{"title":"Inside Back Cover: Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery (EXP2 4/2024)","authors":"Ka-Ying Wong, Yibo Liu, Man-Sau Wong, Juewen Liu","doi":"10.1002/EXP.20240403","DOIUrl":null,"url":null,"abstract":"<p>Via the tissue-SELEX method, a few cornea-targeting aptamers were isolated, facilitating the efficient delivery of cyclosporine A encapsulated in liposomes for both in vivo and in vitro management of dry eye disease. This approach ensures prolonged drug retention on the corneal surface, establishing a general platform for ocular drug delivery.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72997,"journal":{"name":"Exploration (Beijing, China)","volume":"4 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/EXP.20240403","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exploration (Beijing, China)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/EXP.20240403","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Via the tissue-SELEX method, a few cornea-targeting aptamers were isolated, facilitating the efficient delivery of cyclosporine A encapsulated in liposomes for both in vivo and in vitro management of dry eye disease. This approach ensures prolonged drug retention on the corneal surface, establishing a general platform for ocular drug delivery.
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