Exploration (Beijing, China)最新文献

{"title":"From structural design to delivery: mRNA therapeutics for cancer immunotherapy","authors":"Feng Zhou,&nbsp;Lujia Huang,&nbsp;Shiqin Li,&nbsp;Wenfang Yang,&nbsp;Fangmin Chen,&nbsp;Zhixiong Cai,&nbsp;Xiaolong Liu,&nbsp;Wujun Xu,&nbsp;Vesa-Pekka Lehto,&nbsp;Ulrich Lächelt,&nbsp;Rongqin Huang,&nbsp;Yang Shi,&nbsp;Twan Lammers,&nbsp;Wei Tao,&nbsp;Zhi Ping Xu,&nbsp;Ernst Wagner,&nbsp;Zhiai Xu,&nbsp;Haijun Yu","doi":"10.1002/EXP.20210146","DOIUrl":"10.1002/EXP.20210146","url":null,"abstract":"<p>mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in accordance with their superiority in expressing all sequence-known proteins in vivo. In particular, with a small dosage of delivered mRNA, antigen-presenting cells (APCs) can synthesize mutant neo-antigens and multi-antigens and present epitopes to T lymphocytes to elicit antitumor effects. In addition, expressing receptors like chimeric antigen receptor (CAR), T-cell receptor (TCR), CD134, and immune-modulating factors including cytokines, interferons, and antibodies in specific cells can enhance immunological response against tumors. With the maturation of in vitro transcription (IVT) technology, large-scale and pure mRNA encoding specific proteins can be synthesized quickly. However, the clinical translation of mRNA-based anticancer strategies is restricted by delivering mRNA into target organs or cells and the inadequate endosomal escape efficiency of mRNA. Recently, there have been some advances in mRNA-based cancer immunotherapy, which can be roughly classified as modifications of the mRNA structure and the development of delivery systems, especially the lipid nanoparticle platforms. In this review, the latest strategies for overcoming the limitations of mRNA-based cancer immunotherapies and the recent advances in delivering mRNA into specific organs and cells are summarized. Challenges and opportunities for clinical applications of mRNA-based cancer immunotherapy are also discussed.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20210146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139264710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumour-microenvironment-responsive Na2S2O8 nanocrystals encapsulated in hollow organosilica–metal–phenolic networks for cycling persistent tumour-dynamic therapy","authors":"Yang Li,&nbsp;Jinyan Lin,&nbsp;Yueyang He,&nbsp;Kaiyuan Wang,&nbsp;Cailin Huang,&nbsp;Ruifeng Zhang,&nbsp;Xiaolong Liu","doi":"10.1002/EXP.20230054","DOIUrl":"10.1002/EXP.20230054","url":null,"abstract":"<p>Traditional tumour-dynamic therapy still inevitably faces the critical challenge of limited reactive oxygen species (ROS)-generating efficiency due to tumour hypoxia, extreme pH condition for Fenton reaction, and unsustainable mono-catalytic reaction. To fight against these issues, we skilfully develop a tumour-microenvironment-driven yolk-shell nanoreactor to realize the high-efficiency persistent dynamic therapy via cascade-responsive dual cycling amplification of •SO₄⁻/•OH radicals. The nanoreactor with an ultrahigh payload of free radical initiator is designed by encapsulating the Na₂S₂O₈ nanocrystals into hollow tetra-sulphide-introduced mesoporous silica (HTSMS) and afterward enclosed by epigallocatechin gallate (EG)-Fe(II) cross-linking. Within the tumour microenvironment, the intracellular glutathione (GSH) can trigger the tetra-sulphide cleavage of nanoreactors to explosively release Na⁺/S₂O₈²<b>⁻</b>/Fe²⁺ and EG. Then a sequence of cascade reactions will be activated to efficiently generate •SO₄⁻ (Fe²⁺-catalyzed S₂O₈²<b>⁻</b> oxidation), proton (•SO₄⁻-catalyzed H₂O decomposition), and •OH (proton-intensified Fenton oxidation). Synchronously, the oxidation-generated Fe³⁺ will be in turn recovered into Fe²⁺ by excessive EG to circularly amplify •SO₄⁻/•OH radicals. The nanoreactors can also disrupt the intracellular osmolarity homeostasis by Na⁺ overload and weaken the ROS-scavenging systems by GSH exhaustion to further amplify oxidative stress. Our yolk–shell nanoreactors can efficiently eradicate tumours via multiple oxidative stress amplification, which will provide a perspective to explore dynamic therapy.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the improvement mechanism of plasma etching treatment on oxygen reduction reaction catalysts","authors":"Peng Rao,&nbsp;Yanhui Yu,&nbsp;Shaolei Wang,&nbsp;Yu Zhou,&nbsp;Xiao Wu,&nbsp;Ke Li,&nbsp;Anyuan Qi,&nbsp;Peilin Deng,&nbsp;Yonggang Cheng,&nbsp;Jing Li,&nbsp;Zhengpei Miao,&nbsp;Xinlong Tian","doi":"10.1002/EXP.20230034","DOIUrl":"10.1002/EXP.20230034","url":null,"abstract":"<p>Plasma etching treatment is an effective strategy to improve the electrocatalytic activity, but the improvement mechanism is still unclear. In this work, a nitrogen-doped carbon nanotube-encased iron nanoparticles (Fe@NCNT) catalyst is synthesized as the model catalyst, followed by plasma etching treatment with different parameters. The electrocatalytic activity improvement mechanism of the plasma etching treatment is revealed by combining the physicochemical characterizations and electrochemical results. As a result, highly active metal–nitrogen species introduced by nitrogen plasma etching treatment are recognized as the main contribution to the improved electrocatalytic activity, and the defects induced by plasma etching treatment also contribute to the improvement of the electrocatalytic activity. In addition, the prepared catalyst also demonstrates superior ORR activity and stability than the commercial Pt/C catalyst.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed initiation and enhancement of cGAS/STING pathway for tumour immunotherapy via tailor-designed ZnFe2O4-based nanosystem","authors":"Jing Yang,&nbsp;Yuping He,&nbsp;Meng Zhang,&nbsp;Chenglin Liang,&nbsp;Tongtong Li,&nbsp;Tianjiao Ji,&nbsp;Mali Zu,&nbsp;Xu Ma,&nbsp;Zhenzhong Zhang,&nbsp;Chun Liang,&nbsp;Qixu Zhang,&nbsp;Youbai Chen,&nbsp;Lin Hou","doi":"10.1002/EXP.20230061","DOIUrl":"10.1002/EXP.20230061","url":null,"abstract":"<p>The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signalling pathway has been a promising target for anticancer immunity, but rationally activating and enhancing this pathway in tumour cells is critical. Herein, a glutathione sensitive ZnFe₂O₄-based nanosystem is developed to programmatically initiate and enhance the STING signalling pathway in tumour cells. The prepared ZnFe₂O₄ nanoparticles were coated with cancer cell membrane (CCM), which enabled the nanosystem target tumour cells. In tumour cells, ZnFe₂O₄ nanoparticles could be disintegrated by responding to high level glutathione, and the released Fe³⁺ generated reactive oxygen species to induce the DNA leakage into the cytoplasm to stimulate cGAS. Then Zn²⁺ promoted cGAS-DNA phase separation to intensify the cGAS enzymatic activity. In addition, the low dose encapsulation of paclitaxel (PTX) acting as an antimitotic agent (ZnFe₂O₄-PTX@CCM) ensured the sustained activation of cGAS/STING pathway. The in vitro and in vivo results confirmed that ZnFe₂O₄-PTX@CCM elevated the cGAS/STING activity, promoted dendritic cell maturation, increased cytotoxic T lymphocyte and natural killer cells infiltration, eventually inhibiting the tumour progress and postoperative recurrence. This study provided feasible references on constructing STING activation nanosystem for tumour immunotherapy.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durable superhydrophobic surface in wearable sensors: From nature to application","authors":"Ziyi Dai,&nbsp;Ming Lei,&nbsp;Sen Ding,&nbsp;Qian Zhou,&nbsp;Bing Ji,&nbsp;Mingrui Wang,&nbsp;Bingpu Zhou","doi":"10.1002/EXP.20230046","DOIUrl":"10.1002/EXP.20230046","url":null,"abstract":"<p>The current generation of wearable sensors often experiences signal interference and external corrosion, leading to device degradation and failure. To address these challenges, the biomimetic superhydrophobic approach has been developed, which offers self-cleaning, low adhesion, corrosion resistance, anti-interference, and other properties. Such surfaces possess hierarchical nanostructures and low surface energy, resulting in a smaller contact area with the skin or external environment. Liquid droplets can even become suspended outside the flexible electronics, reducing the risk of pollution and signal interference, which contributes to the long-term stability of the device in complex environments. Additionally, the coupling of superhydrophobic surfaces and flexible electronics can potentially enhance the device performance due to their large specific surface area and low surface energy. However, the fragility of layered textures in various scenarios and the lack of standardized evaluation and testing methods limit the industrial production of superhydrophobic wearable sensors. This review provides an overview of recent research on superhydrophobic flexible wearable sensors, including the fabrication methodology, evaluation, and specific application targets. The processing, performance, and characteristics of superhydrophobic surfaces are discussed, as well as the working mechanisms and potential challenges of superhydrophobic flexible electronics. Moreover, evaluation strategies for application-oriented superhydrophobic surfaces are presented.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in implantable neural links based on organic synaptic transistors","authors":"Swarup Biswas,&nbsp;Hyo-won Jang,&nbsp;Yongju Lee,&nbsp;Hyojeong Choi,&nbsp;Yoon Kim,&nbsp;Hyeok Kim,&nbsp;Yangzhi Zhu","doi":"10.1002/EXP.20220150","DOIUrl":"10.1002/EXP.20220150","url":null,"abstract":"<p>The progress of brain synaptic devices has witnessed an era of rapid and explosive growth. Because of their integrated storage, excellent plasticity and parallel computing, and system information processing abilities, various field effect transistors have been used to replicate the synapses of a human brain. Organic semiconductors are characterized by simplicity of processing, mechanical flexibility, low cost, biocompatibility, and flexibility, making them the most promising materials for implanted brain synaptic bioelectronics. Despite being used in numerous intelligent integrated circuits and implantable neural linkages with multiple terminals, organic synaptic transistors still face many obstacles that must be overcome to advance their development. A comprehensive review would be an excellent tool in this respect. Therefore, the latest advancements in implantable neural links based on organic synaptic transistors are outlined. First, the distinction between conventional and synaptic transistors are highlighted. Next, the existing implanted organic synaptic transistors and their applicability to the brain as a neural link are summarized. Finally, the potential research directions are discussed.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20220150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135433426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular imaging of tumour-associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”","authors":"Peisen Zhang,&nbsp;Wenyue Li,&nbsp;Chuang Liu,&nbsp;Feng Qin,&nbsp;Yijie Lu,&nbsp;Meng Qin,&nbsp;Yi Hou","doi":"10.1002/EXP.20230070","DOIUrl":"10.1002/EXP.20230070","url":null,"abstract":"<p>Although the extraordinary progress has been made in molecular biology, the prevention of cancer remains arduous. Most solid tumours exhibit both spatial and temporal heterogeneity, which is difficult to be mimicked in vitro. Additionally, the complex biochemical and immune features of tumour microenvironment significantly affect the tumour development. Molecular imaging aims at the exploitation of tumour-associated molecules as specific targets of customized molecular probe, thereby generating image contrast of tumour markers, and offering opportunities to non-invasively evaluate the pathological characteristics of tumours in vivo. Particularly, there are no “standard markers” as control in clinical imaging diagnosis of individuals, so the tumour pathological characteristics-responsive nanoprobe-based quantitative molecular imaging, which is able to visualize and determine the accurate content values of heterogeneous distribution of pathological molecules in solid tumours, can provide criteria for cancer diagnosis. In this context, a variety of “smart” quantitative molecular imaging nanoprobes have been designed, in order to provide feasible approaches to quantitatively visualize the tumour-associated pathological molecules in vivo. This review summarizes the recent achievements in the designs of these nanoprobes, and highlights the state-of-the-art technologies in quantitative imaging of tumour-associated pathological molecules.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136158569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling of a puzzling dual ionic migration in lead- and iodide-deficient halide perovskites (d-HPs) and its impact on solar cell J–V curve hysteresis","authors":"Liam Gollino,&nbsp;Daming Zheng,&nbsp;Nicolas Mercier,&nbsp;Thierry Pauporté","doi":"10.1002/EXP.20220156","DOIUrl":"10.1002/EXP.20220156","url":null,"abstract":"<p>Halide perovskite solar cells are characterized by a hysteresis between current–voltage (<i>J</i>–<i>V)</i> curves recorded on the reverse and on the forward scan directions, and the suppression of this phenomenon has focused great attention. In the present work, it is shown that a special family of 3D perovskites, that are rendered lead -and iodide- deficient (d-HPs) by incorporating large organic cations, are characterized by a large hysteresis. The strategy of passivating defects by K⁺, which has been successful in reducing the hysteresis of 3D perovskite perovskite solar cells, is inefficient with the d-HPs. By glow discharge optical emission spectroscopy (GD-OES), the existence of the classic iodide migration in these layers is unveiled, which is efficiently blocked by potassium cation insertion. However, it is also shown that it co-exists with the migration of the large organic cations characteristics of d-HPs which are not blocked by the alkali metal ion. The migration of those large cations is intrinsically linked to the special structure of the d-HP. It is suggested that it takes place through channels, present throughout the whole perovskite layer after the substitution of PbI⁺ units by the large cations, making this phenomenon intrinsic to the original structure of d-HPs.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20220156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135618742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced membrane-based electrode engineering toward efficient and durable water electrolysis and cost-effective seawater electrolysis in membrane electrolyzers","authors":"Jiayi Tang,&nbsp;Chao Su,&nbsp;Zongping Shao","doi":"10.1002/EXP.20220112","DOIUrl":"10.1002/EXP.20220112","url":null,"abstract":"<p>Researchers have been seeking for the most technically-economical water electrolysis technology for entering the next-stage of industrial amplification for large-scale green hydrogen production. Various membrane-based electrolyzers have been developed to improve electric-efficiency, reduce the use of precious metals, enhance stability, and possibly realize direct seawater electrolysis. While electrode engineering is the key to approaching these goals by bridging the gap between catalysts design and electrolyzers development, nevertheless, as an emerging field, has not yet been systematically analyzed. Herein, this review is organized to comprehensively discuss the recent progresses of electrode engineering that have been made toward advanced membrane-based electrolyzers. For the commercialized or near-commercialized membrane electrolyzer technologies, the electrode material design principles are interpreted and the interface engineering that have been put forward to improve catalytic sites utilization and reduce precious metal loading is summarized. Given the pressing issues of electrolyzer cost reduction and efficiency improvement, the electrode structure engineering toward applying precious metal free electrocatalysts is highlighted and sufficient accessible sites within the thick catalyst layers with rational electrode architectures and effective ions/mass transport interfaces are enabled. In addition, this review also discusses the innovative ways as proposed to break the barriers of current membrane electrolyzers, including the adjustments of electrode reaction environment, and the feasible cell-voltage-breakdown strategies for durable direct seawater electrolysis. Hopefully, this review may provide insightful information of membrane-based electrode engineering and inspire the future development of advanced membrane electrolyzer technologies for cost-effective green hydrogen production.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20220112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135618003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment (EXP2 5/2023)","authors":"Guoyin Li,&nbsp;Zewen Song,&nbsp;Yi Ru,&nbsp;Jing Zhang,&nbsp;Lianxiang Luo,&nbsp;Wei Yang,&nbsp;Hao Wu,&nbsp;Haibao Jin,&nbsp;Xuanwen Bao,&nbsp;Di Wei,&nbsp;Zhao Yan,&nbsp;Haijing Qu,&nbsp;Zheng Zhu,&nbsp;Gang Zhou","doi":"10.1002/EXP.20230503","DOIUrl":"https://doi.org/10.1002/EXP.20230503","url":null,"abstract":"<p>Overexpression of the EGFR is found in up to 74% of bladder cancer tissue. Two natural products that were found, triptolide (represented by lightning) and hesperidin (represented by orange), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles (represented by oranges containing lightning), which not only remarkably improved their bioavailability and therapeutic but also reduced their systemic toxicity.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50136445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}