Exploration (Beijing, China)最新文献

{"title":"Efficient Ternary Organic Photovoltaic Films for Fast Exciton Separation to Generate Free Radicals for Wastewater Treatment","authors":"Linji Yang,&nbsp;Ciyuan Huang,&nbsp;Yang Zhou,&nbsp;Libin Zhang,&nbsp;Ke Sun,&nbsp;Houjin Luo,&nbsp;Yinna Liang,&nbsp;Yilin Wang,&nbsp;Tao Yang,&nbsp;Wei Ma,&nbsp;Donglou Ren,&nbsp;Cong Liu,&nbsp;Heng Zhang,&nbsp;Kai Chen,&nbsp;Hongxiang Zhu,&nbsp;Jianhua Xiong,&nbsp;Bingsuo Zou,&nbsp;Shuangfei Wang,&nbsp;Tao Liu","doi":"10.1002/EXP.70001","DOIUrl":"https://doi.org/10.1002/EXP.70001","url":null,"abstract":"<p>Given the effectiveness of organic pollutants photodegradation and the excellent photovoltaic nature of organic solar cells (OSCs), this work first innovatively integrated the cross-fields of OSCs and environmental photocatalysis. Using knowledge of OSC morphology, an insertion strategy involved adding a suitable quantity of guest acceptor (Y6-O) to the PM6 donor polymer and BTP-2F-ThCl host small molecule acceptor system. Y6-O leads to tighter π–π packing, reduced domain size, and improved domain purity, resulting in favorable morphology for charge generation and transfer in devices and an improved power conversion efficiency (PCE) from 17.1% to 18.1%. Moreover, terpolymer organic photovoltaic films were applied to wastewater treatment, gaining ions Sb(III) and Sb(V) removals of 100% in 15 min, and guaiacol photodegradations of 90% in 1 h. This work significantly prompts the development of organic photovoltaics and wastewater treatment and opens views for multifunctional organic photovoltaic material applications.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration","authors":"Xiao Yang,&nbsp;Xiankun Cao,&nbsp;Xin Wang,&nbsp;Jiadong Guo,&nbsp;Yangzi Yang,&nbsp;Liqiang Lu,&nbsp;Pu Zhang,&nbsp;Huan Yang,&nbsp;Kewei Rong,&nbsp;Tangjun Zhou,&nbsp;Yongqiang Hao,&nbsp;Jie Zhao,&nbsp;Jingke Fu,&nbsp;Kai Zhang","doi":"10.1002/EXP.20230174","DOIUrl":"https://doi.org/10.1002/EXP.20230174","url":null,"abstract":"<p>Intervertebral disc degeneration (IVDD) is a chronic musculoskeletal disorder causing lower back pain, imposing a considerable burden on global health. Hyperglycemia resulting from diabetes mellitus induces advanced glycation end products (AGEs) accumulation in nucleus pulposus cells, leading to IVDD. Mitigating AGEs accumulation is a novel promising strategy for IVDD management. In our study, palladium nanoparticles (Pd NPs) preferentially colocalized within the endoplasmic reticulum and efficiently degraded AGEs via valosin-containing protein (VCP)-mediated autophagy pathways. Pd NPs promoted the ATPase activity of VCPs, upregulated microtubule-associated proteins 1A/1B light chain 3 (LC3) expression, and increased AGEs-degrading autophagosome production. They ameliorated mitochondrial function, relieved endoplasmic reticulum stress, and counteracted the detrimental oxidative stress microenvironment in a high-glucose/high-fat-induced nucleus pulposus cell degeneration model. Consequently, Pd NPs effectively rescued nucleus pulposus cell degeneration in vitro, restored disc height and partially recovered the degenerated phenotype of IVDD in vivo. We provide novel insights regarding IVDD management by targeting AGEs degradation, showing potential for clinical practice.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic Biology-Based Engineering Cells for Drug Delivery","authors":"Wenzhe Yi,&nbsp;Shuangshuang Hu,&nbsp;Xindi Qian,&nbsp;Wenlu Yan,&nbsp;Yaping Li","doi":"10.1002/EXP.20240095","DOIUrl":"https://doi.org/10.1002/EXP.20240095","url":null,"abstract":"<p>Although drug delivery technology has promoted the clinical translation of small molecule drugs, there is an urgent need for advanced delivery systems to overcome complex physiological barriers and the increasing development of biological drugs. This review overviews the emerging applications of synthetic biology-based engineered cells for drug delivery. We first introduce synthetic biology strategies to engineer cells for biological drug delivery and discuss the benefits in terms of specificity, intelligence, and controllability. Furthermore, we highlight the cutting-edge advancements at the convergence of synthetic biology and nanotechnology in drug delivery. Nanotechnology expands the engineering design and construction concepts of synthetic biology, and synthetic biology drives the development for biotechnology-driven nanomaterial synthesis. In the future, synthetic biology-based engineered cells may be developed to be more modular, standardized, and intelligent, leading to significant breakthroughs in the construction of advanced drug delivery systems.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back Cover: High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption (EXP2 6/2024)","authors":"Dongzhi Chen,&nbsp;Xin Guo,&nbsp;Xuening Sun,&nbsp;Xiang Feng,&nbsp;Kailong Chen,&nbsp;Jinfeng Zhang,&nbsp;Zece Zhu,&nbsp;Xiaofang Zhang,&nbsp;Xin Liu,&nbsp;Min Liu,&nbsp;Li Li,&nbsp;Weilin Xu","doi":"10.1002/EXP.20240602","DOIUrl":"https://doi.org/10.1002/EXP.20240602","url":null,"abstract":"<p>This work presents a high-yield approach to recycle duck feather into carbon dots (CDs) via hydrothermal treatment. The resultant CDs exhibit matrix-free solid-state fluorescence under ultraviolet lamp, and long-lived green room-temperature phosphorescence after removing ultraviolet lamp. Furthermore, their ink demonstrates excellent potential in anticounterfeiting and information encryption, offering a distinctive perspective to reclamation of the feather wastes for environmental sustainability.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontispiece: Advancements and challenges in brain cancer therapeutics (EXP2 6/2024)","authors":"Fan Bai,&nbsp;Yueyang Deng,&nbsp;Long Li,&nbsp;Ming Lv,&nbsp;Jamoliddin Razzokov,&nbsp;Qingnan Xu,&nbsp;Zhen Xu,&nbsp;Zhaowei Chen,&nbsp;Guojun Chen,&nbsp;Zhitong Chen","doi":"10.1002/EXP.20240603","DOIUrl":"https://doi.org/10.1002/EXP.20240603","url":null,"abstract":"<p>This review offers a comprehensive look at brain tumor treatments, including both physical (radiotherapy, ablation, photodynamic therapy, cold plasma) and non-physical approaches (surgery, chemotherapy, immunotherapy). It discusses mechanisms, side effects, and recent advances, stressing the importance of personalized, multi-modal strategies. Balancing efficacy with patient safety is critical, considering the brain's delicate nature and functional preservation needs\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages (EXP2 6/2024)","authors":"Baiyan Sui,&nbsp;Tingting Ding,&nbsp;Xingyi Wan,&nbsp;Yuxiao Chen,&nbsp;Xiaodi Zhang,&nbsp;Yuanbo Cui,&nbsp;Jie Pan,&nbsp;Linlin Li,&nbsp;Xin Liu","doi":"10.1002/EXP.20240601","DOIUrl":"https://doi.org/10.1002/EXP.20240601","url":null,"abstract":"<p>Liu et al. developed a wireless piezoelectric hydrogel with BaTiO₃ nanoparticles, generating piezoelectric potentials to reprogram macrophages towards the M2 phenotype, enhancing osteogenesis in bone marrow stem cells and promoting bone regeneration at load-bearing alveolar sites. This piezoelectric-driven osteoimmunomodulation offers new insights for designing next-generation bioactive materials with combined osteoinductive, immunomodulatory, and piezoelectric properties.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering Exploration for a lasting and sustainable future","authors":"Gaopeng Li,&nbsp;Zhi-Gang Chen,&nbsp;Chengliang Wang","doi":"10.1002/EXP.20240397","DOIUrl":"https://doi.org/10.1002/EXP.20240397","url":null,"abstract":"&lt;p&gt;To address the growing global imperative for a sustainable future, the United Nations (UN) adopted the 2030 Agenda for Sustainable Development with 17 sustainable development goals (SDGs) at the 2015 UN Sustainable Development Summit. The agenda encompasses 17 SDGs, which span critical areas such as life, water, energy, climate, hunger, poverty, justice, peace, good health, high-quality education, decent work and economic growth, science and technology. In 2021, &lt;i&gt;Exploration&lt;/i&gt;, an international, cross-disciplinary journal, was launched to contribute to these efforts, aiming to inspire and support actionable steps toward a more sustainable future.&lt;/p&gt;&lt;p&gt;In a broad sense, all publications in &lt;i&gt;Exploration&lt;/i&gt; can be viewed as contributions by researchers and scientists toward a more sustainable world. These contributions encompass: (1) water/salt separation for clean water&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt;; (2) treatment of obsolete water and degradation of plastics for good sanitation; (3) wearable/implantable electronic devices for biomedical applications and good health&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt;; (4) biotechnology and pharmacology for good health,&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; for example, advanced biomedical materials for disease diagnosis or therapy and progresses in drug delivery and tumor therapy; (5) energy conversion technologies as actions to achieve affordable and clean energy and reduce the carbon emission,&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; such as CO&lt;sub&gt;2&lt;/sub&gt; reduction technologies to convert CO&lt;sub&gt;2&lt;/sub&gt; into organic fuels through electrocatalysis or photocatalysis, hydrogen production from water through electrocatalysis and utilization of solar energy by solar cells or photocatalysis based on perovskites, inverted perovskites, and organics; (6) advanced energy storage technologies with high energy density and long cycle lifespan&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; to better harness clean and renewable energies, mitigate the climate change, and make the energy storage devices more convenient and portable.&lt;/p&gt;&lt;p&gt;We firmly believe that sustainable development is essential for the future of humanity. All scientific and technological advancements that contribute to sustainability fall within the scope of this journal and are, therefore, highly encouraged. Beyond the abovementioned cutting-edge research, we welcome studies in agriculture, electronics, photonics, energies, manufacturing, material science, physical science, environmental science, life science, information science, space science, artificial intelligence, and other fields dedicated to enhancing the quality of life and minimizing humanity's environmental impact. Additionally, topics such as the policies, regulations, and initiatives addressing hunger, poverty, conflicts, and inequalities, aligned with the 17 SDGs, are within our field. Our vision for &lt;i&gt;Exploration&lt;/i&gt; is to serve ","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Oxygen-carrying semiconducting polymer nanoprodrugs induce sono-pyroptosis for deep-tissue tumour treatment”","authors":"","doi":"10.1002/EXP.20240339","DOIUrl":"https://doi.org/10.1002/EXP.20240339","url":null,"abstract":"<p>Wang F., Fan Y., Liu Y., et al. Oxygen-carrying semiconducting polymer nanoprodrugs induce sono-pyroptosis for deep-tissue tumour treatment, <i>Exploration</i>, 2024, <i>4</i>, 20230100.</p><p>In our manuscript titled “Oxygen-carrying semiconducting polymer nanoprodrugs induce sono-pyroptosis for deep-tissue tumour treatment”, H&amp;E staining image of PBS + US group in Figure 4G was misplaced due to an inadvertent error. The error was spotted in time after revisiting the article and we correct this error by providing the revised image.</p><p>The revised Figure 4</p><p>We apologize for this error.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Conducting polymer hydrogels based on supramolecular strategies for wearable sensors (EXP2 5/2024)","authors":"Zhiyuan Sun,&nbsp;Qingdong Ou,&nbsp;Chao Dong,&nbsp;Jinsheng Zhou,&nbsp;Huiyuan Hu,&nbsp;Chong Li,&nbsp;Zhandong Huang","doi":"10.1002/EXP.20240502","DOIUrl":"https://doi.org/10.1002/EXP.20240502","url":null,"abstract":"<p>This cover showcases typical supramolecular strategies for developing high-performance conductive polymer hydrogels, providing a comprehensive review of their applications in the field of wearable sensors.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Neural interfaces: Bridging the brain to the world beyond healthcare (EXP2 5/2024)","authors":"Shumao Xu,&nbsp;Yang Liu,&nbsp;Hyunjin Lee,&nbsp;Weidong Li","doi":"10.1002/EXP.20240501","DOIUrl":"https://doi.org/10.1002/EXP.20240501","url":null,"abstract":"<p>This perspective explores diverse neural interfaces in the brain, offering transformative possibilities for engaging with our environment and enhancing communication. Emphasis is placed on the role of both non-invasive and invasive neural interfaces in transforming practical applications beyond the realm of healthcare, emphasizing the profound implications for remote control, mind connectivity, and integrated urban design.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}