Baiyan Sui, Tingting Ding, Xingyi Wan, Yuxiao Chen, Xiaodi Zhang, Yuanbo Cui, Jie Pan, Linlin Li, Xin Liu
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引用次数: 0
摘要
Liu 等人开发了一种含有 BaTiO3 纳米颗粒的无线压电水凝胶，其产生的压电势能可将巨噬细胞重编程为 M2 表型，从而增强骨髓干细胞的成骨能力，促进承重牙槽部位的骨再生。这种压电驱动的骨免疫调节为设计兼具诱导骨生成、免疫调节和压电特性的下一代生物活性材料提供了新的思路。
Front Cover: Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages (EXP2 6/2024)
Liu et al. developed a wireless piezoelectric hydrogel with BaTiO3 nanoparticles, generating piezoelectric potentials to reprogram macrophages towards the M2 phenotype, enhancing osteogenesis in bone marrow stem cells and promoting bone regeneration at load-bearing alveolar sites. This piezoelectric-driven osteoimmunomodulation offers new insights for designing next-generation bioactive materials with combined osteoinductive, immunomodulatory, and piezoelectric properties.
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