{"title":"后盖：基于工程外泌体的抗衰老疗法通过靶向p21+CD86+小胶质细胞缓解中风（EXP2 3/2025）","authors":"Jialei Yang, Shipo Wu, Miao He","doi":"10.1002/EXP.70059","DOIUrl":null,"url":null,"abstract":"<p>The blue-purple flowers on the tree represent p21<sup>+</sup>CD86<sup>+</sup> microglia in the ischemic region, which secrete pro-inflammatory factors after stroke. The bird symbolizes the therapeutic use of engineered exosomes loaded with Quercetin (Que@micro-Exo), designed to target and eliminate these pathogenic microglia. The gathering of birds forming the tree's roots represents the intravenous administration of Que@micro-Exo, highlighting its potential to promote functional recovery by clearing p21<sup>+</sup>CD86<sup>+</sup> microglia.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":22.5000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70059","citationCount":"0","resultStr":"{\"title\":\"Back Cover: Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia (EXP2 3/2025)\",\"authors\":\"Jialei Yang, Shipo Wu, Miao He\",\"doi\":\"10.1002/EXP.70059\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The blue-purple flowers on the tree represent p21<sup>+</sup>CD86<sup>+</sup> microglia in the ischemic region, which secrete pro-inflammatory factors after stroke. The bird symbolizes the therapeutic use of engineered exosomes loaded with Quercetin (Que@micro-Exo), designed to target and eliminate these pathogenic microglia. The gathering of birds forming the tree's roots represents the intravenous administration of Que@micro-Exo, highlighting its potential to promote functional recovery by clearing p21<sup>+</sup>CD86<sup>+</sup> microglia.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":72997,\"journal\":{\"name\":\"Exploration (Beijing, China)\",\"volume\":\"5 3\",\"pages\":\"\"},\"PeriodicalIF\":22.5000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70059\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exploration (Beijing, China)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/EXP.70059\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.70059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Back Cover: Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia (EXP2 3/2025)
The blue-purple flowers on the tree represent p21+CD86+ microglia in the ischemic region, which secrete pro-inflammatory factors after stroke. The bird symbolizes the therapeutic use of engineered exosomes loaded with Quercetin (Que@micro-Exo), designed to target and eliminate these pathogenic microglia. The gathering of birds forming the tree's roots represents the intravenous administration of Que@micro-Exo, highlighting its potential to promote functional recovery by clearing p21+CD86+ microglia.
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