Front Cover: Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude (EXP2 4/2025)
{"title":"Front Cover: Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude (EXP2 4/2025)","authors":"Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Lina Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao","doi":"10.1002/EXP.70081","DOIUrl":null,"url":null,"abstract":"<p>Young individuals migrating to high altitudes exhibit varying susceptibilities to high-altitude heart disease, often triggered by maladaptation to hypobaric hypoxic environments. The migration to high-altitude plateaus significantly reshaped the gut microbiome and metabolome signatures. Lower abundances of <i>Veillonella rogosae</i>, <i>Streptococcus rubneri</i>, and gut microbiota-associated serum metabolites promoted the remodeling of metabolic processes, thereby increasing susceptibility to high-altitude heart health abnormalities.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70081","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.70081","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Young individuals migrating to high altitudes exhibit varying susceptibilities to high-altitude heart disease, often triggered by maladaptation to hypobaric hypoxic environments. The migration to high-altitude plateaus significantly reshaped the gut microbiome and metabolome signatures. Lower abundances of Veillonella rogosae, Streptococcus rubneri, and gut microbiota-associated serum metabolites promoted the remodeling of metabolic processes, thereby increasing susceptibility to high-altitude heart health abnormalities.
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