Advancements and challenges in brain cancer therapeutics

Fan Bai, Yueyang Deng, Long Li, Ming Lv, Jamoliddin Razzokov, Qingnan Xu, Zhen Xu, Zhaowei Chen, Guojun Chen, Zhitong Chen
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Abstract

Treating brain tumors requires a nuanced understanding of the brain, a vital and delicate organ. Location, size, tumor type, and surrounding tissue health are crucial in developing treatment plans. This review comprehensively summarizes various treatment options that are available or could be potentially available for brain tumors, including physical therapies (radiotherapy, ablation therapy, photodynamic therapy, tumor-treating field therapy, and cold atmospheric plasma therapy) and non-physical therapies (surgical resection, chemotherapy, targeted therapy, and immunotherapy). Mechanisms of action, potential side effects, indications, and latest developments, as well as their limitations, are highlighted. Furthermore, the requirements for personalized, multi-modal treatment approaches in this rapidly evolving field are discussed, emphasizing the balance between efficacy and patient safety.

Abstract Image

脑癌疗法的进展与挑战
治疗脑肿瘤需要对大脑这一重要而脆弱的器官有细致入微的了解。位置、大小、肿瘤类型和周围组织健康状况对制定治疗方案至关重要。本综述全面总结了脑肿瘤现有或潜在的各种治疗方案,包括物理疗法(放射治疗、消融治疗、光动力疗法、肿瘤治疗场疗法和冷大气等离子体疗法)和非物理疗法(手术切除、化疗、靶向治疗和免疫疗法)。重点介绍了这些疗法的作用机制、潜在副作用、适应症、最新进展及其局限性。此外,还讨论了这一快速发展领域对个性化、多模式治疗方法的要求,强调了疗效与患者安全之间的平衡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
17.20
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