Exploration (Beijing, China)最新文献

Back Cover: Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia (EXP2 3/2025) 后盖：基于工程外泌体的抗衰老疗法通过靶向p21+CD86+小胶质细胞缓解中风（EXP2 3/2025）

Exploration (Beijing, China) Pub Date : 2025-06-18 DOI: 10.1002/EXP.70059

Jialei Yang, Shipo Wu, Miao He

引用次数: 0

Inside Front Cover: Understanding the Engineering Tactics to Achieve the Stabilized Anode in Next-Generation Zn-Air Batteries (EXP2 3/2025) 内封面：了解实现下一代锌空气电池稳定阳极的工程策略（EXP2 3/2025）

Exploration (Beijing, China) Pub Date : 2025-06-18 DOI: 10.1002/EXP.70060

Subramani Surendran, Yoongu Lim, Seona Lee, Sebastian Cyril Jesudass, Gnanaprakasam Janani, Heechae Choi, Gibum Kwon, Kyoungsuk Jin, Uk Sim

引用次数: 0

Inside Back Cover: Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges (EXP2 3/2025) 内封底：木质素衍生碳量子点的应用：现状与挑战（EXP2 3/2025）

Exploration (Beijing, China) Pub Date : 2025-06-18 DOI: 10.1002/EXP.70062

Xiuxin Yin, Zhili Zhang, Fengfeng Li, Maoqing Fu, Tianci Qin, Xingxiang Ji, Yuanyuan Wang, Zhiwen Wang, Shaolong Sun

引用次数: 0

Front Cover: Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies (EXP2 3/2025) 封面：结构和功能自适应仿生骨膜：材料、制造和施工策略（expo 3/2025）

Exploration (Beijing, China) Pub Date : 2025-06-18 DOI: 10.1002/EXP.70061

Yuhan Du, Yujie Liu, Yuanchi Zhang, Yangyi Nie, Zili Xu, Ling Qin, Wei Zhang, Yuxiao Lai

引用次数: 0

Back Cover: Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma (EXP2 2/2025) 后盖：用于重编程胶质母细胞瘤免疫抑制微环境的工程脑靶向外泌体（EXP2 /2025）

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI: 10.1002/EXP.70037

Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng, Shaobo Ruan

{"title":"Back Cover: Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma (EXP2 2/2025)","authors":"Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng, Shaobo Ruan","doi":"10.1002/EXP.70037","DOIUrl":"https://doi.org/10.1002/EXP.70037","url":null,"abstract":"<p>Through metabolic glycoengineering and bioorthogonal reactions, engineered extracellular vesicles (EVs) have been developed to preserve their high biocompatibility, natural drug storage capacity, and low immunogenicity. These properties, combined with an enhanced ability to target brain disease tissues, make them a highly versatile and promising platform for therapeutic applications. By loading various types of drugs into the EVs using electroporation, both efficient drug encapsulation and precise targeting of diseased tissues are achieved. With their intrinsic biocompatibility and specialized physiological properties, engineered EVs offer a novel approach to treating brain diseases, presenting new opportunities for drug delivery and therapeutic solution development.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside Back Cover: Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration (EXP2 2/2025) 内后盖：钯纳米颗粒通过含缬草苷蛋白介导的自噬降解晚期糖基化终产物，以减轻高糖/高脂肪诱导的椎间盘退变（EXP2 /2025）

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI: 10.1002/EXP.70036

Xiao Yang, Xiankun Cao, Xin Wang, Jiadong Guo, Yangzi Yang, Liqiang Lu, Pu Zhang, Huan Yang, Kewei Rong, Tangjun Zhou, Yongqiang Hao, Jie Zhao, Jingke Fu, Kai Zhang

引用次数: 0

Front Cover: Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules (EXP2 2/2025) 封面：乘坐血管时间列车，通过治疗气体和生物大分子的双重呈现，在时空上减轻血栓和再狭窄（EXP2 /2025）

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI: 10.1002/EXP.70038

Jingdong Rao, Di Suo, Qing Ma, Yongyi Mo, Ho-Pan Bei, Li Wang, Chuyang Y. Tang, Kai-Hang Yiu, Shuqi Wang, Zhilu Yang, Xin Zhao

引用次数: 0

Inside Front Cover: Elastic Nanoparticle-Reinforced, Conductive Structural Color Hydrogel With Super Stretchability, Self-Adhesion, Self-Healing as Electrical/Optical Dual-Responsive Visual Electronic Skins (EXP2 2/2025) 内封面：弹性纳米颗粒增强，导电结构彩色水凝胶，具有超拉伸性，自粘，自修复，作为电/光学双响应视觉电子皮肤（EXP2 /2025）

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI: 10.1002/EXP.70035

Min Xu, Junlong Liao, Jiajia Li, Yu Shi, Ziyu Zhang, Yifu Fu, Zhongze Gu, Hua Xu

引用次数: 0

Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges 木质素衍生碳量子点的应用现状与挑战

Exploration (Beijing, China) Pub Date : 2025-04-17 DOI: 10.1002/EXP.70039

Xiuxin Yin, Zhili Zhang, Fengfeng Li, Maoqing Fu, Tianci Qin, Xingxiang Ji, Yuanyuan Wang, Zhiwen Wang, Shaolong Sun

{"title":"Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges","authors":"Xiuxin Yin, Zhili Zhang, Fengfeng Li, Maoqing Fu, Tianci Qin, Xingxiang Ji, Yuanyuan Wang, Zhiwen Wang, Shaolong Sun","doi":"10.1002/EXP.70039","DOIUrl":"https://doi.org/10.1002/EXP.70039","url":null,"abstract":"<p>In recent years, lignin has attracted substantial attention from researchers because of its diverse sources, low cost, and renewability. The effective functionalization and enhanced value-added utilization of lignin have successfully addressed the challenges associated with biomass resource waste, low utilization rate, high material cost, and underwhelming performance in energy, environmental protection, and medical applications. The emergence of lignin carbon quantum dots (LCQDs) has opened new avenues for the development and utilization of lignin by offering exciting opportunities for their applications. LCQDs possess unique characteristics such as fluorescence properties, size effect, surface effect, and interface effects, which are promising for applications in many fields. This paper provides a comprehensive overview of the structure and applications of lignin with a specific focus on the preparation method of LCQDs as well as their various applications in drug delivery systems, electrode material fabrication, and antibacterial agent development. Furthermore, this study offers valuable insights into the prospects of LCQDs and aims to contribute to their functional development. Finally, the challenges associated with leveraging the fluorescence properties of LCQDs are discussed, along with potential directions for future research.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cataract-Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation 致白内障突变体βB2晶体蛋白R188C结构稳定性低，对环境应力敏感，易形成聚集体

Exploration (Beijing, China) Pub Date : 2025-04-01 DOI: 10.1002/EXP.20240192

Yibo Yu, Silong Chen, Ying Zhang, Hang Song, Jiarui Guo, Chengpeng Wu, Wei Wu, Jingjie Xu, Xiaoyu Cheng, Chenqi Luo, Jing Guo, Yip Chee Chew, Ke Yao, Xiangjun Chen, Lidan Hu

{"title":"Cataract-Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation","authors":"Yibo Yu, Silong Chen, Ying Zhang, Hang Song, Jiarui Guo, Chengpeng Wu, Wei Wu, Jingjie Xu, Xiaoyu Cheng, Chenqi Luo, Jing Guo, Yip Chee Chew, Ke Yao, Xiangjun Chen, Lidan Hu","doi":"10.1002/EXP.20240192","DOIUrl":"https://doi.org/10.1002/EXP.20240192","url":null,"abstract":"<p>This study investigated a Chinese family with congenital posterior polar cataracts linked to the βB2-R188C mutation. βB2-crystallin, a key structural component of the lens, is crucial for maintaining lens transparency and stability. We examined the effects of the R188C mutation on βB2-crystallin's structural stability and resistance to environmental stressors using purified proteins and cellular models. The βB2-R188C mutant showed poor stability and a tendency to aggregate under physiological and pathological conditions. The mutation disrupted the oligomerization equilibrium, causing dissociation of dimers into monomers. Molecular dynamics simulations and spectroscopic experiments revealed abnormal protein folding induced by the R188C mutation, increasing susceptibility to environmental stressors. Aggregation was observed in both prokaryotic and eukaryotic models under normal conditions, with enhanced severity under environmental stressors. Notably, lanosterol treatment or αB-crystallin partially reversed aggregation. In summary, the R188C mutation promotes abnormal aggregation by destabilizing βB2-crystallin and disrupting oligomerization equilibrium, potentially leading to cataract formation. Targeting aggregate formation with small molecules like lanosterol or enhancing molecular chaperone activity offers a promising strategy for cataract prevention and treatment.</p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0