European heart journal. Digital health最新文献

{"title":"Introducing online multi-language video animations to support patients' understanding of cardiac procedures in a high-volume tertiary centre.","authors":"Jude Almutawa, Peter Calvert, David Wald, Vishal Luther","doi":"10.1093/ehjdh/ztae073","DOIUrl":"10.1093/ehjdh/ztae073","url":null,"abstract":"","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"653-655"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep-learning-driven optical coherence tomography analysis for cardiovascular outcome prediction in patients with acute coronary syndrome.","authors":"Tomoyo Hamana, Makoto Nishimori, Satoki Shibata, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Shunsuke Kakizaki, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Hiroshi Tsunamoto, Hiroya Okamoto, Kotaro Higuchi, Tatsuya Kitagawa, Masakazu Shinohara, Koji Kuroda, Masamichi Iwasaki, Amane Kozuki, Junya Shite, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake","doi":"10.1093/ehjdh/ztae067","DOIUrl":"10.1093/ehjdh/ztae067","url":null,"abstract":"<p><strong>Aims: </strong>Optical coherence tomography (OCT) can identify high-risk plaques indicative of worsening prognosis in patients with acute coronary syndrome (ACS). However, manual OCT analysis has several limitations. In this study, we aim to construct a deep-learning model capable of automatically predicting ACS prognosis from patient OCT images following percutaneous coronary intervention (PCI).</p><p><strong>Methods and results: </strong>Post-PCI OCT images from 418 patients with ACS were input into a deep-learning model comprising a convolutional neural network (CNN) and transformer. The primary endpoint was target vessel failure (TVF). Model performances were evaluated using Harrell's <i>C</i>-index and compared against conventional models based on human observation of quantitative (minimum lumen area, minimum stent area, average reference lumen area, stent expansion ratio, and lesion length) and qualitative (irregular protrusion, stent thrombus, malapposition, major stent edge dissection, and thin-cap fibroatheroma) factors. GradCAM activation maps were created after extracting attention layers by using the transformer architecture. A total of 60 patients experienced TVF during follow-up (median 961 days). The <i>C</i>-index for predicting TVF was 0.796 in the deep-learning model, which was significantly higher than that of the conventional model comprising only quantitative factors (<i>C</i>-index: 0.640) and comparable to that of the conventional model, including both quantitative and qualitative factors (<i>C</i>-index: 0.789). GradCAM heat maps revealed high activation corresponding to well-known high-risk OCT features.</p><p><strong>Conclusion: </strong>The CNN and transformer-based deep-learning model enabled fully automatic prognostic prediction in patients with ACS, with a predictive ability comparable to a conventional survival model using manual human analysis.</p><p><strong>Clinical trial registration: </strong>The study was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000049237).</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"692-701"},"PeriodicalIF":3.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of machine learning-based risk stratification scores for patients with acute coronary syndrome treated with percutaneous coronary intervention.","authors":"Mitchel A Molenaar, Jasper L Selder, Amand F Schmidt, Folkert W Asselbergs, Jelle D Nieuwendijk, Brigitte van Dalfsen, Mark J Schuuring, Berto J Bouma, Steven A J Chamuleau, Niels J Verouden","doi":"10.1093/ehjdh/ztae071","DOIUrl":"10.1093/ehjdh/ztae071","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to validate the machine learning-based Global Registry of Acute Coronary Events (GRACE) 3.0 score and PRAISE (Prediction of Adverse Events following an Acute Coronary Syndrome) in patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) for predicting mortality.</p><p><strong>Methods and results: </strong>Data of consecutive patients with ACS treated with PCI in a tertiary centre in the Netherlands between 2014 and 2021 were used for external validation. The GRACE 3.0 score for predicting in-hospital mortality was evaluated in 2759 patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) treated with PCI. The PRAISE score for predicting one-year mortality was evaluated in 4347 patients with ACS treated with PCI. Both risk scores were compared with the GRACE 2.0 score. The GRACE 3.0 score showed excellent discrimination [c-statistic 0.90 (95% CI 0.84, 0.94)] for predicting in-hospital mortality, with well-calibrated predictions (calibration-in-the large [CIL] -0.19 [95% CI -0.45, 0.07]). The PRAISE score demonstrated moderate discrimination [c-statistic 0.75 (95% CI 0.70, 0.80)] and overestimated the one-year risk of mortality [CIL -0.56 (95% CI -0.73, -0.39)]. Decision curve analysis demonstrated that the GRACE 3.0 score offered improved risk prediction compared with the GRACE 2.0 score, while the PRAISE score did not.</p><p><strong>Conclusion: </strong>This study in ACS patients treated with PCI provides suggestive evidence that the GRACE 3.0 score effectively predicts in-hospital mortality beyond the GRACE 2.0 score. The PRAISE score demonstrated limited potential for predicting one-year mortality risk. Further external validation studies in larger cohorts including patients without PCI are warranted.</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"702-711"},"PeriodicalIF":3.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the detection of acute coronary occlusion with the miniECG.","authors":"Alejandra Zepeda-Echavarria, Rutger R van de Leur, Pieter A Doevendans","doi":"10.1093/ehjdh/ztae065","DOIUrl":"10.1093/ehjdh/ztae065","url":null,"abstract":"","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"656-657"},"PeriodicalIF":3.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac anatomic digital twins: findings from a single national centre.","authors":"Matthias Lippert, Karl-Andreas Dumont, Sigurd Birkeland, Varatharajan Nainamalai, Håvard Solvin, Kathrine Rydén Suther, Bjørn Bendz, Ole Jakob Elle, Henrik Brun","doi":"10.1093/ehjdh/ztae070","DOIUrl":"10.1093/ehjdh/ztae070","url":null,"abstract":"<p><strong>Aims: </strong>New three-dimensional cardiac visualization technologies are increasingly employed for anatomic digital twins in pre-operative planning. However, the role and influence of extended reality (virtual, augmented, or mixed) within heart team settings remain unclear. We aimed to assess the impact of mixed reality visualization of the intracardiac anatomy on surgical decision-making in patients with complex heart defects.</p><p><strong>Methods and results: </strong>Between September 2020 and December 2022, we recruited 50 patients and generated anatomic digital twins and visualized them in mixed reality. These anatomic digital twins were presented to the heart team after initial decisions were made using standard visualization methods. Changes in the surgical strategy were recorded. Additionally, heart team members rated their mixed reality experience through a questionnaire, and post-operative outcomes were registered. Anatomic digital twins changed the initially decided upon surgical strategies for 68% of cases. While artificial intelligence facilitated the rapid creation of digital anatomic twins, manual corrections were always necessary.</p><p><strong>Conclusion: </strong>In conclusion, mixed reality anatomic digital twins added information to standard visualization methods and significantly influenced surgical planning, with evidence that these strategies can be implemented safely without additional risk.</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"725-734"},"PeriodicalIF":3.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the interoperability and transparency of real-world data extraction in clinical research: evaluating the feasibility and impact of a ChatGLM implementation in Chinese hospital settings.","authors":"Bin Wang, Junkai Lai, Han Cao, Feifei Jin, Qiang Li, Mingkun Tang, Chen Yao, Ping Zhang","doi":"10.1093/ehjdh/ztae066","DOIUrl":"10.1093/ehjdh/ztae066","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to assess the feasibility and impact of the implementation of the ChatGLM for real-world data (RWD) extraction in hospital settings. The primary focus of this research is on the effectiveness of ChatGLM-driven data extraction compared with that of manual processes associated with the electronic source data repository (ESDR) system.</p><p><strong>Methods and results: </strong>The researchers developed the ESDR system, which integrates ChatGLM, electronic case report forms (eCRFs), and electronic health records. The LLaMA (Large Language Model Meta AI) model was also deployed to compare the extraction accuracy of ChatGLM in free-text forms. A single-centre retrospective cohort study served as a pilot case. Five eCRF forms of 63 subjects, including free-text forms and discharge medication, were evaluated. Data collection involved electronic medical and prescription records collected from 13 departments. The ChatGLM-assisted process was associated with an estimated efficiency improvement of 80.7% in the eCRF data transcription time. The initial manual input accuracy for free-text forms was 99.59%, the ChatGLM data extraction accuracy was 77.13%, and the LLaMA data extraction accuracy was 43.86%. The challenges associated with the use of ChatGLM focus on prompt design, prompt output consistency, prompt output verification, and integration with hospital information systems.</p><p><strong>Conclusion: </strong>The main contribution of this study is to validate the use of ESDR tools to address the interoperability and transparency challenges of using ChatGLM for RWD extraction in Chinese hospital settings.</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"712-724"},"PeriodicalIF":3.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of cardiovascular markers and diseases using retinal fundus images and deep learning: a systematic scoping review.","authors":"Livie Yumeng Li, Anders Aasted Isaksen, Benjamin Lebiecka-Johansen, Kristian Funck, Vajira Thambawita, Stine Byberg, Tue Helms Andersen, Ole Norgaard, Adam Hulman","doi":"10.1093/ehjdh/ztae068","DOIUrl":"10.1093/ehjdh/ztae068","url":null,"abstract":"<p><p>Rapid development in deep learning for image analysis inspired studies to focus on predicting cardiovascular risk using retinal fundus images. This scoping review aimed to identify and describe studies using retinal fundus images and deep learning to predict cardiovascular risk markers and diseases. We searched MEDLINE and Embase on 17 November 2023. Abstracts and relevant full-text articles were independently screened by two reviewers. We included studies that used deep learning for the analysis of retinal fundus images to predict cardiovascular risk markers or cardiovascular diseases (CVDs) and excluded studies only using predefined characteristics of retinal fundus images. Study characteristics were presented using descriptive statistics. We included 24 articles published between 2018 and 2023. Among these, 23 (96%) were cross-sectional studies and eight (33%) were follow-up studies with clinical CVD outcomes. Seven studies included a combination of both designs. Most studies (96%) used convolutional neural networks to process images. We found nine (38%) studies that incorporated clinical risk factors in the prediction and four (17%) that compared the results to commonly used clinical risk scores in a prospective setting. Three of these reported improved discriminative performance. External validation of models was rare (21%). There is increasing interest in using retinal fundus images in cardiovascular risk assessment with some studies demonstrating some improvements in prediction. However, more prospective studies, comparisons of results to clinical risk scores, and models augmented with traditional risk factors can strengthen further research in the field.</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"660-669"},"PeriodicalIF":3.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital solutions to optimize guideline-directed medical therapy prescription rates in patients with heart failure: a clinical consensus statement from the ESC Working Group on e-Cardiology, the Heart Failure Association of the European Society of Cardiology, the Association of Cardiovascular Nursing & Allied Professions of the European Society of Cardiology, the ESC Digital Health Committee, the ESC Council of Cardio-Oncology, and the ESC Patient Forum.","authors":"Mark Johan Schuuring, Roderick Willem Treskes, Teresa Castiello, Magnus Thorsten Jensen, Ruben Casado-Arroyo, Lis Neubeck, Alexander R Lyon, Nurgul Keser, Marcin Rucinski, Maria Marketou, Ekaterini Lambrinou, Maurizio Volterrani, Loreena Hill","doi":"10.1093/ehjdh/ztae064","DOIUrl":"10.1093/ehjdh/ztae064","url":null,"abstract":"<p><p>The 2021 European Society of Cardiology guideline on diagnosis and treatment of acute and chronic heart failure (HF) and the 2023 Focused Update include recommendations on the pharmacotherapy for patients with New York Heart Association (NYHA) class II-IV HF with reduced ejection fraction. However, multinational data from the EVOLUTION HF study found substantial prescribing inertia of guideline-directed medical therapy (GDMT) in clinical practice. The cause was multifactorial and included limitations in organizational resources. Digital solutions like digital consultation, digital remote monitoring, digital interrogation of cardiac implantable electronic devices, clinical decision support systems, and multifaceted interventions are increasingly available worldwide. The objectives of this Clinical Consensus Statement are to provide (i) examples of digital solutions that can aid the optimization of prescription of GDMT, (ii) evidence-based insights on the optimization of prescription of GDMT using digital solutions, (iii) current evidence gaps and implementation barriers that limit the adoption of digital solutions in clinical practice, and (iv) critically discuss strategies to achieve equality of access, with reference to patient subgroups. Embracing digital solutions through the use of digital consults and digital remote monitoring will future-proof, for example alerts to clinicians, informing them of patients on suboptimal GDMT. Researchers should consider employing multifaceted digital solutions to optimize effectiveness and use study designs that fit the unique sociotechnical aspects of digital solutions. Artificial intelligence solutions can handle larger data sets and relieve medical professionals' workloads, but as the data on the use of artificial intelligence in HF are limited, further investigation is warranted.</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"670-682"},"PeriodicalIF":3.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-empowered treatment decision-making in patients with aortic stenosis via early detection of cardiac amyloidosis.","authors":"Joana M Ribeiro, Rutger Jan Nuis, Peter P T de Jaegere","doi":"10.1093/ehjdh/ztae053","DOIUrl":"https://doi.org/10.1093/ehjdh/ztae053","url":null,"abstract":"","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 5","pages":"505-506"},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning algorithm for predicting left ventricular systolic dysfunction in atrial fibrillation with rapid ventricular response.","authors":"Joo Hee Jeong, Sora Kang, Hak Seung Lee, Min Sung Lee, Jeong Min Son, Joon-Myung Kwon, Hyoung Seok Lee, Yun Young Choi, So Ree Kim, Dong-Hyuk Cho, Yun Gi Kim, Mi-Na Kim, Jaemin Shim, Seong-Mi Park, Young-Hoon Kim, Jong-Il Choi","doi":"10.1093/ehjdh/ztae062","DOIUrl":"10.1093/ehjdh/ztae062","url":null,"abstract":"<p><strong>Aims: </strong>Although evaluation of left ventricular ejection fraction (LVEF) is crucial for deciding the rate control strategy in patients with atrial fibrillation (AF), real-time assessment of LVEF is limited in outpatient settings. We aimed to investigate the performance of artificial intelligence-based algorithms in predicting LV systolic dysfunction (LVSD) in patients with AF and rapid ventricular response (RVR).</p><p><strong>Methods and results: </strong>This study is an external validation of a pre-existing deep learning algorithm based on residual neural network architecture. Data were obtained from a prospective cohort of AF with RVR at a single centre between 2018 and 2023. Primary outcome was the detection of LVSD, defined as a LVEF ≤ 40%, assessed using 12-lead electrocardiography (ECG). Secondary outcome involved predicting LVSD using 1-lead ECG (Lead I). Among 423 patients, 241 with available echocardiography data within 2 months were evaluated, of whom 54 (22.4%) were confirmed to have LVSD. Deep learning algorithm demonstrated fair performance in predicting LVSD [area under the curve (AUC) 0.78]. Negative predictive value for excluding LVSD was 0.88. Deep learning algorithm resulted competent performance in predicting LVSD compared with N-terminal prohormone of brain natriuretic peptide (AUC 0.78 vs. 0.70, <i>P</i> = 0.12). Predictive performance of the deep learning algorithm was lower in Lead I (AUC 0.68); however, negative predictive value remained consistent (0.88).</p><p><strong>Conclusion: </strong>Deep learning algorithm demonstrated competent performance in predicting LVSD in patients with AF and RVR. In outpatient setting, use of artificial intelligence-based algorithm may facilitate prediction of LVSD and earlier choice of drug, enabling better symptom control in AF patients with RVR.</p>","PeriodicalId":72965,"journal":{"name":"European heart journal. Digital health","volume":"5 6","pages":"683-691"},"PeriodicalIF":3.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}