Inside Back Cover: Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning (EXP2 4/2025)
Changwu Wu, Fushu Luo, Yongye Zhu, Chunbo Liu, Zheng Chen, Xiangyu Wang, Jun Tan, Qing Liu
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Abstract
The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe-related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota. Further, the prognostic model based on machine learning and microbiota established in this study, namely microbe-related signature, could robustly predict prognosis of glioma and provide insights for immunotherapy benefits.
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