Exploration (Beijing, China)最新文献_第8页

Back Cover: Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform (EXP2 5/2024) 封底：利用自动机器人驱动的光电化学生物传感平台检测污水中的生物负荷（EXP2 5/2024）

Exploration (Beijing, China) Pub Date : 2024-10-20 DOI: 10.1002/EXP.20240504

Yiming Zhang, Zhi Chen, Songrui Wei, Yujun Zhang, Hai Fu, Han Zhang, Defa Li, Zhongjian Xie

引用次数: 0

Inside Back Cover: Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective (EXP2 5/2024) 封底内页：从免疫学角度看糖尿病对结核病预防、诊断和治疗的影响（EXP2 5/2024）

Exploration (Beijing, China) Pub Date : 2024-10-20 DOI: 10.1002/EXP.20240503

Zhaoyang Ye, Linsheng Li, Ling Yang, Li Zhuang, Ashok Aspatwar, Liang Wang, Wenping Gong

引用次数: 0

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies Mpox 综述：生物特征、流行病学、临床特征、诊断、治疗和预防策略

Exploration (Beijing, China) Pub Date : 2024-10-08 DOI: 10.1002/EXP.20230112

Lin Jiang, Ailan Xu, Lin Guan, Yong Tang, Guangshuai Chai, Junya Feng, Yueqi Wu, Maochen Li, Chuxie Zhang, Xiaojing Liu, Xiaolong Xu, Qingquan Liu, Lihua Song, Yigang Tong, Renald Blundell, Huahao Fan

{"title":"A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies","authors":"Lin Jiang, Ailan Xu, Lin Guan, Yong Tang, Guangshuai Chai, Junya Feng, Yueqi Wu, Maochen Li, Chuxie Zhang, Xiaojing Liu, Xiaolong Xu, Qingquan Liu, Lihua Song, Yigang Tong, Renald Blundell, Huahao Fan","doi":"10.1002/EXP.20230112","DOIUrl":"https://doi.org/10.1002/EXP.20230112","url":null,"abstract":"The outbreak of monkeypox virus (MPXV) was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), and the zoonotic disease caused by viral infection was renamed as “Mpox” on November 28, 2022. Currently, there is no approved vaccine or specific antiviral treatment for Mpox, and a main preventive strategy against MPXV infection remains the smallpox vaccine. Although there was an emergency use authorization (EUA) of Brincidofovir and Tecovirimat for the clinical treatment of clade II Mpox, while Tecovirimat failed to reduce the duration of Mpox lesions among patients infected with clade I Mpox in the Democratic Republic of the Congo (DRC). Therefore, it is still an urgent need to develop an effective medication. This review aims to enhance the understanding of Mpox and contribute to its prevention and treatment strategies, it provides a systemic introduction of the biological and epidemiological characteristics of MPXV, the clinical feature and diagnosis of Mpox, as well as treatment and prevention strategies, which will improve the comprehension about MPXV and offer potential strategies for clinical treatment.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Bioprinted research models of urological malignancy (EXP2 4/2024) 封面：泌尿系统恶性肿瘤生物打印研究模型（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240401

Guanyi Wang, Xiongmin Mao, Wang Wang, Xiaolong Wang, Sheng Li, Zijian Wang

引用次数: 0

Back Cover: Unveiling the importance of the interface in nanocomposite cathodes for proton-conducting solid oxide fuel cells (EXP2 4/2024) 封底：揭示质子传导型固体氧化物燃料电池纳米复合阴极界面的重要性（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240404

Yanru Yin, Yifan Wang, Nan Yang, Lei Bi

引用次数: 0

Inside Back Cover: Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery (EXP2 4/2024) 封底内页：角膜-SELEX：针对眼睛表面和脂质体药物递送的适配体（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240403

Ka-Ying Wong, Yibo Liu, Man-Sau Wong, Juewen Liu

引用次数: 0

Inside Front Cover: Recent advances in mitochondria-targeting theranostic agents (EXP2 4/2024) 封面内页：线粒体靶向治疗药物的最新进展（EXP2 4/2024）

Exploration (Beijing, China) Pub Date : 2024-08-20 DOI: 10.1002/EXP.20240402

Kun Qian, Shu Gao, Zhaoning Jiang, Qihang Ding, Zhen Cheng

引用次数: 0

Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED 在水中直接合成高量子产率无铅 CsCu2I3 粉末及其在黄色 LED 中的应用

Exploration (Beijing, China) Pub Date : 2024-07-18 DOI: 10.1002/EXP.20240004

Heng Guo, Linlin Shi, Zengliang Shi, Yue He, Yizhi Zhu

{"title":"Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED","authors":"Heng Guo, Linlin Shi, Zengliang Shi, Yue He, Yizhi Zhu","doi":"10.1002/EXP.20240004","DOIUrl":"10.1002/EXP.20240004","url":null,"abstract":"Yellow light-emitting diodes (LEDs) with a wavelength of 570–590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection. For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) was used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesized an all-inorganic lead-free yellow light CsCu2I3 powder in water. The prepared CsCu2I3 powder exhibited excellent optical properties and considerable stability. Finally, a phosphor-converted LED (pc-LED) device was fabricated via the CsCu2I3 phosphor coated on a 310 nm ultraviolet chip. The pc-LED device's electroluminescence spectra may be a good fit for the blood's absorption regions. Therefore, this work provides a facile method for the synthesis of novel lead-free metal halide CsCu2I3 powder in eco-friendly solvents. In addition, the stable and efficient CsCu2I3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antigen/adjuvant-free liposome induces adjuvant effects for enhancing cancer immunotherapy 不含抗原/佐剂的脂质体诱导增强癌症免疫疗法的佐剂效应

Exploration (Beijing, China) Pub Date : 2024-07-17 DOI: 10.1002/EXP.20230115

Qianqian Guo, Xiaoxuan Xu, Xiaojiang Lai, Jialin Duan, Dan Yan, Dangge Wang

{"title":"Antigen/adjuvant-free liposome induces adjuvant effects for enhancing cancer immunotherapy","authors":"Qianqian Guo, Xiaoxuan Xu, Xiaojiang Lai, Jialin Duan, Dan Yan, Dangge Wang","doi":"10.1002/EXP.20230115","DOIUrl":"10.1002/EXP.20230115","url":null,"abstract":"Cancer vaccines are promising to treat malignancy by delivering antigens and adjuvants to elicit host immunity. Beyond aluminum adjuvants, liposomes show efficient adjuvant effects through regulating the accumulation, internalization and release of payloads. However, it remains unknown that whether the liposome will perform intrinsic adjuvant effects in the absence of antigens and adjuvants. Herein, a library of antigen/adjuvant-free liposomes with variable surface charges has been developed and it has been found that highly anionic liposomes show promising adjuvant effects for boosting immune responses. The anionic liposome mobilizes the MyD88 pathways of dendritic cells (DCs) to activate T helper cells and CD8+ T cells. The anionic liposomes enhance host immunity by regulating the population of Th1, Th2 and regulatory T cells (Tregs), and boost adaptive CD8+ T cells in lymphoid organs with good biosafety. It shows the most efficient protection against MC38 colorectal cancer in mice after a parallel injection of antigens and anionic liposomes. Overall, this study reveals that the surface charge of liposome affects its adjuvant efficiency and provides an anionic nanosized adjuvant formulation for enhancing immunization.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141828504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood-brain barrier 通过脑甘油系统绕过血脑屏障进入中枢神经系统的给药途径

Exploration (Beijing, China) Pub Date : 2024-07-09 DOI: 10.1002/EXP.20240036

Xiang Wang, Yue Yin, Huaijuan Zhou, Bowen Chi, Ling Guan, Pei Li, Jinhua Li, Yilong Wang

引用次数: 0