{"title":"Back Cover: Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia (EXP2 3/2025)","authors":"Jialei Yang, Shipo Wu, Miao He","doi":"10.1002/EXP.70059","DOIUrl":null,"url":null,"abstract":"<p>The blue-purple flowers on the tree represent p21<sup>+</sup>CD86<sup>+</sup> microglia in the ischemic region, which secrete pro-inflammatory factors after stroke. The bird symbolizes the therapeutic use of engineered exosomes loaded with Quercetin (Que@micro-Exo), designed to target and eliminate these pathogenic microglia. The gathering of birds forming the tree's roots represents the intravenous administration of Que@micro-Exo, highlighting its potential to promote functional recovery by clearing p21<sup>+</sup>CD86<sup>+</sup> microglia.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70059","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.70059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The blue-purple flowers on the tree represent p21+CD86+ microglia in the ischemic region, which secrete pro-inflammatory factors after stroke. The bird symbolizes the therapeutic use of engineered exosomes loaded with Quercetin (Que@micro-Exo), designed to target and eliminate these pathogenic microglia. The gathering of birds forming the tree's roots represents the intravenous administration of Que@micro-Exo, highlighting its potential to promote functional recovery by clearing p21+CD86+ microglia.
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