{"title":"[Suspected histamine intolerance-how to proceed?]","authors":"Imke Reese","doi":"10.1007/s00105-025-05482-4","DOIUrl":"https://doi.org/10.1007/s00105-025-05482-4","url":null,"abstract":"<p><p>\"Histamine intolerance\" is often based on a self-diagnosis. Due to the known range of reactions that can be mediated by the messenger substance histamine, it is postulated that food histamine can trigger the same reactions. Results of studies with double-blind, placebo-controlled oral provocation tests do not confirm this, but rather show that orally administered histamine does not trigger reproducible reactions and that symptoms often occur after placebo, indicating a strong nocebo effect. Without reproducibility, however, the definition for an adverse reaction to food is not fulfilled. As many sufferers are severely affected by their self-diagnosis due to a massive restriction of their food choice, quality of life, and social interaction, allergy societies in German-speaking countries have published a guideline which describes a pragmatic diagnostic and therapeutic approach. The primary aim is to alleviate symptoms by improving digestive function and to expand the choice of foods, rather than to exclude the suspected diagnosis. Collaboration with a dietician/nutritionist with allergological expertise is therefore strongly recommended.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"OMW: Leitsymptome an der Haut in der Schwangerschaft.","authors":"Ann-Sophie Bohne, Katharina Antonia Langen, Regine Gläser","doi":"10.1007/s00105-025-05485-1","DOIUrl":"https://doi.org/10.1007/s00105-025-05485-1","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Digital pathology using ex vivo confocal laser scanning microscopy].","authors":"Alisa Swarlik, M Deußing, D Hartmann","doi":"10.1007/s00105-025-05469-1","DOIUrl":"10.1007/s00105-025-05469-1","url":null,"abstract":"<p><p>Ex vivo confocal laser scanning microscopy (EVCM) is a novel diagnostic method for bedside use with the possibility to perform rapid dermatopathological examinations on fresh tissue, while directly creating digital pictures. The aim of this article is to provide an overview of current study results in the field of EVCM. Due to the large number of studies in dermatology, the focus is set on the diagnosis of dermatological diseases. Nonmelanocytic cancer (NMSC) is considered the most studied disease in EVCM with high potential for clinical application. In addition, more studies on other dermatological diseases, such as neoplastic, infectious and even rare dermatological diseases, have shown promising results. The potential implementation of artificial intelligence (AI) in EVCM could make bedside diagnostics even more efficient and accelerate the clinical workflow. EVCM offers a user-friendly technology that mimics dermatopathology, thus, establishing its importance as an innovative addition to conventional dermatohistopathology. In addition to technical challenges, the current lack of immunohistochemistry in EVCM remains a limitation.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"135-139"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Susanne Triebswetter, Jan C Simon, Anna-Theresa Seitz
{"title":"[Implementation of teledermatological consultations at Leipzig University Medical Center].","authors":"Susanne Triebswetter, Jan C Simon, Anna-Theresa Seitz","doi":"10.1007/s00105-024-05463-z","DOIUrl":"10.1007/s00105-024-05463-z","url":null,"abstract":"<p><strong>Background: </strong>Numerous patients admitted to a general hospital present skin changes as secondary findings. Approximately 800 dermatological consultations are performed annually at the Leipzig University Medical Center.</p><p><strong>Objectives: </strong>The aim of this study was, after implementation of teledermatological consulting, the retrospective evaluation of that and the resulting satisfaction of the physicians involved.</p><p><strong>Materials and methods: </strong>We carried out an analysis of all consultation requests, which were answered using store-and-forward technology via the photo documentation app imitoCAM® (imito AG Zurich/Switzerland) and the clinical information system SAP® (SAP Deutschland SE & Co. KG Walldorf/Germany) from 1 February to 31 July 2023, as well as of questionnaires on satisfaction, which were sent to the participating physicians after the consultation.</p><p><strong>Results: </strong>Our analysis included 419 consultation requests, 90 of which were answered teledermatologically. The consultation dermatologists stated that 92% of the cases could be solved using only telemedical instruments. Moreover, 90.9% of the consulting physicians rated the technical implementation as good to very good and 47.5% of the consultation dermatologists estimated a time saving of at least 30-60 min.</p><p><strong>Conclusions: </strong>Our study shows the enormous potential of teledermatology in the inpatient setting. Implementation of teleconsultation enables more efficient consultations, reduces time- and cost-intensive transportation and offers patients a more comfortable dermatological evaluation with reduced risk of infection.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"152-158"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Skin cancer in a tattoo].","authors":"Andreas Blum","doi":"10.1007/s00105-024-05446-0","DOIUrl":"10.1007/s00105-024-05446-0","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"166"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[WHO classification of melanocytic tumours].","authors":"Maximilian Gassenmaier","doi":"10.1007/s00105-025-05468-2","DOIUrl":"10.1007/s00105-025-05468-2","url":null,"abstract":"<p><strong>Background: </strong>The update of the World Health Organisation (WHO) classification of skin tumours has led to new aspects in the classification of melanocytic tumours.</p><p><strong>Objectives: </strong>Presentation of the classification of melanocytic tumours in light of current clinical, histological and genetic data.</p><p><strong>Materials and methods: </strong>Review of the classification of melanocytic neoplasms in the fifth edition of the WHO classification of skin tumours, taking into account current disease concepts.</p><p><strong>Results: </strong>Malignant melanoma is characterised by stepwise tumour progression and is a heterogeneous disease. Benign and intermediate precursor lesions with characteristic driver mutations can be defined for the different melanoma subtypes. Melanocytomas represent a growing group of intermediate neoplasms which, from a genetic point of view, lie between nevi and melanomas and usually have a benign course.</p><p><strong>Conclusion: </strong>With the update of the WHO classification, genetic parameters are becoming increasingly relevant and shape the terminology. New terms such as 'melanocytoma' require a medical understanding of current disease concepts and good physician-patient communication for appropriate reporting of findings and therapy.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioannis Karagiannidis, Cai Niklaas Feldmann, Christian Hallermann, Alex Rothhaar
{"title":"[Light brown, asymptomatic macula on the sole of the foot of a 27-year-old woman].","authors":"Ioannis Karagiannidis, Cai Niklaas Feldmann, Christian Hallermann, Alex Rothhaar","doi":"10.1007/s00105-024-05458-w","DOIUrl":"10.1007/s00105-024-05458-w","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"186-190"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Diagnosis of pediatric melanocytic tumors].","authors":"Stephan Forchhammer, Valentin Aebischer","doi":"10.1007/s00105-025-05471-7","DOIUrl":"10.1007/s00105-025-05471-7","url":null,"abstract":"<p><p>The histological diagnosis of pediatric melanocytic tumors is challenging, as benign nevi often resemble aggressive tumors. Accurate diagnosis is crucial for the early detection of rare pediatric melanomas. Recent advancements have established a classification based on genetic backgrounds. This classification distinguishes between rarer subtypes and includes groups such as conventional melanomas, Spitz tumors, and melanomas arising from congenital melanocytic nevi. While the most common group, Spitz tumors, generally has a favorable prognosis, conventional melanomas and especially those arising from congenital nevi may exhibit an aggressive course similar to that of adult melanoma.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"127-134"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Möllenhoff, Max Quoss, Eva Salzmann, Marie-Luise Schiffmann, Seila Steger, Stefanie Hübner
{"title":"[DGDC (German Society for Dermatologic Surgery) observation day with live nail surgery by Dr. Christoph Löser at the Ludwigshafen Dermatology Clinic : Insights and inspiration].","authors":"Christian Möllenhoff, Max Quoss, Eva Salzmann, Marie-Luise Schiffmann, Seila Steger, Stefanie Hübner","doi":"10.1007/s00105-025-05475-3","DOIUrl":"10.1007/s00105-025-05475-3","url":null,"abstract":"<p><p>Comprehensive training in nail surgery is usually difficult to provide as part of clinical training and continuing education due to a lack of sufficient case numbers. The Dermatology Clinic and Skin Tumor Center at Ludwigshafen Hospital has been a surgical observation and training center of the German Society for Dermatologic surgery (DGDC) since 2014 and, under the direction of Dr. Christoph Löser, is counteracting this deficiency with observation seminars, including the topic of nail surgery. As part of this one-day work shadowing program, six participants from German-speaking countries were given the opportunity to develop theoretical principles and practical skills of nail surgery in a structured manner. A total of 8 patients with various nail pathologies were treated, providing a representative cross-section of nail diseases. Immediately after each surgery, the individual surgical steps were discussed in detail and, where appropriate, analyzed using photo documentation. Key information covered in the seminar included techniques of systematic nail surgery, which can be implemented in the participants' home clinics and practices in the sense of maximizing their impact. In addition, the participants learned which previously common surgical procedures on the nail unit are now obsolete. The in-depth learning format itself is informative and should continue to be offered in this form.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"179-185"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}