{"title":"Stimuli-responsive linkers and their application in molecular imaging","authors":"Jing Wang, Meng Liu, Xinyue Zhang, Xinning Wang, Menghua Xiong, Dong Luo","doi":"10.1002/EXP.20230027","DOIUrl":"10.1002/EXP.20230027","url":null,"abstract":"<p>Molecular imaging is a non-invasive imaging method that is widely used for visualization and detection of biological events at cellular or molecular levels. Stimuli-responsive linkers that can be selectively cleaved by specific biomarkers at desired sites to release or activate imaging agents are appealing tools to improve the specificity, sensitivity, and efficacy of molecular imaging. This review summarizes the recent advances of stimuli-responsive linkers and their application in molecular imaging, highlighting the potential of these linkers in the design of activatable molecular imaging probes. It is hoped that this review could inspire more research interests in the development of responsive linkers and associated imaging applications.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in reactive oxygen species scavenging nanomaterials for wound healing","authors":"Alireza Joorabloo, Tianqing Liu","doi":"10.1002/EXP.20230066","DOIUrl":"10.1002/EXP.20230066","url":null,"abstract":"<p>Reactive oxygen species play a crucial role in cell signaling pathways during wound healing phases. Treatment strategies to balance the redox level in the deep wound tissue are emerging for wound management. In recent years, reactive oxygen species scavenging agents including natural antioxidants, reactive oxygen species (ROS) scavenging nanozymes, and antioxidant delivery systems have been widely employed to inhibit oxidative stress and promote skin regeneration. Here, the importance of reactive oxygen species in different wound healing phases is critically analyzed. Various cutting-edge bioactive ROS nanoscavengers and antioxidant delivery platforms are discussed. This review also highlights the future directions for wound therapies via reactive oxygen species scavenging. This comprehensive review offers a map of the research on ROS scavengers with redox balancing mechanisms of action in the wound healing process, which benefits development and clinical applications of next-generation ROS scavenging-based nanomaterials in skin regeneration.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139527374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploration of metal-free 2D electrocatalysts toward the oxygen electroreduction","authors":"Joyjit Kundu, Taehyun Kwon, Kwangyeol Lee, Sang-Il Choi","doi":"10.1002/EXP.20220174","DOIUrl":"10.1002/EXP.20220174","url":null,"abstract":"<p>The advancement of economical and readily available electrocatalysts for the oxygen reduction reaction (ORR) holds paramount importance in the advancement of fuel cells and metal-air batteries. Recently, 2D non-metallic materials have obtained substantial attention as viable alternatives for ORR catalysts due to their manifold advantages, encompassing low cost, ample availability, substantial surface-to-volume ratio, high conductivity, exceptional durability, and competitive activity. The augmented ORR performances observed in metal-free 2D materials typically arise from heteroatom doping, defects, or the formation of heterostructures. Here, the authors delve into the realm of electrocatalysts for the ORR, pivoting around metal-free 2D materials. Initially, the merits of metal-free 2D materials are explored and the reaction mechanism of the ORR is dissected. Subsequently, a comprehensive survey of diverse metal-free 2D materials is presented, tracing their evolutionary journey from fundamental concepts to pragmatic applications in the context of ORR. Substantial importance is given on the exploration of various strategies for enhancing metal-free 2D materials and assessing their impact on inherent material performance, including electronic properties. Finally, the challenges and future prospects that lie ahead for metal-free 2D materials are underscored, as they aspire to serve as efficient ORR electrocatalysts.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20220174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scalability of nanopore osmotic energy conversion","authors":"Makusu Tsutsui, Wei-Lun Hsu, Kazumichi Yokota, Iat Wai Leong, Hirofumi Daiguji, Tomoji Kawai","doi":"10.1002/EXP.20220110","DOIUrl":"10.1002/EXP.20220110","url":null,"abstract":"<p>Artificial nanofluidic networks are emerging systems for blue energy conversion that leverages surface charge-derived permselectivity to induce voltage from diffusive ion transport under salinity difference. Here the pivotal significance of electrostatic inter-channel couplings in multi-nanopore membranes, which impose constraints on porosity and subsequently influence the generation of large osmotic power outputs, is illustrated. Constructive interference is observed between two 20 nm nanopores of 30 nm spacing that renders enhanced permselectivity to osmotic power output via the recovered electroneutrality. On contrary, the interference is revealed as destructive in two-dimensional arrays causing significant deteriorations of the ion selectivity even for the nanopores sparsely distributed at an order of magnitude larger spacing than the Dukhin length. Most importantly, a scaling law is provided for deducing the maximal membrane area and porosity to avoid the selectivity loss via the inter-pore electrostatic coupling. As the electric crosstalk is inevitable in any fluidic network, the present findings can be a useful guide to design nanoporous membranes for scalable osmotic power generations.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20220110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioinspired radiative cooling coating with high emittance and robust self-cleaning for sustainably efficient heat dissipation","authors":"Yong Li, Yingnan Song, Hongye Zu, Feilong Zhang, Hui Yang, Wei Dai, Jingxin Meng, Lei Jiang","doi":"10.1002/EXP.20230085","DOIUrl":"10.1002/EXP.20230085","url":null,"abstract":"<p>To overcome the overheating phenomena of electronic devices and energy components, developing advanced energy-free cooling coatings with promising radiative property seem an effective and energy-saving way. However, the further application of these coatings is greatly limited by their sustainability because of their fragile and easy contamination. Herein, it is reported that a bioinspired radiative cooling coating (BRCC) displayed sustainably efficient heat dissipation by the combination of high emittance and robust self-cleaning property. With the hierarchical porous structure constructed by multiwalled carbon nanotubes (MWCNTs), modified SiO<sub>2</sub> and fluorosilicone (FSi) resin, the involvement of the BRCC improves the cooling performance by increasing ≈25% total heat transfer coefficient. During the abrasion and soiling tests, the BRCC-coated Al alloy heat sink always displays stable radiative cooling performance. Moreover, the simulation and experimental results both revealed that reducing surface coverage of BRCC (≈80.9%) can still keep highly cooling efficiency, leading to a cost-effective avenue. Therefore, this study may guide the design and fabrication of advanced radiative cooling coating.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139147869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges","authors":"Hongyu Liu, Yunjian Yu, Alideertu Dong, Mahmoud Elsabahy, Ying-Wei Yang, Hui Gao","doi":"10.1002/EXP.20230092","DOIUrl":"10.1002/EXP.20230092","url":null,"abstract":"<p>Colorectal cancer (CRC) is generally characterized by a high prevalence of <i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>), a spindle-shaped, Gram-negative anaerobe pathogen derived from the oral cavity. This tumor-resident microorganism has been closely correlated with the occurrence, progression, chemoresistance and immunosuppressive microenvironment of CRC. Furthermore, <i>F. nucleatum</i> can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it is crucial to develop efficacious non-antibiotic approaches to eradicate <i>F. nucleatum</i> and its biofilms for CRC treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic chemicals, polymers, inorganic-organic hybrid materials, bacteriophages, probiotics, and vaccines, have been proposed to combat <i>F. nucleatum</i> and <i>F. nucleatum</i> biofilms. This review summarizes the latest advancements in anti-<i>F. nucleatum</i> research, elucidates the antimicrobial mechanisms employed by these systems, and discusses the benefits and drawbacks of each antimicrobial technology. Additionally, this review also provides an outlook on the antimicrobial specificity, potential clinical implications, challenges, and future improvements of these antimicrobial strategies in the treatment of CRC.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yufang He, Li Wang, Aiping Wang, Bo Zhang, Hiep Pham, Jonghyun Park, Xiangming He
{"title":"Insight into uniform filming of LiF-rich interphase via synergistic adsorption for high-performance lithium metal anode","authors":"Yufang He, Li Wang, Aiping Wang, Bo Zhang, Hiep Pham, Jonghyun Park, Xiangming He","doi":"10.1002/EXP.20230114","DOIUrl":"10.1002/EXP.20230114","url":null,"abstract":"<p>Multi-scale simulation is an important basis for constructing digital batteries to improve battery design and application. LiF-rich solid electrolyte interphase (SEI) is experimentally proven to be crucial for the electrochemical performance of lithium metal batteries. However, the LiF-rich SEI is sensitive to various electrolyte formulas and the fundamental mechanism is still unclear. Herein, the structure and formation mechanism of LiF-rich SEI in different electrolyte formulas have been reviewed. On this basis, it further discussed the possible filming mechanism of LiF-rich SEI determined by the initial adsorption of the electrolyte-derived species on the lithium metal anode (LMA). It proposed that individual LiF species follow the Volmer–Weber mode of film growth due to its poor wettability on LMA. Whereas, the synergistic adsorption of additive-derived species with LiF promotes the Frank-Vander Merwe mode of film growth, resulting in uniform LiF deposition on the LMA surface. This perspective provides new insight into the correlation between high LiF content, wettability of LiF, and highperformance of uniform LiF-rich SEI. It disclosed the importance of additive assistant synergistic adsorption on the uniform growth of LiF-rich SEI, contributing to the reasonable design of electrolyte formulas and high-performance LMA, and enlightening the way for multi-scale simulation of SEI.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frontispiece: Progress on quantum dot photocatalysts for biomass valorization (EXP2 6/2023)","authors":"Weijing Cao, Wenjun Zhang, Lin Dong, Zhuang Ma, Jingsan Xu, Xiaoli Gu, Zupeng Chen","doi":"10.1002/EXP.20230605","DOIUrl":"https://doi.org/10.1002/EXP.20230605","url":null,"abstract":"<p>Chen et al. review the recent advancements in quantum dots (QDs)-catalyzed photocatalytic biomass valorization, with special emphasis on the design principles for efficient catalysts (e.g., tuning their particle size, structure, and surface properties) and the effect of the ligands for selectively cleaving the chemical bonds of biomass.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139042227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Back Cover: Early monitoring-to-warning Internet of Things system for emerging infectious diseases via networking of light-triggered point-of-care testing devices (EXP2 6/2023)","authors":"Yu Fu, Yan Liu, Wenlu Song, Delong Yang, Wenjie Wu, Jingyan Lin, Xiongtiao Yang, Jian Zeng, Lingzhi Rong, Jiaojiao Xia, Hongyi Lei, Ronghua Yang, Mingxia Zhang, Yuhui Liao","doi":"10.1002/EXP.20230604","DOIUrl":"https://doi.org/10.1002/EXP.20230604","url":null,"abstract":"<p>We developed a rapid point-of-care (POC) testing device for detecting pathogens. Through multi-device networking and the assistance of artificial intelligence technology, an early monitoring and warning system was developed to prevent and control the spread of epidemic diseases.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139042226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)","authors":"Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou","doi":"10.1002/EXP.20230602","DOIUrl":"https://doi.org/10.1002/EXP.20230602","url":null,"abstract":"<p>Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate <i>Salmonella</i> and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139042225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}