Exploration (Beijing, China)最新文献_第8页

Front Cover: Programmed initiation and enhancement of cGAS/STING pathway for tumour immunotherapy via tailor-designed ZnFe2O4-based nanosystem (EXP2 6/2023) 封面：通过基于 ZnFe2O4 的定制纳米系统，为肿瘤免疫疗法启动和增强 cGAS/STING 通路（EXP2 6/2023）

Exploration (Beijing, China) Pub Date : 2023-12-22 DOI: 10.1002/EXP.20230601

Jing Yang, Yuping He, Meng Zhang, Chenglin Liang, Tongtong Li, Tianjiao Ji, Mali Zu, Xu Ma, Zhenzhong Zhang, Chun Liang, Qixu Zhang, Youbai Chen, Lin Hou

引用次数: 0

Frontispiece: Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress (EXP2 6/2023) 头图：慢性社会失败压力后小鼠大脑的空间转录组分析（EXP2 6/2023）

Exploration (Beijing, China) Pub Date : 2023-12-22 DOI: 10.1002/EXP.20230606

Ting Wang, Zhihong Song, Xin Zhao, Yan Wu, Liying Wu, Abbas Haghparast, Haitao Wu

引用次数: 0

Inside Back Cover: Molecular imaging of tumour-associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring” (EXP2 6/2023) 封底内页利用智能纳米探针对肿瘤相关病理生物标记物进行分子成像：从 "看见 "到 "测量"（EXP2 6/2023）

Exploration (Beijing, China) Pub Date : 2023-12-22 DOI: 10.1002/EXP.20230603

Peisen Zhang, Wenyue Li, Chuang Liu, Feng Qin, Yijie Lu, Meng Qin, Yi Hou

引用次数: 0

Self-supported bimetallic array superstructures for high-performance coupling electrosynthesis of formate and adipate 用于甲酸酯和己二酸酯高性能耦合电合成的自支撑双金属阵列上层结构

Exploration (Beijing, China) Pub Date : 2023-12-21 DOI: 10.1002/EXP.20230043

Li Liu, Yingchun He, Qing Li, Changsheng Cao, Minghong Huang, Dong-Dong Ma, Xin-Tao Wu, Qi-Long Zhu

{"title":"Self-supported bimetallic array superstructures for high-performance coupling electrosynthesis of formate and adipate","authors":"Li Liu, Yingchun He, Qing Li, Changsheng Cao, Minghong Huang, Dong-Dong Ma, Xin-Tao Wu, Qi-Long Zhu","doi":"10.1002/EXP.20230043","DOIUrl":"10.1002/EXP.20230043","url":null,"abstract":"The coupling electrosynthesis involving CO2 upgrade conversion is of great significance for the sustainable development of the environment and energy but is challenging. Herein, we exquisitely constructed the self-supported bimetallic array superstructures from the Cu(OH)2 array architecture precursor, which can enable high-performance coupling electrosynthesis of formate and adipate at the anode and the cathode, respectively. Concretely, the faradaic efficiencies (FEs) of CO2-to-formate and cyclohexanone-to-adipate conversion simultaneously exceed 90% at both electrodes with excellent stabilities. Such high-performance coupling electrosynthesis is highly correlated with the porous nanosheet array superstructure of CuBi alloy as the cathode and the nanosheet-on-nanowire array superstructure of CuNi hydroxide as the anode. Moreover, compared to the conventional electrolysis process, the cell voltage is substantially reduced while maintaining the electrocatalytic performance for coupling electrosynthesis in the two-electrode electrolyzer with the maximal FEformate and FEadipate up to 94.2% and 93.1%, respectively. The experimental results further demonstrate that the bimetal composition modulates the local electronic structures, promoting the reactions toward the target products. Prospectively, our work proposes an instructive strategy for constructing adaptive self-supported superstructures to achieve efficient coupling electrosynthesis.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalytic and biocatalytic degradation of microplastics 微塑料的催化和生物催化降解

Exploration (Beijing, China) Pub Date : 2023-12-19 DOI: 10.1002/EXP.20230018

Mohamad Zandieh, Erin Griffiths, Alexander Waldie, Shuhuan Li, John Honek, Fereidoun Rezanezhad, Philippe Van Cappellen, Juewen Liu

{"title":"Catalytic and biocatalytic degradation of microplastics","authors":"Mohamad Zandieh, Erin Griffiths, Alexander Waldie, Shuhuan Li, John Honek, Fereidoun Rezanezhad, Philippe Van Cappellen, Juewen Liu","doi":"10.1002/EXP.20230018","DOIUrl":"10.1002/EXP.20230018","url":null,"abstract":"In recent years, there has been a surge in annual plastic production, which has contributed to growing environmental challenges, particularly in the form of microplastics. Effective management of plastic and microplastic waste has become a critical concern, necessitating innovative strategies to address its impact on ecosystems and human health. In this context, catalytic degradation of microplastics emerges as a pivotal approach that holds significant promise for mitigating the persistent effects of plastic pollution. In this article, we critically explored the current state of catalytic degradation of microplastics and discussed the definition of degradation, characterization methods for degradation products, and the criteria for standard sample preparation. Moreover, the significance and effectiveness of various catalytic entities, including enzymes, transition metal ions (for the Fenton reaction), nanozymes, and microorganisms are summarized. Finally, a few key issues and future perspectives regarding the catalytic degradation of microplastics are proposed.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139171790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel nanobody broadly neutralizes SARS-CoV-2 via induction of spike trimer dimers conformation 新型纳米抗体通过诱导尖峰三聚体二聚体构象广泛中和 SARS-CoV-2

Exploration (Beijing, China) Pub Date : 2023-12-15 DOI: 10.1002/EXP.20230086

Yang Yang, Junfang Zhang, Shengnan Zhang, Chenhui Zhang, Chenguang Shen, Shuo Song, Yanqun Wang, Yun Peng, Xiaohua Gong, Jun Dai, Chongwei Xie, Tatyana Aleksandrovna Khrustaleva, Vladislav Victorovich Khrustalev, Yongting Huo, Di Lu, Da Yao, Jincun Zhao, Yingxia Liu, Hongzhou Lu

{"title":"A novel nanobody broadly neutralizes SARS-CoV-2 via induction of spike trimer dimers conformation","authors":"Yang Yang, Junfang Zhang, Shengnan Zhang, Chenhui Zhang, Chenguang Shen, Shuo Song, Yanqun Wang, Yun Peng, Xiaohua Gong, Jun Dai, Chongwei Xie, Tatyana Aleksandrovna Khrustaleva, Vladislav Victorovich Khrustalev, Yongting Huo, Di Lu, Da Yao, Jincun Zhao, Yingxia Liu, Hongzhou Lu","doi":"10.1002/EXP.20230086","DOIUrl":"10.1002/EXP.20230086","url":null,"abstract":"The ongoing mutations of the SARS-CoV-2 pose serious challenges to the efficacy of the available antiviral drugs, and new drugs with fantastic efficacy are always deserved investigation. Here, a nanobody called IBT-CoV144 is reported, which exhibits broad neutralizing activity against SARS-CoV-2 by inducing the conformation of spike trimer dimers. IBT-CoV144 was isolated from an immunized alpaca using the RBD of wild-type SARS-CoV-2, and it showed strong cross-reactive binding and neutralizing potency against diverse SARS-CoV-2 variants, including Omicron subvariants. Moreover, the prophylactically and therapeutically intranasal administration of IBT-CoV144 confers fantastic protective efficacy against the challenge of Omicron BA.1 variant in BALB/c mice model. The structure analysis of the complex between spike (S) protein, conducted using Cryo-EM, revealed a special conformation known as the trimer dimers. This conformation is formed by two trimers, with six RBDs in the “up” state and bound by six VHHs. IBT-CoV144 binds to the lateral region of the RBD on the S protein, facilitating the aggregation of S proteins. This aggregation results in steric hindrance, which disrupts the recognition of the virus by ACE2 on host cells. The discovery of IBT-CoV144 will provide valuable insights for the development of advanced therapeutics and the design of next-generation vaccines.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of heterogeneous catalyst for molecular hydrogen ortho-para conversion 分子氢原位转化的异质催化剂探索

Exploration (Beijing, China) Pub Date : 2023-12-14 DOI: 10.1002/EXP.20230040

Hideki Abe, Hiroshi Mizoguchi, Ryuto Eguchi, Hideo Hosono

引用次数: 0

A red blood cell-derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery 一种源自红细胞的仿生微型机器人，能够分层适应全身给药过程中的五个关键阶段

Exploration (Beijing, China) Pub Date : 2023-12-10 DOI: 10.1002/EXP.20230105

Ya-Xuan Zhu, Hao-Ran Jia, Yao-Wen Jiang, Yuxin Guo, Qiu-Yi Duan, Ke-Fei Xu, Bai-Hui Shan, Xiaoyang Liu, Xiaokai Chen, Fu-Gen Wu

{"title":"A red blood cell-derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery","authors":"Ya-Xuan Zhu, Hao-Ran Jia, Yao-Wen Jiang, Yuxin Guo, Qiu-Yi Duan, Ke-Fei Xu, Bai-Hui Shan, Xiaoyang Liu, Xiaokai Chen, Fu-Gen Wu","doi":"10.1002/EXP.20230105","DOIUrl":"10.1002/EXP.20230105","url":null,"abstract":"The tumour-targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all-in-one” red blood cell (RBC)-derived microrobot that can hierarchically adapt to five critical stages during systemic drug delivery, that is, circulation, accumulation, release, extravasation, and penetration, is developed. The microrobots behave like natural RBCs in blood circulation, due to their almost identical surface properties, but can be magnetically manipulated to accumulate at regions of interest such as tumours. Next, the microrobots are “immolated” under laser irradiation to release their therapeutic cargoes and, by generating heat, to enhance drug extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) can inhibit the formation of extracellular matrix and increase the penetration depth of chemodrugs in the solid tumour. It is demonstrated that this system effectively suppresses both primary and metastatic tumours in mouse models without evident side effects, and may represent a new class of intelligent biomimicking robots for biomedical applications.","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20230105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139184390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the treatment of atherosclerosis with ligand-modified nanocarriers 配体修饰纳米载体在治疗动脉粥样硬化方面的进展

Exploration (Beijing, China) Pub Date : 2023-12-07 DOI: 10.1002/EXP.20230090

Xiujiao Deng, Jinghao Wang, Shanshan Yu, Suiyi Tan, Tingting Yu, Qiaxin Xu, Nenghua Chen, Siqi Zhang, Ming-Rong Zhang, Kuan Hu, Zeyu Xiao

引用次数: 0

Nitrogen deficiency modulates carbon allocation to promote nodule nitrogen fixation capacity in soybean 缺氮调节碳分配，促进大豆的结核固氮能力

Exploration (Beijing, China) Pub Date : 2023-11-30 DOI: 10.1002/EXP.20230104

Xiaolong Ke, Han Xiao, Yaqi Peng, Xue Xia, Xuelu Wang

引用次数: 0