Exploration (Beijing, China)最新文献

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Unveiling Structure-Activity Relationship With Structurally Defined and Stabilized Cu-Based Molecular Hybrid Electrocatalysts in CO2 Electroreduction. 揭示结构明确和稳定的cu基分子杂化电催化剂在CO2电还原中的构效关系。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-13 DOI: 10.1002/exp2.70231
Jian-Hao Wu, Zhi-Mei Luo, Rong-Jie Guo, Jia-Wei Wang, Bingbao Mei, Fu-Jun Niu, Lie-Jin Guo, Gangfeng Ouyang
{"title":"Unveiling Structure-Activity Relationship With Structurally Defined and Stabilized Cu-Based Molecular Hybrid Electrocatalysts in CO<sub>2</sub> Electroreduction.","authors":"Jian-Hao Wu, Zhi-Mei Luo, Rong-Jie Guo, Jia-Wei Wang, Bingbao Mei, Fu-Jun Niu, Lie-Jin Guo, Gangfeng Ouyang","doi":"10.1002/exp2.70231","DOIUrl":"10.1002/exp2.70231","url":null,"abstract":"<p><p>Deciphering the structure-activity relationship on Cu-based electrocatalysts is critical to rationally optimize their performances in CO<sub>2</sub> to multicarbon (C<sub>2+</sub>) conversion, which nonetheless remains highly challenging due to their ill-defined and electrochemically unstable structures. Herein, this study explores Cu-based molecular hybrids with defined structures to establish structure-activity relationships in CO<sub>2</sub>-C<sub>2+</sub> electrocatalysis, where a Ni(II) phthalocyanine anchored on Cu<sub>2</sub>O nanocubes via 2-(3-thienyl)ethoxy groups outperforms its Co(II) analog and unmodified prototype in C<sub>2+</sub> synthesis (78.3% selectivity, 330 mA<sup>.</sup>cm<sup>-2</sup>), rivaling top catalysts. Structural analysis revealed the functional 2-(3-thienyl)ethoxy anchors pose superior Cu<sub>2</sub>O affinity to retain the Cu(I) structure and the grafted metal phthalocyanines during catalysis. Such stabilized and well-defined catalyst structures enable the structure-activity relationship unveiled by in situ spectroscopies and theoretical calculations. The results show that the synergy between the molecular metal centers and surface Cu atoms fine-tunes the energy barriers for both CO transfer and *OCCO hydrogenation, which are minimized by the optimal Cu-S-Ni coordination endowing abundant Cu(I)Cu(0)-paired active sites with an electron-rich Ni center. This work demonstrates the essential role of metal-ligand cooperativity in C-C coupling and successfully bridges mechanistic insights with catalyst design for efficient CO<sub>2</sub>-C<sub>2+</sub> conversion.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70231"},"PeriodicalIF":22.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to Break Through the Ceiling of Scientific Progress?-Innovation Challenges and Pathways Based on the Fitness Landscape Framework. 如何突破科学进步的天花板?-基于健身景观框架的创新挑战与路径。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-13 DOI: 10.1002/exp2.70225
Kunjie Zhu, Li Sun, Peng Du
{"title":"How to Break Through the Ceiling of Scientific Progress?-Innovation Challenges and Pathways Based on the Fitness Landscape Framework.","authors":"Kunjie Zhu, Li Sun, Peng Du","doi":"10.1002/exp2.70225","DOIUrl":"10.1002/exp2.70225","url":null,"abstract":"<p><p>Science has not hit an absolute ceiling; it is stranded on a local peak. Viewed through Wright's fitness landscape, today's evaluation and funding systems over-select, refining work within established paradigms while suppressing the drift and recombination needed to cross fitness valleys. Restoring room for non-consensus, curiosity-driven and interdisciplinary research is an institutional task as much as an intellectual one.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70225"},"PeriodicalIF":22.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond. 改变人工智能时代药物创新的格局:AlphaFold 3及以后。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-11 DOI: 10.1002/exp2.70236
Songlin He, Liangbin Zhou, Xiaoshuai Wang, Chenzhong Li, Cheng Jiang, Rocky S Tuan, Zhong Alan Li
{"title":"Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond.","authors":"Songlin He, Liangbin Zhou, Xiaoshuai Wang, Chenzhong Li, Cheng Jiang, Rocky S Tuan, Zhong Alan Li","doi":"10.1002/exp2.70236","DOIUrl":"https://doi.org/10.1002/exp2.70236","url":null,"abstract":"<p><p>The traditional drug discovery and development (DDD) pipeline has long been characterized by inefficiency and high costs. The rapid evolution of artificial intelligence (AI), especially AI-based toolkits for protein structure and interaction prediction, exemplified by AlphaFold 3 (AF3), promises to reshape the landscape of drug innovation. AF3 advances structural biology by predicting protein structures and their interactions with a range of biomolecules, including nucleic acids, small-molecule ligands, and ions, potentially changing the conventional DDD paradigm, although prediction accuracy varies substantially across these categories. This perspective examines the impact of AF3 on drug target identification and validation, hit identification, lead optimization, and personalized clinical decision-making, while addressing the technical challenges, ethical considerations, and governance implications. Solutions to overcome current limitations are proposed to advance the development of novel therapeutics.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70236"},"PeriodicalIF":22.5,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset. 八子补肾方通过AMPK-Sirtuins轴激活和髓细胞重置逆转慢性应激性炎症。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-11 DOI: 10.1002/exp2.70235
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia
{"title":"Reversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.","authors":"Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia","doi":"10.1002/exp2.70235","DOIUrl":"https://doi.org/10.1002/exp2.70235","url":null,"abstract":"<p><p>Chronic stress potentially accelerates aging and increases age-related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12-month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significantly exacerbates systemic inflammation, causing widespread tissue damage and lifespan shortening. Integrated single-cell RNA sequencing analysis of multiple tissues suggests a common feature of lymphocyte reduction and myeloid cell expansion. The lungs and kidneys exhibited pronounced stress responses, including epigenetic dysregulation and mitochondrial dysfunction. Both β-nicotinamide mononucleotide (NMN) and compound medicine Bazi Bushen (BZBS) effectively alleviate the UCMS-induced aging phenotypes. BZBS restores immune system homeostasis and reduces stress/inflammation levels in various tissues. Bioactive compounds from BZBS constituents<i>-Schisandra chinensis (Turcz.) Baill. and Cnidium monnieri (L.) Cusson-</i>improved mitochondrial function via AMPK-SIRT-PGC-1α signaling activation. The present study underscores the importance of early intervention in chronic stress to prevent or delay age-related diseases, with significant implications for public health strategies aimed at healthy aging.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70235"},"PeriodicalIF":22.5,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Nitric Oxide-Based STING Agonist Nanoadjuvant With ICD-Derived Membrane Antigens Unleashes Robust Antitumor Immunity. 含icd衍生膜抗原的一氧化氮STING激动剂纳米佐剂释放出强大的抗肿瘤免疫。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-11 DOI: 10.1002/exp2.70238
Shuyu Xu, Yang Song, Tianjiao Zhang, Yan Wang, Mengxin Wang, Xinxin Xie, Qingfeng Chen, Xiaolong Liang
{"title":"A Nitric Oxide-Based STING Agonist Nanoadjuvant With ICD-Derived Membrane Antigens Unleashes Robust Antitumor Immunity.","authors":"Shuyu Xu, Yang Song, Tianjiao Zhang, Yan Wang, Mengxin Wang, Xinxin Xie, Qingfeng Chen, Xiaolong Liang","doi":"10.1002/exp2.70238","DOIUrl":"https://doi.org/10.1002/exp2.70238","url":null,"abstract":"<p><p>Despite significant advances in nanovaccine development, their efficacy remains hindered by poor antigen presentation, limited antigen repertoire, and suboptimal T cell priming. Immune adjuvants such as polyinosinic-polycytidylic acid (POLY(I:C)) exert antitumor effects by promoting dendritic cell (DC) maturation and stimulating innate immunity, but their efficacy is limited by poor antigen presenting cell (APC) uptake and weak CD8<sup>+</sup> T cell responses. Here, we propose a novel adjuvant strategy using nitric oxide (NO), a bioactive gaseous molecule, to upregulate MHC-I and enhance DC cross-presentation, thereby synergistically improving the adjuvant efficacy of POLY(I:C). We developed a nanovaccine, Im@NOnanoPL, by co-encapsulating a preassembled complex of DOTAP, NOC-18, and POLY(I:C) into a PLGA shell, which was further modified with DSPE-PEG<sub>2000</sub> and camouflaged with immunogenic cell death (ICD)-derived tumor membranes for broad-spectrum tumor antigen coverage. Im@NOnanoPL elicited robust and durable CD8<sup>+</sup> T cell responses, conferring near-complete prophylactic protection and, in combination with αPD-1 therapy, eradicating established tumors while inducing long-term immune memory. Im@NOnanoPL constitutes a novel vaccine platform that integrates a gas-based adjuvant with broad-spectrum antigens, exhibiting strong translational potential.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70238"},"PeriodicalIF":22.5,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells. 微/纳米结构材料和微流控诊断平台使循环肿瘤细胞的多模式检测成为可能。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-11 DOI: 10.1002/exp2.70239
Hao Li, Jiaojiao Sun, Kunguo Liu, Shijie Wang, Bowen Fu, Hong Zhu, Peng Cao, Xin Han
{"title":"Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells.","authors":"Hao Li, Jiaojiao Sun, Kunguo Liu, Shijie Wang, Bowen Fu, Hong Zhu, Peng Cao, Xin Han","doi":"10.1002/exp2.70239","DOIUrl":"https://doi.org/10.1002/exp2.70239","url":null,"abstract":"<p><p>Circulating tumor cells (CTCs), as pivotal targets in liquid biopsy, offer dynamic, multidimensional insights into tumor heterogeneity and metastatic progression. However, their extreme rarity, pronounced heterogeneity, and the complexity of the blood microenvironment severely constrain detection accuracy. Advances in micro/nanomaterials and functional device engineering have enabled substantial improvements in CTC enrichment efficiency by refining the topographical and chemical properties of capture interfaces. These innovations also provide a compatible foundation for multimodal molecular profiling. This review systematically outlines the structure-function relationships of functionalized nanomaterials, microfiltration substrates, and biomimetic microfluidic devices, highlighting how material parameters-such as nanoscale architectures and membrane pore sizes-govern CTC capture performance. We further explore the integration of micro/nanomaterials with functional platforms for multidimensional molecular analyses across DNA, RNA, and protein levels. Coupled with emerging digital PCR technologies, these systems show promise in overcoming the sensitivity barriers associated with rare mutation detection and protein quantification, enabling multi-omics data fusion. We also discuss how artificial intelligence (AI)-driven feature selection, clustering, and prediction integrate multidimensional data to decode tumor heterogeneity and guide disease monitoring. Despite rapid progress, key challenges remain-including the lack of standardization, limited integration of multi-omic datasets, and the need for robust clinical validation. Future directions may lie in the convergence of microfluidic-integrated materials, single-cell multi-omics, and AI-driven analytics to establish dynamic, high-resolution monitoring platforms that bridge the gap between fundamental research and clinical precision oncology.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70239"},"PeriodicalIF":22.5,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage. 可溶性纳米药物对抗可溶性神经致敏剂有效缓解骨关节炎疼痛和关节损伤。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-08 DOI: 10.1002/exp2.70233
Junyan Liu, Feixiang Ding, Jiayi Li, Min Liu, Lingyu Su, Zixi Wang, Congying Pi, Shilong Jiang, Zhaokui Zeng, Changjun Li, Chao Zeng, Guanghua Lei, Kelong Ai
{"title":"Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage.","authors":"Junyan Liu, Feixiang Ding, Jiayi Li, Min Liu, Lingyu Su, Zixi Wang, Congying Pi, Shilong Jiang, Zhaokui Zeng, Changjun Li, Chao Zeng, Guanghua Lei, Kelong Ai","doi":"10.1002/exp2.70233","DOIUrl":"https://doi.org/10.1002/exp2.70233","url":null,"abstract":"<p><p>Targeting soluble neurosensitizers in the osteoarthritis (OA) joint cavity is a key strategy for alleviating OA pain. Soluble neurosensitizers are ubiquitous in the joint cavity and cause uncontrollable growth and sensitization of nociceptor axons therein. However, eliminating these soluble nerve growth factors (NGFs) remains a considerable challenge due to the diversity of neurosensitizers and the complexity of OA pathology. This study introduces an innovative soluble nanodrug (LAC)-based strategy to eliminate three key neurosensitizers (H<sup>+</sup>, NGF, and netrin-1) to simultaneously relieve OA-associated pain and joint damage. In two animal model experiments, LAC significantly reduced pain and alleviated OA progression by reducing synovial inflammation and inhibiting cartilage and subchondral bone damage. This strategy of using soluble nanomedicine to counter soluble neurosensitizers not only provides inspiration for eliminating pain, but also sheds light on possible solutions for advancing OA treatment strategies.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70233"},"PeriodicalIF":22.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous Trigeminal Neurons Induce Schwann Differentiation of Donor Stem Cells in Dental Pulp Regeneration via Reciprocal Extracellular Vesicles Interplay. 内源性三叉神经细胞通过细胞外囊泡相互作用诱导供体干细胞在牙髓再生中的雪旺分化。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-08 DOI: 10.1002/exp2.70229
Wanmin Zhao, Wenzhe Wang, Jia Guo, Jiani Liu, Wei Wang, Dihao Tao, Jiayi Dong, Zhonghan Li, Shiyu Liu, Songtao Shi, Tao Chen, Yan Jin, Bei Li
{"title":"Endogenous Trigeminal Neurons Induce Schwann Differentiation of Donor Stem Cells in Dental Pulp Regeneration via Reciprocal Extracellular Vesicles Interplay.","authors":"Wanmin Zhao, Wenzhe Wang, Jia Guo, Jiani Liu, Wei Wang, Dihao Tao, Jiayi Dong, Zhonghan Li, Shiyu Liu, Songtao Shi, Tao Chen, Yan Jin, Bei Li","doi":"10.1002/exp2.70229","DOIUrl":"https://doi.org/10.1002/exp2.70229","url":null,"abstract":"<p><p>The potential of stem cells transplantation to restore organ function in recipients is hindered by the poor integration of donor cells into host tissues. Here, we successfully regenerated tooth pulp in the root canal of minipigs by transplanting human deciduous tooth stem cells (SHED). The implanted SHED differentiated into several functional cells, particularly Schwann cells (SCs), which attracted and enwrapped regrown host axons in regenerated pulp. The reciprocal extracellular vesicles (EVs) communication between SHED and the host trigeminal ganglion (TG) regulated the regeneration of dental nerves. EVs derived from SHED (SHED-EVs) facilitated axonal growth, while those released by TG neurons (TGN) induced the differentiation of SHED into SCs. TGN that engulfed SHED-EVs secreted endogenous EVs (ST-EVs) and migrated to the regenerated pulp tissue. ST-EVs from TGN are enriched with TUFM (Tu translation elongation factor, mitochondrial), which, in turn promotes Schwann cell differentiation (SC differentiation) of SHED. This study highlights the importance of cellular signal exchange during the integration of donor cells and host tissues for organ regeneration.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70229"},"PeriodicalIF":22.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cold-adapted Ligninolytic Nanozyme Unveiling New Horizons in Black Liquor Treatment Under Mild Condition. 冷适应木质素降解纳米酶在温和条件下处理黑液的新进展。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-07 DOI: 10.1002/exp2.70237
Qing Tian, Huile Liu, Yao Chen, Xiaohe Miao, Rong Yang, Yangjun Guo, Mato Knez, Xiyun Yan, Kelong Fan, Lianbing Zhang
{"title":"Cold-adapted Ligninolytic Nanozyme Unveiling New Horizons in Black Liquor Treatment Under Mild Condition.","authors":"Qing Tian, Huile Liu, Yao Chen, Xiaohe Miao, Rong Yang, Yangjun Guo, Mato Knez, Xiyun Yan, Kelong Fan, Lianbing Zhang","doi":"10.1002/exp2.70237","DOIUrl":"10.1002/exp2.70237","url":null,"abstract":"<p><p>Kraft black liquor, characterised by high lignin content, poses significant challenges for efficient treatment under mild conditions. This study unveils a pioneering solution via a novel cold-adapted ligninolytic nanozyme constructed from an amorphous manganese-containing metal-organic framework (aMnMOF). The aMnMOF features low-coordination Mn within mixed-valence trinuclear Mn-O clusters integrated with a long-range disordered MOF architecture. This unique design significantly lowered the reaction energy barrier of the rate-determining step to an exothermic process, endowing it with broad-spectrum oxidase-like activities over a wide temperature range (4°C-37°C) without additional oxidants. Based on these advancements, aMnMOF serves not only as a superior nanozyme for oxidative degradation of monomeric, dimeric and complex lignin compounds, but also as a sustainable pathway for real kraft black liquor treatment even under cold conditions, underscoring its superiority over existing methods. This innovative discovery not only advances the rational design of cold-adapted nanozymes but also provides a significant breakthrough in the field of industrial wastewater treatment.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70237"},"PeriodicalIF":22.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacting Fuelling Dynamics Towards Tunable Liquid Metal Machine. 影响可调液态金属机床的燃料动力学。
IF 22.5
Exploration (Beijing, China) Pub Date : 2026-10-06 DOI: 10.1002/exp2.70227
Jingyi Li, Minghui Guo, Ju Wang, Xi Zhao, Jing Liu
{"title":"Impacting Fuelling Dynamics Towards Tunable Liquid Metal Machine.","authors":"Jingyi Li, Minghui Guo, Ju Wang, Xi Zhao, Jing Liu","doi":"10.1002/exp2.70227","DOIUrl":"10.1002/exp2.70227","url":null,"abstract":"<p><p>Self-propelled liquid metal-aluminium hybrid machines represent a promising class of autonomous motion systems capable of sustained movement without external power sources. While interactions between machines and their environment inevitably occur, the fundamental question of how spatial confinement affects the motion dynamics and the controllability of speed, direction and lifetime of such liquid metal machines (LMMs) remains underexplored. Understanding these confined dynamics is essential for practical applications. Here, we present a comprehensive investigation of the non-symmetrical fuelling principle governing the direction-tuning effect in LMMs. By confining LMMs within one-dimensional semi-open channels, we thoroughly disclose their impact and turning dynamics with different end obstacles throughout their lifecycle, with particular focus on fuel region morphological evolution, overall motion and local flow characteristics after reaction times exceeding one hour. Utilising ultra-high-speed imaging techniques, we systematically clarify how fuel region evolution and end-obstacle interactions influence symmetry-breaking mechanisms and reciprocating dynamics. Our findings reveal complex interactions between material properties, charge transfer processes and fluid dynamics during end-turning processes, establishing a theoretical foundation for LMM driving dynamics. Beyond the theoretical mechanisms, we further demonstrate that LMM exhibits efficient heat and mass transfer capabilities, paving the way for applications in controlled transport systems and autonomous robotics.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":" ","pages":"70227"},"PeriodicalIF":22.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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