Exploration (Beijing, China)最新文献_第6页

Front Cover: Artificial sensory system based on memristive devices (EXP2 1/2024) 封面：基于记忆装置的人工感觉系统（EXP2 1/2024）

Exploration (Beijing, China) Pub Date : 2024-02-14 DOI: 10.1002/EXP.20240101

Ju Young Kwon, Ji Eun Kim, Jong Sung Kim, Suk Yeop Chun, Keunho Soh, Jung Ho Yoon

引用次数: 0

Frontispiece: Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges (EXP2 1/2024) 前言：在结直肠癌治疗中抗击核酸镰刀菌的新策略：系统回顾、改进和未来挑战（EXP2 1/2024）

Exploration (Beijing, China) Pub Date : 2024-02-14 DOI: 10.1002/EXP.20240106

Hongyu Liu, Yunjian Yu, Alideertu Dong, Mahmoud Elsabahy, Ying-Wei Yang, Hui Gao

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Inside Back Cover: Understanding the improvement mechanism of plasma etching treatment on oxygen reduction reaction catalysts (EXP2 1/2024) 封底内页：了解等离子蚀刻处理对氧还原反应催化剂的改进机理（EXP2 1/2024）

Exploration (Beijing, China) Pub Date : 2024-02-14 DOI: 10.1002/EXP.20240103

Peng Rao, Yanhui Yu, Shaolei Wang, Yu Zhou, Xiao Wu, Ke Li, Anyuan Qi, Peilin Deng, Yonggang Cheng, Jing Li, Zhengpei Miao, Xinlong Tian

引用次数: 0

Back Cover: Deep-learning enabled smart insole system aiming for multifunctional foot-healthcare applications (EXP2 1/2024) 封底：支持深度学习的智能鞋垫系统，旨在实现多功能足部保健应用（EXP2 1/2024）

Exploration (Beijing, China) Pub Date : 2024-02-14 DOI: 10.1002/EXP.20240104

Yu Tian, Lei Zhang, Chi Zhang, Bo Bao, Qingtong Li, Longfei Wang, Zhenqiang Song, Dachao Li

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Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery 针对眼睛表面和脂质体给药的适配体的 Cornea-SELEX

Exploration (Beijing, China) Pub Date : 2024-02-09 DOI: 10.1002/EXP.20230008

Ka-Ying Wong, Yibo Liu, Man-Sau Wong, Juewen Liu

{"title":"Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery","authors":"Ka-Ying Wong, Yibo Liu, Man-Sau Wong, Juewen Liu","doi":"10.1002/EXP.20230008","DOIUrl":"10.1002/EXP.20230008","url":null,"abstract":"Cornea is the major barrier to drug delivery to the eye, which results in low bioavailability and poor efficacy of topical eye treatment. In this work, we first select cornea-binding aptamers using tissue-SELEX on pig cornea. The top two abundant aptamers, Cornea-S1 and Cornea-S2, could bind to pig cornea, and their Kd values to human corneal epithelial cells (HCECs) were 361 and 174 nм, respectively. Aptamer-functionalized liposomes loaded with cyclosporine A (CsA) were developed as a treatment for dry eye diseases. The Kd of Cornea-S1- or Cornea-S2-functionalized liposomes reduces to 1.2 and 15.1 nм, respectively, due to polyvalent binding. In HCECs, Cornea-S1 or Cornea-S2 enhanced liposome uptake within 15 min and extended retention to 24 h. Aptamer CsA liposomes achieved similar anti-inflammatory and tight junction modulation effects with ten times less CsA than a free drug. In a rabbit dry eye disease model, Cornea-S1 CsA liposomes demonstrated equivalence in sustaining corneal integrity and tear break-up time when compared to commercial CsA eye drops while utilizing a lower dosage of CsA. The aptamers obtained from cornea-SELEX can serve as a general ligand for ocular drug delivery, suggesting a promising avenue for the treatment of various eye diseases and even other diseases.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoperoxide-enhanced self-assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy 内过氧化物增强型自组装 ROS 生成器作为细胞内原药用于肿瘤化疗和化学动力疗法

Exploration (Beijing, China) Pub Date : 2024-02-09 DOI: 10.1002/EXP.20230127

JunJie Tang, Yadong Liu, Yifan Xue, Zhaozhong Jiang, Baizhu Chen, Jie Liu

{"title":"Endoperoxide-enhanced self-assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy","authors":"JunJie Tang, Yadong Liu, Yifan Xue, Zhaozhong Jiang, Baizhu Chen, Jie Liu","doi":"10.1002/EXP.20230127","DOIUrl":"10.1002/EXP.20230127","url":null,"abstract":"Prodrug-based self-assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant promise for chemodynamic therapy (CDT) by generating highly toxic reactive oxygen species (ROS). However, the insufficient level of intracellular ROS and the limited drug accumulation remain major challenges for further clinical transformation. In this study, the PSNs for the delivery of artesunate (ARS) are demonstrated by designing the pH-responsive ARS-4-hydroxybenzoyl hydrazide (HBZ)-5-amino levulinic acid (ALA) nanoparticles (AHA NPs) with self-supplied ROS for excellent chemotherapy and CDT. The PSNs greatly improved the loading capacity of artesunate and the ROS generation from endoperoxide bridge using the electron withdrawing group attached directly to C10 site of artesunate. The ALA and ARS-HBZ could be released from AHA NPs under the cleavage of hydrazone bonds triggered by the acidic surroundings. Besides, the ALA increased the intracellular level of heme in mitochondria, further promoting the ROS generation and lipid peroxidation with ARS-HBZ for excellent anti-tumor effects. Our study improved the chemotherapy of ARS through the chemical modification, pointing out the potential applications in the clinical fields.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the importance of the interface in nanocomposite cathodes for proton-conducting solid oxide fuel cells 揭示质子传导型固体氧化物燃料电池纳米复合阴极界面的重要性

Exploration (Beijing, China) Pub Date : 2024-02-01 DOI: 10.1002/EXP.20230082

Yanru Yin, Yifan Wang, Nan Yang, Lei Bi

{"title":"Unveiling the importance of the interface in nanocomposite cathodes for proton-conducting solid oxide fuel cells","authors":"Yanru Yin, Yifan Wang, Nan Yang, Lei Bi","doi":"10.1002/EXP.20230082","DOIUrl":"10.1002/EXP.20230082","url":null,"abstract":"Designing a high-performance cathode is essential for the development of proton-conducting solid oxide fuel cells (H-SOFCs), and nanocomposite cathodes have proven to be an effective means of achieving this. However, the mechanism behind the nanocomposite cathodes' remarkable performance remains unknown. Doping the Co element into BaZrO3 can result in the development of BaCoO3 and BaZr0.7Co0.3O3 nanocomposites when the doping concentration exceeds 30%, according to the present study. The construction of the BaCoO3/BaZr0.7Co0.3O3 interface is essential for the enhancement of the cathode catalytic activity, as demonstrated by thin-film studies using pulsed laser deposition to simulate the interface of the BCO and BZCO individual particles and first-principles calculations to predict the oxygen reduction reaction steps. Eventually, the H-SOFC with a BaZr0.4Co0.6O3 cathode produces a record-breaking power density of 2253 mW cm−2 at 700°C.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139826949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedicine-medical “snack community”-PHS ecosystem: Insights into the double-edged sword role of telemedicine in clinical practice and medical education during the COVID-19 pandemic and beyond 远程医疗--医疗 "零食社区"--PHS 生态系统：洞察远程医疗在 COVID-19 大流行期间及之后的临床实践和医学教育中的双刃剑作用

Exploration (Beijing, China) Pub Date : 2024-01-23 DOI: 10.1002/EXP.20230111

Dechao Feng, Xu Shi, Jie Wang, Liying Zhang, Yuhan Xiao, Dengxiong Li, Ruicheng Wu, Wuran Wei, Akira Miyamoto, Koo Han Yoo, Xing Ye, Chi Zhang, Ping Han

{"title":"Telemedicine-medical “snack community”-PHS ecosystem: Insights into the double-edged sword role of telemedicine in clinical practice and medical education during the COVID-19 pandemic and beyond","authors":"Dechao Feng, Xu Shi, Jie Wang, Liying Zhang, Yuhan Xiao, Dengxiong Li, Ruicheng Wu, Wuran Wei, Akira Miyamoto, Koo Han Yoo, Xing Ye, Chi Zhang, Ping Han","doi":"10.1002/EXP.20230111","DOIUrl":"10.1002/EXP.20230111","url":null,"abstract":"Telemedicine has gained tremendous development during the COVID-19 pandemic. With deblocking and opening, telemedicine accelerates the evolvution of the medical “snack community” and undermines the perception of medical students and staff, which promotes the incidence of psychosocial-related disorders. Moreover, the inconsistent telemedicine adaptability between medical workers and patients aggravates the doctor–patient conflict due to the aging population and COVID-19 squeal. Telemedicine is colliding with the national healthcare system, whose synchronization with conventional medical service is crucial to coordinate the relationship among medical payment, patient privacy and qualifications of clinicians. This study puts more emphasis on the double-edged sword role of telemedicine in clinical practice and medical education during the COVID-19 pandemic and beyond. Overall, while telemedicine has demonstrated its utility in health care throughout the COVID pandemic, it is pretty critical to continue evaluating the efficacy and limitations of telemedicine in order to maintain equal access to medical service and high-quality medical education. A new concept as telemedicine-medical “snack community”-PHS ecosystem, where the psychological health education system and partners healthcare system with enough bandwidth, especially 5G technology, could optimize the effect of telemedicine on medical practice and education, is proposed.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139602817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in quantitative analysis of self-assembled peptides 自组装肽定量分析的最新进展

Exploration (Beijing, China) Pub Date : 2024-01-23 DOI: 10.1002/EXP.20230064

Xiaoyao Cai, Wei Xu, Chunhua Ren, Liping Zhang, Congrou Zhang, Jianfeng Liu, Cuihong Yang

{"title":"Recent progress in quantitative analysis of self-assembled peptides","authors":"Xiaoyao Cai, Wei Xu, Chunhua Ren, Liping Zhang, Congrou Zhang, Jianfeng Liu, Cuihong Yang","doi":"10.1002/EXP.20230064","DOIUrl":"10.1002/EXP.20230064","url":null,"abstract":"Self-assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. Over the past decades, substantial progress and breakthroughs have been made in designing self-assembled peptides with multifaceted biomedical applications. The techniques for quantitative analysis, including imaging-based quantitative techniques, chromatographic technique and computational approach (molecular dynamics simulation), are becoming powerful tools for exploring the structure, properties, biomedical applications, and even supramolecular assembly processes of self-assembled peptides. However, a comprehensive review concerning these quantitative techniques remains scarce. In this review, recent progress in techniques for quantitative investigation of biostability, cellular uptake, biodistribution, self-assembly behaviors of self-assembled peptide etc., are summarized. Specific applications and roles of these techniques are highlighted in detail. Finally, challenges and outlook in this field are concluded. It is believed that this review will provide technical guidance for researchers in the field of peptide-based materials and pharmaceuticals, and facilitate related research for newcomers in this field.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioimaging and prospects of night pearls-based persistence phosphors in cancer diagnostics 生物成像和夜明珠持久性荧光粉在癌症诊断中的应用前景

Exploration (Beijing, China) Pub Date : 2024-01-23 DOI: 10.1002/EXP.20230124

Ruipu Shang, Feifei Yang, Ge Gao, Yu Luo, Hongpeng You, Lile Dong

{"title":"Bioimaging and prospects of night pearls-based persistence phosphors in cancer diagnostics","authors":"Ruipu Shang, Feifei Yang, Ge Gao, Yu Luo, Hongpeng You, Lile Dong","doi":"10.1002/EXP.20230124","DOIUrl":"10.1002/EXP.20230124","url":null,"abstract":"Inorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With the prominent advantages of near-infrared light, such as deep penetration, high resolution, low autofluorescence, and tissue absorption, persistent phosphors can be used for deep bioimaging. We focus on highlighting inorganic persistent phosphors, emphasizing the synthesis methods and applications in cancer diagnostics. Typical synthetic methods such as the high-temperature solid state, thermal decomposition, hydrothermal/solvothermal, and template methods are proposed to obtain small-size phosphors for biological organisms. The luminescence mechanisms of inorganic persistent phosphors with different excitation are discussed and effective matrixes including galliumate, germanium, aluminate, and fluoride are explored. Finally, the current directions where inorganic persistent phosphors can continue to be optimized and how to further overcome the challenges in cancer diagnosis are summarized.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139604332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0