Exploration (Beijing, China)最新文献_第3页

Front Cover: Dichroic switching of core–shell plasmonic nanoparticles on reflective surfaces (EXP2 3/2024) 封面：反射表面上核壳质子纳米粒子的分色开关（EXP2 3/2024）

Exploration (Beijing, China) Pub Date : 2024-06-18 DOI: 10.1002/EXP.20240301

Tian Liang, Zhiwei Li, Yaocai Bai, Yadong Yin

引用次数: 0

Back Cover: Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling (EXP2 3/2024) 封底：离子鸡尾酒疗法通过协同调节结构和电重塑治疗心肌梗死（EXP2 3/2024）

Exploration (Beijing, China) Pub Date : 2024-06-18 DOI: 10.1002/EXP.20240302

Yumei Que, Jiaxin Shi, Zhaowenbin Zhang, Lu Sun, Hairu Li, Xionghai Qin, Zhen Zeng, Xiao Yang, Yanxin Chen, Chong Liu, Chang Liu, Shijie Sun, Qishu Jin, Yanxin Zhang, Xin Li, Ming Lei, Chen Yang, Hai Tian, Jiawei Tian, Jiang Chang

引用次数: 0

Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases 基于竹子的生物启发分层空气过滤器，可高效去除颗粒物和有毒气体

Exploration (Beijing, China) Pub Date : 2024-06-10 DOI: 10.1002/EXP.20240012

Qi Gao, Jian Gan, Pixiang Wang, Yuxiang Huang, Daihui Zhang, Wenji Yu

{"title":"Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases","authors":"Qi Gao, Jian Gan, Pixiang Wang, Yuxiang Huang, Daihui Zhang, Wenji Yu","doi":"10.1002/EXP.20240012","DOIUrl":"10.1002/EXP.20240012","url":null,"abstract":"Air pollution is caused by the perilous accumulation of particulate matter (PM) and harmful gas molecules of different sizes. There is an urgent need to develop highly efficient air filtration systems capable of removing particles with a wide size distribution. However, the efficiency of current air filters is compromised by controlling their hierarchical pore size. Inspired by the graded filtration mechanisms in the human respiratory system, microporous ZIF-67 is in situ synthesized on a 3D interconnected network of bamboo cellulose fibers (BCFs) to fabricate a multiscale porous filter with a comprehensive pore size distribution. The macropores between the BCFs, mesopores formed by the BCF microfibers, and micropores within the ZIF-67 synergistically facilitate the removal of particulates of different sizes. The filtration capabilities of PM2.5 and PM0.3 could reach 99.3% and 98.6%, respectively, whereas the adsorption of formaldehyde is 88.7% within 30 min. In addition, the filter exhibits excellent antibacterial properties (99.9%), biodegradability (80.1% degradation after 14 days), thermal stability, and skin-friendly properties (0 irritation). This study may inspire the research of using natural features of renewable resources to design high-performance air-filtration materials for various applications.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages 压电刺激通过对巨噬细胞进行代谢重编程，促进牙槽骨缺损的骨再生

Exploration (Beijing, China) Pub Date : 2024-06-10 DOI: 10.1002/EXP.20230149

Baiyan Sui, Tingting Ding, Xingyi Wan, Yuxiao Chen, Xiaodi Zhang, Yuanbo Cui, Jie Pan, Linlin Li, Xin Liu

{"title":"Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages","authors":"Baiyan Sui, Tingting Ding, Xingyi Wan, Yuxiao Chen, Xiaodi Zhang, Yuanbo Cui, Jie Pan, Linlin Li, Xin Liu","doi":"10.1002/EXP.20230149","DOIUrl":"10.1002/EXP.20230149","url":null,"abstract":"Immunomodulation has emerged as a promising strategy for promoting bone regeneration. However, designing osteoimmunomodulatory biomaterial that can respond to mechanical stress in the unique microenvironment of alveolar bone under continuous occlusal stress remains a significant challenge. Herein, a wireless piezoelectric stimulation system, namely, piezoelectric hydrogel incorporating BaTiO3 nanoparticles (BTO NPs), is successfully developed to generate piezoelectric potentials for modulating macrophage reprogramming. The piezoelectric stimulation reprograms macrophages towards the M2 phenotype, which subsequently induces osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). RNA sequencing analysis reveals that piezoelectricity-modulated macrophage M2 polarization is closely associated with metabolic reprogramming, including increased amino acid biosynthesis and fatty acid oxidation. The composite hydrogel with excellent biocompatibility exhibits immunomodulatory and osteoinductive activities. In a rat model of alveolar bone defects, the piezoelectric hydrogel effectively promotes endogenous bone regeneration at the load-bearing sites. The piezoelectric-driven osteoimmunomodulation proposed in this study not only broadens understanding of the mechanism underlying piezoelectric biomaterials for tissue regeneration but also provides new insights into the design and development of next-generation immunomodulatory biomaterials.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141365942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced electrocatalysts for fuel cells: Evolution of active sites and synergistic properties of catalysts and carrier materials 燃料电池的先进电催化剂：催化剂和载体材料活性位点的演变及协同特性

Exploration (Beijing, China) Pub Date : 2024-06-10 DOI: 10.1002/EXP.20230052

Zhijie Kong, Jingcheng Wu, Zhijuan Liu, Dafeng Yan, Zhi-Peng Wu, Chuan-Jian Zhong

{"title":"Advanced electrocatalysts for fuel cells: Evolution of active sites and synergistic properties of catalysts and carrier materials","authors":"Zhijie Kong, Jingcheng Wu, Zhijuan Liu, Dafeng Yan, Zhi-Peng Wu, Chuan-Jian Zhong","doi":"10.1002/EXP.20230052","DOIUrl":"10.1002/EXP.20230052","url":null,"abstract":"Proton exchange-membrane fuel cell (PEMFC) is a clean and efficient type of energy storage device. However, the sluggish reaction rate of the cathode oxygen reduction reaction (ORR) has been a significant problem in its development. This review reports the recent progress of advanced electrocatalysts focusing on the interface/surface electronic structure and exploring the synergistic relationship of precious-based and non-precious metal-based catalysts and support materials. The support materials contain non-metal (C/N/Si, etc.) and metal-based structures, which have demonstrated a crucial role in the synergistic enhancement of electrocatalytic properties, especially for high-temperature fuel cell systems. To improve the strong interaction, some exciting synergistic strategies by doping and coating heterogeneous elements or connecting polymeric ligands containing carbon and nitrogen were also shown herein. Besides the typical role of the crystal surface, phase structure, lattice strain, etc., the evolution of structure-performance relations was also highlighted in real-time tests. The advanced in situ characterization techniques were also reviewed to emphasize the accurate structure-performance relations. Finally, the challenge and prospect for developing the ORR electrocatalysts were concluded for commercial applications in low- and high-temperature fuel cell systems.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing stimuli-responsive biomaterials for advanced biomedical applications

Exploration (Beijing, China) Pub Date : 2024-05-30 DOI: 10.1002/EXP.20230133

Ziming Liao, Tingting Liu, Zhimin Yao, Tian Hu, Xiaoyuan Ji, Bin Yao

{"title":"Harnessing stimuli-responsive biomaterials for advanced biomedical applications","authors":"Ziming Liao, Tingting Liu, Zhimin Yao, Tian Hu, Xiaoyuan Ji, Bin Yao","doi":"10.1002/EXP.20230133","DOIUrl":"https://doi.org/10.1002/EXP.20230133","url":null,"abstract":"Cell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular behavior toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, and magnetism, simultaneously harnessed through biomaterial-mediated responses. These external triggers become focal points within the body due to interactions with biomaterials, facilitating a range of cellular pathways: electrical signal transmission, biochemical cues, drug release, cell loading, and modulation of mechanical stress. Stimulus-responsive biomaterials hold immense potential in biomedical research, establishing themselves as a pivotal focal point in interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli and their corresponding biomaterial response mechanisms. Moreover, it delves deeply into the application of biomaterials within the domain of biomedicine. A balanced assessment of distinct physical stimulation techniques is provided, along with a discussion of their merits and limitations. The review aims to shed light on the future trajectory of physical stimulus-responsive biomaterials in disease treatment and outline their application prospects and potential for future development. This review is poised to spark novel concepts for advancing intelligent, stimulus-responsive biomaterials.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Exploration (Beijing, China) Pub Date : 2024-05-24 DOI: 10.1002/EXP.20230165

Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun

{"title":"Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery","authors":"Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun","doi":"10.1002/EXP.20230165","DOIUrl":"https://doi.org/10.1002/EXP.20230165","url":null,"abstract":"Immune-mediated inflammatory diseases (IMIDs) impose an immeasurable burden on individuals and society. While the conventional use of immunosuppressants and disease-modifying drugs has provided partial relief and control, their inevitable side effects and limited efficacy cast a shadow over finding a cure. Promising nucleic acid drugs have shown the potential to exert precise effects at the molecular level, with different classes of nucleic acids having regulatory functions through varying mechanisms. For the better delivery of nucleic acids, safe and effective viral vectors and non-viral delivery systems (including liposomes, polymers, etc.) have been intensively explored. Herein, after describing a range of nucleic acid categories and vectors, we focus on the application of therapeutic nucleic acid delivery in various IMIDs, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis, asthma, ankylosing spondylitis, systemic lupus erythematosus, and uveitis. Molecules implicated in inflammation and immune dysregulation are abnormally expressed in a series of IMIDs, and their meticulous modulation through nucleic acid therapy results in varying degrees of remission and improvement of these diseases. By synthesizing findings centered on specific molecular targets, this review delivers a systematic elucidation and perspective towards advancing and utilization of nucleic acid therapeutics for managing IMIDs.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements and challenges in brain cancer therapeutics 脑癌疗法的进展与挑战

Exploration (Beijing, China) Pub Date : 2024-05-16 DOI: 10.1002/EXP.20230177

Fan Bai, Yueyang Deng, Long Li, Ming Lv, Jamoliddin Razzokov, Qingnan Xu, Zhen Xu, Zhaowei Chen, Guojun Chen, Zhitong Chen

引用次数: 0

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer 基于金属酚网络的铁蛋白诱导和免疫疗法级联循环，用于结直肠癌的联合治疗

Exploration (Beijing, China) Pub Date : 2024-05-15 DOI: 10.1002/EXP.20230117

Yuwei Li, Yuxi Duan, Yunyi Li, Yuan Gu, Lu Zhou, Zhongting Xiao, Xinying Yu, Yanjun Cai, Erzhuo Cheng, Qianqian Liu, Yong Jiang, Quan Yang, Feng Zhang, Qi Lei, Bin Yang

{"title":"Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer","authors":"Yuwei Li, Yuxi Duan, Yunyi Li, Yuan Gu, Lu Zhou, Zhongting Xiao, Xinying Yu, Yanjun Cai, Erzhuo Cheng, Qianqian Liu, Yong Jiang, Quan Yang, Feng Zhang, Qi Lei, Bin Yang","doi":"10.1002/EXP.20230117","DOIUrl":"10.1002/EXP.20230117","url":null,"abstract":"Cancer immunotherapy is the most promising method for tumor therapy, while ferroptosis could activate the immunogenicity of cancer and strengthen the cellular immune response. However, limited by the complex tumor microenvironment, the abundant glutathione (GSH) and low reactive oxygen species (ROS) seriously weaken ferroptosis and the immune response. Herein, the authors report photothermal metal-phenolic networks (MPNs) supplied with buthionine sulfoximine (BSO) by reducing levels of GSH and then trapping the tumor cells in the ferroptosis and immunotherapy cascade loop to eliminate colorectal cancer (CRC). The MPNs coated with the model antigen ovalbumin can accumulate at the tumor site, mediate immunogenic cell death (ICD) under NIR irradiation, and initiate tumoricidal immunity. Then the activated CD8+ T cells would release IFN-γ to inhibit GPX4 and promote the immunogenic ferroptosis induced by Fe3+ and BSO. Finally, the tumor cells at intertumoral and intratumoral levels would be involved in the ferroptosis-dominated cancer-immunity circle for CRC eradication, resulting in outstanding therapeutic outcomes in both primary and distant tumor models. Overall, this strategy employs a photothermal nanoplatform to rapidly stimulate ICD and restrain the oxidation defense system, which provides a promising approach to significantly amplify the “cascade loop” of ferroptosis induction and immunotherapy for treatment of CRC.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches 用于全印刷智能传感器贴片的基于氧化物半导体的深亚阈值操作读出电子器件

Exploration (Beijing, China) Pub Date : 2024-05-15 DOI: 10.1002/EXP.20230167

Jyoti Ranjan Pradhan, Sushree Sangita Priyadarsini, Sanjana R. Nibgoor, Manvendra Singh, Subho Dasgupta

{"title":"Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches","authors":"Jyoti Ranjan Pradhan, Sushree Sangita Priyadarsini, Sanjana R. Nibgoor, Manvendra Singh, Subho Dasgupta","doi":"10.1002/EXP.20230167","DOIUrl":"10.1002/EXP.20230167","url":null,"abstract":"The ability to fabricate an entire smart sensor patch with read-out electronics using commercial printing techniques may have a wide range of potential applications. Although solution-processed oxide thin film transistors (TFTs) are capable of providing high mobility electron transport, resulting in large ON-state current and power output, there is hardly any literature report that uses the printed oxide TFTs at the sensor interfaces. Here, printed amorphous indium-gallium-zinc oxide (a-IGZO)-based deep-subthreshold operated TFTs that comprise signal amplifiers and analog-to-digital converters (ADCs) that can successfully digitalize the analog sensor signals up to a frequency range of 1 kHz are reported. In addition, exploiting the high current oxide TFTs, a current drive circuit placed after the ADC unit has been found useful in producing easy-to-detect visual recognition of the sensor signal at a predefined threshold crossover. Notably, the entire smart sensor patch is demonstrated to operate at a low supply voltage of ≤2 V, thereby ensuring that it can be an on-chip energy source compatible and standalone detection unit.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0