Exploration (Beijing, China)最新文献_第9页

Well-defined nanostructures of high entropy alloys for electrocatalysis 用于电催化的定义明确的高熵合金纳米结构

Exploration (Beijing, China) Pub Date : 2024-07-02 DOI: 10.1002/EXP.20230036

Jie Chen, Liping Ren, Xin Chen, Qi Wang, Chunying Chen, Jinpeng Fan, Shuai Wang, Vasileios Binas, Shaohua Shen

{"title":"Well-defined nanostructures of high entropy alloys for electrocatalysis","authors":"Jie Chen, Liping Ren, Xin Chen, Qi Wang, Chunying Chen, Jinpeng Fan, Shuai Wang, Vasileios Binas, Shaohua Shen","doi":"10.1002/EXP.20230036","DOIUrl":"10.1002/EXP.20230036","url":null,"abstract":"High-entropy alloys (HEAs) have attracted significant attention for electrocatalytic energy conversion by virtue of their promisingly high efficiency, stability, and low cost. Recently, encouraging progress has been made in tuning the structure and composition of HEAs used in electrolyzers and fuel cells. However, the understanding on the synthetic methods and the structure-property-performance relationship of well-defined HEAs nanostructures is still inadequate. To gain insight into the future research directions on HEAs for electrocatalysis, in this paper, the synthetic methods commonly used to obtain well-defined HEAs nanostructures (0D nanoparticles, 1D nanowires, 2D nanosheets/nanoplates, 3D nanoporous structures, and other three-dimensional morphologies) are first summarized. Then, the authors discuss the application of well-defined HEAs nanostructures in several typical electrocatalytic reactions, including hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, alcohol oxidation reaction, carbon dioxide reduction reaction, nitrogen reduction reaction, and formic acid oxidation reaction. Finally, a practical perspective on the future research directions on well-defined HEAs nanostructured electrocatalysts is provided.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications 基于有机分子的免洗荧光工具：设计原则和生物医学应用

Exploration (Beijing, China) Pub Date : 2024-06-28 DOI: 10.1002/EXP.20230094

Jingyun Tan, Chunfei Wang, Zhangjun Hu, Xuanjun Zhang

{"title":"Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications","authors":"Jingyun Tan, Chunfei Wang, Zhangjun Hu, Xuanjun Zhang","doi":"10.1002/EXP.20230094","DOIUrl":"https://doi.org/10.1002/EXP.20230094","url":null,"abstract":"Fluorescence-assisted tools based on organic molecules have been extensively applied to interrogate complex biological processes in a non-invasive manner with good sensitivity, high resolution, and rich contrast. However, the signal-to-noise ratio is an essential factor to be reckoned with during collecting images for high fidelity. In view of this, the wash-free strategy is proven as a promising and important approach to improve the signal-to-noise ratio, thus a thorough introduction is presented in the current review about wash-free fluorescent tools based on organic molecules. Firstly, generalization and summarization of the principles for designing wash-free molecular fluorescent tools (WFTs) are made. Subsequently, to make the thought of molecule design more legible, a wash-free strategy is highlighted in recent studies from four diverse but tightly binding aspects: (1) special chemical structures, (2) molecular interactions, (3) bio-orthogonal reactions, (4) abiotic reactions. Meanwhile, biomedical applications including bioimaging, biodetection, and therapy, are ready to be accompanied by. Finally, the prospects for WFTs are elaborated and discussed. This review is a timely conclusion about wash-free strategy in the fluorescence-guided biomedical applications, which may bring WFTs to the forefront and accelerate their extensive applications in biology and medicine.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma 工程脑靶向外泌体重编程胶质母细胞瘤免疫抑制微环境

Exploration (Beijing, China) Pub Date : 2024-06-26 DOI: 10.1002/EXP.20240039

Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng, Shaobo Ruan

{"title":"Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma","authors":"Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng, Shaobo Ruan","doi":"10.1002/EXP.20240039","DOIUrl":"https://doi.org/10.1002/EXP.20240039","url":null,"abstract":"The immunosuppressive microenvironment of glioblastoma multiforme (GBM) severely impacts the response to various treatments, including systemic chemotherapy. Targeted reprogramming of immunosuppressive GBM microenvironment using RNA interference (RNAi) is largely restricted by poor brain delivery efficiency and targeting specificity. Herein, an acid-cleavable transferrin (Tf) decorated engineering exosome-based brain-targeting delivery system (ACTE) was proposed to efficiently deliver small interference RNA towards transform growth factor-β (siTGF-β) and doxorubicin (DOX) to GBM site for combination chemo-immunotherapy. The siTGF-β and DOX co-loaded ACTE, termed as DOX&siTGF-β@ACTE (Ds@ACTE), is designed to specifically recognize the Tf receptor (TfR) on the blood-brain barrier (BBB). Subsequently, Ds@ACTE undergoes acid-responsive detachment of Tf within lysosome of brain capillary endothelial cells, leading to the separation of DOX&siTGF-β@Exo (Ds@Exo) from the Tf-TfR complex and enhanced BBB transcytosis. After crossing BBB, the separated Ds@Exo can further target GBM cells via the homing effect. In vivo studies validated that Ds@ACTE significantly downregulated the TGF-β expression to reprogram the immunosuppressive microenvironment, and thereby reinforce the chemotherapeutic effect of DOX and DOX-induced anti-tumor immune response. The effectiveness of this strategy not only can provide thinking for designing a more intelligent brain-targeting system based on engineered exosomes but also explore an effective treatment regimen for GBM.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications 贻贝启发的银纳米团簇自组装成多功能银气凝胶，用于增强催化和杀菌应用

Exploration (Beijing, China) Pub Date : 2024-06-26 DOI: 10.1002/EXP.20240034

Yunshan Gao, Jie Xu, Shaohua Qu, Yixiao Li, Gleb B. Sukhorukov, Li Shang

{"title":"Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications","authors":"Yunshan Gao, Jie Xu, Shaohua Qu, Yixiao Li, Gleb B. Sukhorukov, Li Shang","doi":"10.1002/EXP.20240034","DOIUrl":"https://doi.org/10.1002/EXP.20240034","url":null,"abstract":"Silver nanoclusters (AgNCs) have shown broad application prospects in catalysis, sensing, and biological fields. However, the limited stability of AgNCs has become the main challenge restricting their practical application in complex environments. Herein, a mussel-inspired, dopamine-assisted self-assembly approach is reported to fabricate 3D AgNC aerogels (PDA/AgNCs), which possess significantly enhanced structural stability and synergistic functional properties. The prepared AgNC aerogels display a hierarchical network structure with an ultrafine ligament size of 10.3 ± 1.2 nm and a high specific surface area of 50.7 m2 g−1. The gelation mechanism is elucidated by in-depth characterization and time-lapse monitoring of the gelation process vis spectroscopic and microscopic approaches. Owing to the distinct features of aerogels and the synergistic effect of AgNCs and PDA, the fabricated aerogels can not only efficiently decolorize dyes with a faster kinetic than individual AgNCs, but also exhibit remarkable broad-spectrum antimicrobial activity. Consequently, a conceptual water-treatment device is established by depositing PDA/AgNC aerogels on the cotton substrate, which shows good performance in both catalytic dye degradation and bacterial killing in the flowing system. This mussel-inspired self-assembly strategy has great potential in developing robust AgNC-based functional materials, which also provides a new guideline for designing sophisticated materials with integrated functions and synergistic properties.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway 一种通过SLC7A11/ACSL4/LPCAT3途径联合声动力免疫治疗铁下垂和钙离子过载的pH响应纳米复合材料

Exploration (Beijing, China) Pub Date : 2024-06-26 DOI: 10.1002/EXP.20240002

Xue Bai, Jun Kang, Silong Wei, Yun Wang, Yangsui Liu, Bo Yuan, Qian Lu, Huansong Li, Jun Yan, Xi Yang, Jin Chang

{"title":"A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway","authors":"Xue Bai, Jun Kang, Silong Wei, Yun Wang, Yangsui Liu, Bo Yuan, Qian Lu, Huansong Li, Jun Yan, Xi Yang, Jin Chang","doi":"10.1002/EXP.20240002","DOIUrl":"https://doi.org/10.1002/EXP.20240002","url":null,"abstract":"Sonodynamic therapy offers a non-invasive approach to induce the death of tumor cells. By harnessing ultrasound waves in tandem with sonosensitizers, this method produces reactive oxygen species (ROS) that inflict oxidative damage upon tumor cells, subsequently causing their demise. Ferroptosis is a regulatory form of cell death that differs from other forms, characterized by iron accumulation, ROS accumulation, and lipid peroxidation. In the presented research, a nanoparticle formulation, parthenolide/ICG-CaCO3@lipid (PTL/ICG-CaCO3@Lip), has been engineered to amplify ferroptosis in tumor cells, positioning it as a potent agent for sonodynamic cancer immunotherapy. This nanoparticle significantly augments ROS levels within tumor cells, inducing oxidative stress that leads to cell death. The therapeutic potential of PTL/ICG-CaCO3@Lip, both in vivo and in vitro, has been convincingly demonstrated. Furthermore, RNA-seq analysis insights revealed that PTL/ICG-CaCO3@Lip facilitates tumor cell ferroptosis by regulating P53 to downregulate SLC7A11 protein expression, thereby inhibiting the glutamate-cystine antiporter system Xc− and stimulating ACSL4/LPCAT3 pathways. This pioneering work uncovers an innovative strategy for combatting tumors, leveraging enhanced oxidative stress to promote cell ferroptosis, and paves the way for groundbreaking cancer immunotherapeutic interventions.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages 生物工程间充质干细胞通过IL-12介导的微环境重编程和nCD47-SLAMF7介导的巨噬细胞吞噬调节治疗胶质瘤

Exploration (Beijing, China) Pub Date : 2024-06-25 DOI: 10.1002/EXP.20240027

Man Li, Lisen Lu, Qungen Xiao, Ali Abdi Maalim, Bin Nie, Yanchao Liu, Ulf D. Kahlert, Kai Shu, Ting Lei, Mingxin Zhu

{"title":"Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages","authors":"Man Li, Lisen Lu, Qungen Xiao, Ali Abdi Maalim, Bin Nie, Yanchao Liu, Ulf D. Kahlert, Kai Shu, Ting Lei, Mingxin Zhu","doi":"10.1002/EXP.20240027","DOIUrl":"https://doi.org/10.1002/EXP.20240027","url":null,"abstract":"High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors contributing to glioma's resistance to immunotherapy. Nonetheless, technology to modify the expression of glioma cellular self-molecules through gene editing requires further development. This project advances cell therapy strategies to reverse the immunosuppressive microenvironment of glioma (TIME). Bone marrow-derived mesenchymal stem cells (MSCs) are engineered to express bioactive proteins and demonstrate tumor-homing characteristics upon activation by TGF-β. These MSCs are designed to secrete the anti-tumor immune cytokine IL-12 and the nCD47-SLAMF7 fusion protein, which regulates T-cell activity and macrophage phagocytosis. The engineered MSCs are then injected in situ into the glioma site, circumventing the blood-brain barrier to deliver high local concentrations of bioactive proteins. This approach aims to enhance the M1 polarization of infiltrating macrophages, stimulate macrophage-mediated tumor cell phagocytosis, activate antigen-presenting cells, and promote effector CD8+ T cell infiltration, effectively controlling glioma. Additionally, the engineered MSCs may serve as a universal treatment for other tumors that express TGF-β at high levels. This study proposes a novel treatment strategy for the clinical management of glioma patients.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tau-targeting nanoparticles for treatment of Alzheimer's disease 靶向tau的纳米颗粒用于治疗阿尔茨海默病

Exploration (Beijing, China) Pub Date : 2024-06-21 DOI: 10.1002/EXP.20230137

Shreya Pawar, Mohd Ahmar Rauf, Hosam Abdelhady, Arun K. Iyer

{"title":"Tau-targeting nanoparticles for treatment of Alzheimer's disease","authors":"Shreya Pawar, Mohd Ahmar Rauf, Hosam Abdelhady, Arun K. Iyer","doi":"10.1002/EXP.20230137","DOIUrl":"https://doi.org/10.1002/EXP.20230137","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the loss of neural connections and decreased brain tissue volume. Initially affecting the hippocampus and entorhinal complex, which are responsible for memory, the disease later impacts the cerebral cortex, controlling language, logic, and social conduct. While the exact cause is unknown, genetic mutations and environmental factors are implicated. Diagnosis involves computed tomography (CT) scans, Magnetic resonance imaging (MRIs), Positron emission tomography (PET) scans, and lumbar punctures to detect brain abnormalities, protein deposits, and cerebrospinal fluid biomarkers. AD features beta-amyloid plaques and neurofibrillary tau tangles that disrupt neuronal function, chronic inflammation, blood-brain barrier impairment, brain atrophy, and neuronal death. There is no cure; current treatments manage symptoms and slow cognitive decline. Research into genetic, cellular, and molecular pathways aims to develop targeted therapies. Tau tangle accumulation is closely linked to AD, making it crucial to explore therapies that restore normal tau pathways and prevent tau accumulation. Nanoparticulate drug delivery technologies offer promise in this area. This review discusses the potential of nanotechnology-based therapies to target AD-related tau accumulation and restore normal tau protein mechanics, which could preserve neuronal transmission, synaptic integrity, and brain tissue volume.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontispiece: Advances in the treatment of atherosclerosis with ligand-modified nanocarriers (EXP2 3/2024) 前言：配体修饰纳米载体治疗动脉粥样硬化的进展（EXP2 3/2024）

Exploration (Beijing, China) Pub Date : 2024-06-18 DOI: 10.1002/EXP.20240303

Xiujiao Deng, Jinghao Wang, Shanshan Yu, Suiyi Tan, Tingting Yu, Qiaxin Xu, Nenghua Chen, Siqi Zhang, Ming-Rong Zhang, Kuan Hu, Zeyu Xiao

引用次数: 0

Front Cover: Dichroic switching of core–shell plasmonic nanoparticles on reflective surfaces (EXP2 3/2024) 封面：反射表面上核壳质子纳米粒子的分色开关（EXP2 3/2024）

Exploration (Beijing, China) Pub Date : 2024-06-18 DOI: 10.1002/EXP.20240301

Tian Liang, Zhiwei Li, Yaocai Bai, Yadong Yin

引用次数: 0

Back Cover: Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling (EXP2 3/2024) 封底：离子鸡尾酒疗法通过协同调节结构和电重塑治疗心肌梗死（EXP2 3/2024）

Exploration (Beijing, China) Pub Date : 2024-06-18 DOI: 10.1002/EXP.20240302

Yumei Que, Jiaxin Shi, Zhaowenbin Zhang, Lu Sun, Hairu Li, Xionghai Qin, Zhen Zeng, Xiao Yang, Yanxin Chen, Chong Liu, Chang Liu, Shijie Sun, Qishu Jin, Yanxin Zhang, Xin Li, Ming Lei, Chen Yang, Hai Tian, Jiawei Tian, Jiang Chang

引用次数: 0