Food frontiers最新文献

{"title":"Hypoglycemic and hypolipidemic bioactive compounds from edible traditional Chinese medicines and their action of mechanisms explored by multitarget affinity ultrafiltration with liquid chromatography–mass spectrometry","authors":"Xiaowen Hua,&nbsp;Mengjia Xu,&nbsp;Ming Yang,&nbsp;Yingying Zhang,&nbsp;Jianke Ma,&nbsp;Li Cheng,&nbsp;Chu Chu,&nbsp;Zimiao Wu,&nbsp;Mingquan Guo","doi":"10.1002/fft2.488","DOIUrl":"https://doi.org/10.1002/fft2.488","url":null,"abstract":"<p>Edible traditional Chinese medicines (TCMs) have a long-standing history in tackling obesity, diabetes, and metabolic diseases, which, in turn, significantly promotes the exploration of functional food products derived from edible TCMs with lower toxicity and reduced side effects. However, most of bioactive components from TCMs and their mechanisms in regulating blood glucose and lipids remain elusive, which poses a challenge for the development of safer and more effective TCM products. In this context, the development of high-throughput screening methods has become even more important for the identification of active components and the in-depth evaluation of hypoglycemic and hypolipidemic activity in vitro and in vivo. Therefore, this work provides an overview of edible TCMs for managing glucose and lipid metabolism disorders and summarizes the most recent progresses in identifying hypoglycemic and hypolipidemic bioactive compounds in edible TCMs through various screening methods. One significant approach involves the utilization of multitarget-based ultrafiltration liquid chromatography coupled with mass spectrometry. This technique enables the concurrent screening and identification of potential pharmacodynamically active components in TCMs, as well as the investigation of their mechanisms of action. The bioactive compounds identified may serve as crucial active agents in reducing blood glucose and lipids, exhibiting promising potential for incorporation into functional foods or natural health products.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"65-85"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From small-scale studies to an encompassing view: Inhibiting inflammation and clinically relevant enzymes with various extracts of Primula vulgaris using in vitro and in silico techniques","authors":"Inci Kurt-Celep,&nbsp; Nilofar,&nbsp;Mehmet Veysi Cetiz,&nbsp;Dimitrina Zheleva-Dimitrova,&nbsp;Reneta Gevrenova,&nbsp;Engin Celep,&nbsp;Kouadio Ibrahime Sinan,&nbsp;Evren Yildiztugay,&nbsp;Claudio Ferrante,&nbsp;Gokhan Zengin","doi":"10.1002/fft2.473","DOIUrl":"https://doi.org/10.1002/fft2.473","url":null,"abstract":"<p>The genus <i>Primula</i> holds great importance as a source of traditional remedies in various folk medicine systems. In the present study, we investigated the chemical composition and biological properties of different extracts (ethyl acetate, ethanol, ethanol/water, and water) of aerial parts and rhizomes of <i>Primula vulgaris</i>. To determine the chemical profile, the extracts were analyzed using ultrahigh performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) technique and flavonoids were a major group in this profile. The antioxidant capacity was demonstrated by in vitro chemical tests and in general the ethanol/water extract was found to be the most potent. Enzyme inhibition was studied against various enzymes and ethanol and ethanol/water extracts were more active than others. To assess the anti-inflammatory potential of the extracts at the molecular level, human dermal fibroblasts (HDF) were treated with lipopolysaccharide (LPS). In vitro experiments showed that the levels of nuclear factor kappa B (NFKB), receptor for advanced glycation endproducts (RAGE), activator protein-1 (AP-1), interleukin 6 (IL-6), interleukin 17 (IL-17) and tumor necrosis factor (TNF)-alpha were significantly reduced after treatment with the tested extracts. In addition, the extracts showed an inhibitory effect on the enzymes collagenase, elastase, and hyaluronidase, which are involved in the inflammatory process and destabilization of the extracellular matrix (ECM). <i>P. vulgaris</i> has been observed to modulate matrix metalloproteinase (MMP) synthesis by decreasing the concentration of cellular reactive oxygen species (ROS) during LPS-induced inflammation. This study also examined the molecular binding and dynamic behavior of various enzymes and proteins associated with skin and infections using ligands derived from the tested extracts. Simulations with AutoDock Vina V1.1.2 and GROMACS 2023.1 showed that isoquercetin in particular showed superior performance in interactions with hyaluronidase. These findings are important for the development of potential therapeutic strategies for skin health and infection control. In summary, <i>P. vulgaris</i> can be considered as an important source of natural bioactive compounds for the development of effective health-promoting applications in nutraceuticals, pharmaceuticals, and cosmetics</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"329-359"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yeast protein-derived γ-glutamyl peptides prepared by transpeptidation reaction exhibit a pronounced taste-enhancing effect","authors":"Jiaying Liu,&nbsp;Yu Fu,&nbsp;Liang Ma,&nbsp;Hongjie Dai,&nbsp;Hongxia Wang,&nbsp;Hai Chen,&nbsp;Hankun Zhu,&nbsp;Yong Yu,&nbsp;Xin Liu,&nbsp;Zhengfang Liu,&nbsp;Yuhao Zhang","doi":"10.1002/fft2.479","DOIUrl":"https://doi.org/10.1002/fft2.479","url":null,"abstract":"<p>A high-salt diet can induce hypertension, so salt reduction can prevent hypertension. γ-Glutamyl peptides (GGPs) have obvious taste-enhancing effects, while their contents in natural foods are relatively low. Yeast protein rich in Glu/Gln is a good precursor for the preparation of GGPs. In this study, yeast protein-derived GGPs were prepared through hydrolysis and transpeptidation reactions, followed by sensory evaluation and E-tongue analysis. Peptide sequences were identified by LC−MS/MS and screened for molecular docking. The optimal reaction conditions were hydrolysis for 4 h, enzyme concentration of 16 U/g, and transpeptidation for 4 h. GGPs could increase salt and umami intensity by 60.78% and 40.93% based on sensory evaluation, 22.52%, and 16.40% according to E-tongue analysis. Fifteen γ-glutamyl peptides with different peptide lengths were selected for molecular docking. Molecular docking confirmed their binding to calcium-sensing receptors (CaSr) through hydrogen bonds and hydrophobic interaction, while interaction between CaSR receptor and γ-glutamyl di-, tri-, and oligo-peptides varied in binding energy. The stimulation received by CaSR lasted a longer time and varied in intensity. It was further proved that the flavor of mixed peptides has a layered sense and can give people a rich taste experience. Overall, yeast protein-derived GGPs can enhance salt and umami taste, which can reduce salt usage without compromising taste.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2782-2795"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing lutein stability and bioaccessibility with high internal phase emulsions stabilized by octenylsuccinylated starch","authors":"Yanqi Zhang,&nbsp;Songnan Li,&nbsp;Jiannan Feng,&nbsp;Lauren Binkley,&nbsp;Libo Tan,&nbsp;Lingyan Kong","doi":"10.1002/fft2.475","DOIUrl":"https://doi.org/10.1002/fft2.475","url":null,"abstract":"<p>Lutein possesses antioxidant properties and is a main component of the macular pigment, vital for infant eye and brain development. However, its use is constrained by its poor aqueous solubility and low stability. High internal phase emulsions (HIPEs) are valued in food development for encapsulating and protecting hydrophobic nutraceuticals. The objective of this study is to improve lutein's stability and bioaccessibility using HIPEs stabilized by biopolymer octenylsuccinylated starch (OSS). Three types of commercial OSS, including CAPSUL TA (CTA), HI-CAP 100 (HC), and Purity Gum 2000, were tested for their emulsification properties in forming lutein HIPEs. Lutein HIPEs stabilized by 15%–25% CTA and 15%–30% HC had no phase separation and were selected for subsequent testing. After 21 days of storage at room temperature, lutein HIPEs showed higher lutein retention compared to free lutein. Lutein HIPEs stabilized with higher emulsifier concentrations (25% CTA and 30% HC) exhibited greater droplet diameter stability than those with lower concentrations. Additionally, lutein HIPEs significantly enhanced lutein retention under UV exposure and thermal stress. The <i>in vitro</i> bioaccessibility of lutein was highest in the HIPE stabilized by 20% CTA, reaching 54.36%. In conclusion, lutein HIPEs stabilized by 20% CTA demonstrated superior lutein stability and bioaccessibility, showing significant potential as an effective lutein delivery system.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"316-328"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functions of immunologically active peptides and their roles in intestinal inflammation","authors":"Litong Wang,&nbsp;Yi Li,&nbsp;Kunlun Huang,&nbsp;Qin Wang,&nbsp;Xiaoyun He","doi":"10.1002/fft2.441","DOIUrl":"https://doi.org/10.1002/fft2.441","url":null,"abstract":"<p>Immunologically active peptides are a class of peptides with immune functions such as enhancing body immunity, regulating cell growth and differentiation, migration, chemotaxis, neurotransmission, and inducing apoptosis of tumor cells. They have many features, such as small molecular weight, strong stability, high biological activity, easy to adjust the structure accurately, and easy to synthesize. Exploring the mechanism of action of immunologically active peptides can help the modification and development of immunologically active peptides. In this article, the functional properties of immunologically active peptides are described from the perspectives of structural classification of immunologically active peptides and regulatory mechanisms. The relationship between structure and function and the application of different mechanisms in diseases are reviewed, focusing on the role in intestinal inflammation.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"124-141"},"PeriodicalIF":7.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From structure to function: A comprehensive overview of polysaccharide roles and applications","authors":"Bo-wen Xu,&nbsp;Sai-sai Li,&nbsp;Wen-li Ding,&nbsp;Cai Zhang,&nbsp;Mujeeb Ur Rehman,&nbsp;Muhammad Farooq Tareen,&nbsp;Li Wang,&nbsp;Shu-cheng Huang","doi":"10.1002/fft2.490","DOIUrl":"https://doi.org/10.1002/fft2.490","url":null,"abstract":"<p>Polysaccharides, also known as glycans, are biological macromolecules consisting of many monosaccharide units. Alongside proteins, nucleic acids, and lipids, they constitute the four fundamental substances crucial for life activities and essential for the growth and development of living organisms. As natural products with inherent biological activity, polysaccharides are widely available, nontoxic, and possess numerous functional properties, holding immense potential for advancement in food, medicine, and cosmetics. Furthermore, the exploration of polysaccharide-based drugs, as an alternative to conventional therapies, emerges as a promising avenue for addressing future disease challenges. This article comprehensively reviews the sources, structural characteristics, synthesis, degradation, functions, and applications of polysaccharides. The potential of polysaccharides for pharmacological applications, in antitumor, antiaging, antioxidant, hypoglycemic, anti-inflammatory, antiviral, and anticoagulant properties, is summarized. Additionally, the role of polysaccharides in environmental protection is discussed. It is anticipated that this review will offer innovative strategic insights, serving as a theoretical foundation and inspiration for the subsequent research on polysaccharides in healthcare.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"15-39"},"PeriodicalIF":7.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matcha and exercise synergy: Elucidating mechanisms and central signaling pathways modulating glycolipid metabolism in high-fat diet-induced obese mice","authors":"Jihong Zhou,&nbsp;Lejia Ding,&nbsp;Wei Chen,&nbsp;Yanliang Tan,&nbsp;Dengchao Xie,&nbsp;Yuefei Wang","doi":"10.1002/fft2.465","DOIUrl":"https://doi.org/10.1002/fft2.465","url":null,"abstract":"<p>Matcha green tea, renowned for its rich composition of catechin, theanine, caffeine, and fiber-bound polyphenols, distinguishes itself with heightened bioavailability and promising potential in addressing obesity and metabolic disorders. Our comprehensive analysis delved into matcha's components and antioxidant activity. Employing a multi-omics approach, we explored the synergistic effects of matcha combined with voluntary exercise, focusing on anti-obesity outcomes in high-fat diet mice. Our findings revealed that matcha co-exercise significantly mitigates glycolipid metabolism abnormalities, increasing serum antioxidant enzymes. This combination notably influences peripheral metabolism, especially amino acids and their metabolisms. Moreover, the observed activation of the BMP-SMAD signaling in the hypothalamus implies a central regulatory role mediating matcha co-exercise effects. Collectively, these findings underscore matcha's potential as a robust adjunct in mitigating obesity through antioxidant and metabolic regulation, supporting its use as a promising supplement to enhance exercise benefits in combating obesity.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2766-2781"},"PeriodicalIF":7.4,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gross to gourmet: A social media analysis of Naked Clams as a sustainable delicacy","authors":"J Reuben Shipway,&nbsp;Mark Tupper,&nbsp;David F Willer","doi":"10.1002/fft2.487","DOIUrl":"https://doi.org/10.1002/fft2.487","url":null,"abstract":"<p>Amidst a global food crisis, securing sustainable food sources is vital. Bivalves such as Naked Clams, historically known as shipworms, offer a promising solution due to their low environmental impact, high nutritional value, and rapid growth rates. Contrary to their image as pests, Naked Clams are the fastest growing bivalves and have various health benefits. Believed to be the world's first aquaculture species, cultivated by Aboriginal Australians 8000 years ago, they are a delicacy in Southeast Asia. Public perception of Naked Clams remains largely unexplored, hindered by their association as pests and worm-like appearance. This study assesses the perception of Naked Clams through social media, analyzing 40 posts across Facebook, Instagram, TikTok, and YouTube, with millions of views and likes. Analysis of nearly 8000 comments revealed that public perception was split, though generally more positive than negative. Concerns included appearance, potential religious dietary conflicts, and the risk of parasites, which can be addressed with educational campaigns. Importantly, 84% of commenters who tried Naked Clams reported liking them. Naked Clams are noted for their high protein content, nutrient density, and health benefits, and are enjoyed in diverse culinary forms, from traditional raw dishes, to battered calamari-style street foods, to innovative recipes like Naked Clam ice cream. This study highlights the untapped potential of Naked Clams in global diets and calls for further exploration into moving Naked Clams from “gross to gourmet.”</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2641-2651"},"PeriodicalIF":7.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsaicin-mediated repair of circadian disruption-induced Intestinal barrier damage via the gut microbiota","authors":"Yupei Deng,&nbsp;Bolin Lin,&nbsp;Chi-Tang Ho,&nbsp;Jie Xiao,&nbsp;Yong Cao,&nbsp;Jun-qing Huang,&nbsp;Muwen Lu","doi":"10.1002/fft2.467","DOIUrl":"https://doi.org/10.1002/fft2.467","url":null,"abstract":"<p>Circadian clock serves as a regulator of gastrointestinal health, and the disruption of circadian rhythm may trigger the dysregulation of the intestinal barrier functions. This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by circadian disruption in male SPF C57BL/6J mice. Our findings indicated that CAP supplementation attenuated abnormal weight gain, alterations in serum lipid levels, and misalignment in hepatic and colonic circadian clock gene expressions in mice caused by constant darkness (CD) treatment. The restoration of the intestinal barrier integrity was also observed through the increase in mucosal thickness and goblet cell numbers. Both the diversity and the circadian rhythm of gut microbiota were improved in CAP-treated group. Correlation analysis indicated that CAP could modulate the gut microbiota by affecting intestinal barrier function and systemic metabolism in CD-treated mice. These results highlight the potential of CAP as a functional food component in maintaining the intestinal barrier homeostasis through regulating gut microbiota.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2579-2590"},"PeriodicalIF":7.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of highly sensitive cuvette-type localized surface plasmon resonance (LSPR) sensing chips for the rapid detection of tyramine in spiked samples of beef, mackerel, and cheese","authors":"Soobin Han,&nbsp;Ji Hong Kim,&nbsp;Vivek Kumar Gupta,&nbsp;Ju Eun Bae,&nbsp;Chae Hwan Cho,&nbsp;Hanseung Kim,&nbsp;Yonghyeon Park,&nbsp;Mi-Hwa Oh,&nbsp;Jong Pil Park,&nbsp;Yun Suk Huh","doi":"10.1002/fft2.464","DOIUrl":"https://doi.org/10.1002/fft2.464","url":null,"abstract":"<p>The globalization of food distribution has made it necessary to ensure the delivery of fresh food to the consumers. Protein-rich foods produce a significant amount of tyramine when spoiled. Therefore, it was envisaged to develop localized surface plasmon resonance (LSPR)—sensor for monitoring tyramine content in beef, mackerel, and cheese. For this purpose, the sensors were developed by coating the LSPR chip with gold nanoparticles (AuNPs) followed by conjugation of tyramine-specific peptide (TYR1). The TYR1 was synthesized and screened by phage display and binding efficiency was evaluated by DockThor. The optimized LSPR sensor showed highest binding efficiency at TYR1 concentration of 20 µg/mL with reaction time of 40 min. The sensor also showed an excellent detection range for beef, mackerel, and cheese were 0.01–10 ppb, 0.01–10 ppm, and 0.01–10 ppb, respectively, in comparison to standard. These findings indicated that this sensor can be used as a promising tool for on-site monitoring of food quality.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"5 6","pages":"2591-2604"},"PeriodicalIF":7.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}