Clear cell adenocarcinoma of the cervix, a rare entity of young females: A case report.

Discoveries (Craiova, Romania) Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI:10.15190/d.2025.4
Paramita Paul, Paramita Rudra Pal, Sadaf Hayat
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Abstract

Clear cell adenocarcinoma of the cervix is a rare neoplasm that accounts for about 4-9% of all uterine cervical adenocarcinoma. It was first reported in young women with in-utero exposure of diethylstilbesterol (DES). However, many cases have been reported post-ban of DES that are not associated with diethylstilbesterol (DES). Here, we are reporting a case of clear cell adenocarcinoma in an 18-year-old woman without any exposure history of DES. An exophytic mass arising from the anterior lip was found in MRI. Biopsy from the mass was diagnosed as Clear cell adenocarcinoma of the cervix based on histopathological and immunohistochemical findings. The patient then underwent a total hysterectomy and bilateral salpingo-oophorectomy. One each of the right pelvic lymph nodes and external iliac lymph nodes showed metastatic deposits. The patient was staged as FIGO stage I [AJCC TNM staging (8th Edition): pT2b pN1]. Post 6 months follow up there is no evidence of any recurrence.

宫颈透明细胞腺癌,罕见的年轻女性:1例报告。
宫颈透明细胞腺癌是一种罕见的肿瘤,约占所有子宫颈腺癌的4-9%。首次报道的是宫内暴露于己烯雌酚(DES)的年轻女性。然而,据报道,许多禁用DES后的病例与己烯雌酚(DES)无关。在此,我们报告一例透明细胞腺癌,患者为18岁女性,无DES暴露史。MRI发现前唇外生性肿块。根据组织病理学和免疫组织化学结果,肿块活检诊断为宫颈透明细胞腺癌。患者随后接受了全子宫切除术和双侧输卵管卵巢切除术。右侧盆腔淋巴结和髂外淋巴结各有一例有转移灶。患者分期为FIGO I期[AJCC TNM分期(第8版):pT2b pN1]。随访6个月后无复发迹象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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