Exploration (Beijing, China)最新文献_第4页

Cataract-Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation 致白内障突变体βB2晶体蛋白R188C结构稳定性低，对环境应力敏感，易形成聚集体

Exploration (Beijing, China) Pub Date : 2025-04-01 DOI: 10.1002/EXP.20240192

Yibo Yu, Silong Chen, Ying Zhang, Hang Song, Jiarui Guo, Chengpeng Wu, Wei Wu, Jingjie Xu, Xiaoyu Cheng, Chenqi Luo, Jing Guo, Yip Chee Chew, Ke Yao, Xiangjun Chen, Lidan Hu

{"title":"Cataract-Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation","authors":"Yibo Yu, Silong Chen, Ying Zhang, Hang Song, Jiarui Guo, Chengpeng Wu, Wei Wu, Jingjie Xu, Xiaoyu Cheng, Chenqi Luo, Jing Guo, Yip Chee Chew, Ke Yao, Xiangjun Chen, Lidan Hu","doi":"10.1002/EXP.20240192","DOIUrl":"https://doi.org/10.1002/EXP.20240192","url":null,"abstract":"This study investigated a Chinese family with congenital posterior polar cataracts linked to the βB2-R188C mutation. βB2-crystallin, a key structural component of the lens, is crucial for maintaining lens transparency and stability. We examined the effects of the R188C mutation on βB2-crystallin's structural stability and resistance to environmental stressors using purified proteins and cellular models. The βB2-R188C mutant showed poor stability and a tendency to aggregate under physiological and pathological conditions. The mutation disrupted the oligomerization equilibrium, causing dissociation of dimers into monomers. Molecular dynamics simulations and spectroscopic experiments revealed abnormal protein folding induced by the R188C mutation, increasing susceptibility to environmental stressors. Aggregation was observed in both prokaryotic and eukaryotic models under normal conditions, with enhanced severity under environmental stressors. Notably, lanosterol treatment or αB-crystallin partially reversed aggregation. In summary, the R188C mutation promotes abnormal aggregation by destabilizing βB2-crystallin and disrupting oligomerization equilibrium, potentially leading to cataract formation. Targeting aggregate formation with small molecules like lanosterol or enhancing molecular chaperone activity offers a promising strategy for cataract prevention and treatment.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials 基于纳米材料靶向肿瘤微生物群的肿瘤治疗

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-03-24 DOI: 10.1002/EXP.20210185

Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan

{"title":"Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials","authors":"Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan","doi":"10.1002/EXP.20210185","DOIUrl":"https://doi.org/10.1002/EXP.20210185","url":null,"abstract":"Intra-tumoral microbiota, which is a potential component of the tumor microenvironment (TME), has been emerging as a key participant and driving factor in cancer. Previously, due to technical issues and low biological content, little was known about the microbial community within tumors. With the development of high-throughput sequencing technology and molecular biology techniques, it has been demonstrated that tumors harbor highly heterogeneous symbiotic microbial communities, which affect tumor progression mechanisms through various pathways, such as inducing DNA damage, activating carcinogenic pathways, and inducing an immunesuppressive environment. Faced with the harmful microbial communities in the TME, efforts have been made to develop new technologies specifically targeting the microbiome and tumor microecology. Given the success of nanotechnology in cancer diagnosis and treatment, the development of nanotechnology to regulate microscale and molecular-scale interactions occurring in the microbiome and tumor microecology holds promise for providing new approaches for cancer therapy. This article reviews the latest progress in this field, including the microbial community within tumors and its pro-cancer mechanisms, as well as the anti-tumor strategies targeting intra-tumoral microorganisms using nanotechnology. Additionally, this article delivers prospects for the potential clinical significance and challenges of anti-tumor strategies against intra-tumoral microorganisms.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20210185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials-Involved Construction of Extracellular Matrices for Tumor Blockade Therapy 用于肿瘤阻断治疗的细胞外基质的生物材料参与构建

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-03-16 DOI: 10.1002/EXP.20240229

Jinfeng Sun, Yang Liu, Jingshan Sun, Jianxun Ding, Xuesi Chen

引用次数: 0

Self-Warning and Self-Repairing Mechanisms in Functional Coatings: A Review 功能涂层的自我预警与自我修复机制研究进展

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-03-07 DOI: 10.1002/EXP.20240066

Yixin Chen, Qian Wang, Lifeng Hou, Hao Huang, Zhiqiang Gao, Yinghui Wei

{"title":"Self-Warning and Self-Repairing Mechanisms in Functional Coatings: A Review","authors":"Yixin Chen, Qian Wang, Lifeng Hou, Hao Huang, Zhiqiang Gao, Yinghui Wei","doi":"10.1002/EXP.20240066","DOIUrl":"https://doi.org/10.1002/EXP.20240066","url":null,"abstract":"Coatings have attracted widespread attention in the field of corrosion protection of metals because of their corrosion resistance and convenient techniques. Unfortunately, till now, traditional coatings have the shortcomings of vulnerability and passive corrosion protection, hence functional coatings progressively replace them. Endowing coatings with additional functions not only transform them into active protection mechanisms but also significantly improve life cycle of coatings. However, there is only limited success in combining multiple functions of coatings, which poses considerable obstacles to further advancement of their application researches. In this paper, we summarize the research progress of self-warning and self-repairing coatings in the field of metal corrosion protection as much as possible from the perspective of functional material selection. Meanwhile, the current progress of substituting dual-functional coatings for single-functional coatings is also highlighted. We aim to provide more options and strategic guidance for the design and fabrication of functional coatings on metal surfaces and to explore the possibilities of these designs in practical applications. Last but not least, the remaining challenges and future growth regarding this field are also outlined at the end. It is hope that such an elaborately organized review will benefit the readers interested to foster more possibilities in the future.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy 负载BACE1 sirna的普鲁士蓝纳米复合物对阿尔茨海默病协同治疗的血脑屏障穿透性增强

IF 22.5

Exploration (Beijing, China) Pub Date : 2025-03-07 DOI: 10.1002/EXP.20230178

Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan

{"title":"Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy","authors":"Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan","doi":"10.1002/EXP.20230178","DOIUrl":"https://doi.org/10.1002/EXP.20230178","url":null,"abstract":"Amyloid-β (Aβ) deposition was an important pathomechanisms of Alzheimer's disease (AD). Aβ generation was highly regulated by beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. The silence of BACE1 function to slow down Aβ production was accepted as an effective strategy for combating AD. Herein, BACE1 interfering RNA, metallothionein (MT) and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in Prussian blue nanoparticles (PRM-siRNA). PRM-siRNA under near-infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood-brain barrier (BBB) for enhanced drug delivery. BACE1 siRNA slowed down Aβ production and Cu2+ chelation by metallothionein (MT) synergistically inhibited Aβ aggregation. Ruthenium (Ru) could real-timely track Aβ degradation and aggregation. The results indicated that PRM-siRNA significantly blocked Aβ aggregation and attenuated Aβ-induced neurotoxicity and apoptosis in vitro by inhibiting ROS-mediated oxidative damage and mitochondrial dysfunction through regulating the Bcl-2 family. PRM-siRNA in vivo effectively improved APP/PS1 mice learning and memory by alleviating neural loss, neurofibrillary tangles and activation of astrocytes and microglial cells in APP/PS1 mice by inhibiting BACE1, oxidative damage and tau phosphorylation. Taken together, our findings validated that BACE1 siRNA-loaded Prussian blue nanocomplexes showed enhanced BBB penetrability and AD synergy therapy.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 4","pages":""},"PeriodicalIF":22.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts 加速活动部位创面愈合的多功能PHC绷带

Exploration (Beijing, China) Pub Date : 2025-03-06 DOI: 10.1002/EXP.20230176

Liqi Wei, Xin Liu, Yuanqiang Li, Yu Han, Yiping Ren, Tianshu Zou, Pengcheng Yu, Yining Chen, Biao Zhang, Zixuan Wang, Jingyi Jiang, Yumi Kim, Rui Chen, Yan Cheng, Hongxia Ma

{"title":"Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts","authors":"Liqi Wei, Xin Liu, Yuanqiang Li, Yu Han, Yiping Ren, Tianshu Zou, Pengcheng Yu, Yining Chen, Biao Zhang, Zixuan Wang, Jingyi Jiang, Yumi Kim, Rui Chen, Yan Cheng, Hongxia Ma","doi":"10.1002/EXP.20230176","DOIUrl":"https://doi.org/10.1002/EXP.20230176","url":null,"abstract":"Wound healing in movable parts poses challenges owing to frequent activities, leading to delayed recovery and heightened susceptibility to bacterial infections and inflammation. Although hydrogel-based dressings have been explored, their therapeutic effectiveness is limited by poor resistance to stimuli and low mechanical strength. Here, we present a novel multifunctional PHC bandage that prevents bacterial infection and capitalizes on the inherent mobility of the affected area to expedite the wound-healing process. A PHC bandage was fabricated by incorporating photothermal copper bismuth sulfide (Cu3BiS3) nanomaterials into piezoelectric and pyroelectric polyvinylidene fluoride (PVDF). Upon exposure to alternating near-infrared light, the embedded Cu3BiS3 generated localized heat, activated PVDF, and induced the production of abundant reactive oxygen species for bacterial inactivation. Furthermore, continuous movement of the wound area triggers the PVDF to generate a sustained electrical field, promoting cell migration and proliferation to facilitate wound healing. The wound healing rate of PHC was 13.17 ± 2.09% higher than medical gauze. The robust encapsulation of PVDF ensured secure containment of the loaded Cu3BiS3 nanoparticles, improving the biocompatibility and sustainable utilization of this innovative wound dressing. This innovative design offers a promising and effective solution for improving wound healing in movable parts, potentially revolutionizing wound care technology.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-Anchored Ticagrelor Gelatin Nanoparticles-Platelets System for Enhanced Anti-PD-L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines 表面锚定替格瑞洛明胶纳米颗粒-血小板系统增强抗pd - l1治疗反应和提高纳米药物的化疗疗效

Exploration (Beijing, China) Pub Date : 2025-03-06 DOI: 10.1002/EXP.20240084

Qi Lu, Hao Ye, Jian Zhao, Xiaoyuan Fan, Kaiyuan Wang, Zeyu Han, Tian Liu, Lili Du, Jiaxuan Song, Helin Wang, Haotian Zhang, Zhonggui He, Jin Sun

{"title":"Surface-Anchored Ticagrelor Gelatin Nanoparticles-Platelets System for Enhanced Anti-PD-L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines","authors":"Qi Lu, Hao Ye, Jian Zhao, Xiaoyuan Fan, Kaiyuan Wang, Zeyu Han, Tian Liu, Lili Du, Jiaxuan Song, Helin Wang, Haotian Zhang, Zhonggui He, Jin Sun","doi":"10.1002/EXP.20240084","DOIUrl":"https://doi.org/10.1002/EXP.20240084","url":null,"abstract":"The tumor microenvironment is characterized by immunosuppression and compromised intratumoral perfusion, which impairs the effectiveness of immune checkpoint inhibitors and nanomedicines. A significant challenge is the role of activated platelets, as they increase transfer-mediated PD-L1 expression from tumor cells and maintain the integrity of tumor vasculature. These platelets support tumor growth by stabilizing the vasculature and enabling immune evasion, as well as shielding tumor cells from immune detection. To address these platelet-mediated negative antitumor effects, we have developed bioengineered platelets (PTNPs) with surface-anchored ticagrelor-loaded gelatin nanoparticles. This study utilizes the natural tendency of platelets to localize their activated counterparts into tumors. Upon binding to tumor-associated activated platelets, the PTNPs release ticagrelor in response to the secreted matrix metalloproteinases by activated platelet, inhibiting further platelet activation. This reduction in platelet activation lessens platelet-facilitated immunosuppression and diminishes the transferred-PD-L1 expression from cancer cells to platelets, thus enhancing the immune response of anti-PD-L1 therapy. Additionally, this strategy weakens the activated platelets’ contribution to tumor vascular integrity, improving the extravasation and chemotherapeutic efficacy of nanomedicines. Our findings highlight the crucial role of platelet activation in tumor biology and introduce PTNPs as an effective approach to disrupt tumor-supporting platelet activities and enhance anticancer treatments efficacy.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia 基于工程外泌体的抗衰老疗法通过靶向p21+CD86+小胶质细胞缓解卒中

Exploration (Beijing, China) Pub Date : 2025-03-06 DOI: 10.1002/EXP.20240349

Jialei Yang, Shipo Wu, Miao He

{"title":"Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia","authors":"Jialei Yang, Shipo Wu, Miao He","doi":"10.1002/EXP.20240349","DOIUrl":"https://doi.org/10.1002/EXP.20240349","url":null,"abstract":"Stroke remains the leading cause of neurological mortality and disability worldwide, with post-stroke inflammation significantly hindering neural repair. Despite its critical impact, mechanism-based therapeutic strategies are scarce. In this study, we uncovered a critically important yet previously unexamined cell population, p21+CD86+ microglia, which accumulated in ischemic region. Unexpectedly, we discovered that p21 interacted with C/EBPβ, driving C/EBPβ-dependent transcription and upregulating key pro-inflammatory factors such as Il6, Il1β, Cxcl2, and Cxcl10. To specifically target and eliminate these pathogenic p21+CD86+ microglia, we engineered exosomes with a peptide that selectively binds CD86+ microglia and loaded them with the senolytic Quercetin. Furthermore, we developed an optimized, stable Que@micro-Exo therapeutic formulation. Systemic administration of Que@micro-Exo robustly reduced p21+CD86+ microglia and suppressed their pro-inflammatory phenotype. Notably, functional analyses revealed that Que@micro-Exo treatment mitigated blood-brain barrier disruption, promoted beneficial microglial polarization, decreased neutrophil infiltration, and significantly enhanced functional recovery following cerebral ischemia, all with a favorable safety profile. Our preclinical findings lay the foundation for targeting p21+CD86+ microglia as a novel therapeutic strategy, highlighting the potential of exosome-based senolytic anti-inflammatory therapy for stroke and other central nervous system disorders.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme-Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy 级联酶样催化和同时铁下垂/铜下垂的单铜(I)位点的空间分离促进了免疫治疗

Exploration (Beijing, China) Pub Date : 2025-03-06 DOI: 10.1002/EXP.20240275

Yuanyuan Zhang, Shengnan Ya, Jingnan Huang, Yangyang Ju, Xueyang Fang, Xinteng Ouyang, Qingdong Zeng, Xinyao Zhou, Xiyun Yan, Guohui Nie, Kelong Fan, Bin Zhang

{"title":"Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme-Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy","authors":"Yuanyuan Zhang, Shengnan Ya, Jingnan Huang, Yangyang Ju, Xueyang Fang, Xinteng Ouyang, Qingdong Zeng, Xinyao Zhou, Xiyun Yan, Guohui Nie, Kelong Fan, Bin Zhang","doi":"10.1002/EXP.20240275","DOIUrl":"https://doi.org/10.1002/EXP.20240275","url":null,"abstract":"Nanozyme-based immunogenic cell death (ICD) inducers that effectively induce a strong immune response via enzyme-like process have attracted great attention, but how to ensure controllable active sites and maximize site utilization remains a problem. Here, we report a structurally well-defined and highly functional single-site copper(I) nanomodulators termed CuNTD, constructed by precisely anchoring atomically dispersed self-assembly S-Cu(I)-S sites onto a two-dimensional Ti3C2 surface. Leveraging Cu+ with a higher catalytic efficiency than Cu2+, CuNTD generates reactive oxygen species (ROS) storms through photothermal-enhanced cascade catalysis, further inducing mitochondrial dysfunction, ferroptosis and cuproptosis. Multifunctional CuNTD triggers strong ICD through cascade-regulatory pathways of photothermal-amplified ROS storms, cuproptosis and ferroptosis, effectively promoting dendritic cell maturation while reducing monotherapies side effects and resistance. In vivo, CuNTD combined with FDA-approved immunoadjuvants significantly prolong the survival of mice. With its demonstrated biosafety and high efficiency as an ICD inducer, this study provides a promising framework for advancing augmented tumor immunotherapy with significant clinical potential.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer 利用生物标志物激活探针进行早期分层和及时评估癌症治疗效果

Exploration (Beijing, China) Pub Date : 2025-03-06 DOI: 10.1002/EXP.20240037

Qinrui Fu

{"title":"Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer","authors":"Qinrui Fu","doi":"10.1002/EXP.20240037","DOIUrl":"https://doi.org/10.1002/EXP.20240037","url":null,"abstract":"The advancements in early stratification and timely evaluation of therapeutic effects have revolutionized the ability to assess curative outcomes promptly. The separation between diagnosis/treatment and timely assessment of treatment response, along with delays in evaluating therapy efficacy, are significant contributors to treatment failures. Traditional approaches for evaluating curative effects face challenges posed by tumor heterogeneity and resistance, making it challenging to determine the effectiveness of a given therapeutic regimen at an early stage in clinical practice. However, molecular imaging using activatable probes has overcome these obstacles and transformed the field by shifting focus towards developing functional probes for visualizing tumors as well as enabling early stratification or timely evaluation of therapy effects. In this article, we emphasize the importance of diverse activatable molecular imaging probes and provide insights into early stratification or timely evaluation of various therapies’ effects. Finally, we discuss the challenges faced in this field and propose future research directions.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0