Exploration (Beijing, China)最新文献

{"title":"Metal-Organic Frameworks-Based Copper Catalysts for CO2 Electroreduction Toward Multicarbon Products","authors":"Chen Qin,&nbsp;Xuheng Li,&nbsp;Ting Wang,&nbsp;Zhen Xu,&nbsp;Kai-Jie Chen,&nbsp;Fuping Pan","doi":"10.1002/EXP.70011","DOIUrl":"https://doi.org/10.1002/EXP.70011","url":null,"abstract":"<p>Copper (Cu) is the most promising catalyst for electrochemical CO₂-to-C₂₊ conversion, whereas performance remains below practical thresholds due to the high energy barrier of C−C coupling and lack of effective approaches to steer the reaction pathway. Recent advances show that metal-organic frameworks (MOF) could be a promising platform as support, pre-catalyst, and co-catalyst to modify the electronic structure and local reaction environment of Cu catalysts for promoting CO₂-to-C₂₊ reduction by virtue of their great tunability over compositions and pore architectures. In this review, we discussed general design principles, catalytic mechanisms, and performance achievements of MOF-based Cu catalysts, aiming to boost catalyst refinement for steering CO₂ reduction pathway to C₂₊ products. The fundamentals and challenges of CO₂-to-C₂₊ reduction are first introduced. Then, we summarized design conceptions of MOF-based Cu catalysts from three aspects: engineering the electronic properties of Cu, regulating the local reaction environment, and managing site exposure and mass transport. Further, the latest progress of CO₂ reduction to C₂₊ products over MOF-based Cu catalysts, namely Cu-based MOF, MOF-derived Cu, and Cu@MOF hybrid catalysts, are discussed. Finally, future research opportunities and strategies are suggested to innovate the rational design of advanced MOF-based Cu catalysts for electrifying CO₂-to-C₂₊ transformation.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core-Shell Manganese Phosphate/siPD-L1 Modulator","authors":"Fei Xia,&nbsp;Yuqian Lu,&nbsp;Zipeng Gong,&nbsp;Qingchao Tu,&nbsp;Shuntao Liang,&nbsp;Chen Wang,&nbsp;HaiLu Yao,&nbsp;LinYing Zhong,&nbsp;Yuanfeng Fu,&nbsp;Pengbo Guo,&nbsp;Yichong Hou,&nbsp;Xinyu Zhou,&nbsp;Li Zou,&nbsp;Licheng Gan,&nbsp;Weiqi Chen,&nbsp;Jiawei Yan,&nbsp;Junzhe Zhang,&nbsp;Huanhuan Pang,&nbsp;Yuqing Meng,&nbsp;Qiaoli Shi,&nbsp;Chen Pan,&nbsp;Xiaomei Tao,&nbsp;Jigang Wang,&nbsp;Qingfeng Du,&nbsp;Chong Qiu","doi":"10.1002/EXP.70009","DOIUrl":"https://doi.org/10.1002/EXP.70009","url":null,"abstract":"<p>The insufficient infiltration and functional inhibition of CD8⁺ T cells due to tumor microenvironment (TME) are considered enormous obstacles to anti-tumor immunotherapy. Herein, a pH-responsive core-shell manganese phosphate nanomodulator co-loading siPD-L1 and Mn²⁺ into nanoparticles coated with hyaluronic acid was prepared, which was aimed at the bidirectional reprogramming the tumor microenvironment: (1) “Brakes off,” restoring CD8⁺ T cells function by siPD-L1 knockdowning PD-L1 expression of tumor cells; (2) “Step on the accelerator,” promoting CD8⁺ T cells infiltration in tumors tissue based on the multidimensional immune effects of Mn²⁺ (immunogenic cell death induced the enhancing cGAS-STING pathway, the proliferation and maturation of relative immune cells). Additionally, this strategy could induce macrophage polarization and inhibit the regulatory T cells in tumor site. This work provided a manganese phosphate nanomodulator to reprogram the immune TME for an enhanced comprehensive anti-tumor effect of triple negative breast cancer, which offers a robust method for tumor immunotherapy in future clinical applications.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Responsive Multi-Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury","authors":"Guibin Gao,&nbsp;Juanjuan Li,&nbsp;Yanming Ma,&nbsp;Min Xie,&nbsp;Jianxian Luo,&nbsp;Ke Wang,&nbsp;Cheng Peng,&nbsp;Hua Yang,&nbsp;Tianjun Chen,&nbsp;Guowei Zhang,&nbsp;Jiang Ouyang,&nbsp;Hongsheng Lin,&nbsp;Zhisheng Ji","doi":"10.1002/EXP.70012","DOIUrl":"https://doi.org/10.1002/EXP.70012","url":null,"abstract":"<p>Preserved/rescued mitochondrial functions have a significant effect on maintaining neurogenesis, axonal carriage, and synaptic plasticity following spinal cord injury (SCI). We fabricated an ingenious redox-responsive strategy for commanded liberation of NADH (reduced form of nicotinamide-adenine dinucleotide) by bioactive diselenide-containing biodegradable mesoporous silica nanoparticles (<b>Se@NADH</b>). The nanocarrier-embedded NADH can be liberated in a controlled pattern through the cleavage of diselenide bonds in the presence of reactive oxygen species (ROS) or glutathione (GSH). The NAD⁺ was regenerated by the reactions between released NADH and harmful ROS to antagonize mitochondrial dysfunction and increase ATP synthesis, promoting axon regeneration across SCI areas. This nanosystem increased the stability of NADH during prolonged blood circulation time, reduced the clearance rate, exhibited significant anti-inflammatory as well as neuroprotective effects and enhanced the regeneration of electrophysiological conduction capacity across SCI areas. Importantly, <b>Se@NADH</b> suppressed glial scar formation and promoted neuronal generation as well as stretching of long axons throughout the glial scar, thereby improving actual restoration of locomotor functions in mice with SCI and exerting ascendant therapeutic effects. Targeting of mitochondrial dysfunction is a potential approach for SCI treatment and may be applied to other central nervous system diseases.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Diagnosis and Treatment Based on Stimuli-Responsive Aggregation of Gold Nanoparticles","authors":"Xiaowei Chang,&nbsp;Huaiyu Wang,&nbsp;Xin Chen","doi":"10.1002/EXP.70006","DOIUrl":"https://doi.org/10.1002/EXP.70006","url":null,"abstract":"<p>Gold nanomaterials have been used in the diagnosis and treatment of different tumors due to their unique physical and chemical properties. Among them, gold nanoparticles with stimuli-responsive aggregation functions have attracted extensive attention because they can meet the unique needs of tumor diagnosis and treatment at different stages through structural changes. However, how to effectively modify gold nanoparticles to achieve structural transformation for specific stimuli, and the role of corresponding structural transformation in improving the effect of diagnosis and treatment still lack systematic summary. In this review, we comprehensively summarized the current strategies for inducing gold nanoparticles aggregation and its advances in tumor diagnosis and treatment.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elastic Nanoparticle-Reinforced, Conductive Structural Color Hydrogel With Super Stretchability, Self-Adhesion, Self-Healing as Electrical/Optical Dual-Responsive Visual Electronic Skins","authors":"Min Xu,&nbsp;Junlong Liao,&nbsp;Jiajia Li,&nbsp;Yu Shi,&nbsp;Ziyu Zhang,&nbsp;Yifu Fu,&nbsp;Zhongze Gu,&nbsp;Hua Xu","doi":"10.1002/EXP.70008","DOIUrl":"https://doi.org/10.1002/EXP.70008","url":null,"abstract":"<p>Developing smart hydrogel with excellent physicochemical properties and multiple signal output capability for interactively electronic skin still remains challenging. Here, conductive structural color hydrogels with desirable physicochemical properties (including high stretchability and robustness, self-adhesion and self-healing) were developed to provide synchronous electronic and visual color signals for e-skins. Highly charged elastic nanoparticles were elaborately used as building units for structural color and the hydrogel were prepared by the self-assembly of the nanoparticle to form a non-close-packed array in a mixture comprised of acrylamide, silkworm silk fiber proteins (SF), reduced graphene oxide (rGO) and then photopolymerization. Benefiting from the improved interfacial compatibility between flexible hydrogel network and elastic nanoparticle, covalent cross-linking network structure and synergistic multiple non-covalent bonding interactions, the hydrogel exhibits extraordinary mechanical properties, excellent self-adhesion to diverse substrates and self-healing at room temperature. In addition, the hydrogel exhibited sensitive resistance changes and synchronous structural color changes under strain. As a proof-to-concept, the hydrogel displayed superior capability for the color-response and the electrical signal response of various human motions, the spatial distribution of external mechanical stimuli as well as identification of different external stimuli, indicating promising applications in the fields of interactive visual electronic skin, wearable devices, and human–machine interfaces.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in Photocathode Interface Engineering for Photoelectrochemical CO2 Reduction Reaction to C1 or C2+ Products","authors":"Jae Hak Kim,&nbsp;Sung Hyun Hong,&nbsp;Sang Hyun Ahn,&nbsp;Soo Young Kim","doi":"10.1002/EXP.20240014","DOIUrl":"https://doi.org/10.1002/EXP.20240014","url":null,"abstract":"<p>Photoelectrochemical (PEC) systems harness light absorption to initiate chemical reactions, while electrochemical reactions facilitate the conversion of reactants into desired products, ensuring more efficient and sustainable energy conversion in PECs. Central to optimizing the performance of PECs was the pivotal role played by interface engineering. This intricate process involves manipulating material interfaces at the atomic or nanoscale to enhance charge transfer, improve catalytic activity, and address limitations associated with bulk materials. The careful tuning of factors such as band gap, surface energy, crystallinity, defect characteristics, and structural attributes through interface engineering led to superior catalytic efficiency. Specifically, interface engineering significantly enhanced the efficiency of semiconductor-based PECs. Engineers strategically designed heterojunctions and manipulated catalyst surface properties to optimize the separation and migration of photogenerated charge carriers, minimizing recombination losses and improving performance overall. This review categorizes the discussion into four sections focusing on the interface engineering of PECs, providing valuable insights into recent research trends. Overall, the synergy between PECs and interface engineering holds tremendous promise for advancing renewable energy technologies and addressing environmental challenges by offering innovative solutions for sustainable energy conversion and storage.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules","authors":"Jingdong Rao,&nbsp;Di Suo,&nbsp;Qing Ma,&nbsp;Yongyi Mo,&nbsp;Ho-Pan Bei,&nbsp;Li Wang,&nbsp;Chuyang Y. Tang,&nbsp;Kai-Hang Yiu,&nbsp;Shuqi Wang,&nbsp;Zhilu Yang,&nbsp;Xin Zhao","doi":"10.1002/EXP.70004","DOIUrl":"https://doi.org/10.1002/EXP.70004","url":null,"abstract":"<p>Endothelial injury is a common occurrence following stent implantation, often leading to complications such as restenosis and thrombosis. To address this issue, we have developed a multi-functional stent coating that combines a dopamine-copper (DA-Cu) base with therapeutic biomolecule modification, including nitric oxide (NO) precursor L-arginine, endothelial glycocalyx heparin, and endothelial cell (EC) catcher vascular endothelial growth factor (VEGF). In our stent coating, the incorporated Cu acts as a sustainable catalyst for converting endogenous NO donors into NO, and the immobilized arginine serves as a precursor for NO generation under the effect of endothelial nitric oxide synthase (eNOS). The presence of heparin endows the stent coating with anticoagulant ability and enhances eNOS activity, whilst rapid capture of EC by VEGF accelerates re-endothelialization. After in vivo implantation, the antioxidant elements and produced NO alleviate the inflammatory response, establishing a favorable healing environment. The conjugated VEGF contributes to the formation of a new and intact endothelium on the stent surface to counteract inappropriate vascular cell behaviors. The long-lasting NO flux inhibits smooth muscle cell (SMC) migration and prevents its excessive proliferation, reducing the risk of endothelial hyperplasia. This innovative coating enables the dual delivery of VEGF and NO to target procedural vascular repair phases: promoting rapid re-endothelialization, effectively preventing thrombosis, and suppressing inflammation and restenosis. Ultimately, this innovative coating has the potential to improve therapeutic outcomes following stent implantation.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Engineered Brain-Targeting Exosome for Reprogramming Immunosuppressive Microenvironment of Glioblastoma”","authors":"","doi":"10.1002/EXP.70002","DOIUrl":"https://doi.org/10.1002/EXP.70002","url":null,"abstract":"<p>Jun Yang^1,#, Yong Li^1,#, Shaoping Jiang¹, Yuxin Tian¹, Mengjie Zhang¹, Shuai Guo¹, Pengfei Wu¹, Jianan Li¹, Lin Xu¹, Wenpei Li¹, Yushu Wang², Huile Gao³, Yuanyu Huang¹, Yuhua Weng^1,*, Shaobo Ruan^1,*</p><p>¹School of Life Science, Advanced Research Institute of Multidisciplinary Science, Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing, China</p><p>²Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA</p><p>³West China School of Pharmacy, Sichuan University, Chengdu, China</p><p>J. Yang, Y. Li, S. Jiang, Y. Tian, M. Zhang, S. Guo, P. Wu, J. Li, L. Xu, W. Li, Y. Wang, H. Gao, Y. Huang, Y. Weng, S. Ruan, <i>Exploration</i> 2024, 20240039.</p><p>In our manuscript titled “Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma,” the in vivo living images of G4 group at 0.5 and 1 h in Figure 5A were misplaced, and the in vivo living image of G3 group at 2 h used the wrong mouse due to a formatting error. The error was spotted in time after revisiting the article and we corrected this error by providing the revised image.</p><p>We apologize for this error.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrovoltaic Power Generation Depend on Wettability at the Liquid–Solid Interface: Mechanisms, Materials, and Applications With Various Resource","authors":"Yejin Lee,&nbsp;Minwoo Lee,&nbsp;Junwoo Lee,&nbsp;Ho Won Jang,&nbsp;Ji-Soo Jang","doi":"10.1002/EXP.70007","DOIUrl":"https://doi.org/10.1002/EXP.70007","url":null,"abstract":"<p>With the global increase in energy consumption, there is a growing demand for green energy production, which has prompted the development of novel renewable energy sources. Recently, significant momentum has been observed in research on new energy harvesting methods suitable for small devices. In this context, hydrovoltaic power generation, utilizing water due to its ubiquitous presence and easy availability, has emerged as a promising technology. Hydrovoltaic power generation operates by converting the potential energy of water into electrical energy through the interaction between water and materials capable of inducing an electrical potential gradient. The control of material surface wettability, which determines the interaction with water, plays a crucial role in enhancing the electrical output and long-term stability of power generation systems. This review categorizes the mechanisms of hydrovoltaic power generation into flow and diffusion mechanisms, discussing respective case studies based on hydrophobic and hydrophilic substrates. Additionally, representative materials used in hydrovoltaic power generation are discussed and the potential to expand this technology across various fields based on the diverse resources of water is demonstrated. The review concludes with future perspectives, highlighting the applications of hydrovoltaic power generation across multiple domains and outlining directions for future research and development.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Recent Progress in Quantitative Analysis of Self-Assembled Peptides”","authors":"","doi":"10.1002/EXP.20250016","DOIUrl":"https://doi.org/10.1002/EXP.20250016","url":null,"abstract":"<p>X. Cai, W. Xu, C. Ren, et al. Recent Progress in Quantitative Analysis of Self-Assembled Peptides. <i>Exploration</i> 4 (2024): 20230064.</p><p>In our manuscript titled “Recent Progress in Quantitative Analysis of Self-Assembled Peptides,” there was a mistake regarding the citation of Figure 10A–F. The true source of these data is from the publication https://doi.org/10.1021/acs.nanolett.1c03683. However, in Figure 10B, the first image in the first row is identical to the fourth image, and the first image in the third row also exhibits similarity to the fourth image. This related work was from Ye's group other than our own study. Thus, we have replaced the relevant Figure 10A–F with the data from another reference (https://doi.org/10.1021/jacs.9b03649). This revision will not affect the conclusions of this manuscript. This corrigendum corrects this error by providing the following revised section.</p><p>For multimodal imaging induced by enzyme catalysis, Ye's group designed an activable FLI/PET bimodal nanoprobe (P-CyFF-Gd) for bimodal imaging of ALP enzyme activity.^[112] As shown in Figure 10A, an overexpressed enzyme, alkaline phosphatase (ALP), on the cell membrane was employed to activate the fluorescence by dephosphorylation, after which P-CyFF-Gd in situ co-assembled into nanoparticles, simultaneously switching on FLI signals and enhancing MRI imaging. In vivo bimodal imaging results showed that after intravenous injection of P-CyFF-Gd, fluorescence (Figure 10B,D) in the tumor region reached the highest level at 2 h, which was approximately 2.8 folds as high as that pretreated with ALP inhibitor (Na₃VO₄). Akin to FLI, MRI imaging (Figure 10C and E) displayed maximum signal enhancement (%SE) at 4 h in tumors upon injection of P-CyFF-Gd. Moreover, the distribution in tumor was higher than in other organs (Figure 10F). These studies corroborated that concomitant NIR FLI and MRI imaging of self-assembly of P-CyFF-Gd are capable of efficiently detection of enzyme activity in vivo.</p><p>We apologize for this error.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20250016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}