Back Cover: Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma (EXP2 2/2025)

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI:10.1002/EXP.70037

Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng, Shaobo Ruan

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Abstract

Through metabolic glycoengineering and bioorthogonal reactions, engineered extracellular vesicles (EVs) have been developed to preserve their high biocompatibility, natural drug storage capacity, and low immunogenicity. These properties, combined with an enhanced ability to target brain disease tissues, make them a highly versatile and promising platform for therapeutic applications. By loading various types of drugs into the EVs using electroporation, both efficient drug encapsulation and precise targeting of diseased tissues are achieved. With their intrinsic biocompatibility and specialized physiological properties, engineered EVs offer a novel approach to treating brain diseases, presenting new opportunities for drug delivery and therapeutic solution development.

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后盖：用于重编程胶质母细胞瘤免疫抑制微环境的工程脑靶向外泌体（EXP2 /2025）

通过代谢糖工程和生物正交反应，开发出具有高生物相容性、天然药物储存能力和低免疫原性的工程细胞外囊泡（ev）。这些特性，加上针对脑部疾病组织的增强能力，使它们成为一个高度通用和有前途的治疗应用平台。通过电穿孔将不同类型的药物加载到ev中，既实现了药物的高效包封，又实现了病变组织的精确靶向。由于其内在的生物相容性和特殊的生理特性，工程化电动汽车为治疗脑部疾病提供了一种新的方法，为药物输送和治疗溶液的开发提供了新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Exploration (Beijing, China)

CiteScore

17.20

自引率

0.00%

发文量