Exploration (Beijing, China)最新文献_第3页

Inside Front Cover: Elastic Nanoparticle-Reinforced, Conductive Structural Color Hydrogel With Super Stretchability, Self-Adhesion, Self-Healing as Electrical/Optical Dual-Responsive Visual Electronic Skins (EXP2 2/2025) 内封面：弹性纳米颗粒增强，导电结构彩色水凝胶，具有超拉伸性，自粘，自修复，作为电/光学双响应视觉电子皮肤（EXP2 /2025）

Exploration (Beijing, China) Pub Date : 2025-04-24 DOI: 10.1002/EXP.70035

Min Xu, Junlong Liao, Jiajia Li, Yu Shi, Ziyu Zhang, Yifu Fu, Zhongze Gu, Hua Xu

引用次数: 0

Advancements in Understanding Catalyst Reconstruction During Electrochemical CO2 Reduction 电化学CO2还原过程中催化剂重构的研究进展

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-22 DOI: 10.1002/EXP.20240019

Woosuck Kwon, Dohun Kim, Yujin Lee, Jinoh Jung, Dae-Hyun Nam

{"title":"Advancements in Understanding Catalyst Reconstruction During Electrochemical CO2 Reduction","authors":"Woosuck Kwon, Dohun Kim, Yujin Lee, Jinoh Jung, Dae-Hyun Nam","doi":"10.1002/EXP.20240019","DOIUrl":"https://doi.org/10.1002/EXP.20240019","url":null,"abstract":"Electrochemical CO2 reduction reaction (CO2RR) has received great attention to solve CO2- induced global warming and carbon neutrality. It is essential to enhance the electrochemical CO2RR selectivity, activity, and long-term stability for sustainable manufacturing of specific chemicals via CO2RR. To produce multi-carbon (C2+) chemicals, Cu-based heterogeneous catalysts have been developed in terms of defect engineering, morphological design, and facet control. Despite the substantial efforts for the design of efficient Cu-based heterogeneous catalysts, there exist inevitable structural changes of catalysts with continuous dissolution and redeposition during CO2RR. This reconstruction modifies the as-synthesized catalysts into an unpredictable structure and leads to changes in active site. Here, we review the reconstruction of Cu-based catalysts during CO2RR, which occurs via continuous dissolution and redeposition process. This includes fundamental principles of reconstruction and the effect of microenvironment on reconstruction during CO2RR. We offer research progress about the reconstruction of Cu-based electrocatalysts, analysis methodologies to track the reconstruction, and the insight to improve the activity, selectivity, and stability of CO2RR. We provide perspective to understand and harness the reconstruction for the development of efficient CO2RR catalysts.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol 新兴靶点发现策略推动天然产物治疗能力的解码和进一步的药物开发：以Celastrol为例

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-22 DOI: 10.1002/EXP.20240247

Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen

{"title":"Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol","authors":"Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen","doi":"10.1002/EXP.20240247","DOIUrl":"https://doi.org/10.1002/EXP.20240247","url":null,"abstract":"Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses a significant challenge in transitioning CEL from a traditional remedy to a modern pharmaceutical agent. Recently, the emerging target discovery approaches of natural products have broadened extensive avenues for uncovering comprehensive target information of CEL and promoting its drug development. Herein, diverse target discovery strategies are overviewed for the pharmacological and toxicological studies of CEL, including chemical proteomics, protein microarray, degradation-based protein profiling, proteome-wide label-free approaches, network pharmacology, target-based drug screening, multi-omics analysis, and hypothesis-driven target confirmation. Dozens of CEL targets have been identified, which significantly suggests that CEL functions as a multi-target therapeutic agent. Further network interaction analysis and frequency analysis of collected targets reveal that PRDXs, HMGB1, HSP90, STAT3, and PKM2 may serve as key targets for CEL. Additionally, this review highlights the positive role of target discovery in facilitating CEL-based combination therapy and drug delivery, which is essential for further advancing the clinical applications of CEL. Efforts in CEL target identification not only aid in unraveling the scientific underpinnings of its multiple pharmacological effects but also offer crucial insights for further drug development of CEL-based drugs.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalysts Design and Atomistic Reaction Modulation by Atomic Layer Deposition for Energy Conversion and Storage Applications 用于能量转换和存储的催化剂设计和原子层沉积原子反应调制

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-21 DOI: 10.1002/EXP.20240010

Myung-Jin Jung, Alireza Razazzadeh, Hasmat Khan, Se-Hun Kwon

{"title":"Catalysts Design and Atomistic Reaction Modulation by Atomic Layer Deposition for Energy Conversion and Storage Applications","authors":"Myung-Jin Jung, Alireza Razazzadeh, Hasmat Khan, Se-Hun Kwon","doi":"10.1002/EXP.20240010","DOIUrl":"https://doi.org/10.1002/EXP.20240010","url":null,"abstract":"Atomic layer deposition (ALD) technique has emerged as a fascinating tool for the design and synthesis of heterogeneous catalysts with atomic precision for energy conversion, generation, and storage applications. Here, we demonstrate the importance of the ALD for catalyst design by citing recently reported works, in particular, the emphasis has been given to the surface/interface engineering of catalysts for improving their catalytic efficiency in energy applications. To get insight into the reaction mechanism, the ALD-based routes for catalyst synthesis may revolutionize the field of sustainable energy conversion and storage. Moreover, the synthesis of supported nanoparticles with controlled shape and size has attracted great attention in catalysis owing to their unique properties. By taking advantage of the ALD, it is possible to synthesize catalysts at the atomic scale, particularly, site-selective ALD provides tremendous opportunities in catalytic efficiency and selectivity studies. Moreover, this review illustrates diverse heterogeneous catalysts with their limitations for energy-related applications and how the ALD technique can facilitate overcoming them. Finally, we deliberate the advancement in the ALD technique on heterogeneous catalyst design, and interface engineering of catalysts, and outline future perspectives of this technology in catalysis.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges 木质素衍生碳量子点的应用现状与挑战

Exploration (Beijing, China) Pub Date : 2025-04-17 DOI: 10.1002/EXP.70039

Xiuxin Yin, Zhili Zhang, Fengfeng Li, Maoqing Fu, Tianci Qin, Xingxiang Ji, Yuanyuan Wang, Zhiwen Wang, Shaolong Sun

{"title":"Applications of Lignin-Dervied Carbon Quantum Dots: Current Status and Challenges","authors":"Xiuxin Yin, Zhili Zhang, Fengfeng Li, Maoqing Fu, Tianci Qin, Xingxiang Ji, Yuanyuan Wang, Zhiwen Wang, Shaolong Sun","doi":"10.1002/EXP.70039","DOIUrl":"https://doi.org/10.1002/EXP.70039","url":null,"abstract":"In recent years, lignin has attracted substantial attention from researchers because of its diverse sources, low cost, and renewability. The effective functionalization and enhanced value-added utilization of lignin have successfully addressed the challenges associated with biomass resource waste, low utilization rate, high material cost, and underwhelming performance in energy, environmental protection, and medical applications. The emergence of lignin carbon quantum dots (LCQDs) has opened new avenues for the development and utilization of lignin by offering exciting opportunities for their applications. LCQDs possess unique characteristics such as fluorescence properties, size effect, surface effect, and interface effects, which are promising for applications in many fields. This paper provides a comprehensive overview of the structure and applications of lignin with a specific focus on the preparation method of LCQDs as well as their various applications in drug delivery systems, electrode material fabrication, and antibacterial agent development. Furthermore, this study offers valuable insights into the prospects of LCQDs and aims to contribute to their functional development. Finally, the challenges associated with leveraging the fluorescence properties of LCQDs are discussed, along with potential directions for future research.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces 高精度，低阈值神经调节与超柔性电极阵列脑对脑接口

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-17 DOI: 10.1002/EXP.70040

Yifei Ye, Ye Tian, Haifeng Liu, Jiaxuan Liu, Cunkai Zhou, Chengjian Xu, Ting Zhou, Yanyan Nie, Yu Wu, Lunming Qin, Zhitao Zhou, Xiaoling Wei, Jianlong Zhao, Zhenyu Wang, Meng Li, Tiger H. Tao, Liuyang Sun

{"title":"High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces","authors":"Yifei Ye, Ye Tian, Haifeng Liu, Jiaxuan Liu, Cunkai Zhou, Chengjian Xu, Ting Zhou, Yanyan Nie, Yu Wu, Lunming Qin, Zhitao Zhou, Xiaoling Wei, Jianlong Zhao, Zhenyu Wang, Meng Li, Tiger H. Tao, Liuyang Sun","doi":"10.1002/EXP.70040","DOIUrl":"https://doi.org/10.1002/EXP.70040","url":null,"abstract":"Neuromodulation is crucial for advancing neuroscience and treating neurological disorders. However, traditional methods using rigid electrodes have been limited by large stimulating currents, low precision, and the risk of tissue damage. In this work, we developed a biocompatible ultraflexible electrode array that allows for both neural recording of spike firings and low-threshold, high-precision stimulation for neuromodulation. Specifically, mouse turning behavior can be effectively induced with approximately five microamperes of stimulating current, which is significantly lower than that required by conventional rigid electrodes. The array's densely packed microelectrodes enable highly selective stimulation, allowing precise targeting of specific brain areas critical for turning behavior. This low-current, targeted stimulation approach helps maintain the health of both neurons and electrodes, as evidenced by stable neural recordings after extended stimulations. Systematic validations have confirmed the durability and biocompatibility of the electrodes. Moreover, we extended the flexible electrode array to a brain-to-brain interface system that allows human brain signals to directly control mouse behavior. Using advanced decoding methods, a single individual can issue eight commands to simultaneously control the behaviors of two mice. This study underscores the effectiveness of the flexible electrode array in neuromodulation, opening new avenues for interspecies communication and potential neuromodulation applications.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Room-Temperature Direct Homolysis of Csp3─H Bond via Catalyst-Free Photoexcitation 无催化剂光激发下Csp3氢键的室温直接均解

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-10 DOI: 10.1002/EXP.20240237

Qi Miao, Meng Liu, Jun Wang, Pan Wu, Changjun Liu, Jian He, Giacomo Lo Zupone, Wei Jiang

{"title":"Room-Temperature Direct Homolysis of Csp3─H Bond via Catalyst-Free Photoexcitation","authors":"Qi Miao, Meng Liu, Jun Wang, Pan Wu, Changjun Liu, Jian He, Giacomo Lo Zupone, Wei Jiang","doi":"10.1002/EXP.20240237","DOIUrl":"https://doi.org/10.1002/EXP.20240237","url":null,"abstract":"The C─H bond is the most abundant chemical bond in organic compounds. Therefore, the development of the more direct methods for C─H bond cleavage and the elucidation of their mechanisms will provide an important theoretical basis for achieving more efficient C─H functionalization and target molecule construction. In this study, the catalyst-free photon-induced direct homolysis of Csp3─H bonds at room temperature was discovered for the first time. The applicable substrate scope of this phenomenon is very wide, expanding from the initial benzyl compounds to aliphatic alcohols, alkanes, olefins, polymers containing benzyl hydrogens, and even gaseous methane. Experiments and calculations have demonstrated that this process involves rapid vibrational relaxation on the femtosecond time scale, leading to the formation of hydrogen radical and carbon radical. Importantly, the direct homolysis of Csp3─H bonds is independent of the presence of oxidants, highlighting its spontaneous nature. Additionally, the cleaved hydrogen radical exhibits diverse reactivity, including coupling reactions to produce hydrogen gas (H2), reduction of oxygen to generate hydrogen peroxide (H2O2), and reduction of carbon dioxide to formic acid (HCOOH). Notably, in the field of H2O2 production, the absence of a catalyst allows for the bypassing of inherent drawbacks associated with photocatalysts, thereby presenting significant potential for practical application. Furthermore, the cleaved carbon radicals display enhanced reactivity, providing excellent opportunities for direct functionalization, thereby enabling efficient C─H bond activation and molecular construction. Overall, this significant discovery offers a valuable new strategy for the production of bulk chemicals, organic synthesis, low-carbon and hydrogen energy industries, as well as environmental treatment.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric Oxygen Regulates Tumor pH to Boost Copper-Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells 高压氧调节肿瘤pH值，促进铜掺杂羟乙基淀粉缀合纳米颗粒对抗癌症干细胞

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-03 DOI: 10.1002/EXP.20240080

Qingyuan Deng, Ao Hua, Shiyou Li, Zhijie Zhang, Xiang Chen, Qiang Wang, Xing Wang, Zhiqin Chu, Xiangliang Yang, Zifu Li

{"title":"Hyperbaric Oxygen Regulates Tumor pH to Boost Copper-Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells","authors":"Qingyuan Deng, Ao Hua, Shiyou Li, Zhijie Zhang, Xiang Chen, Qiang Wang, Xing Wang, Zhiqin Chu, Xiangliang Yang, Zifu Li","doi":"10.1002/EXP.20240080","DOIUrl":"https://doi.org/10.1002/EXP.20240080","url":null,"abstract":"An extracellular acidic environment and an intracellular mildly alkaline environment induced by carbonic anhydrase 9 (CA9) play a critical role in self-renewal, invasion, migration, and drug resistance of cancer stem cells (CSCs) within hypoxic solid tumors. Here, we report an antitumor strategy leveraging hyperbaric oxygen therapy (HBO) to regulate tumor pH and boost hydroxyethyl starch-doxorubicin-copper nanoparticles (HHD-Cu NPs) against CSCs. HBO overcomes tumor hypoxia, downregulates pH-regulatory proteins such as CA9, and leads to intracellular accumulation of acidic metabolites. As a result, HBO promotes intracellular acidification of both tumor cells and CSCs, triggering efficient doxorubicin release and the potent copper-mediated chemical dynamic effect of subsequently administered dual-acid-responsive HHD-Cu NPs. The combination of HBO with HHD-Cu NPs not only eliminates tumor cells but also inhibits CSCs, altogether leading to potent tumor inhibition. This study explores a new function of clinical-widely used HBO and establishes a novel combination therapy for treating CSCs abundant hypoxic solid tumors.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Biology-Based Engineering Living Therapeutics for Antimicrobial Application 基于合成生物学的抗菌工程活疗法

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-03 DOI: 10.1002/EXP.20240045

Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo

{"title":"Synthetic Biology-Based Engineering Living Therapeutics for Antimicrobial Application","authors":"Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo","doi":"10.1002/EXP.20240045","DOIUrl":"https://doi.org/10.1002/EXP.20240045","url":null,"abstract":"There is currently a pressing issue of antimicrobial resistance, with numerous pathogenic superbugs continually emerging, posing significant threats to both human health and the economy. However, the development of new antibiotics has not kept up in pace with the development of microbial resistance, necessitating the exploration of more effective approaches to combat microbes. Synthetic biology offers a novel paradigm by employing selective screening and assembling diverse biological components to redesign biological systems that can specifically target and eliminate microbes. In particular, engineering living therapeutics enables the detection and precise eradication of pathogenic microorganisms in a controlled means. This review provides an overview of recent advancements in engineering living therapeutics using synthetic biology for antibacterial treatment. It focuses on modifying bacteriophages, microbes, and mammalian cells through engineering approaches for antibacterial therapy. The advantages of each approach are delineated along with potential challenges they may encounter. Finally, a prospective outlook is presented highlighting the potential impact and future prospects of this innovative antimicrobial strategy.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders 探讨硒的神经保护作用：中枢神经系统疾病的意义和前景

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-04-01 DOI: 10.1002/EXP.20240415

Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen

{"title":"Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders","authors":"Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen","doi":"10.1002/EXP.20240415","DOIUrl":"https://doi.org/10.1002/EXP.20240415","url":null,"abstract":"Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. As a selenium-rich organ, the central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. However, decreased Se levels are prevalent in a variety of neurological disorders, which is not conducive to the treatment and prognosis of patients. Thus, the biological study of Se has emerged as a focal point in investigating the pivotal role of trace elements in neuroprotection. This paper presents a comprehensive review of the pathogenic mechanism of neurological diseases, the protective mechanism of Se, and the neurological protective function of selenoproteins. Additionally, the application of Se as a neuroprotective agent in neurological disorder therapy, including ischemic stroke, Alzheimer's, Parkinson's, and other neurological diseases, is summarized. The present review aims to offer novel insights and methodologies for the prevention and treatment of neurological disorders with trace Se, providing a scientific basis for the development of innovative Se-based neuroprotectants to promote their clinical application against neurological diseases.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0