Inside Back Cover: Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration (EXP2 2/2025)
Xiao Yang, Xiankun Cao, Xin Wang, Jiadong Guo, Yangzi Yang, Liqiang Lu, Pu Zhang, Huan Yang, Kewei Rong, Tangjun Zhou, Yongqiang Hao, Jie Zhao, Jingke Fu, Kai Zhang
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引用次数: 0
Abstract
Palladium nanoparticles (Pd NPs) mitigate High-Glucose/High-Fat (or advanced glycation end products, AGEs)-induced intervertebral disc degeneration (IVDD) by facilitating AGEs degradation. They enhance the ATPase activity of Valosin-containing protein (VCP) and promote autophagosome formation, leading to effective AGEs clearance. As a result, Pd NPs reduce oxidative and endoplasmic reticulum stress, preserve mitochondrial structure and function, and ultimately contribute to IVDD alleviation.
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