Exploration (Beijing, China)最新文献_第4页

High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption 将羽毛废料高产升级再利用为固态超长磷光碳点，用于先进防伪和信息加密

Exploration (Beijing, China) Pub Date : 2024-05-14 DOI: 10.1002/EXP.20230166

Dongzhi Chen, Xin Guo, Xuening Sun, Xiang Feng, Kailong Chen, Jinfeng Zhang, Zece Zhu, Xiaofang Zhang, Xin Liu, Min Liu, Li Li, Weilin Xu

{"title":"High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption","authors":"Dongzhi Chen, Xin Guo, Xuening Sun, Xiang Feng, Kailong Chen, Jinfeng Zhang, Zece Zhu, Xiaofang Zhang, Xin Liu, Min Liu, Li Li, Weilin Xu","doi":"10.1002/EXP.20230166","DOIUrl":"10.1002/EXP.20230166","url":null,"abstract":"Recently, biomass-derived carbon dots (CDs) have attracted considerable attention in high-technology fields due to their prominent merits, including brilliant luminescence, superior biocompatibility, and low toxicity. However, most of the biomass-derived CDs only show bright fluorescence in diluted solution because of aggregation-induced quenching effect, hence cannot exhibit solid-state long-lived room-temperature phosphorescence (RTP) in ambient conditions. Herein, matrix-free solid-state RTP with an average lifetime of 0.50 s is realized in the CDs synthesized by one-pot hydrothermal treatment of duck feather waste powder. To further enhance RTP lifetime, hydrogen bonding is introduced by employing polyols like polyvinyl alcohol (PVA) and phytic acid (PA), and a bimodal luminescent CDs/PVA/PA ink is exploited by mixing the CDs and polyols. Astonishingly, the CDs/PVA/PA ink screen-printed onto cellulosic substrates exhibits unprecedented green RTP with average lifetime of up to 1.97 s, and the afterglow lasts for more than 14 s after removing UV lamp. Such improvement on RTP is proposed to the populated excited triplet excitons stabilized by rigid chains. Furthermore, the CDs/PVA/PA ink demonstrates excellent potential in anticounterfeiting and information encryption. To the best of the authors' knowledge, this work is the first successful attempt to fabricate matrix-free ultra-long RTP CDs by reclamation of the feather wastes for environmental sustainability.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing 智能细菌靶向 ZIF-8 复合材料，用于荧光成像引导的光动力疗法，治疗耐药超级细菌感染和烧伤创面愈合

Exploration (Beijing, China) Pub Date : 2024-04-19 DOI: 10.1002/EXP.20230113

Xiaoxue Li, Wei Wang, Qiuxia Gao, Shanshan Lai, Yan Liu, Sitong Zhou, Yan Yan, Jie Zhang, Huanhuan Wang, Jiamei Wang, Yi Feng, Ronghua Yang, Jianyu Su, Bin Li, Yuhui Liao

{"title":"Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing","authors":"Xiaoxue Li, Wei Wang, Qiuxia Gao, Shanshan Lai, Yan Liu, Sitong Zhou, Yan Yan, Jie Zhang, Huanhuan Wang, Jiamei Wang, Yi Feng, Ronghua Yang, Jianyu Su, Bin Li, Yuhui Liao","doi":"10.1002/EXP.20230113","DOIUrl":"10.1002/EXP.20230113","url":null,"abstract":"Infected burn wounds are characterized by persistent drug-resistant bacterial infection coupled with an inflammatory response, impeding the wound-healing process. In this study, an intelligent nanoparticle system (CCM+TTD@ZIF-8 NPs) was prepared using curcumin (CCM), an aggregation-induced emission luminogens (TTD), and ZIF-8 for infection-induced wound healing. The CCM+TTD@ZIF-8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response-guided photodynamic therapy (PDT), and anti-inflammatory. The positive charges of ZIF-8 NPs allowed the targeting of drug-resistant bacteria in infected wounds, thereby realizing fluorescence imaging of bacteria by emitting red fluorescence at the infected site upon blue light irradiation. The pH-responsive characteristics of the CCM+TTD@ZIF-8 NPs also enabled controllable CCM release onto the infected wound site, thereby promoting the specific accumulation of ROS at the infected site, with outstanding bactericidal efficacy against drug-resistant Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) strains in vitro/in vivo. Additionally, due to the excellent bactericidal effect and anti-inflammatory properties of CCM+TTD@ZIF-8 NPs combined with blue light irradiation, the regeneration of epidermal tissue, angiogenesis, and collagen deposition was achieved, accelerating the healing process of infected burn wounds. Therefore, this CCM+TTD@ZIF-8 NPs with multifunctional properties provides great potential for infected burn wound healing.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside Back Cover: Scalability of nanopore osmotic energy conversion (EXP2 2/2024) 封底内页：纳米孔渗透能量转换的可扩展性（EXP2 2/2024）

Exploration (Beijing, China) Pub Date : 2024-04-17 DOI: 10.1002/EXP.20240203

Makusu Tsutsui, Wei-Lun Hsu, Kazumichi Yokota, Iat Wai Leong, Hirofumi Daiguji, Tomoji Kawai

引用次数: 0

Front Cover: Nitrogen deficiency modulates carbon allocation to promote nodule nitrogen fixation capacity in soybean (EXP2 2/2024) 封面：缺氮调节碳分配以促进大豆的结核固氮能力 (EXP2 2/2024)

Exploration (Beijing, China) Pub Date : 2024-04-17 DOI: 10.1002/EXP.20240201

Xiaolong Ke, Han Xiao, Yaqi Peng, Xue Xia, Xuelu Wang

引用次数: 0

Inside Front Cover: Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system (EXP2 2/2024) 封面内页：脑脊液通过静脉上的动态旁孔流出是大脑排水系统缺失的一环（EXP2 2/2024）

Exploration (Beijing, China) Pub Date : 2024-04-17 DOI: 10.1002/EXP.20240202

Yaqiong Dong, Ting Xu, Lan Yuan, Yahan Wang, Siwang Yu, Zhi Wang, Shizhu Chen, Chunhua Chen, Weijiang He, Tessandra Stewart, Weiguang Zhang, Xiaoda Yang

引用次数: 0

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration 可控雌二醇释放的仿生三层支架用于子宫组织再生

Exploration (Beijing, China) Pub Date : 2024-04-17 DOI: 10.1002/EXP.20230141

Shangsi Chen, Junzhi Li, Liwu Zheng, Jie Huang, Min Wang

{"title":"Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration","authors":"Shangsi Chen, Junzhi Li, Liwu Zheng, Jie Huang, Min Wang","doi":"10.1002/EXP.20230141","DOIUrl":"10.1002/EXP.20230141","url":null,"abstract":"Scaffold-based tissue engineering provides an efficient approach for repairing uterine tissue defects and restoring fertility. In the current study, a novel trilayer tissue engineering scaffold with high similarity to the uterine tissue in structure was designed and fabricated via 4D printing, electrospinning and 3D bioprinting for uterine regeneration. Highly stretchable poly(l-lactide-co-trimethylene carbonate) (PLLA-co-TMC, “PTMC” in short)/thermoplastic polyurethane (TPU) polymer blend scaffolds were firstly made via 4D printing. To improve the biocompatibility, porous poly(lactic acid-co-glycolic acid) (PLGA)/gelatin methacryloyl (GelMA) fibers incorporated with polydopamine (PDA) particles were produced on PTMC/TPU scaffolds via electrospinning. Importantly, estradiol (E2) was encapsulated in PDA particles. The bilayer scaffolds thus produced could provide controlled and sustained release of E2. Subsequently, bone marrow derived mesenchymal stem cells (BMSCs) were mixed with gelatin methacryloyl (GelMA)-based inks and the formulated bioinks were used to fabricate a cell-laden hydrogel layer on the bilayer scaffolds via 3D bioprinting, forming ultimately biomimicking trilayer scaffolds for uterine tissue regeneration. The trilayer tissue engineering scaffolds thus formed exhibited a shape morphing ability by transforming from the planar shape to tubular structures when immersed in the culture medium at 37°C. The trilayer tissue engineering scaffolds under development would provide new insights for uterine tissue regeneration.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontispiece: Insight into uniform filming of LiF-rich interphase via synergistic adsorption for high-performance lithium metal anode (EXP2 2/2024) 前言：高性能锂金属负极协同吸附富含 LiF 的中间相均匀成膜的启示（EXP2 2/2024）

Exploration (Beijing, China) Pub Date : 2024-04-17 DOI: 10.1002/EXP.20240205

Yufang He, Li Wang, Aiping Wang, Bo Zhang, Hiep Pham, Jonghyun Park, Xiangming He

引用次数: 0

Back Cover: A red blood cell-derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery (EXP2 2/2024) 封底：一种源自红细胞的仿生微型机器人，能够分层适应全身给药过程中的五个关键阶段（EXP2 2/2024）

Exploration (Beijing, China) Pub Date : 2024-04-17 DOI: 10.1002/EXP.20240204

Ya-Xuan Zhu, Hao-Ran Jia, Yao-Wen Jiang, Yuxin Guo, Qiu-Yi Duan, Ke-Fei Xu, Bai-Hui Shan, Xiaoyang Liu, Xiaokai Chen, Fu-Gen Wu

引用次数: 0

A perspective of lipid nanoparticles for RNA delivery 从脂质纳米粒子的角度看 RNA 的传递

Exploration (Beijing, China) Pub Date : 2024-04-15 DOI: 10.1002/EXP.20230147

Yutian Ma, Shiyao Li, Xin Lin, Yupeng Chen

{"title":"A perspective of lipid nanoparticles for RNA delivery","authors":"Yutian Ma, Shiyao Li, Xin Lin, Yupeng Chen","doi":"10.1002/EXP.20230147","DOIUrl":"10.1002/EXP.20230147","url":null,"abstract":"Over the last two decades, lipid nanoparticles (LNPs) have evolved as an effective biocompatible and biodegradable RNA delivery platform in the fields of nanomedicine, biotechnology, and drug delivery. They are novel bionanomaterials that can be used to encapsulate a wide range of biomolecules, such as mRNA, as demonstrated by the current successes of COVID-19 mRNA vaccines. Therefore, it is important to provide a perspective on LNPs for RNA delivery, which further offers useful guidance for researchers who want to work in the RNA-based LNP field. This perspective first summarizes the approaches for the preparation of LNPs, followed by the introduction of the key characterization parameters. Then, the in vitro cell experiments to study LNP performance, including cell selection, cell viability, cellular association/uptake, endosomal escape, and their efficacy, were summarized. Finally, the in vivo animal experiments in the aspects of animal selection, administration, dosing and safety, and their therapeutic efficacy were discussed. The authors hope this perspective can offer valuable guidance to researchers who enter the field of RNA-based LNPs and help them understand the crucial parameters that RNA-based LNPs demand.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations 用于组织工程的生物活性支架：脱细胞细胞外基质应用与创新综述

Exploration (Beijing, China) Pub Date : 2024-04-11 DOI: 10.1002/EXP.20230078

Juan Liu, Qingru Song, Wenzhen Yin, Chen Li, Ni An, Yinpeng Le, Qi Wang, Yutian Feng, Yuelei Hu, Yunfang Wang

引用次数: 0