Exploration (Beijing, China)最新文献_第9页

Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater 冷大气等离子体可有效消毒废水中的 SARS-CoV-2

Exploration (Beijing, China) Pub Date : 2023-11-30 DOI: 10.1002/EXP.20230012

Hongbo Qin, Hengju Qiu, Ke Liu, Bixia Hong, Yuchen Liu, Chun Li, Mengzhe Li, Xiaoping An, Lihua Song, Eric Robert, Yigang Tong, Huahao Fan, Ruixue Wang

{"title":"Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater","authors":"Hongbo Qin, Hengju Qiu, Ke Liu, Bixia Hong, Yuchen Liu, Chun Li, Mengzhe Li, Xiaoping An, Lihua Song, Eric Robert, Yigang Tong, Huahao Fan, Ruixue Wang","doi":"10.1002/EXP.20230012","DOIUrl":"10.1002/EXP.20230012","url":null,"abstract":"COVID-19 is currently pandemic and the detection of SARS-CoV-2 variants in wastewater is causing widespread concern. Herein, cold atmospheric plasma (CAP) is proposed as a novel wastewater disinfection technology that effectively inactivates SARS-CoV-2 transcription- and replication-competent virus-like particles, coronavirus GX_P2V, pseudotyped SARS-CoV-2 variants, and porcine epidemic diarrhoea virus in a large volume of water within 180 s (inhibition rate > 99%). Further, CAP disinfection did not adversely affect the viability of various human cell lines. It is identified that CAP produced peroxynitrite (ONOO−), ozone (O3), superoxide anion radicals (O2−), and hydrogen peroxide (H2O2) as the major active substances for coronavirus disinfection. Investigation of the mechanism showed that active substances not only reacted with the coronavirus spike protein and affected its infectivity, but also destroyed the nucleocapsid protein and genome, thus affecting virus replication. This method provides an efficient and environmentally friendly strategy for the elimination of SARS-CoV-2 and other coronaviruses from wastewater.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139202459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system 脑脊液通过静脉上的动态旁孔流出，是大脑排水系统中缺失的一环

Exploration (Beijing, China) Pub Date : 2023-11-27 DOI: 10.1002/EXP.20230029

Yaqiong Dong, Ting Xu, Lan Yuan, Yahan Wang, Siwang Yu, Zhi Wang, Shizhu Chen, Chunhua Chen, Weijiang He, Tessandra Stewart, Weiguang Zhang, Xiaoda Yang

{"title":"Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system","authors":"Yaqiong Dong, Ting Xu, Lan Yuan, Yahan Wang, Siwang Yu, Zhi Wang, Shizhu Chen, Chunhua Chen, Weijiang He, Tessandra Stewart, Weiguang Zhang, Xiaoda Yang","doi":"10.1002/EXP.20230029","DOIUrl":"10.1002/EXP.20230029","url":null,"abstract":"The glymphatic system plays a key role in the clearance of waste from the parenchyma, and its dysfunction has been associated with the pathogenesis of Alzheimer's disease (AD). However, questions remain regarding its complete mechanisms. Here, we report that efflux of cerebrospinal fluid (CSF)/interstitial fluid (ISF) solutes occurs through a triphasic process that cannot be explained by the current model, but rather hints at the possibility of other, previously undiscovered routes from paravenous spaces to the blood. Using real-time, in vivo observation of efflux, a novel drainage pathway was discovered, in which CSF molecules enter the bloodstream directly through dynamically assembled, trumpet-shaped pores (basolateral ϕ<8 μm; apical ϕ < 2 μm) on the walls of brain venules. As Zn2+ could facilitate the brain clearance of macromolecular ISF solutes, Zn2+-induced reconstruction of the tight junctions (TJs) in vascular endothelial cells may participate in pore formation. Thus, an updated model for glymphatic clearance of brain metabolites and potential regulation is postulated. In addition, deficient clearance of Aβ through these asymmetric venule pores was observed in AD model mice, supporting the notion that impaired brain drainage function contributes to Aβ accumulation and pathogenic dilation of the perivascular space in AD.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139231401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted protein delivery based on stimuli-triggered nanomedicine 基于刺激触发纳米医学的靶向蛋白质输送

Exploration (Beijing, China) Pub Date : 2023-11-23 DOI: 10.1002/EXP.20230025

Jinzhao Liu, Yang Zhou, Qingyang Lyu, Xiaotong Yao, Weiping Wang

引用次数: 0

Viscoelastic blood coagulation testing system enabled by a non-contact triboelectric angle sensor 利用非接触式三电角传感器实现的粘弹性血液凝固测试系统

Exploration (Beijing, China) Pub Date : 2023-11-23 DOI: 10.1002/EXP.20230073

Baocheng Wang, Xuelian Wei, Hanlin Zhou, Xiaole Cao, Enyang Zhang, Zhong Lin Wang, Zhiyi Wu

{"title":"Viscoelastic blood coagulation testing system enabled by a non-contact triboelectric angle sensor","authors":"Baocheng Wang, Xuelian Wei, Hanlin Zhou, Xiaole Cao, Enyang Zhang, Zhong Lin Wang, Zhiyi Wu","doi":"10.1002/EXP.20230073","DOIUrl":"10.1002/EXP.20230073","url":null,"abstract":"Thromboelastography (TEG) remains a convenient and effective viscoelastic blood coagulation testing device for guiding blood component transfusion and assessing the risk of thrombosis. Here, a TEG enabled by a non-contact triboelectric angle sensor (NTAS) with a small size (∼7 cm3) is developed for assessing the blood coagulation system. With the assistance of a superelastic torsion wire structure, the NTAS-TEG realizes the detection of blood viscoelasticity. Benefiting from a grating and convex design, the NTAS holds a collection of compelling features, including accurate detection of rotation angles from −2.5° to 2.5°, high linearity (R2 = 0.999), and a resolution of 0.01°. Besides, the NTAS exhibits merits of low cost and simplified fabrication. Based on the NTAS-TEG, a viscoelastic blood coagulation detection and analysis system is successfully constructed, which can provide a graph and parameters associated with clot initiation, formation, and stability for clinicians by using 0.36 mL of whole blood. The system not only validates the feasibility of the triboelectric coagulation testing sensor, but also further expands the application of triboelectric sensors in healthcare.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dissolution, reassembly and further clearance of amyloid-β fibrils by tailor-designed dissociable nanosystem for Alzheimer's disease therapy 通过量身定制的可解离纳米系统溶解、重组和进一步清除淀粉样蛋白-β纤维，治疗阿尔茨海默病

Exploration (Beijing, China) Pub Date : 2023-11-23 DOI: 10.1002/EXP.20230048

Qianhua Feng, Xueli Zhang, Nan Zhang, Huan Gu, Ning Wang, Jing Chen, Xiaomin Yuan, Lei Wang

{"title":"The dissolution, reassembly and further clearance of amyloid-β fibrils by tailor-designed dissociable nanosystem for Alzheimer's disease therapy","authors":"Qianhua Feng, Xueli Zhang, Nan Zhang, Huan Gu, Ning Wang, Jing Chen, Xiaomin Yuan, Lei Wang","doi":"10.1002/EXP.20230048","DOIUrl":"10.1002/EXP.20230048","url":null,"abstract":"The fibrillation of amyloid-β (Aβ) is the critical causal factor in Alzheimer's disease (AD), the dissolution and clearance of which are promising for AD therapy. Although many Aβ inhibitors are developed, their low Aβ-binding affinity results in unsatisfactory effect. To solve this challenge, the Aβ sequence-matching strategy is proposed to tail-design dissociable nanosystem (B6-PNi NPs). Herein, B6-PNi NPs aim to improve Aβ-binding affinity for effective dissolution of amyloid fibrils, as well as to interfere with the in vivo fate of amyloid for Aβ clearance. Results show that B6-PNi NPs decompose into small nanostructures and expose Aβ-binding sites in response to AD microenvironment, and then capture Aβ via multiple interactions, including covalent linkage formed by nucleophilic substitution reaction. Such high Aβ-binding affinity disassembles Aβ fibrils into Aβ monomers, and induces the reassembly of Aβ&nanostructure composite, thereby promoting microglial Aβ phogocytosis/clearance via Aβ receptor-mediated endocytosis. After B6-PNi NPs treatment, the Aβ burden, neuroinflammation and cognitive impairments are relieved in AD transgenic mice. This work provides the Aβ sequence-matching strategy for Aβ inhibitor design in AD treatment, showing meaningful insight in biomedicine.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139243303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling 离子鸡尾酒疗法通过协同调节结构和电重塑治疗心肌梗死

Exploration (Beijing, China) Pub Date : 2023-11-23 DOI: 10.1002/EXP.20230067

Yumei Que, Jiaxin Shi, Zhaowenbin Zhang, Lu Sun, Hairu Li, Xionghai Qin, Zhen Zeng, Xiao Yang, Yanxin Chen, Chong Liu, Chang Liu, Shijie Sun, Qishu Jin, Yanxin Zhang, Xin Li, Ming Lei, Chen Yang, Hai Tian, Jiawei Tian, Jiang Chang

{"title":"Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling","authors":"Yumei Que, Jiaxin Shi, Zhaowenbin Zhang, Lu Sun, Hairu Li, Xionghai Qin, Zhen Zeng, Xiao Yang, Yanxin Chen, Chong Liu, Chang Liu, Shijie Sun, Qishu Jin, Yanxin Zhang, Xin Li, Ming Lei, Chen Yang, Hai Tian, Jiawei Tian, Jiang Chang","doi":"10.1002/EXP.20230067","DOIUrl":"10.1002/EXP.20230067","url":null,"abstract":"Myocardial infarction (MI) is a leading cause of death worldwide. Few drugs hold the ability to depress cardiac electrical and structural remodeling simultaneously after MI, which is crucial for the treatment of MI. The aim of this study is to investigate an effective therapy to improve both electrical and structural remodeling of the heart caused by MI. Here, an “ion cocktail therapy” is proposed to simultaneously reverse cardiac structural and electrical remodeling post-MI in rats and minipigs by applying a unique combination of silicate, strontium (Sr) and copper (Cu) ions due to their specific regulatory effects on the behavior of the key cells involved in MI including angiogenesis of endothelial cells, M2 polarization of macrophages and apoptosis of cardiomyocyte. The results demonstrate that ion cocktail treatment attenuates structural remodeling post-MI by ameliorating infarct size, promoting angiogenesis in both peri-infarct and infarct areas. Meantime, to some extent, ion cocktail treatment reverses the deteriorative electrical remodeling by reducing the incidence rate of early/delayed afterdepolarizations and minimizing the heterogeneity of cardiac electrophysiology. This ion cocktail therapy reveals a new strategy to effectively treat MI with great clinical translation potential due to the high effectiveness and safety of the ion cocktail combination.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-learning enabled smart insole system aiming for multifunctional foot-healthcare applications 支持深度学习的智能鞋垫系统，旨在实现多功能足部保健应用

Exploration (Beijing, China) Pub Date : 2023-11-23 DOI: 10.1002/EXP.20230109

Yu Tian, Lei Zhang, Chi Zhang, Bo Bao, Qingtong Li, Longfei Wang, Zhenqiang Song, Dachao Li

{"title":"Deep-learning enabled smart insole system aiming for multifunctional foot-healthcare applications","authors":"Yu Tian, Lei Zhang, Chi Zhang, Bo Bao, Qingtong Li, Longfei Wang, Zhenqiang Song, Dachao Li","doi":"10.1002/EXP.20230109","DOIUrl":"10.1002/EXP.20230109","url":null,"abstract":"Real-time foot pressure monitoring using wearable smart systems, with comprehensive foot health monitoring and analysis, can enhance quality of life and prevent foot-related diseases. However, traditional smart insole solutions that rely on basic data analysis methods of manual feature extraction are limited to real-time plantar pressure mapping and gait analysis, failing to meet the diverse needs of users for comprehensive foot healthcare. To address this, we propose a deep learning-enabled smart insole system comprising a plantar pressure sensing insole, portable circuit board, deep learning and data analysis blocks, and software interface. The capacitive sensing insole can map both static and dynamic plantar pressure with a wide range over 500 kPa and excellent sensitivity. Statistical tools are used to analyze long-term foot pressure usage data, providing indicators for early prevention of foot diseases and key data labels for deep learning algorithms to uncover insights into the relationship between plantar pressure patterns and foot issues. Additionally, a segmentation method assisted deep learning model is implemented for exercise-fatigue recognition as a proof of concept, achieving a high classification accuracy of 95%. The system also demonstrates various foot healthcare applications, including daily activity statistics, exercise injury avoidance, and diabetic foot ulcer prevention.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139244289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dichroic switching of core–shell plasmonic nanoparticles on reflective surfaces 反射表面上核壳质子纳米粒子的分色开关

Exploration (Beijing, China) Pub Date : 2023-11-20 DOI: 10.1002/EXP.20210234

Tian Liang, Zhiwei Li, Yaocai Bai, Yadong Yin

引用次数: 0

Artificial sensory system based on memristive devices 基于记忆装置的人工感觉系统

Exploration (Beijing, China) Pub Date : 2023-11-20 DOI: 10.1002/EXP.20220162

Ju Young Kwon, Ji Eun Kim, Jong Sung Kim, Suk Yeop Chun, Keunho Soh, Jung Ho Yoon

{"title":"Artificial sensory system based on memristive devices","authors":"Ju Young Kwon, Ji Eun Kim, Jong Sung Kim, Suk Yeop Chun, Keunho Soh, Jung Ho Yoon","doi":"10.1002/EXP.20220162","DOIUrl":"10.1002/EXP.20220162","url":null,"abstract":"In the biological nervous system, the integration and cooperation of parallel system of receptors, neurons, and synapses allow efficient detection and processing of intricate and disordered external information. Such systems acquire and process environmental data in real-time, efficiently handling complex tasks with minimal energy consumption. Memristors can mimic typical biological receptors, neurons, and synapses by implementing key features of neuronal signal-processing functions such as selective adaption in receptors, leaky integrate-and-fire in neurons, and synaptic plasticity in synapses. External stimuli are sensitively detected and filtered by “artificial receptors,” encoded into spike signals via “artificial neurons,” and integrated and stored through “artificial synapses.” The high operational speed, low power consumption, and superior scalability of memristive devices make their integration with high-performance sensors a promising approach for creating integrated artificial sensory systems. These integrated systems can extract useful data from a large volume of raw data, facilitating real-time detection and processing of environmental information. This review explores the recent advances in memristor-based artificial sensory systems. The authors begin with the requirements of artificial sensory elements and then present an in-depth review of such elements demonstrated by memristive devices. Finally, the major challenges and opportunities in the development of memristor-based artificial sensory systems are discussed.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20220162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in battery characterization using in situ XAFS, SAXS, XRD, and their combining techniques: From single scale to multiscale structure detection 利用原位 XAFS、SAXS、XRD 及其组合技术进行电池表征的最新进展：从单一尺度到多尺度结构检测

Exploration (Beijing, China) Pub Date : 2023-11-20 DOI: 10.1002/EXP.20230056

Weidong Cheng, Mengyuan Zhao, Yuecheng Lai, Xin Wang, Huanyan Liu, Peng Xiao, Guang Mo, Bin Liu, Yunpeng Liu

{"title":"Recent advances in battery characterization using in situ XAFS, SAXS, XRD, and their combining techniques: From single scale to multiscale structure detection","authors":"Weidong Cheng, Mengyuan Zhao, Yuecheng Lai, Xin Wang, Huanyan Liu, Peng Xiao, Guang Mo, Bin Liu, Yunpeng Liu","doi":"10.1002/EXP.20230056","DOIUrl":"10.1002/EXP.20230056","url":null,"abstract":"Revealing and clarifying the chemical reaction processes and mechanisms inside the batteries will bring a great help to the controllable preparation and performance modulation of batteries. Advanced characterization techniques based on synchrotron radiation (SR) have accelerated the development of various batteries over the past decade. In situ SR techniques have been widely used in the study of electrochemical reactions and mechanisms due to their excellent characteristics. Herein, the three most wide and important synchrotron radiation techniques used in battery research were systematically reviewed, namely X-ray absorption fine structure (XAFS) spectroscopy, small-angle X-ray scattering (SAXS), and X-ray diffraction (XRD). Special attention is paid to how these characterization techniques are used to understand the reaction mechanism of batteries and improve the practical characteristics of batteries. Moreover, the in situ combining techniques advance the acquisition of single scale structure information to the simultaneous characterization of multiscale structures, which will bring a new perspective to the research of batteries. Finally, the challenges and future opportunities of SR techniques for battery research are featured based on their current development.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0