Food frontiersPub Date : 2025-02-24DOI: 10.1002/fft2.70001
Phatharachanok Siangphloen, Daniel Shepherd, Kevin Kantono, Nazimah Hamid
{"title":"Tune Your Appetite: How Music Impacts Food Choice, Intake, and Emotions During a Meal","authors":"Phatharachanok Siangphloen, Daniel Shepherd, Kevin Kantono, Nazimah Hamid","doi":"10.1002/fft2.70001","DOIUrl":"10.1002/fft2.70001","url":null,"abstract":"<p>Auditory cues, such as music, can potentially impact our eating behavior. In the present study, the effects of listening to music that varied in liking while consuming a meal on hunger, meal duration, food intake, and hedonic ratings were investigated. Measures of emotion were also obtained to understand the changes in meal duration, and both food intake and a 10-point visual analogue scale rating. A crossover experimental design involving 66 participants (27 males, 39 females) was employed, in which participants consumed lunch in a control condition, and while listening to music that they either liked or disliked. The results showed that listening to liked music significantly increased eating time, the intake of healthy food, and the consumption of afternoon snacks. Conversely, listening to disliked music significantly increased the consumption of unhealthy food. Additionally, the study explored the role of emotions in explaining these changes. It was found that ratings of hunger were higher, and more negative emotions were evoked, when participants consumed lunch while listening to disliked music. The silent and liked music conditions, which evoked more positive emotions, resulted in higher ratings of food pleasantness, overall liking of healthy and unhealthy food, and food satisfaction. Overall, the findings of this study highlight the significant influence of music upon appetite, food liking, and emotional responses during a lunch meal, emphasizing the potential practical applications in promoting healthier eating behaviors in real-world food-eating environments.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 3","pages":"1423-1438"},"PeriodicalIF":6.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2025-02-24DOI: 10.1002/fft2.544
Wibke Heidig, Thomas Dobbelstein, Roger B. Mason
{"title":"Food for Thought: How Culture Shapes Intentions to Reduce Food Waste in South Africa","authors":"Wibke Heidig, Thomas Dobbelstein, Roger B. Mason","doi":"10.1002/fft2.544","DOIUrl":"10.1002/fft2.544","url":null,"abstract":"<p>In the context of increasing food scarcity, the issue of household food waste has garnered significant attention, particularly in developing nations. Despite its critical importance, there remains a paucity of empirical research exploring the underlying behavioral and cultural factors that shape individuals’ intentions to reduce food waste within their homes. This article seeks to bridge this gap by drawing on the theory of planned behavior to examine how personal cultural values impact attitudes toward food waste reduction, subjective norms, and perceived behavioral control (PBC), which serve as key determinants of behavioral intention. To empirically test the proposed model, a comprehensive quantitative survey was conducted among 529 South African consumers. The data were analyzed using structural equation modeling, revealing that consumers who exhibit stronger adherence to cultural dimensions such as uncertainty avoidance and long-term orientation, coupled with lower scores on power distance, are likely, through the influence of attitude, subjective norms, and PBC, to possess higher intentions to actively reduce food waste. These findings offer valuable insights for marketers and policymakers, highlighting the potential to leverage cultural values in designing effective interventions aimed at encouraging more sustainable consumer behaviors and reducing household food waste.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 2","pages":"956-978"},"PeriodicalIF":6.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.544","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2025-02-18DOI: 10.1002/fft2.70002
Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li
{"title":"Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C","authors":"Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li","doi":"10.1002/fft2.70002","DOIUrl":"10.1002/fft2.70002","url":null,"abstract":"<p>A class of flavonoid aminated derivatives that had been consistently overlooked in literature was shown to be formed as artefacts in cell culture medium. In this study, 34 flavonoids from different subclasses were incubated in Dulbecco's modified Eagle's Medium (DMEM) at 37°C for 2 h to identify the reaction mechanism behind aminated derivatives formation from flavonoids. Baicalein, scutellarein, dihydromyricetin, (−)-gallocatechin (GC), (−)-epigallocatechin (EGC), (−)-GC gallate, and (−)-EGC gallate were found to yield corresponding nitrogenous derivatives in both DMEM and amino acid solution. The nitrogen source of these seven flavonoid -aminated derivatives was revealed to be amino acids in DMEM. The pyrogallol group of the flavonoids was a key structural motif, being first oxidized into quinone and then further reacting with amino acids (Strecker degradation) to yield aminated flavonoids and corresponding aldehydes. A slightly alkaline environment accelerated the amination of flavonoids, possibly via the formation of flavonoid quinone. These results provide the mechanistic evidence for the in vitro generation of flavonoid -aminated derivatives, yet to be tested using in vivo assays.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 2","pages":"1058-1078"},"PeriodicalIF":6.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2025-02-11DOI: 10.1002/fft2.545
Mehmet Cengiz Baloglu, Lutfiye Yildiz Ozer, Buket Pirci, Yasemin Celik Altunoglu, Sanam Iram Soomro, Gokhan Zengin, Mehmet Veysi Cetiz, Simone Carradori, Zoltán Cziáky, József Jekő
{"title":"Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods","authors":"Mehmet Cengiz Baloglu, Lutfiye Yildiz Ozer, Buket Pirci, Yasemin Celik Altunoglu, Sanam Iram Soomro, Gokhan Zengin, Mehmet Veysi Cetiz, Simone Carradori, Zoltán Cziáky, József Jekő","doi":"10.1002/fft2.545","DOIUrl":"10.1002/fft2.545","url":null,"abstract":"<p><i>Liquidambar orientalis</i>, the Anatolian sweetgum tree, is a relict and endemic species in Southwestern Turkey, traditionally used for therapeutic purposes. Our study comprehensively evaluated the therapeutic potential of <i>L. orientalis</i> extracts from its aerial parts to maximize bioactive compound extraction using methanol, ethyl acetate, and water as solvents. The methanolic extract exhibited the highest phenolic (73.04 ± 3.94 mg gallic acid equivalent [GAE]/g) and flavonoid content (48.86 ± 0.76 mg rutin equivalent [RE]/g), demonstrating superior antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) (256.61 ± 1.70 mg Trolox equivalent [TE]/g), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (308.41 ± 3.14 mg TE/g), and cupric ion–reducing antioxidant capacity (CUPRAC) (411.13 ± 8.48 mg TE/g) assays. It also showed significant enzyme inhibition for acetylcholinesterase (4.43 ± 0.09 mg galanthamine equivalent [GALAE]/g), tyrosinase (149.16 ± 1.14 mg kojic acid equivalent [KAE]/g), amylase (0.93 ± 0.02 mmol acarbose equivalent [ACAE]/g), and glucosidase (1.60 ± 0.01 mmol ACAE/g), suggesting potential applications in neurodegenerative disease management, skincare, and diabetes treatment. Furthermore, methanol and water extracts displayed promising antimicrobial activity due to phenolic compounds such as chlorogenic acid and methyl-3-<i>O</i>-caffeoyl quinate. The methanolic extract exhibited potent anticancer effects against lung cancer (A549) cells, with significant reductions in cell viability and induction of autophagy. The aqueous extract showed remarkable efficacy against prostate cancer (PC3) cells, modulating apoptosis markers. Breast cancer cells (MDA-MB-231) exhibited differential responses, with ethyl acetate extract promoting apoptosis and water extract–enhancing autophagy. Furthermore, molecular docking and dynamics simulations provided additional evidence supporting the therapeutic potential of key phytochemicals from <i>L. orientalis</i>, particularly afzelin and epigallocatechin, against cancer-related targets and bacterial enzymes. Overall, this study fills a gap in understanding the enzyme inhibitory and diverse anticancer effects of <i>L. orientalis</i> extracts, highlighting its potential multi-targeted therapeutic applications, particularly in cancer therapy.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 3","pages":"1376-1408"},"PeriodicalIF":6.9,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Berries: Health Effects via Modulation of the Gut Microbiota","authors":"Manjin Xu, Yunfeng Xu, Lizhi Wu, Huixia Niu, Bei Gao, Kai Sun, Xueqing Li, Mingluan Xing, Zhe Mo, Zhijian Chen, Pengcheng Tu, Xiaoming Lou","doi":"10.1002/fft2.542","DOIUrl":"10.1002/fft2.542","url":null,"abstract":"<p>Berries are widely regarded as beneficial foods, rich in polyphenols, flavonoids, and other bioactive compounds that could positively influence human health. Although the gut microbiota plays a crucial role in metabolism and physiology of humans, the interaction between berries and human gut microbiota activity remains unclear. This review systematically summarizes the antioxidant, anti-inflammatory, and gut microbiota-regulating effects of various berries. It focuses on the impact of berries on several related metabolic diseases in addition to adverse outcomes associated with environmental exposures from the perspective of modulation of the gut microbiota. Overall, berries may actively modulate the gut microbiota, influencing the composition of the microbiota especially production of bioactive metabolites, thereby conferring health effects. This review aims to provide a comprehensive understanding of health impact of berries via interactions with the gut microbiota, offering insights into the potential application of berries in maintaining human health.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 3","pages":"1173-1204"},"PeriodicalIF":6.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2025-01-26DOI: 10.1002/fft2.541
Asem M. Abdelshafy, Hala A. Younis, Ahmed I. Osman, Saleh M. Hussein, Amr S. Abou El-Ela, Elsayed A. Mahmoud, Osama Elsherbiny, Ahmed K. Rashwan
{"title":"Recent Advances in Detection and Control Strategies for Foodborne Bacteria in Raw and Ready-to-Eat Fruits and Vegetables","authors":"Asem M. Abdelshafy, Hala A. Younis, Ahmed I. Osman, Saleh M. Hussein, Amr S. Abou El-Ela, Elsayed A. Mahmoud, Osama Elsherbiny, Ahmed K. Rashwan","doi":"10.1002/fft2.541","DOIUrl":"10.1002/fft2.541","url":null,"abstract":"<p>The prevalence of foodborne outbreaks due to the consumption of uncooked and ready-to-eat fruits and vegetables has seen a noticeable increase, particularly in environments lacking sanitation. This article extensively explores recent advancements in the detection of foodborne pathogens in uncooked and ready-to-eat fruits and vegetables, alongside potential prevention strategies. Predominantly, pathogens like <i>Listeria monocytogenes</i>, <i>Escherichia coli</i>, and <i>Salmonella enterica</i> are the main culprits in outbreaks linked to these food items globally. Notably, contamination is more prevalent in fresh leafy greens than in fruit products. Various detection methods such as culturing, microscopy, immunological assays, polymerase chain reaction (PCR), biosensors, and hyperspectral imaging have proven effective in identifying pathogens in these foods. Nonetheless, these methods come with challenges, including time consumption, accuracy concerns, and high costs. Research is ongoing to refine these detection techniques, with efforts including combining methodologies like PCR–enzyme-linked immunosorbent assay and integrating culturing with PCR. Additionally, several interventions, including cold plasma treatment, ultraviolet irradiation, and the application of edible coatings, have shown promise in mitigating contamination risks, thereby enhancing the safety of these fresh produce items.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 2","pages":"605-629"},"PeriodicalIF":6.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2025-01-20DOI: 10.1002/fft2.520
Afsaneh Taheri, Fatin Natasha Binte Abdul Halim, Juan Du
{"title":"Dynamic Evolution of Mung Bean Protein in Alkaline Solutions: Unravelling Vicilin Function Through Molecular Simulation","authors":"Afsaneh Taheri, Fatin Natasha Binte Abdul Halim, Juan Du","doi":"10.1002/fft2.520","DOIUrl":"10.1002/fft2.520","url":null,"abstract":"<p>This study explored the effects of pH-shifting over 0, 10, 20, and 30 min on the physicochemical characteristics of mung bean protein (MBP) isolates, identified as MBP<sub>0</sub>, MBP<sub>10</sub>, MBP<sub>20</sub>, and MBP<sub>30</sub>. The conformational features of vicilin-type (8S), the primary component of MBP, were studied using molecular dynamics simulations. Our findings revealed the time-dependent nature of pH-shifting on protein flexibility, which caused changes in surface charges of MBP from 0 to 30 min. An increase in particle size, solubility, and more uniform distribution among all pH-shifted samples were observed due to swelling. Smoother and flakier structures in pH-shifted proteins were detected by scanning electron microscope. Molecular simulations at pH 12.0 revealed enhanced stability of vicilin with greater fluctuation of hydrophilic residues and increased flexibility, which correlated to the experimental results, highlighting vicilin's pivotal role in the flexibility and solubility of MBP during pH changes.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 2","pages":"909-920"},"PeriodicalIF":6.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amauroderma rugosum Extract Improves Brain Function in d-Galactose-Induced Aging Mouse Models via the Regulatory Effects of Its Polysaccharides on Oxidation, the mTOR-Dependent Pathway, and Gut Microbiota","authors":"Panthakarn Rangsinth, Chengwen Zheng, Polly Ho-Ting Shiu, Wen Wang, Tsz Ching Kwong, Chi Tung Choy, Susan Wai-Sum Leung, Tewin Tencomnao, Siriporn Chuchawankul, Anchalee Prasansuklab, Timothy Man-Yau Cheung, Yiu-Wa Kwan, Priya Kannan, Jingjing Li, George Pak-Heng Leung","doi":"10.1002/fft2.543","DOIUrl":"10.1002/fft2.543","url":null,"abstract":"<p>The pharmacological effects of <i>Amauroderma rugosum</i> (AR), an edible mushroom found mainly in Southeast Asia, are not well studied, particularly its neuroprotective properties. This study investigated the neuroprotective effects of AR aqueous extract (ARW) in a <span>d</span>-galactose-induced accelerated aging mouse model and senescent SH-SY5Y neuronal cells. Behavioral tests (open field, Morris water maze, Y-maze, and rotarod) demonstrated that <span>d</span>-galactose-induced aging mice exhibited impaired cognitive function, memory loss, anxiety, and reduced locomotor ability, all of which were alleviated by ARW treatment. Histological analysis showed that ARW reduced neuropathological lesions in the hippocampus. In SH-SY5Y neuronal cells, ARW and AR polysaccharide extract (ARP) enhanced cell viability and decreased intracellular reactive oxygen species (ROS) levels in a concentration-dependent manner. ARW and ARP also reduced cellular senescence and apoptosis in <span>d</span>-galactose-treated cells. Western blot analysis indicated that ARW and ARP upregulated the phosphorylation of mTOR and increased the expression of antioxidant enzymes, including superoxide dismutase 1 and heme-oxygenase-1. Additionally, ARW altered the gut microbiota, increasing the relative abundance of beneficial bacteria such as <i>Lactobacillus reuteri</i> and decreasing harmful bacteria like <i>Clostridium scindens</i>. These findings suggest that AR exerts neuroprotective effects primarily through its polysaccharides by modulating oxidative stress, activating the mTOR-dependent pathway, and influencing the gut microbiota. Consequently, AR could serve as a potential dietary supplement for the prevention and treatment of neurodegenerative diseases.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 2","pages":"872-890"},"PeriodicalIF":6.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2024-12-31DOI: 10.1002/fft2.540
{"title":"Correction to “The Algal Polysaccharide Ulvan Suppresses Growth of Hepatoma Cells”","authors":"","doi":"10.1002/fft2.540","DOIUrl":"10.1002/fft2.540","url":null,"abstract":"<p>Zhao, C., G. Lin, D. Wu, et al. 2020. “The Algal Polysaccharide Ulvan Suppresses Growth of Hepatoma Cells.” <i>Food Frontiers</i> 1: 83–101. https://doi.org/10.1002/fft2.13.</p><p>In the version of this article initially published, there was an error in Figure 10. The p65 in Figure 10(b) is identical to TRAF2. The other elements of the figure remain the same, and the interpretation of the results remains unchanged. The corrected Figure 10 is reproduced below.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 1","pages":"599-600"},"PeriodicalIF":6.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food frontiersPub Date : 2024-12-25DOI: 10.1002/fft2.539
Chia-Chi Kung, Mei-Zhen Lin, Bing-Huei Chen
{"title":"Preparation of Collagen Peptide Nanoliposomes From Sturgeon Fish Cartilage and Explore Their Anti-Osteoarthritis Effects in Rats","authors":"Chia-Chi Kung, Mei-Zhen Lin, Bing-Huei Chen","doi":"10.1002/fft2.539","DOIUrl":"10.1002/fft2.539","url":null,"abstract":"<p>This study aims to extract pepsin soluble collagen (PSC) from sturgeon cartilage, hydrolyze to sturgeon cartilage collagen peptides (SCCP), and prepare SCCP nanoliposomes to explore the treatment effects of osteoarthritis (OA) in rats. PSC was extracted using 0.5 M acetic acid and pepsin (10%) and enzymatically hydrolyzed with 4.5% alcalase plus 4.5% flavourzyme to obtain SCCP. Amino acid analysis revealed the presence of glycine, proline, and hydroxyproline in high amounts, while SDS-PAGE showed that the PSC belonged to type II collagen with molecular weight (MW) of SCCP being <2 kDa and MALDI-TOF-MS indicated the MW distribution to range from 302.594 to 683.050 Da with the peptide fragments <500 Da accounting for 89.71%. SCCP nanoliposomes composed of phosphatidylcholine, fatty acid sucrose ester, glycerol, and deionized water were prepared with size at 34.58 nm, polydispersity index at 0.19, zeta potential at -54.53 mV, and encapsulation efficiency at 88.14%. Tube feeding of SCCP/SCCP nanoliposomes into OA rats alleviated pain responses by joint damage through reduction in hind limb weight-bearing difference, knee joint width difference, and levels of serum biomarkers including CTX-II, TGF-β1, PIICP, and COMP. Histopathologic images demonstrated the mitigation of joint damage symptoms in the tissue by reducing cartilage joint damage, inhibiting chondrocyte apoptosis, promoting chondrocyte regeneration, and reducing synovitis. Collectively, the high dose of SCCP nanoliposomes was the most effective in alleviating OA possessing a great potential to be developed into a health food or botanic drug for the treatment of joint-related disease.</p>","PeriodicalId":73042,"journal":{"name":"Food frontiers","volume":"6 2","pages":"727-749"},"PeriodicalIF":6.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fft2.539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}