis","authors":"Narathip Sujinda,&nbsp;Jaturapatr Varith","doi":"10.1002/fft2.508","DOIUrl":"https://doi.org/10.1002/fft2.508","url":null,"abstract":"<p>This research intended to investigate the transport phenomena that occur during microwave freeze-drying (MFD) of potato slices using drying kinetics and finite element analysis (FEA). The impacts of microwave power levels and potato slice thickness on drying rate constant (<i>DR</i>) and average moisture diffusion (<i>D_AVG</i>) were analyzed using MFD kinetics and were then incorporated in the simulation. It was found that the <i>DR</i> and <i>D_AVG</i> were in the range of 301.3 × 10⁻³–775.4 × 10⁻³ min⁻¹ and 1.045 × 10⁻¹⁰–3.336 × 10⁻¹⁰ m²/s, respectively. In the sublimation phase, the <i>DR</i> and <i>D_AVG</i> were higher than those in the desorption phase. The <i>DR</i> and <i>D_AVG</i> increased as the microwave power level increased but decreased as the thickness increased. The FEA of temperature and moisture distribution within the potato slices demonstrated the outward transfer of heat and mass from the center to the exterior and closely matched the experimental data with an error margin of within 5%, leading to the proposed schematic shrinkage model corresponding to the MFD simulation.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"532-548"},"PeriodicalIF":7.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allicin: A natural weapon against Taxol resistance in non-small cell lung cancer through Cathepsin B inhibition and lysosomal-autophagy disruption","authors":"Xudong Gao,&nbsp;Chang Xu,&nbsp;Ramesh Kumar Santhanam,&nbsp;Yingshi Zhang,&nbsp;Qingchun Zhao","doi":"10.1002/fft2.491","DOIUrl":"https://doi.org/10.1002/fft2.491","url":null,"abstract":"<p>Drug resistance in non-small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC. This study aimed to explore the potential mechanism by which allicin reverses Taxol resistance in NSCLC. The potential mechanism of allicin reversing Taxol resistance in vitro was evaluated using cytotoxicity assays, evaluation of cell autophagy and lysosomal function. In addition, the in vivo model was established to evaluate the effectiveness of allicin in reversing Taxol resistance. The results showed that allicin effectively inhibited cell proliferation, induced apoptosis, and reversed Taxol resistance. It inhibits P-gp expression, reduces drug efflux, and disrupts cell autophagy. In particular, allicin inhibited Cathepsin B (CTSB), disrupted lysosomal function, blocked autophagy flux, reduced mitochondrial membrane potential, and enhanced the sensitivity to Taxol. Allicin combined with Taxol significantly inhibited the growth of tumor nodules and reduced their number, demonstrating its potential to reverse Taxol resistance in vivo. In summary, allicin reversed Taxol resistance by inhibiting P-gp and CTSB activity and disrupting the lysosomal-autophagy pathway. These findings highlight the potential of allicin for cancer treatment and drug development.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"549-562"},"PeriodicalIF":7.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic amelioration of obesity in high-fat diet–fed mice by Bifidobacterium longum and green banana powder through targeting multiple pathways","authors":"Yi-Yao Lu,&nbsp;Zhi Jia,&nbsp;Meng-Yue Zhang,&nbsp;Juan Cheng,&nbsp;Ze-Xu Yu,&nbsp;Ye Li,&nbsp;Yi-Xuan Zhang,&nbsp;Xin Wu","doi":"10.1002/fft2.502","DOIUrl":"https://doi.org/10.1002/fft2.502","url":null,"abstract":"<p>Long-term consumption of high-fat diet (HFD) is a major significant risk factor for various diseases, including hyperlipidemia, diabetes, cardiovascular disease, and certain cancers. Recently, there has been a focus on effective dietary methods to improve lipid absorption and accumulation in the body. Simultaneously, exploring non-pharmacological interventions to counteract the adverse consequences of obesity is crucial. Probiotics and prebiotics emerge as promising alternatives in this context, with their combined utilization yielding substantial effects surpassing those achieved by individual application alone. The aim of this study was to investigate the combined effects of <i>Bifidobacterium longum</i> (BL) SYP-B4138 and green banana powder (GBP) on HFD-induced obesity while exploring their underlying mechanisms. The findings demonstrated that the combined intervention exhibited significantly greater efficacy than BL or GBP alone, including in mitigating weight gain and organ weight among obese mice, while also improving lipid profile, glucose tolerance, and inflammation levels. Furthermore, it effectively reduced liver fat accumulation. The mechanism study revealed that the combined intervention increased the expression of gene-related lipid metabolism, such as <i>Ppar</i>α, <i>Cpt1</i>a, <i>Fxr</i>, <i>Cyp7a1</i>, and <i>Bsep</i>, while decreasing expression of the regulatory genes involved in fat synthesis, <i>Acc1</i>, <i>Srebpf1</i>, and <i>Pparγ</i>. The correlation analysis of gut microbes and metabolites suggests that the combined effect of BL and GBP can reverse the intestinal microecological imbalance, leading to changes in bile acids, glycerophospholipids, and other related metabolites. Overall, this study demonstrates that BL combined with GBP can effectively alleviate dietary obesity, highlighting its potential as a non-pharmacological intervention for weight reduction.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"485-499"},"PeriodicalIF":7.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness-related lncRNA 667012","authors":"Xiaxia Fan,&nbsp;Mangmang Feng,&nbsp;Dan Guo,&nbsp;Songtao Li,&nbsp;Yuxuan An,&nbsp;Jinmiao Tian,&nbsp;Zhuoyu Li","doi":"10.1002/fft2.503","DOIUrl":"https://doi.org/10.1002/fft2.503","url":null,"abstract":"<p>Chemoresistance is a major cause of breast cancer (BC) recurrence and metastasis, and chemotherapy resistance comes from tumor stemness. Our previous study showed that quinoa bran terpenoids (QBT) exhibited significant antitumor activity. In this study, we found that QBT increased the sensitivity of drug-resistant BC cells to the chemotherapeutic drugs adriamycin (ADR) and taxol (TAX). A novel lncRNA 667012 was identified along with QBT treatment. Moreover, overexpression of lncRNA 667012 promoted drug resistance, and the reduction of 667012 restored the drug sensitivity of resistant BC cells. More importantly, the findings revealed that lncRNA 667012 promoted stemness maintenance via the stemness-related Wnt pathway. Furthermore, the result showed that QBT reduced 667012 expression and inhibited the activation of β-catenin, thereby attenuating the stemness characteristics of BC and enhancing chemosensitivity. Consistently, the data were confirmed in the xenograft mice model. These results suggest that QBT could reverse chemoresistance by inhibiting stemness. It has the potential to be developed as a novel chemotherapeutic agent or chemosensitizer for BC treatment.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"516-531"},"PeriodicalIF":7.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactiplantibacillus plantarum YY-112 ameliorates mouse immunosuppression by enhancing B/T-cell activation and maintaining Th1/Th2 homeostasis","authors":"Ying Yang,&nbsp;Mengfan Luo,&nbsp;Wanyi Zhou,&nbsp;Wenyang Tao,&nbsp;Jingrui Li,&nbsp;Jianrong Xing,&nbsp;Quanqin Tan,&nbsp;Yuxing Guo","doi":"10.1002/fft2.477","DOIUrl":"https://doi.org/10.1002/fft2.477","url":null,"abstract":"<p>In recent years, the development of immunosuppression has become common, and probiotics are a vital immunomodulatory strategy. This study evaluated the alleviating effect of <i>Lactiplantibacillus plantarum</i> (<i>L. plantarum</i>) YY-112 on cyclophosphamide-induced immune imbalance and resolved the possible mechanism of action. <i>L. plantarum</i> YY-112 at 10⁹ CFU/mL lowered loss of body weight and alleviated splenic injury, intestinal injury, and inflammation, according to the hematoxylin and eosin staining. Biochemical results showed that 10⁹ CFU/mL <i>L. plantarum</i> YY-112 increased interleukin-10 and immunoglobulin M levels and decreased interferon-γ levels. Additionally, the immunoregulatory effect at the molecular levels of <i>L. plantarum</i> YY-112 was analyzed by transcriptome sequencing. <i>L. plantarum</i> YY-112 significantly upregulated <i>Cr2</i> and downregulated <i>C5aR1</i> to regulate the complement system; downregulated <i>S100a8</i>, <i>S100a9</i>, and <i>Mmp9</i> to inhibit neutrophil aggregation; upregulated <i>Cd19</i>, <i>Cd72</i>, <i>Cd3e</i>, <i>Cd28</i>, <i>Cd80</i>, <i>Cd8a</i>, and histocompatibility-2-related genes to regulate B- and T-cell activation; and upregulated <i>Xiap</i>, <i>Malt1</i>, <i>Ikbkb</i>, <i>Mapk11</i>, <i>Mef2c</i>, <i>Mapk12</i>, <i>Ras</i>, and <i>Myc</i> to activate immune signaling pathways. Furthermore, <i>L. plantarum</i> YY-112 improved intestinal microbial structure and reduced enrichment of <i>Lachnospiraceae_NK4A136_group</i>, <i>norank_f_Lachnospiraceae</i>, <i>Desulfovibrio</i>, <i>Colidextribacter</i>, and <i>Helicobacter</i>. In conclusion, these findings offer valuable insights into the potential mechanisms through which <i>L. plantarum</i> YY-112 regulates immune imbalance.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"465-484"},"PeriodicalIF":7.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143116014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}