Exploration (Beijing, China)最新文献_第2页

Front Cover: Bioprinted research models of urological malignancy (EXP2 4/2024) 封面：泌尿系统恶性肿瘤生物打印研究模型（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240401

Guanyi Wang, Xiongmin Mao, Wang Wang, Xiaolong Wang, Sheng Li, Zijian Wang

引用次数: 0

Back Cover: Unveiling the importance of the interface in nanocomposite cathodes for proton-conducting solid oxide fuel cells (EXP2 4/2024) 封底：揭示质子传导型固体氧化物燃料电池纳米复合阴极界面的重要性（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240404

Yanru Yin, Yifan Wang, Nan Yang, Lei Bi

引用次数: 0

Inside Back Cover: Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery (EXP2 4/2024) 封底内页：角膜-SELEX：针对眼睛表面和脂质体药物递送的适配体（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240403

Ka-Ying Wong, Yibo Liu, Man-Sau Wong, Juewen Liu

引用次数: 0

Inside Front Cover: Recent advances in mitochondria-targeting theranostic agents (EXP2 4/2024) 封面内页：线粒体靶向治疗药物的最新进展（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240402

Kun Qian, Shu Gao, Zhaoning Jiang, Qihang Ding, Zhen Cheng

引用次数: 0

Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED 在水中直接合成高量子产率无铅 CsCu2I3 粉末及其在黄色 LED 中的应用

Exploration (Beijing, China) Pub Date : 2024-07-18 DOI: 10.1002/EXP.20240004

Heng Guo, Linlin Shi, Zengliang Shi, Yue He, Yizhi Zhu

{"title":"Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED","authors":"Heng Guo, Linlin Shi, Zengliang Shi, Yue He, Yizhi Zhu","doi":"10.1002/EXP.20240004","DOIUrl":"10.1002/EXP.20240004","url":null,"abstract":"Yellow light-emitting diodes (LEDs) with a wavelength of 570–590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection. For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) was used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesized an all-inorganic lead-free yellow light CsCu2I3 powder in water. The prepared CsCu2I3 powder exhibited excellent optical properties and considerable stability. Finally, a phosphor-converted LED (pc-LED) device was fabricated via the CsCu2I3 phosphor coated on a 310 nm ultraviolet chip. The pc-LED device's electroluminescence spectra may be a good fit for the blood's absorption regions. Therefore, this work provides a facile method for the synthesis of novel lead-free metal halide CsCu2I3 powder in eco-friendly solvents. In addition, the stable and efficient CsCu2I3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications

Exploration (Beijing, China) Pub Date : 2024-06-28 DOI: 10.1002/EXP.20230094

Jingyun Tan, Chunfei Wang, Zhangjun Hu, Xuanjun Zhang

{"title":"Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications","authors":"Jingyun Tan, Chunfei Wang, Zhangjun Hu, Xuanjun Zhang","doi":"10.1002/EXP.20230094","DOIUrl":"https://doi.org/10.1002/EXP.20230094","url":null,"abstract":"Fluorescence-assisted tools based on organic molecules have been extensively applied to interrogate complex biological processes in a non-invasive manner with good sensitivity, high resolution, and rich contrast. However, the signal-to-noise ratio is an essential factor to be reckoned with during collecting images for high fidelity. In view of this, the wash-free strategy is proven as a promising and important approach to improve the signal-to-noise ratio, thus a thorough introduction is presented in the current review about wash-free fluorescent tools based on organic molecules. Firstly, generalization and summarization of the principles for designing wash-free molecular fluorescent tools (WFTs) are made. Subsequently, to make the thought of molecule design more legible, a wash-free strategy is highlighted in recent studies from four diverse but tightly binding aspects: (1) special chemical structures, (2) molecular interactions, (3) bio-orthogonal reactions, (4) abiotic reactions. Meanwhile, biomedical applications including bioimaging, biodetection, and therapy, are ready to be accompanied by. Finally, the prospects for WFTs are elaborated and discussed. This review is a timely conclusion about wash-free strategy in the fluorescence-guided biomedical applications, which may bring WFTs to the forefront and accelerate their extensive applications in biology and medicine.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications

Exploration (Beijing, China) Pub Date : 2024-06-26 DOI: 10.1002/EXP.20240034

Yunshan Gao, Jie Xu, Shaohua Qu, Yixiao Li, Gleb B. Sukhorukov, Li Shang

{"title":"Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications","authors":"Yunshan Gao, Jie Xu, Shaohua Qu, Yixiao Li, Gleb B. Sukhorukov, Li Shang","doi":"10.1002/EXP.20240034","DOIUrl":"https://doi.org/10.1002/EXP.20240034","url":null,"abstract":"Silver nanoclusters (AgNCs) have shown broad application prospects in catalysis, sensing, and biological fields. However, the limited stability of AgNCs has become the main challenge restricting their practical application in complex environments. Herein, a mussel-inspired, dopamine-assisted self-assembly approach is reported to fabricate 3D AgNC aerogels (PDA/AgNCs), which possess significantly enhanced structural stability and synergistic functional properties. The prepared AgNC aerogels display a hierarchical network structure with an ultrafine ligament size of 10.3 ± 1.2 nm and a high specific surface area of 50.7 m2 g−1. The gelation mechanism is elucidated by in-depth characterization and time-lapse monitoring of the gelation process vis spectroscopic and microscopic approaches. Owing to the distinct features of aerogels and the synergistic effect of AgNCs and PDA, the fabricated aerogels can not only efficiently decolorize dyes with a faster kinetic than individual AgNCs, but also exhibit remarkable broad-spectrum antimicrobial activity. Consequently, a conceptual water-treatment device is established by depositing PDA/AgNC aerogels on the cotton substrate, which shows good performance in both catalytic dye degradation and bacterial killing in the flowing system. This mussel-inspired self-assembly strategy has great potential in developing robust AgNC-based functional materials, which also provides a new guideline for designing sophisticated materials with integrated functions and synergistic properties.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway

Exploration (Beijing, China) Pub Date : 2024-06-26 DOI: 10.1002/EXP.20240002

Xue Bai, Jun Kang, Silong Wei, Yun Wang, Yangsui Liu, Bo Yuan, Qian Lu, Huansong Li, Jun Yan, Xi Yang, Jin Chang

{"title":"A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway","authors":"Xue Bai, Jun Kang, Silong Wei, Yun Wang, Yangsui Liu, Bo Yuan, Qian Lu, Huansong Li, Jun Yan, Xi Yang, Jin Chang","doi":"10.1002/EXP.20240002","DOIUrl":"https://doi.org/10.1002/EXP.20240002","url":null,"abstract":"Sonodynamic therapy offers a non-invasive approach to induce the death of tumor cells. By harnessing ultrasound waves in tandem with sonosensitizers, this method produces reactive oxygen species (ROS) that inflict oxidative damage upon tumor cells, subsequently causing their demise. Ferroptosis is a regulatory form of cell death that differs from other forms, characterized by iron accumulation, ROS accumulation, and lipid peroxidation. In the presented research, a nanoparticle formulation, parthenolide/ICG-CaCO3@lipid (PTL/ICG-CaCO3@Lip), has been engineered to amplify ferroptosis in tumor cells, positioning it as a potent agent for sonodynamic cancer immunotherapy. This nanoparticle significantly augments ROS levels within tumor cells, inducing oxidative stress that leads to cell death. The therapeutic potential of PTL/ICG-CaCO3@Lip, both in vivo and in vitro, has been convincingly demonstrated. Furthermore, RNA-seq analysis insights revealed that PTL/ICG-CaCO3@Lip facilitates tumor cell ferroptosis by regulating P53 to downregulate SLC7A11 protein expression, thereby inhibiting the glutamate-cystine antiporter system Xc− and stimulating ACSL4/LPCAT3 pathways. This pioneering work uncovers an innovative strategy for combatting tumors, leveraging enhanced oxidative stress to promote cell ferroptosis, and paves the way for groundbreaking cancer immunotherapeutic interventions.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages 生物工程间充质干细胞通过IL-12介导的微环境重编程和nCD47-SLAMF7介导的巨噬细胞吞噬调节治疗胶质瘤

Exploration (Beijing, China) Pub Date : 2024-06-25 DOI: 10.1002/EXP.20240027

Man Li, Lisen Lu, Qungen Xiao, Ali Abdi Maalim, Bin Nie, Yanchao Liu, Ulf D. Kahlert, Kai Shu, Ting Lei, Mingxin Zhu

{"title":"Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages","authors":"Man Li, Lisen Lu, Qungen Xiao, Ali Abdi Maalim, Bin Nie, Yanchao Liu, Ulf D. Kahlert, Kai Shu, Ting Lei, Mingxin Zhu","doi":"10.1002/EXP.20240027","DOIUrl":"https://doi.org/10.1002/EXP.20240027","url":null,"abstract":"High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors contributing to glioma's resistance to immunotherapy. Nonetheless, technology to modify the expression of glioma cellular self-molecules through gene editing requires further development. This project advances cell therapy strategies to reverse the immunosuppressive microenvironment of glioma (TIME). Bone marrow-derived mesenchymal stem cells (MSCs) are engineered to express bioactive proteins and demonstrate tumor-homing characteristics upon activation by TGF-β. These MSCs are designed to secrete the anti-tumor immune cytokine IL-12 and the nCD47-SLAMF7 fusion protein, which regulates T-cell activity and macrophage phagocytosis. The engineered MSCs are then injected in situ into the glioma site, circumventing the blood-brain barrier to deliver high local concentrations of bioactive proteins. This approach aims to enhance the M1 polarization of infiltrating macrophages, stimulate macrophage-mediated tumor cell phagocytosis, activate antigen-presenting cells, and promote effector CD8+ T cell infiltration, effectively controlling glioma. Additionally, the engineered MSCs may serve as a universal treatment for other tumors that express TGF-β at high levels. This study proposes a novel treatment strategy for the clinical management of glioma patients.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontispiece: Advances in the treatment of atherosclerosis with ligand-modified nanocarriers (EXP2 3/2024) 前言：配体修饰纳米载体治疗动脉粥样硬化的进展（EXP2 3/2024）

Exploration (Beijing, China) Pub Date : 2024-06-18 DOI: 10.1002/EXP.20240303

Xiujiao Deng, Jinghao Wang, Shanshan Yu, Suiyi Tan, Tingting Yu, Qiaxin Xu, Nenghua Chen, Siqi Zhang, Ming-Rong Zhang, Kuan Hu, Zeyu Xiao

引用次数: 0