Discoveries (Craiova, Romania)最新文献

Echoes of Trauma: DSA-Guided Coil Embolization for Carotid Cavernous Fistula Presenting with Ocular Bruit and Pulsatile Exophthalmos. 创伤回声：dsa引导线圈栓塞治疗颈动脉海绵瘘，表现为眼部杂音和搏动性眼球突出。

Discoveries (Craiova, Romania) Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.15190/d.2025.2

Erekle Ekvtimishvil, Arpita Meher, Jessen Johnson

{"title":"Echoes of Trauma: DSA-Guided Coil Embolization for Carotid Cavernous Fistula Presenting with Ocular Bruit and Pulsatile Exophthalmos.","authors":"Erekle Ekvtimishvil, Arpita Meher, Jessen Johnson","doi":"10.15190/d.2025.2","DOIUrl":"https://doi.org/10.15190/d.2025.2","url":null,"abstract":"Carotid-Cavernous Fistulas (CCFs) are abnormal arteriovenous connections between the carotid artery and the cavernous sinus, resulting from trauma. This case report presents a 47-year-old male who developed a CCF following a road traffic accident. The patient exhibited symptoms such as pulsatile exophthalmos and an ocular bruit, characteristic of CCFs. Diagnosis was confirmed through Digital Subtraction Angiography (DSA), revealed the origin of the fistula. The patient was treated using a novel combined approach of microsurgery and endovascular intervention, involving ligation of the internal carotid artery and transarterial coil embolization. The treatment resulted in rapid resolution of symptoms, including the pulsatile exophthalmos and ocular bruit. This case highlights the importance of a multidisciplinary approach, blending microsurgical and advanced endovascular techniques, in effectively managing traumatic CCFs. The study underscores the value of early diagnosis and the evolving role of minimally invasive procedures in improving patient outcomes.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"13 1","pages":"e203"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytological Diagnosis of Hepatic Metastasis from Rectal Gastrointestinal Stromal Tumor: A Case Report. 直肠胃肠道间质瘤肝转移的细胞学诊断1例。

Discoveries (Craiova, Romania) Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.15190/d.2025.1

Gauri Niranjan, Pallavi Prasad, Archana Verma, Ashok Kumar

{"title":"Cytological Diagnosis of Hepatic Metastasis from Rectal Gastrointestinal Stromal Tumor: A Case Report.","authors":"Gauri Niranjan, Pallavi Prasad, Archana Verma, Ashok Kumar","doi":"10.15190/d.2025.1","DOIUrl":"https://doi.org/10.15190/d.2025.1","url":null,"abstract":"Gastrointestinal stromal tumours (GIST) are rare mesenchymal tumours which represent 1% to 3% of all gastrointestinal neoplasms. Rectal location of GIST is extremely rare accounting for 5% of GIST and only 0.1% of rectal tumours. They usually metastasise to the liver (65%). We hereby report a case of rectal stromal tumour with hepatic metastasis. A 55-year-old female presented with pelvic pain, associated with rectal bleeding. A thoracoabdominal computed tomography showed a large heterogeneous enhancing mass, arising from the rectum, anal canal and distal sigmoid colon measuring 12.3x8.7x7.6cm. Based on histopathological examination followed by immunohistochemistry, she was diagnosed with locally advanced rectal GIST. The tumour reduced in size after neoadjuvant-targeted treatment with imatinib. A local resection of the rectal GIST was successfully performed, and a diversion colostomy was done, later colostomy bag was attached. Following the operation, oral imatinib treatment was continued. On subsequent follow-up, her triple phase CECT whole abdomen showed multiple small well-defined peripherally enhancing hypodense liver lesions, the largest measuring 29x18mm suggestive of metastases. Ultrasound-guided fine needle aspiration from a liver lesion was reported as metastatic GIST. The patient underwent surgery, sunitinib was started and was discharged in stable condition. Thus, cytologic examination provides rapid interpretation, is a less invasive technique than open biopsy, and provides a cost-effective modality for diagnosing and managing inaccessible lesions.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"13 1","pages":"e202"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear cell adenocarcinoma of the cervix, a rare entity of young females: A case report. 宫颈透明细胞腺癌，罕见的年轻女性：1例报告。

Discoveries (Craiova, Romania) Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.15190/d.2025.4

Paramita Paul, Paramita Rudra Pal, Sadaf Hayat

引用次数: 0

Impact of Triton X-100 on Notch 1 Surface Receptor Immunofluorescence: A Cautionary Study. Triton X-100对Notch 1表面受体免疫荧光影响的警示研究

Discoveries (Craiova, Romania) Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.15190/d.2025.5

Maha Shahid, Kanwal Iftikhar, Shabana Usman Simjee

引用次数: 0

Clinical Insights and Advancements in Human Metapneumovirus Management and Prognosis. 人偏肺病毒治疗和预后的临床见解和进展。

Discoveries (Craiova, Romania) Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.15190/d.2025.3

Harsahaj Singh Wilkhoo, Afra Wasama Islam, Harkirat Singh Wilkhoo, Suhaib Hussain, Bharat Singh, Saumya Rajesh Kadam

{"title":"Clinical Insights and Advancements in Human Metapneumovirus Management and Prognosis.","authors":"Harsahaj Singh Wilkhoo, Afra Wasama Islam, Harkirat Singh Wilkhoo, Suhaib Hussain, Bharat Singh, Saumya Rajesh Kadam","doi":"10.15190/d.2025.3","DOIUrl":"https://doi.org/10.15190/d.2025.3","url":null,"abstract":"Human metapneumovirus is a respiratory pathogen that infects children, the elderly, and immunocompromised individuals. Despite its global prevalence, underdiagnosis persists because of clinical overlap with other respiratory viruses. The current approach is mostly supportive, with oxygen therapy and hydration being crucial interventions. Ribavirin contains antiviral properties but has little clinical application. Vaccine development is moving forward, with prospects including live-attenuated, subunit-based, and virus-like particle vaccines. Molecular diagnostics, such as RT-PCR and metagenomic sequencing, have increased detection rates, which aids epidemiological monitoring. Monoclonal antibodies targeting the fusion (F) protein are being studied for passive immunity, while immunomodulatory treatments such as corticosteroids and intravenous immunoglobulins may help treat severe cases. Emerging treatments include fusion inhibitors and pan-pneumovirus vaccinations that protect against HMPV and RSV. Future research should concentrate on optimizing antiviral methods, increasing vaccination trials, and improving surveillance to detect outbreaks. A multidisciplinary approach that combines virology, immunology, and epidemiology is required to reduce HMPV's effect and improve patient outcomes. This review serves as a comprehensive literature about HMPV which provides all the crucial clinical perspectives and the latest advancements in management, antivirals, patient prognosis as well and diagnostic modalities.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"13 1","pages":"e204"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Rare Breast Neoplasms: Diagnostic Challenges and Insights. 揭示罕见乳腺肿瘤：诊断的挑战和见解。

Discoveries (Craiova, Romania) Pub Date : 2024-12-31 eCollection Date: 2024-10-01 DOI: 10.15190/d.2024.19

Rasheeda Mohamedali, Nilay Nishith, Rahul Raj, Nishtha Ahuja, Aishwarya Sharma, Puneet Kaur Somal, Ravikiran N Pawar, Sankalp Sancheti

{"title":"Unveiling Rare Breast Neoplasms: Diagnostic Challenges and Insights.","authors":"Rasheeda Mohamedali, Nilay Nishith, Rahul Raj, Nishtha Ahuja, Aishwarya Sharma, Puneet Kaur Somal, Ravikiran N Pawar, Sankalp Sancheti","doi":"10.15190/d.2024.19","DOIUrl":"https://doi.org/10.15190/d.2024.19","url":null,"abstract":"Breast neoplasm encompasses a diversified range of different diseases characterized by unique biological and pathological features, clinical presentation, response to treatments, clinical behavior, and outcome. The histological variability has profound prognostic implications, thus playing a pivotal role in diagnosing breast neoplasm. Special histologies can occur rarely, and most information on outcomes and treatments is mainly derived from small series and case reports. Thus, reporting such unusual occurrences is of utmost importance. This is a retrospective study of four years in which 11 cases of breast neoplasm diagnosed on histopathology were assessed. The clinical details were acquired from an electronic search. The hematoxylin and eosin and immunohistochemistry slides were retrieved from the archives to review the histopathological features. The patient's age ranged from 32 to 72 years (median: 51 years). Eleven unusual cases of breast neoplasms were diagnosed and categorized according to the latest World Health Organisation (WHO) classification. These cases include rare and salivary gland type tumors (2 cases), neuroendocrine neoplasms (1 case), hamartomas of the breast (2 cases), fibroblastic and myofibroblastic tumors of the breast (1 case), peripheral nerve sheath tumor (1 case) and hematolymphoid tumors of the breast (4 cases). The management of unusual breast cancer histotypes represents a real challenge in daily clinical practice. Our data suggest that these variants are distinct clinicopathological entities with unique hormonal receptor statuses. The occurrence of such entities is rare, and they demonstrate different clinical behaviors and responses to treatment, suggesting that a few genomic-specific events might also drive them. Therefore, it is important to indulge in future research on such rare breast neoplasms.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"12 4","pages":"e200"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and Pathological Insights into the rs7216389 Polymorphism in Gasdermin B and Its Association with Childhood Asthma. Gasdermin B rs7216389多态性及其与儿童哮喘相关性的遗传学和病理学研究

Discoveries (Craiova, Romania) Pub Date : 2024-12-31 eCollection Date: 2024-10-01 DOI: 10.15190/d.2024.15

Qudsia Umaira Khan, Afreen Banu, Ismail Mazhar, Aimen Binte Asif, Aan Waseem

{"title":"Genetic and Pathological Insights into the rs7216389 Polymorphism in Gasdermin B and Its Association with Childhood Asthma.","authors":"Qudsia Umaira Khan, Afreen Banu, Ismail Mazhar, Aimen Binte Asif, Aan Waseem","doi":"10.15190/d.2024.15","DOIUrl":"10.15190/d.2024.15","url":null,"abstract":"This review provides an overview of genetic and pathological mechanisms associated with childhood asthma, focusing on the Gasdermin B (GSDMB) gene variant rs7216389. Accordingly, asthma is outlined as the most common chronic disease in children, with increased incidence in the worldwide community, critically important complications, and mortality related to severe manifestations, primarily exacerbations. The review provides a clinical definition of asthma exacerbation, briefly goes into the cost aspects, and explains the features of pediatric asthma compared to adult-onset asthma. It recognizes the influence of genetic factors such as single nucleotide polymorphisms at the 17q21 locus concerning asthma and its severe attacks while stressing the need to understand those genetic factors that could be potential targets for treatment. The review also stresses the difficulties in implementing the discovery in the clinic, and the potential of additional research dedicated to unveiling the relationship between genetic risk factors, environmental exposures, and immune reactions in the pathological process of childhood asthma. To this end, the current work should be viewed as an attempt to provide a broad overview of asthma pathogenesis and contribute to the development of novel hypotheses and therapeutic approaches in future studies.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"12 4","pages":"e196"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diphenoxylate Toxicity in a Young Child with Acute Gastroenteritis: A Clinical Case Report. 地苯氧酸钠对急性胃肠炎患儿的毒性：1例临床报告。

Discoveries (Craiova, Romania) Pub Date : 2024-12-31 eCollection Date: 2024-10-01 DOI: 10.15190/d.2024.20

Muhammad Romail Manan, Iqra Nawaz, Ahmad Zulaid, Muhammad Usama Afzal, Muhammad Atif, Muhammad Huzaifa, Anosha Fayyaz

{"title":"Diphenoxylate Toxicity in a Young Child with Acute Gastroenteritis: A Clinical Case Report.","authors":"Muhammad Romail Manan, Iqra Nawaz, Ahmad Zulaid, Muhammad Usama Afzal, Muhammad Atif, Muhammad Huzaifa, Anosha Fayyaz","doi":"10.15190/d.2024.20","DOIUrl":"10.15190/d.2024.20","url":null,"abstract":"Lomotil (diphenoxylate-atropine) toxicity in the pediatric population remains a significant concern particularly in low and lower middle-income countries. This may result from accidental ingestion or inappropriate therapeutic administration which can lead to life threatening complications including respiratory and central nervous system depression. A 2-year-old child presented to the pediatric emergency room in an altered state of consciousness. Clinical examination revealed dry mucous membranes, and a prolonged capillary refill time with weak radial pulses. Keeping in view the one-day history of 10-12 episodes of acute onset loose, watery stools, patient was initially treated as a case of hypovolemic shock. With rehydration therapy, his perfusion improved. However, the Glasgow Coma Scale score remained 8, as was observed on initial presentation. Upon further probing, it was revealed by the parents that the child had been given Lomotil by a local general practitioner for unresolved watery diarrhea. Pinpoint pupils and slow shallow vesicular breathing confirmed this diagnosis of Lomotil overdose. Administration of 0.1mg/kg/dose Naloxone repeated once, completely reversed the toxic effects. The child was able to make a full recovery and was discharged the following day. This case highlights the importance of recognizing and managing diphenoxylate toxicity in children, emphasizing the need for increased clinical awareness. A lack of consensus regarding the toxic dose of this drug reveals a gap warranting further research and establishment of standardized guidelines to ensure accurate dosing and improved patient safety.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"12 4","pages":"e201"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public Health Threats Posed by Biofilms and Innovative Strategies for their Control. 生物膜对公共卫生的威胁及其创新控制策略

Discoveries (Craiova, Romania) Pub Date : 2024-12-31 eCollection Date: 2024-10-01 DOI: 10.15190/d.2024.16

Syed Hamza Abbas, Shahzar Khan, Majid Shah, Jawad Aslam, Humaira Nawaz, Nadia Ilyas, Asim Gamaryani, Saba Qadir Afridi, Izaz Khan, Brekhna Shah, Kashmala Shah, Abdul Rashid, Dilawaiz Khan, Samiullah Khan

{"title":"Public Health Threats Posed by Biofilms and Innovative Strategies for their Control.","authors":"Syed Hamza Abbas, Shahzar Khan, Majid Shah, Jawad Aslam, Humaira Nawaz, Nadia Ilyas, Asim Gamaryani, Saba Qadir Afridi, Izaz Khan, Brekhna Shah, Kashmala Shah, Abdul Rashid, Dilawaiz Khan, Samiullah Khan","doi":"10.15190/d.2024.16","DOIUrl":"10.15190/d.2024.16","url":null,"abstract":"Biofilms are communities of microorganisms that adhere to surfaces within a self-produced protective matrix. The structural complexity of biofilms and their inherent resistance to conventional antimicrobial treatments make them a significant public health challenge. These microbial communities, embedded within a self-produced extracellular matrix, are associated with numerous persistent infections, especially those occurring in healthcare settings where they colonize medical devices and chronic wounds. The effects of biofilms go beyond healthcare environments and persist in water treatment facilities, food processing plants, and nature, in which biofilms aid in pollution and transmission of disease. This review article discusses multifaceted public health complications related to biofilms and the search for existing control strategies, the process of biofilm formation, mechanisms of persistence, and limitations of traditional antimicrobial approaches. Additionally, this article explores new innovative solutions, such as bacteriophage therapy, matrix-degrading enzymes, and quorum sensing inhibitors. The potential of a combination of antimicrobial agents with biofilm-disrupting compounds for the improvement of efficacy is also paid special attention. This review seeks to contribute to these ongoing efforts by presenting an overview of biofilm biology and assessing the efficacy of a variety of possible control strategies. Subsequently, the insights derived from this study may be used to inform future research directions and aid in the development of more effective interventions for biofilm-associated infections and contamination in various settings.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"12 4","pages":"e197"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Patient-Centered Perspectives and Future Directions in AI-powered Teledentistry. 以患者为中心的视角和人工智能远程牙科的未来方向。

Discoveries (Craiova, Romania) Pub Date : 2024-12-31 eCollection Date: 2024-10-01 DOI: 10.15190/d.2024.18

Richa Kaushik, Ravindra Rapaka

{"title":"A Patient-Centered Perspectives and Future Directions in AI-powered Teledentistry.","authors":"Richa Kaushik, Ravindra Rapaka","doi":"10.15190/d.2024.18","DOIUrl":"10.15190/d.2024.18","url":null,"abstract":"This scoping review investigates the integration of AI into teledentistry with a focus on patient-centered perspectives and future directions. Teledentistry has progressed rapidly in the COVID-19 pandemic period, providing remote dental care by means of digital communication technologies.The introduction of AI has made diagnosis more precise, treatment planning more personalized, and processes more efficient and have also made dental services better accessible to the underserved. AI algorithms help in early diagnosis of dental issues, provides customized treatment plans, and improve patient outcomes. Despite the advantages, still many challenges exist. These are ethical concerns, data privacy issues, and regulatory hurdles that prevent widespread adoption. Use of AI in dental settings results in patients having mixed sentiments surrounding trust and data security arising out of fear of having reduced personal interactions with providers. Additionally, AI driven teledentistry is not validated in large scale clinical setting and cost effectiveness assessment which undermines scalability. This review identifies gaps in existing research and provides guidance for how patient-centered applications further facilitate increased transparency, AI education, and cross-disciplinary collaboration among dentists, computer scientists, ethicists, and policymakers. The future research should include clinical validation, economics, and ethical standards to make AI teledentistry use responsible and inclusive. This scoping review equips clinicians and researchers with a roadmap for responsible, patient-centered implementation of AI-enabled teledentistry, offering practical strategies and insights to enhance the quality and accessibility of remote dental care.","PeriodicalId":72829,"journal":{"name":"Discoveries (Craiova, Romania)","volume":"12 4","pages":"e199"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0