Exploration (Beijing, China)最新文献

{"title":"Front Cover: Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude (EXP2 4/2025)","authors":"Yongqiang Zhou,&nbsp;Zhexin Ni,&nbsp;Jingjing Liu,&nbsp;Dezhi Sun,&nbsp;Pan Shen,&nbsp;Xi Chen,&nbsp;Gaofu Li,&nbsp;Zhijie Bai,&nbsp;Yangyi Hu,&nbsp;Ningning Wang,&nbsp;Rui Wang,&nbsp;Lina Guan,&nbsp;Yihao Wang,&nbsp;Xianglin Tang,&nbsp;Yungang Lu,&nbsp;Baokun He,&nbsp;Haitao Lu,&nbsp;Wei Zhou,&nbsp;Yue Gao","doi":"10.1002/EXP.70081","DOIUrl":"https://doi.org/10.1002/EXP.70081","url":null,"abstract":"<p>Young individuals migrating to high altitudes exhibit varying susceptibilities to high-altitude heart disease, often triggered by maladaptation to hypobaric hypoxic environments. The migration to high-altitude plateaus significantly reshaped the gut microbiome and metabolome signatures. Lower abundances of <i>Veillonella rogosae</i>, <i>Streptococcus rubneri</i>, and gut microbiota-associated serum metabolites promoted the remodeling of metabolic processes, thereby increasing susceptibility to high-altitude heart health abnormalities.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces (EXP2 4/2025)","authors":"Yifei Ye,&nbsp;Ye Tian,&nbsp;Haifeng Liu,&nbsp;Jiaxuan Liu,&nbsp;Cunkai Zhou,&nbsp;Chengjian Xu,&nbsp;Ting Zhou,&nbsp;Yanyan Nie,&nbsp;Yu Wu,&nbsp;Lunming Qin,&nbsp;Zhitao Zhou,&nbsp;Xiaoling Wei,&nbsp;Jianlong Zhao,&nbsp;Zhenyu Wang,&nbsp;Meng Li,&nbsp;Tiger H. Tao,&nbsp;Liuyang Sun","doi":"10.1002/EXP.70079","DOIUrl":"https://doi.org/10.1002/EXP.70079","url":null,"abstract":"<p>This study introduces an ultraflexible electrode array enabling both neural recording and neuromodulation. The densely packed microelectrodes allow precise targeting of brain regions, with stimulating currents as low as 5 μA inducing mouse turning behavior. Additionally, the array is integrated into a brain-to-brain interface system, achieving over 95% accuracy in controlling turning behaviors of multiple mice using human brain signals.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning (EXP2 4/2025)","authors":"Changwu Wu,&nbsp;Fushu Luo,&nbsp;Yongye Zhu,&nbsp;Chunbo Liu,&nbsp;Zheng Chen,&nbsp;Xiangyu Wang,&nbsp;Jun Tan,&nbsp;Qing Liu","doi":"10.1002/EXP.70078","DOIUrl":"https://doi.org/10.1002/EXP.70078","url":null,"abstract":"<p>The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe-related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota. Further, the prognostic model based on machine learning and microbiota established in this study, namely microbe-related signature, could robustly predict prognosis of glioma and provide insights for immunotherapy benefits.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back Cover: MiR-29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation (EXP2 4/2025)","authors":"Yingying Lin,&nbsp;Yuqi Wang,&nbsp;Yuning Zhang,&nbsp;Yao Lu,&nbsp;Juan Chen,&nbsp;Yongting Luo,&nbsp;Jian He,&nbsp;Qingfeng Luo,&nbsp;Heng Quan,&nbsp;Weiru Yu,&nbsp;Yujia Luo,&nbsp;Peng Xue,&nbsp;Yi Xue,&nbsp;Xiaoya Lin,&nbsp;Rui Ding,&nbsp;Lining Chen,&nbsp;Yiran Wang,&nbsp;Zenghui Xia,&nbsp;Liang Zhao,&nbsp;Hao Zhang,&nbsp;Ran Wang,&nbsp;Qingyu Wang,&nbsp;Xifan Wang,&nbsp;Jiaqi Su,&nbsp;Fazheng Ren,&nbsp;Cong Lv,&nbsp;Yixuan Li,&nbsp;Huiyuan Guo","doi":"10.1002/EXP.70080","DOIUrl":"https://doi.org/10.1002/EXP.70080","url":null,"abstract":"<p>The wind from Sun Wukong's Banana Leaf Fan, like miR-29, suppresses the inflammatory activities of CD8+ T cells. This wind not only extinguishes the flames of inflammation but also cools the surrounding environment, creating a soothing microclimate that promotes healing and homeostasis.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Intelligent Bacteria-Targeting ZIF-8 Composite for Fluorescence Imaging-Guided Photodynamic Therapy of Drug-Resistant Superbug Infections and Burn Wound Healing\"","authors":"","doi":"10.1002/EXP.20250443","DOIUrl":"https://doi.org/10.1002/EXP.20250443","url":null,"abstract":"<p>X. Li, W. Wang, Q. Gao, et al., “Intelligent Bacteria-Targeting ZIF-8 Composite for Fluorescence Imaging-Guided Photodynamic Therapy of Drug-Resistant Superbug Infections and Burn Wound Healing,” <i>Exploration (Beijing, China)</i> 4, no. 6 (2024): 20230113. https://doi.org/10.1002/EXP.20230113.</p><p>The images in Figure 4G (skin photographs) and Figure 5C (bacterial plate—NPs group) were erroneously utilized. The authors identified these inaccuracies and have provided the corrected versions of Figures 4G and 5C below:</p><p>We apologize for this error.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20250443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back Cover: Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia (EXP2 3/2025)","authors":"Jialei Yang,&nbsp;Shipo Wu,&nbsp;Miao He","doi":"10.1002/EXP.70059","DOIUrl":"https://doi.org/10.1002/EXP.70059","url":null,"abstract":"<p>The blue-purple flowers on the tree represent p21⁺CD86⁺ microglia in the ischemic region, which secrete pro-inflammatory factors after stroke. The bird symbolizes the therapeutic use of engineered exosomes loaded with Quercetin (Que@micro-Exo), designed to target and eliminate these pathogenic microglia. The gathering of birds forming the tree's roots represents the intravenous administration of Que@micro-Exo, highlighting its potential to promote functional recovery by clearing p21⁺CD86⁺ microglia.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Understanding the Engineering Tactics to Achieve the Stabilized Anode in Next-Generation Zn-Air Batteries (EXP2 3/2025)","authors":"Subramani Surendran,&nbsp;Yoongu Lim,&nbsp;Seona Lee,&nbsp;Sebastian Cyril Jesudass,&nbsp;Gnanaprakasam Janani,&nbsp;Heechae Choi,&nbsp;Gibum Kwon,&nbsp;Kyoungsuk Jin,&nbsp;Uk Sim","doi":"10.1002/EXP.70060","DOIUrl":"https://doi.org/10.1002/EXP.70060","url":null,"abstract":"<p>In article 20240054, Prof. Kyoungsuk Jin and Prof. Uk sim et al. present a comprehensive overview of engineering strategies for anode stabilization to enhance efficiency and longevity in next-generation zinc-air batteries. This review is intended for a broad audience, from novice researchers to industry professionals, and provides valuable guidance, offering key insights to accelerate advancements in zinc-air battery technology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Back Cover: Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges (EXP2 3/2025)","authors":"Xiuxin Yin,&nbsp;Zhili Zhang,&nbsp;Fengfeng Li,&nbsp;Maoqing Fu,&nbsp;Tianci Qin,&nbsp;Xingxiang Ji,&nbsp;Yuanyuan Wang,&nbsp;Zhiwen Wang,&nbsp;Shaolong Sun","doi":"10.1002/EXP.70062","DOIUrl":"https://doi.org/10.1002/EXP.70062","url":null,"abstract":"<p>This cover artfully intertwines dendritic foliage and radial tree rings with lignin's molecular architectures, symbolizing nature-derived carbon precursors. Fluorescent accents illuminate emergent blue CQDs clusters, visualizing their photonic applications. The interplay of organic motifs and geometric patterns mirrors this structured review - dissecting lignin-derived quantum dots' transformative potential while critically examining scalability hurdles in sustainable nanotechnology development.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Cover: Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies (EXP2 3/2025)","authors":"Yuhan Du,&nbsp;Yujie Liu,&nbsp;Yuanchi Zhang,&nbsp;Yangyi Nie,&nbsp;Zili Xu,&nbsp;Ling Qin,&nbsp;Wei Zhang,&nbsp;Yuxiao Lai","doi":"10.1002/EXP.70061","DOIUrl":"https://doi.org/10.1002/EXP.70061","url":null,"abstract":"<p>On the cover: Nezha paints a multi-dimensional scroll of the bionic periosteum: haphazard fibers evolve into orderly ridges, dotted with stardust-like nanoscale particles that spark regenerative activity; bilayers stack like a dense forest, providing structural support and controlled release; hydrogel flows like an ocean, enriched with active particles—together, they create a dynamic microenvironment that synergistically drives bone regeneration.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude","authors":"Yongqiang Zhou,&nbsp;Zhexin Ni,&nbsp;Jingjing Liu,&nbsp;Dezhi Sun,&nbsp;Pan Shen,&nbsp;Xi Chen,&nbsp;Gaofu Li,&nbsp;Zhijie Bai,&nbsp;Yangyi Hu,&nbsp;Ningning Wang,&nbsp;Rui Wang,&nbsp;Lina Guan,&nbsp;Yihao Wang,&nbsp;Xianglin Tang,&nbsp;Yungang Lu,&nbsp;Baokun He,&nbsp;Haitao Lu,&nbsp;Wei Zhou,&nbsp;Yue Gao","doi":"10.1002/EXP.20240332","DOIUrl":"https://doi.org/10.1002/EXP.20240332","url":null,"abstract":"<p>Young migrants, particularly those at high altitudes, are predisposed to heart health abnormalities, including high-altitude heart disease. Despite the profound impact of hypobaric hypoxia on the gut microbial community, the understanding of the roles played by gut microbiota and gut microbiota-associated serum metabolites in high-altitude heart diseases remains limited. Therefore, we conducted a comprehensive multi-omics analysis involving 230 graduates from the same university, with 163 Tibetan Plateau migrants and 67 Chengdu Plain residents, and identified 206 differential metabolites (82 in serum and 124 in feces) and 369 species that differed between migrants and residents. Among these, 27 microbial species and four metabolites (Ketoglutaric acid, L-Aspartic acid, 3-Guanidinopropionic acid, betaine) detected in both serum and feces were found to be associated with migrants exhibiting compromised heart health, as diagnosed through clinical examinations. Notably, the abundances of <i>Veillonella rogosae</i> and <i>Streptococcus rubneri</i> were correlated with serum levels of L-Aspartic acid, betaine, and Ketoglutaric acid in heart health-abnormal individuals. Validation of these microbiome biomarkers and gut microbiota-associated serum metabolites in an independent cohort demonstrated their excellent predictive ability for indicating heart health abnormalities in migrants (AUC = 0.7857). Furthermore, supplementation with these identified species or gut microbiota-associated serum metabolites effectively mitigated hypobaric hypoxia-induced increases in serum lactate, glycolysis, myocardial damage, and cardiac hypertrophy. Integrated analysis revealed that the alterations in the gut microbiome negatively regulated key metabolic pathways such as the malate-aspartate shuttle, tricarboxylic acid cycle, and oxidative phosphorylation in heart health-abnormal individuals. The migration to high-altitude plateaus significantly reshaped the gut microbiome and metabolome signatures. Lower abundances of <i>Veillonella rogosae</i>, <i>Streptococcus rubneri</i>, and gut microbiota-associated serum metabolites promoted the remodeling of metabolic processes, thereby increasing susceptibility to high-altitude heart health abnormalities. Overall, our findings elucidate the microbial mechanisms underlying high-altitude heart disease and provide valuable insights for potential early intervention strategies in this context.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}