Exploratory research in clinical and social pharmacy最新文献

{"title":"Unveiling the complementariness of robotic tablet dispensing machines for elderly care: A bibliometric data analysis","authors":"Sunday Adewale Olaleye ,&nbsp;Olaleye Esther Olubunmi ,&nbsp;Berhanemeskel Weldegerima Atsbeha ,&nbsp;Mulugeta Negash Wodaje","doi":"10.1016/j.rcsop.2024.100545","DOIUrl":"10.1016/j.rcsop.2024.100545","url":null,"abstract":"<div><div>This study conducts a bibliometric analysis of academic papers and conference proceedings related to tablet dispensers, medicine dispensers, and pill dispensers within the framework of Sustainable Development Goal 03: Good Health and Well-Being. The analysis spans literature published between 1997 and 2023. Utilizing the Web of Science database, the study employs keywords such as “tablet dispenser,” “medicine dispenser,” and “pill dispenser” to gather relevant English-language papers classified as Proceeding Papers or Articles. The inclusion and exclusion criteria filtered 79 initial records down to 40, focusing on articles pertinent to SDG 03. Data analysis was performed using the Biblioshiny App through RStudio, examining publication trends, authorship patterns, citation networks, and other bibliometric indicators. The findings reveal a steady increase in research output, moderate citation impact, extensive references, and collaborative authorship, with limited international collaboration. The study underscores the growing interest and research activity in robotic tablet dispensing machines for elderly care while highlighting areas for further global engagement.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"17 ","pages":"Article 100545"},"PeriodicalIF":1.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges prescribing and dispensing oral antibiotics with poor palatability for paediatric patients: A qualitative interview study with GPs and pharmacists","authors":"Ayat Elgammal ,&nbsp;Joseph Ryan ,&nbsp;Colin Bradley ,&nbsp;Abina Crean ,&nbsp;Margaret Bermingham","doi":"10.1016/j.rcsop.2024.100546","DOIUrl":"10.1016/j.rcsop.2024.100546","url":null,"abstract":"<div><h3>Background</h3><div>Poor palatability of antibiotics is a key cause for non-adherence to antibiotic treatment among children. Failure to complete antibiotic treatment because of poor palatability can cause disease recurrence and may contribute to increasing rates of antimicrobial resistance. The aim of this study was to investigate the experience and challenges faced by general practitioners (GPs) and community pharmacists regarding prescribing and dispensing oral liquid antibiotics for children and the impact of poorly palatable antibiotic formulations on patients and the health-system.</div></div><div><h3>Methods</h3><div>One-to-one semi-structured interviews with GPs and pharmacists were conducted via an online video-conferencing platform. Data were analysed using thematic analysis.</div></div><div><h3>Results</h3><div>Twenty participants (7 GPs and 13 pharmacists) were interviewed. Three main themes and eight subthemes were identified. Theme 1: <em>challenges reported by GPs and pharmacists</em> included four subthemes; (i) factors affecting prescribing and dispensing antibiotics, (ii) reasons to select poorly palatable antibiotics, (iii) palatability discussion with parents, and (iv) formulation factors affecting oral liquid antibiotic acceptability. Theme 2: <em>the impact of prescribing or dispensing poorly palatable oral liquid antibiotics</em> encompassed two sub themes; (i) patient impact and (ii) health-system impact. Theme 3: <em>overcoming palatability challenges</em> involved two subthemes; (i) raising awareness of flavour and palatability issues among healthcare professionals and (ii) counselling parents while prescribing and before dispensing.</div></div><div><h3>Conclusions</h3><div>There is a need to increase palatability awareness among healthcare professionals and parents. The development of more palatable oral liquid formulations can play a role in improving prescribing and medicines taking practices.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"17 ","pages":"Article 100546"},"PeriodicalIF":1.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-dispensed prescriptions – A nationwide descriptive study","authors":"Heini Kari ,&nbsp;Fredriikka Nurminen ,&nbsp;Hanna Rättö ,&nbsp;Hanna Koskinen","doi":"10.1016/j.rcsop.2024.100541","DOIUrl":"10.1016/j.rcsop.2024.100541","url":null,"abstract":"<div><h3>Background</h3><div>Medication non-adherence is associated with suboptimal health outcomes, higher mortality, and increased healthcare costs.</div></div><div><h3>Objective</h3><div>The aim of this study was to estimate the number and share of non-dispensed prescriptions at a national level and in specific patient and medicine subgroups.</div></div><div><h3>Methods</h3><div>The study was a nationwide retrospective register-based study. The data consisted of prescriptions prescribed in Finland in 2020 and dispensed between 2020 and 2022. A prescription was considered non-dispensed if it had not been dispensed within the two-year validity period. For each prescription, information on the patient's birth date, sex, and income as well as details of the prescribed medicine and physician's employment sector (public/private) were collected. Distributions and odds ratios (ORs) with corresponding 95 % confidence intervals (CI) were used in the analyses.</div></div><div><h3>Results</h3><div>Of the 26 million prescriptions, 13.3 % were never filled. Over 1.7 million people (43.3 % of all people with prescriptions issued in 2020) had at least one non-dispensed prescription. The share of non-dispensed prescriptions was lower in men than women (12.9 % vs. 13.5 %; OR:0.95; CI:0.95–0.95). Compared to the youngest age group, the share of non-dispensed prescriptions was lower in the older age groups. The lowest share of non-dispensed medicines was in antineoplastic and immunomodulating agents (7.8 %) and in cardiovascular system medicines (8.1 %), whereas the highest was in dermatologicals (20.2 %). The proportion of non-dispensed prescriptions varied between medicine groups, from 5 % for thyroid therapy to 38 % for other nervous system drugs. The most frequently non-dispensed medications were paracetamol, ibuprofen, and salbutamol.</div></div><div><h3>Conclusion</h3><div>The share and number of non-dispensed prescriptions varied across therapeutic areas, medicine groups, active pharmaceutical ingredients, and patient groups. Healthcare professionals should avoid unnecessary prescribing and improve medication adherence to ensure safer and more effective care.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100541"},"PeriodicalIF":1.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the evolution and impact of OTC vending machines in Global Healthcare Systems","authors":"Ammar Abdulrahman Jairoun ,&nbsp;Sabaa Saleh Al-Hemyari ,&nbsp;Moyad Shahwan ,&nbsp;Sahab Alkhoujah ,&nbsp;Faris El-Dahiyat ,&nbsp;Ammar Ali Saleh Jaber ,&nbsp;Sa'ed H. Zyoud","doi":"10.1016/j.rcsop.2024.100540","DOIUrl":"10.1016/j.rcsop.2024.100540","url":null,"abstract":"<div><h3>Background</h3><div>The study of over the counter (OTC) vending machines is crucial given their growing popularity and potential impact on the pharmaceutical industry and consumer behaviour.</div></div><div><h3>Objectives</h3><div>This study involves a bibliometric quantitative analysis of academic literature to evaluate OTC vending machines in terms of their evolution, current trends, and potential areas for future research<strong>.</strong></div></div><div><h3>Methods and materials</h3><div>The Scopus database was searched using its advanced search tool, focusing on papers that included the search query in their titles, abstracts, and keywords. Data analysis included bibliometric indicators such as publication counts, citation trends, and co-authorship networks, which were visualized using VOSviewer software (version 1.6.20) to highlight key research themes and collaboration patterns.</div></div><div><h3>Results</h3><div>A total of 399 publications on OTC vending machines were found between 1833 and 2024. Over the last 20 years, there has been an annual increase in the number of publications related to OTC vending machines, rising from 1 in 2001 to 31 in 2023. The United States (<em>n</em> = 118; 29.57 %) led in productivity, followed by the United Kingdom (45; 11.27 %), India (30; 7.51 %), Australia (27; 6.76 %), Canada (16; 4 %), Italy (15; 3.75 %), and China (15; 3.75 %). A total of 35 institutions have been involved in research on OTC vending machines. The Dubai Municipality contributed the highest percentage of articles (<em>n</em> = 3, 0.75 %), followed by the Emirates Health Services (n = 3, 0.75 %), Al Ain University (<em>n</em> = 2, 0.5 %), and Baystate Medical Center (n = 2, 0.5 %). Before 2016, much of the research on OTC vending machines focused on terms related to healthcare policy and health promotion, indicating the early exploration of this field. Present trends highlight terms associated with pharmacy practice, such as pharmacists, pharmacy, and prescription-related subjects.</div></div><div><h3>Conclusions</h3><div>This study emphasises the practical necessity for enhanced regulatory structures to mitigate risks such as medication abuse, unfavourable drug interactions, and incorrect dispensing practices. Additionally, the study highlights the need for interdisciplinary collaboration among technologists, policymakers, and healthcare professionals to maximize the benefits of OTC vending machines while addressing consumer behaviour and safety issues.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100540"},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and referral programs for diabetes and cardiovascular disease: Can community pharmacists bridge the care gap?","authors":"Melanie Livet ,&nbsp;Amber Watson ,&nbsp;Shweta Pathak ,&nbsp;Courtney Humphries ,&nbsp;Jessica Roller ,&nbsp;Jon Easter","doi":"10.1016/j.rcsop.2024.100539","DOIUrl":"10.1016/j.rcsop.2024.100539","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Heart disease and diabetes are leading causes of death in the U.S., with timely screening, referrals, and education being critical for effective treatment. The Community-based Valued-driven Care Initiative (CVCI) aimed to develop, implement, and evaluate the feasibility of delivering patient-centered care interventions for high priority disease states in community pharmacies. This article focuses specifically on two of the selected interventions, both of which were screening and referral (S&amp;R) programs for the prevention and treatment of cardiovascular disease (CVD) and diabetes (DM) respectively. This exploratory evaluation was designed as an effectiveness-implementation hybrid Type II study. Its objectives were to assess both implementation and preliminary program effectiveness using mixed data.</div></div><div><h3>Methods</h3><div>Fifteen community pharmacies opted to implement one of the two programs over a 12-month period. Implementation feasibility involved examining program adoption rates by sites and patients; acceptability, appropriateness, feasibility, and intent to sustain use survey scores; and pharmacists' interviews. Program effectiveness was based on patient referral rates, physician follow-up communication rates, and perceived outcomes, collected via patient logs, surveys, and interviews.</div></div><div><h3>Results</h3><div>Two of the 15 sites discontinued participation, yielding an 87 % adoption rate. Patient adoption varied based on contact and screening rates, due to differences in patient recruitment, staffing, and workflow. Pharmacist acceptability, compatibility, and feasibility remained high throughout implementation; however, only three pharmacy sites planned on continuing offering the programs. All at-risk patients were appropriately referred based on screening results, with 65 % having their screening results communicated to their primary healthcare providers. The programs were perceived as beneficial, increasing pharmacists' knowledge and motivation, enhancing relationships with patients, and producing an impact on patients'' health.</div></div><div><h3>Discussion</h3><div>Results highlight the implementation feasibility and preliminary outcomes of delivering DM and CVD S&amp;R programs in community pharmacies. However, despite these positive results, most pharmacies did not intend to continue the programs, underscoring the continued need for sustainable clinical services models in non-traditional settings. Success with broader implementation will require a paradigm shift in support of community pharmacists as clinical care extenders.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"17 ","pages":"Article 100539"},"PeriodicalIF":1.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists","authors":"Andrea L. Murphy ,&nbsp;Korolos Sawires ,&nbsp;Sophie M. Peltekian ,&nbsp;Melissa Helwig ,&nbsp;Marilyn Macdonald ,&nbsp;Ruth Martin-Misener ,&nbsp;Bandana Saini ,&nbsp;Heather Neyedli ,&nbsp;Chris Giacomantonio ,&nbsp;David M. Gardner","doi":"10.1016/j.rcsop.2024.100538","DOIUrl":"10.1016/j.rcsop.2024.100538","url":null,"abstract":"<div><h3>Background</h3><div>Benzodiazepines and <em>Z</em>-drugs (e.g., zopiclone, zolpidem) (benzodiazepine receptor agonists or BZRAs), are prescribed for anxiety and insomnia disorders. However, they are not indicated as first line therapies for long-term management due to harms and efficacy limitations. BZRAs have also been associated with traffic accident risks. Patients taking BZRAs are told to consult with health care providers regarding motor vehicle operation safety. However, advice on driving is variable. The objective of this scoping review is to identify, map, and characterize the evidence for assessments that measure driving performance in people taking BZRAs.</div></div><div><h3>Methods</h3><div>Embase (Elsevier), MEDLINE (Ovid), and PsycINFO (EBSCO) were searched. Covidence was used for screening. Each stage of screening included two independent reviewers. A REDCap database was used for data extraction by two independent reviewers. Results were tabulated and summarised as a narrative.</div></div><div><h3>Results</h3><div>Driving performance was assessed with 20 unique BZRAs across 183 studies (<em>n</em> = 92 experimental; <em>n</em> = 91 observational) in 178 publications. Zopiclone was the most studied. In experimental studies, the Standard Deviation of Lateral Position (SDLP) was used most often (<em>n</em> = 54, 62 %) and many studies (<em>n</em> = 35, 38 %) were conducted in the Netherlands. For observational studies, biological detection (e.g., urine, blood) (<em>n</em> = 73, 80 %) followed by prescription drug/dispensing records (<em>n</em> = 17, 19 %) were the most common impairment measures and Norway (<em>n</em> = 20) is where most studies took place. In experimental studies, most (<em>n</em> = 89, 97 %) were conducted using only one driving setting. Simulated driving in a car (<em>n</em> = 36) and road driving in traffic (n = 36) were common as compared to nontraffic driving course (n = 8) and simulated driving (<em>n</em> = 9). In experimental studies, seventy-eight of the 92 studies (85 %) had at least one measure that identified impairment.</div></div><div><h3>Conclusions</h3><div>BZRA effects on motor vehicle driving performance have been studied using heterogenous protocols with multiple measures and settings, ranging from simulation to authentic traffic situations in experimental studies to biological detection and dispensing records in observational studies. Many BZRAs have been studied but study representation does not match prescribing pattern prevalence. The interpretation and contextualization of results for clinical practice is challenging due to the complexity (i.e., protocols, measures, settings). Future work in this area should work to improve knowledge translation of results so information is more readily accessible and applicable to health care providers and patients.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100538"},"PeriodicalIF":1.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk medication errors: Insight from the UK National Reporting and learning system","authors":"Abdulrhman Alrowily ,&nbsp;Khalid Alfaraidy ,&nbsp;Saleh Almutairi ,&nbsp;Abdullah Alamri ,&nbsp;Wejdan Alrowily ,&nbsp;Mohammed Abutaleb ,&nbsp;Mohammad Zaitoun ,&nbsp;Waddad Sarawi ,&nbsp;Mashael Aljead","doi":"10.1016/j.rcsop.2024.100531","DOIUrl":"10.1016/j.rcsop.2024.100531","url":null,"abstract":"<div><h3>Background</h3><div>Ensuring patient safety is of paramount importance in healthcare systems. Rising concerns about medical errors in the UK have necessitated a greater focus on studying the nature of such errors, particularly those involving high-risk medications.</div></div><div><h3>Objectives</h3><div>To conduct a retrospective analysis of incidents related to patient safety in the UK based on data from the National Rporting and Learning System (NRLS).</div></div><div><h3>Methods</h3><div>This study was conducted based on a review of the National Reporting and Learning System <strong>(</strong>NRLS) patient safety reports published between January 1, 2015, and December 31, 2015. NHS Improvement provides details regarding incidents following approval using a data-sharing agreement. In total, 1500 incidents were analszed and equally divided among the three categories of high-risk drugs: opioids, insulin, and anticoagulants. Excel® features and deductive reasoning (thematic analysis) were used for data analysis.</div></div><div><h3>Results</h3><div>The results showed that the insulin category had both the highest risk and most errors compared with anticoagulants and opioids. These errors primarily result from issues related to administering, prescribing, and dispensing the drugs. Inadequate drug checks, communication difficulties among staff and patients, and high staff workloads are often linked to these errors.</div></div><div><h3>Conclusion</h3><div>This study confirms that the NRLS database is a valuable source of data, and the suggestions put forth, based on these results, could contribute to the formulation of measures that diminish the occurrence of errors related to high-risk drugs in healthcare settings. Information technology should enhance medication safety by tracking the process of medication use.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"17 ","pages":"Article 100531"},"PeriodicalIF":1.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Thai community pharmacists in combating antimicrobial resistance: Qualitative insight and sentiment analysis","authors":"Rojjares Netthong ,&nbsp;Sisira Donsamak ,&nbsp;Dai N. John ,&nbsp;Ros Kane ,&nbsp;Keivan Armani","doi":"10.1016/j.rcsop.2024.100535","DOIUrl":"10.1016/j.rcsop.2024.100535","url":null,"abstract":"<div><h3>Background</h3><div>Antimicrobial resistance (AMR) is increasing globally and poses a significant public health challenge. Community pharmacists, especially in primary care settings, play a pivotal role in mitigating the irrational use of antibiotics, a key driver of AMR.</div></div><div><h3>Objectives</h3><div>This study aims to explore qualitative insights from community pharmacists regarding antibiotic supply and usage, analyze sentiments related to AMR, and highlight the crucial role of community pharmacists in AMR stewardship at the primary care/community level.</div></div><div><h3>Methods</h3><div>This study engaged community pharmacists in Thailand through semi-structured interviews to obtain in-depth insights into the antibiotic supply and perceptions of AMR. Additionally, sentiment analysis, which evaluates the emotional tone of the pharmacists' responses, was conducted to enrich the findings.</div></div><div><h3>Results</h3><div>Interviews with 23 community pharmacists highlighted the practices, challenges, and strategies related to antibiotic supply and use. Key findings include the identification of barriers such as patient demand and lack of awareness about antimicrobial resistance (AMR), alongside strategies for improvement such as public education and professional development. Sentiment analysis reveals a cautiously optimistic perspective toward enhancing rational antibiotic use, underscoring the importance of comprehensive approaches that combine education, ethics, and regulatory measures to address the complexities of antibiotic management at community pharmacies.</div></div><div><h3>Conclusion</h3><div>This study underscores the necessity of public awareness, pharmacist–patient relationships, and regulatory reforms for the rational use of antibiotics in community pharmacies. These findings emphasize that pharmacist education and adherence to professional ethics are essential for mitigating antimicrobial resistance and promoting rational antibiotic use.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100535"},"PeriodicalIF":1.8,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deprescribing oral antidiabetics in elderly patients: Do electronic leaflets across the world address it?","authors":"Kitete Tunda Bunnel,&nbsp;Silvio José Elisei Carvalho Jr,&nbsp;Mariana Linhares Pereira,&nbsp;Renê Oliveira Couto,&nbsp;André Oliveira Baldoni","doi":"10.1016/j.rcsop.2024.100537","DOIUrl":"10.1016/j.rcsop.2024.100537","url":null,"abstract":"<div><div>Diabetes caused 6.7 million deaths in 2021, equating to one death every five seconds, with its global financial burden projected to rise from $1.32 trillion in 2015 to $2.12 trillion by 2030. Severe hypoglycemia necessitates interventions like deprescribing, behavioral strategies, and technology for prevention. Deprescribing aims to reduce unnecessary medication use, enhance rational prescribing, prevent prescribing cascades, and improve health outcomes in elderly patients. Evaluating electronic leaflets can support deprescribing based on patient-centered care and shared decision-making.</div></div><div><h3>Objective</h3><div>To analyze information on deprescribing in oral antidiabetic leaflets from national medicines regulatory authorities, focusing on elderly patients with type 2 diabetes.</div></div><div><h3>Methods</h3><div>This documental study analyzed electronic leaflets of oral antidiabetics from the official websites of nine Medicines Regulatory Authorities: Australia, Brazil, Canada, New Zealand, Singapore, South Africa, UK, USA, and EU, covering drugs listed in the WHO's Essential Medicines List 2023. The analysis focused on the alignment of deprescribing information with the Ontario deprescribing algorithm for oral antidiabetics developed by the Bruyère Institute in Canada.</div></div><div><h3>Results</h3><div>Out of 72 expected leaflets, 64 (88.9 %) were retrieved. Only 18 leaflets (28.1 %) explicitly discussed deprescribing oral antihyperglycemics. Hypoglycemia and drug interaction risks were addressed in 55 leaflets (85.9 %). Caution for use in patients over 65 was mentioned in 32 leaflets (50 %), and 23 leaflets (35.9 %) addressed the risks of tight glucose and HbA1c targets.</div></div><div><h3>Conclusion</h3><div>Despite a high retrieval rate, 11.1 % of leaflets were missing, and those available contained inconsistent deprescribing information. There are significant disparities in guidance across regulatory authorities. Standardized, updated leaflets that address deprescribing in frail older patients could enhance prescribers' confidence and support shared decision-making</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100537"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pharmacist-led interventions in identifying and resolving drug related problems and potentially inappropriate prescriptions among rural patients: A pilot study","authors":"Salvador Gutiérrez-Igual ,&nbsp;Rut Lucas-Domínguez ,&nbsp;José Sendra-Lillo ,&nbsp;Alberto Martí-Rodrigo ,&nbsp;Isabel Romero Crespo ,&nbsp;M. Carmen Montesinos","doi":"10.1016/j.rcsop.2024.100536","DOIUrl":"10.1016/j.rcsop.2024.100536","url":null,"abstract":"<div><h3>Background</h3><div>Drug-related problems are a major problem that can lead to increased morbidity, mortality, and healthcare costs due to heightened medical visits, hospital readmissions, or emergency room visits. In rural areas, new tools for clinical pharmacy services, such as medication review, could decrease this problem.</div></div><div><h3>Objective</h3><div>To analyze the prevalence of clinically relevant drug-related problems (DRPs) and potentially inappropriate prescriptions (PIPs) identified by new medication review software (Revisem®) in rural pharmacies. The effectiveness of resolving DRPs and PIPs in patients who received pharmacist-led intervention (PLI) was also evaluated.</div></div><div><h3>Methods</h3><div>A prospective, multicenter, observational pilot study in 17 rural pharmacies from the Valencian region (Spain) was conducted over a period of 6 months. Revisem®, a type 1 medication review software, was developed and implemented to detect and resolve drug-related issues (DRPs and PIPs). The clinical history of 135 polymedicated patients was recorded, as well as the PLI conducted after the identification of incidences. The mean number of DRPs and PIPs before and after PLI were analyzed and compared.</div></div><div><h3>Findings</h3><div>A total of 1545 drug-related issues were detected in 135 patients (86 women). 1166 were DRPs and 379 were PIPs. Interactions were the most common incidence (43.7 %), with furosemide and omeprazole being the drugs with the highest number of significant interactions. In the before-after intervention study, the mean number of incidents detected per patient by Revisem® decreased from 9.7 ± 6.9 to 8.8 ± 6.9 (<em>p</em> &lt; 0.05) after PLI. Written reports were the most frequent means of communication between pharmacists and physicians (45.0 %). The acceptance rate of pharmacists' suggestions was 45.2 %.</div></div><div><h3>Conclusion</h3><div>The impact of pharmacist-led interventions in rural pharmacies allowed the detection of a high number of drug-related issues and significantly reduced the number of DRPs and PIPs, preventing negative health outcomes.</div></div>","PeriodicalId":73003,"journal":{"name":"Exploratory research in clinical and social pharmacy","volume":"16 ","pages":"Article 100536"},"PeriodicalIF":1.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}