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[Dermoscopy of melanocytoma-groundbreaking or established knowledge]. [黑色素细胞瘤的皮肤镜检查--突破性还是成熟的知识]。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1007/s00105-024-05423-7
Teresa Kränke, Andreas Blum
{"title":"[Dermoscopy of melanocytoma-groundbreaking or established knowledge].","authors":"Teresa Kränke, Andreas Blum","doi":"10.1007/s00105-024-05423-7","DOIUrl":"10.1007/s00105-024-05423-7","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"972-975"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Recurrent, painful ulcers of the lower extremities and abdomen]. [下肢和腹部溃疡反复发作，疼痛难忍]。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1007/s00105-024-05421-9
Hannah Zillikens, Birte Burgdorf, Eva Hadaschik, Joachim Dissemond
{"title":"[Recurrent, painful ulcers of the lower extremities and abdomen].","authors":"Hannah Zillikens, Birte Burgdorf, Eva Hadaschik, Joachim Dissemond","doi":"10.1007/s00105-024-05421-9","DOIUrl":"10.1007/s00105-024-05421-9","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"976-979"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunohistochemical examinations in malignant melanoma : Fundamentals and special aspects]. [恶性黑色素瘤的免疫组化检查：基础和特殊方面]。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1007/s00105-024-05424-6
Cornelia Sigrid Lissi Müller
{"title":"[Immunohistochemical examinations in malignant melanoma : Fundamentals and special aspects].","authors":"Cornelia Sigrid Lissi Müller","doi":"10.1007/s00105-024-05424-6","DOIUrl":"10.1007/s00105-024-05424-6","url":null,"abstract":"<p><p>Immunohistochemical examinations have been used for many years in dermatopathology and pathology and have become an integral part of tumor diagnostics. The aim is to identify and classify tumor cells that express distinct antigens. Malignant melanoma can be characterized by a large number of well-described and standardized antibodies, so that immunohistochemical staining is used in the diagnosis of melanoma, the differential diagnosis of other tumors, the determination of tumor thickness, the diagnosis of tumor metastases, and also in the diagnosis of sentinel lymph nodes. Comprehensive knowledge of the expression profiles and specific staining patterns of the antibodies used is of great diagnostic relevance, with the aim of preventing misdiagnosis. The perfect antibody with high sensitivity and maximum specificity does not exist. Hence, immunohistochemistry does not replace the conventional assessment and interpretation of tumor samples. Only in symbiosis with clinical and conventional histological findings do immunohistochemical stains have a diagnostic value.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"947-966"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Skin fragility].
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-12-03 DOI: 10.1007/s00105-024-05426-4
Meropi Karakioulaki, Cristina Has
{"title":"[Skin fragility].","authors":"Meropi Karakioulaki, Cristina Has","doi":"10.1007/s00105-024-05426-4","DOIUrl":"https://doi.org/10.1007/s00105-024-05426-4","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":"75 12","pages":"905-906"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Skin fragility in autoimmune blistering diseases of the skin]. [自身免疫性皮肤大疱病的皮肤脆性］
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1007/s00105-024-05428-2
Farzan Solimani, Dario Didona, Michael Hertl
{"title":"[Skin fragility in autoimmune blistering diseases of the skin].","authors":"Farzan Solimani, Dario Didona, Michael Hertl","doi":"10.1007/s00105-024-05428-2","DOIUrl":"10.1007/s00105-024-05428-2","url":null,"abstract":"<p><p>In many disorders, skin and/or mucosal changes are dominated by blisters, wounds, or erosions. While these changes can be observed during infective, traumatic, metabolic, or inflammatory processes, these are normally clinical hallmarks of the disruption of the cytoarchitectural stability of the skin. Several proteins, such as those located in the dermal-epidermal junction zone and forming the hemidesmosomes, or those forming epidermal desmosomes are crucial for the maintenance of skin integrity. Defective function may be genetically determined due to impaired or absent production of specific proteins (i.e., epidermolysis bullosa) or due to autoimmune disorders that lead to the production of autoreactive antibodies targeting desmosomal or hemidesmosomal skin antigens. The latter group of diseases are classically named autoimmune blistering diseases of the skin. These can be divided in the pemphigoid group, where antigens are components of the hemidesmosomes, and pemphigus group, where desmosomal proteins are targeted. In this review, we provide a short vademecum of autoimmune skin disorders that are associated with skin fragility.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"924-933"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Onychopapilloma : Diagnosis and surgical treatment of a rare nail tumor]. [甲状软骨瘤：一种罕见指甲肿瘤的诊断和手术治疗]。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1007/s00105-024-05432-6
Céline Willmann, Irina Ivanova, Maria-Isabel von Eichborn, Anna Halupczok, Michael Spindler, Mark Berneburg, Julian Kögel
{"title":"[Onychopapilloma : Diagnosis and surgical treatment of a rare nail tumor].","authors":"Céline Willmann, Irina Ivanova, Maria-Isabel von Eichborn, Anna Halupczok, Michael Spindler, Mark Berneburg, Julian Kögel","doi":"10.1007/s00105-024-05432-6","DOIUrl":"10.1007/s00105-024-05432-6","url":null,"abstract":"<p><p>We report on two cases of nail tumors associated with onychorrhexis, distal V‑shaped onycholysis, and subungual keratosis. Surgical exposure was performed in each case to confirm the diagnosis. Histopathological examination revealed skin changes consistent with onychopapilloma. We describe two common surgical techniques in the treatment of onychopapilloma: classical longitudinal excision and alternative tangential excision with corresponding follow-up.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"967-971"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Erratum zu: Konventionelle und molekulare Diagnostik bei Onychomykose – Teil 1. 出版商对《甲癣的常规诊断和分子诊断--第一部分》的勘误。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 DOI: 10.1007/s00105-023-05291-7
Carolin Mehlhorn, Silke Uhrlaß, Esther Klonowski, Constanze Krüger, Uwe Paasch, Jan C Simon, Pietro Nenoff
{"title":"Publisher Erratum zu: Konventionelle und molekulare Diagnostik bei Onychomykose – Teil 1.","authors":"Carolin Mehlhorn, Silke Uhrlaß, Esther Klonowski, Constanze Krüger, Uwe Paasch, Jan C Simon, Pietro Nenoff","doi":"10.1007/s00105-023-05291-7","DOIUrl":"10.1007/s00105-023-05291-7","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One Minute Wonder. 一分钟奇迹
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 DOI: 10.1007/s00105-024-05435-3
Thomas Dirschka
{"title":"One Minute Wonder.","authors":"Thomas Dirschka","doi":"10.1007/s00105-024-05435-3","DOIUrl":"10.1007/s00105-024-05435-3","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"946"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular pathology of skin fragility]. [皮肤脆弱的分子病理学]。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2024-11-07 DOI: 10.1007/s00105-024-05425-5
Cristina Has, Meropi Karakioulaki
{"title":"[Molecular pathology of skin fragility].","authors":"Cristina Has, Meropi Karakioulaki","doi":"10.1007/s00105-024-05425-5","DOIUrl":"10.1007/s00105-024-05425-5","url":null,"abstract":"<p><p>The skin's barrier function is primarily maintained by the cohesion of its layers and the specialized stratum corneum. Genetic and autoimmune disorders that result in skin fragility have significantly contributed to understanding the role of various molecular components in the skin. These conditions, characterized by blisters, erosions, wounds, and impaired wound healing, are rare but must be considered in clinical differential diagnoses. Key cutaneous adhesion structures include the epidermal basement membrane, anchoring fibrils, cell-matrix adhesions (e.g., hemidesmosomes and focal adhesions), and cell-cell adhesions (e.g., desmosomes and corneodesmosomes). These multiprotein suprastructures not only provide structural support but also participate in signaling processes and physiological or pathological conditions such as skin aging and wound healing. Additionally, dermal connective tissue plays a structural role and serves as a reservoir for proteases, growth factors, and cytokines. Modern techniques like single-cell and spatial transcriptomics, combined with artificial intelligence algorithms, are advancing the molecular mapping of human skin. Moreover, this review highlights the molecular composition of adhesion structures and the specific diseases associated with deficiencies in these components.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"907-912"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complications and their management in the surgical treatment of Lipohyperplasia dolorosa. English version. 多色性脂肪增生症手术治疗中的并发症及其处理。英文版。
Dermatologie (Heidelberg, Germany) Pub Date : 2024-12-01 Epub Date: 2022-12-22 DOI: 10.1007/s00105-022-05075-5
Manuel Cornely, Matthias Gensior
{"title":"Complications and their management in the surgical treatment of Lipohyperplasia dolorosa. English version.","authors":"Manuel Cornely, Matthias Gensior","doi":"10.1007/s00105-022-05075-5","DOIUrl":"10.1007/s00105-022-05075-5","url":null,"abstract":"<p><strong>Background: </strong>There are both conservative and surgical treatment options for Lipohyperplasia dolorosa (LiDo). A procedure that has been established since 1997 is the surgical treatment through Lymphological Liposculpture according to Cornely™.</p><p><strong>Aim: </strong>After extensive suctioning of the extremities, an extensive subcutaneous wound cavity with a trabecular connective tissue scaffold remains. Nevertheless, surgery-related complications are rare. Postoperative management and administration of antibiotics and antithrombotics are reviewed. The therapies for complications are presented in detail.</p><p><strong>Materials and methods: </strong>Retrospectively, the frequencies of adverse events in 1400 LiDo surgeries in 2020 were evaluated. The mean age of the patients was 47.81 years (range 16-78 years). Symmetrically, 504 outer legs (outer half of the limb [BO]), 504 inner legs (inner half of the limb [BI]), and 392 arms [A] were surgically treated.</p><p><strong>Results: </strong>Relevant adverse events rarely occurred: infections (1.79%), seromas (0.79%), erysipelas (0.28%), necrosis (0.14%) and deep vein thrombosis (0.07).</p><p><strong>Discussion: </strong>We were able to reduce the rate of postoperative complications to 3.07% in the Lymphological Liposculpture™ regime for the surgical treatment of LiDo. In their meta-analysis on liposuction, Kanapathy et al. reported an overall incidence of major surgical complications of 3.35%. The overall incidence of minor surgical complications was 11.62%, with seroma (5.51%) being the most common minor complication [26]. Kruppa et al. report that the liposuction procedure including fat removal for esthetic reasons has a complication rate of 9.5%. Wound infections with 4.5% and the formation of erysipelas with 4% are clearly in the foreground [20].</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10764198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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