{"title":"Advancing Mechanical Computing: Modular Design and Multi-Dimensional Signal Transmission","authors":"Bihui Zou, Zhipeng Liu, Qinyun Ding, Dijia Zhong, Yuhao Wang, Jingjing Zhang, Jaehyung Ju","doi":"10.1002/admt.202401979","DOIUrl":"https://doi.org/10.1002/admt.202401979","url":null,"abstract":"<p>Mechanical computing, while not poised to replace electronic computing, presents a complementary solution in areas where electronic systems face challenges like high power consumption and environmental vulnerability. Despite the inherent limitations of mechanical systems in speed, size, and functional scalability, their unique 2D and 3D geometries offer multi-dimensional signal transmission and non-volatile logic computing, potentially enhancing computational density. However, a lack of advanced modular design strategies for complex systems has hindered progress in mechanical computing. This study introduces a top-down design approach to non-volatile logic mechanical computing using multi-output logic gates designed with square lattices and bistable beams, addressing functional scalability through a modular design that facilitates the assembly of mechanical circuits. This innovation not only enhances computational density but also reduces system size, offering new avenues for research in fields like soft robotics and active metamaterials, and setting the stage for advances in mechanical computing systems.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 8","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catarina M. Abreu, Ana C. Lima, Nuno M. Neves, Subhas C. Kundu, Rui L. Reis, David Caballero
{"title":"MicroVasculoid-Chip: A 3D Self-Assembled Human Microcirculation-on-a-Chip Model Reveals Enhanced Lymphangiogenic Lung Cancer-Induced Vessel Remodeling and Invasion","authors":"Catarina M. Abreu, Ana C. Lima, Nuno M. Neves, Subhas C. Kundu, Rui L. Reis, David Caballero","doi":"10.1002/admt.202400883","DOIUrl":"https://doi.org/10.1002/admt.202400883","url":null,"abstract":"<p>The microvasculature within the tumor microenvironment is crucial for the invasion and dissemination of cancer cells throughout the body. Given its importance and dynamic behavior, several microfluidic models have been developed to study microvascular infiltration and its interaction with cancer cells. However, most of these models primarily focus on blood vessels and use microfluidic channels coated with endothelial cells, which fail to replicate near-physiological conditions. To address this limitation, the <i>MicroVasculoid-chip</i> is introduced, a novel human microcirculation-on-a-chip model that features self-organized 3D blood and lymphatic microvasculature alongside tumor spheroids. This innovative platform enables the exploration of interactions between multi-cellular tumors and both microvascular networks. Using lung cancer as a case study, how tumor-released mediators influence vessel morphology is investigated in relation to tumor invasion capacity, identifying molecular factors potentially associated with microvascular remodeling. Overall, the <i>MicroVasculoid-chip</i> provides a robust tool for investigating and modeling critical events of cancer neo-vascularization, for deciphering fundamental mechanisms of cancer cell invasion into the microvasculature, and for future drug screening applications.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 6","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supercapacitive Multimode Sensing with Tunable Graphene Sheet Film Electrodes (Adv. Mater. Technol. 1/2025)","authors":"Chunfeng Yin, Peimei Dong, Zengcai Zhao, Yaping Lu, Yuzhu Jin, Qiaolan Fan, Weitao Su, Yu Zhang, Xudong Liu, Zhenyu Xue, Dihua Wu, Yangxin Zhou","doi":"10.1002/admt.202570006","DOIUrl":"https://doi.org/10.1002/admt.202570006","url":null,"abstract":"<p><b>Supercapacitive Multimode Sensing</b></p><p>In article number 2400644, Zhenyu Xue, Dihua Wu, Yangxin Zhou, and co-workers present a graphene sheet film, with its ability to be patterned, that spontaneously detaches from the filter membrane following vacuum filtration, which allows nondestructive transfer and integration of the graphene sheet film into a thin film supercapacitor as electrodes. The film's porous structure endows the device with the capacity for capacitive strain sensing. Together with its ionotropic temperature sensing capability due to the solid electrolyte layer, this dual functionality empowers the thin film supercapacitor to achieve multimode sensing in a single device.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202570006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedikt Keitel, Sandra Dietl, Tom Philipp, Gregor Neusser, Christine Kranz, Harald Sobek, Boris Mizaikoff, Mehmet Dinc
{"title":"3D-Printed Highly Porous Functional Materials for the Efficient Removal of Adenovirus (Adv. Mater. Technol. 1/2025)","authors":"Benedikt Keitel, Sandra Dietl, Tom Philipp, Gregor Neusser, Christine Kranz, Harald Sobek, Boris Mizaikoff, Mehmet Dinc","doi":"10.1002/admt.202570003","DOIUrl":"https://doi.org/10.1002/admt.202570003","url":null,"abstract":"<p><b>Porous Polymers</b></p><p>The image presents a laser-scanning confocal microscopy image of a syringe insert for virus removal from suspensions. The hierarchical porosity of these advanced functional monoliths enables highly efficient virus removal and highlights the potential of 3D printing in creating tailored filtration solutions. More information can be found in article number 2401178 by Boris Mizaikoff, Mehmet Dinc, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202570003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mujeeb Yousuf, Jean-Christophe (Chris) Rochet, Pushpapraj Singh, Muhammad Mustafa Hussain
{"title":"Advancing Brain Organoid Electrophysiology: Minimally Invasive Technologies for Comprehensive Characterization","authors":"Mujeeb Yousuf, Jean-Christophe (Chris) Rochet, Pushpapraj Singh, Muhammad Mustafa Hussain","doi":"10.1002/admt.202401585","DOIUrl":"https://doi.org/10.1002/admt.202401585","url":null,"abstract":"<p>Human brain organoids, which originate from pluripotent stem cells, serve as valuable tools for a wide range of research endeavors, replicating brain function. Their capacity to replicate cellular interactions, morphology, and division provides invaluable insights into brain development, disease modeling, and drug screening. However, conventional morphological analysis methods are often invasive and lack real-time monitoring capabilities, posing limitations to achieving a comprehensive understanding. Therefore, advancing the comprehension of brain organoid electrophysiology necessitates the development of minimally invasive measurement technologies with long-term, high-resolution capabilities. This review highlights the significance of human brain organoids and emphasizes the need for electrophysiological characterization. It delves into conventional assessment methods, particularly focusing on 3D microelectrode arrays, electrode insertion mechanisms, and the importance of flexible electrode arrays to facilitate minimally invasive recordings. Additionally, various sensors tailored to monitor organoid properties are introduced, enriching the understanding of their chemical, thermal, and mechanical dynamics.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 7","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202401585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tendon-Driven Stiffness-Tunable Soft Actuator via Thermoelectric-based Bidirectional Temperature Control (Adv. Mater. Technol. 1/2025)","authors":"Yunlong Gao, Shikun Lin, Chuanwei Liang, Siqi Qiu, Chengyun Long, Yingjun Wang, Yunquan Li, Yuan-Fang Zhang","doi":"10.1002/admt.202570004","DOIUrl":"https://doi.org/10.1002/admt.202570004","url":null,"abstract":"<p><b>Stiffness-Tunable Soft Actuators</b></p><p>In article number 2401293, Yuan-Fang Zhang and co-workers present a tendon-driven soft actuator having both high load capacity and shape adaptability. By employing thermoelectric modules for bidirectional temperature control and graphene for efficient heat transfer in the actuator body, rapid stiffness tuning is achieved without extra cooling systems. The simplistic design further enhances the manufacturability and maneuverability of the actuator.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202570004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Y. Belinky, Nouha El Amri, Parker K. Lewis, Allie Karakosta LeMay, Rachel E. Pollard, Nathalie M. Pinkerton
{"title":"Design of Modular, 3D-Printed Millifluidic Mixers to Enable Sequential NanoPrecipitation (SNaP) for the Tunable Synthesis of Drug-Loaded Nanoparticles and Microparticles (Adv. Mater. Technol. 1/2025)","authors":"Thomas Y. Belinky, Nouha El Amri, Parker K. Lewis, Allie Karakosta LeMay, Rachel E. Pollard, Nathalie M. Pinkerton","doi":"10.1002/admt.202570002","DOIUrl":"https://doi.org/10.1002/admt.202570002","url":null,"abstract":"<p><b>Sequential NanoPrecipitation</b></p><p>In article number 2400583, Nathalie M. Pinkerton and co-workers present a 3D-printed sequential mixer platform that enables Sequential NanoPrecipitation (SNaP), a nascent two-step, controlled precipitation process for the robust synthesis of particles for drug delivery and bioimaging applications.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202570002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manuel Alonso-Orts, Ruben J. T. Neelissen, Daniel Carrasco, Marco Schowalter, Andreas Rosenauer, Emilio Nogales, Bianchi Méndez, Martin Eickhoff
{"title":"Accurate and Robust Wide-Range Luminescent Microthermometer Based on ALD-Encapsulated Ga2O3:Cr DBR Microcavities (Adv. Mater. Technol. 1/2025)","authors":"Manuel Alonso-Orts, Ruben J. T. Neelissen, Daniel Carrasco, Marco Schowalter, Andreas Rosenauer, Emilio Nogales, Bianchi Méndez, Martin Eickhoff","doi":"10.1002/admt.202570001","DOIUrl":"https://doi.org/10.1002/admt.202570001","url":null,"abstract":"<p><b>Luminescence Thermometry</b></p><p>Atomic layer deposition (ALD) is a powerful technique for achieving smooth and robust distributed Bragg reflector (DBR) coatings on microwire ends. In article number 2400881, Manuel Alonso-Orts and co-workers create optical microcavities with ALD-coated, chromium-doped gallium oxide (Ga<sub>2</sub>O<sub>3</sub>:Cr) microwires and demonstrate their use for wide-range temperature sensors with high stability, precision and accuracy, monitoring the temperature-induced spectral shifts of the resonant peaks.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202570001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weinan Liu, Siyan Li, Edmond Chow, Seemesh Bhaskar, Ying Fang, Brian T. Cunningham
{"title":"Photonic Crystal Enhanced Microscopy on a 2D Photonic Crystal Surface","authors":"Weinan Liu, Siyan Li, Edmond Chow, Seemesh Bhaskar, Ying Fang, Brian T. Cunningham","doi":"10.1002/admt.202401837","DOIUrl":"https://doi.org/10.1002/admt.202401837","url":null,"abstract":"<p>Digital-resolution biosensing based on resonant reflection from photonic crystals (PC) has demonstrated significant potential for detection of proteomic and genomic biomarkers in serology, infectious disease diagnostics, and cancer diagnostics. An important intrinsic characteristic of resonant metamaterial surfaces is that enhanced electromagnetic fields are not uniformly distributed, resulting in spatially variable light-matter interactions with nanoparticle tags that signal the presence of biomarker molecules. In this work, the spatial uniformity of resonantly enhanced, surface-confined electromagnetic fields of a 1D PC is compared with a 2D PC with fourfold symmetry. When illuminated with unpolarized light, the simultaneously excited electromagnetic fields of transverse electric and transverse magnetic modes of the 2D PC present equally strong but complementary spatial distribution, leading to a >100% increased average near-field intensity accompanied with a >50% compressed standard deviation compared to the 1D PC. Utilizing Photonic Resonator Absorption Microscopy (PRAM) to experimentally measure the absorption uniformity of ≈80 nm gold nanoparticles distributed upon the PC surface, a >100% improvement of the signal uniformity is observed when using the 2D PC. Overall, improvement in AuNP detection contrast, uniformity, and point spread function is demonstrated by PRAM performed upon a 2D PC surface.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 6","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202401837","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Shahali, Farzan Akbaridoust, Adrian Neild, Reza Nosrati
{"title":"Advancements in Microfluidic Technologies for Male Infertility","authors":"Sahar Shahali, Farzan Akbaridoust, Adrian Neild, Reza Nosrati","doi":"10.1002/admt.202401520","DOIUrl":"https://doi.org/10.1002/admt.202401520","url":null,"abstract":"<p>Infertility affects ≈15% of couples worldwide, with ≈45% of these cases involving male factors. Semen analysis and sperm selection are critical and routine steps in achieving successful assisted reproductive outcomes. Conventional methods, which are widely used in clinics, are manual, subjective, time-consuming, and simply not sufficient for the highly complex and multifaceted task of sperm analysis. Recently, microfluidics-based devices, combined with high-resolution microscopy, have offered promising opportunities for evaluating sperm quality, gaining a fundamental understanding of sperm motion, and selection of high-quality sperm. Machine learning (ML) has also introduced automation and standardization in analyzing sperm morphology, intracellular characteristics, and motility. In this review, these state-of-the-art methods are comprehensively discussed and provide directions to address unresolved challenges.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"10 8","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}