内后盖：钯纳米颗粒通过含缬草苷蛋白介导的自噬降解晚期糖基化终产物，以减轻高糖/高脂肪诱导的椎间盘退变（EXP2 /2025）

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI:10.1002/EXP.70036

Xiao Yang, Xiankun Cao, Xin Wang, Jiadong Guo, Yangzi Yang, Liqiang Lu, Pu Zhang, Huan Yang, Kewei Rong, Tangjun Zhou, Yongqiang Hao, Jie Zhao, Jingke Fu, Kai Zhang

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引用次数: 0

摘要

钯纳米颗粒（Pd NPs）通过促进AGEs降解来减轻高糖/高脂肪（或晚期糖基化终产物，AGEs）诱导的椎间盘退变（IVDD）。它们增强了含缬草苷蛋白（VCP）的atp酶活性，促进了自噬体的形成，导致有效的AGEs清除。因此，Pd NPs减少氧化和内质网应激，保持线粒体结构和功能，最终有助于缓解IVDD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inside Back Cover: Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration (EXP2 2/2025)

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Palladium nanoparticles (Pd NPs) mitigate High-Glucose/High-Fat (or advanced glycation end products, AGEs)-induced intervertebral disc degeneration (IVDD) by facilitating AGEs degradation. They enhance the ATPase activity of Valosin-containing protein (VCP) and promote autophagosome formation, leading to effective AGEs clearance. As a result, Pd NPs reduce oxidative and endoplasmic reticulum stress, preserve mitochondrial structure and function, and ultimately contribute to IVDD alleviation.

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来源期刊

Exploration (Beijing, China)

CiteScore

17.20

自引率

0.00%

发文量