Dermatologie (Heidelberg, Germany)最新文献_第10页

[Drug reaction with eosinophilia and systemic symptoms (DRESS): a hypersensitivity reaction with various symptoms]. [伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）：伴有各种症状的超敏反应]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-05-29 DOI: 10.1007/s00105-024-05364-1

A Hansel, E Oms, M Tronnier

引用次数: 0

[Rare semen allergy]. [罕见的精液过敏］

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-06-07 DOI: 10.1007/s00105-024-05345-4

Valerie Glatzel, Mattis Bertlich, Eva Maria Oppel

引用次数: 0

[Phosphodiesterase 4 inhibitors in dermatology : Role in the treatment of skin diseases]. [皮肤病学中的磷酸二酯酶 4 抑制剂：在治疗皮肤病中的作用]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-08-30 DOI: 10.1007/s00105-024-05407-7

Morna F Schmidt, Nicole Albuscheit, Amir S Yazdi

{"title":"[Phosphodiesterase 4 inhibitors in dermatology : Role in the treatment of skin diseases].","authors":"Morna F Schmidt, Nicole Albuscheit, Amir S Yazdi","doi":"10.1007/s00105-024-05407-7","DOIUrl":"10.1007/s00105-024-05407-7","url":null,"abstract":"Background: Chronic inflammatory skin diseases are of great social and medical importance and require effective drug therapy. Phosphodiesterase 4 (PDE4) inhibitors represent a possible therapeutic option by regulating inflammatory processes. PDEs cause the release of proinflammatory cytokines by interfering with signaling pathways. The PDE4 inhibitors apremilast (treatment of psoriasis and Behçet's disease), roflumilast (treatment of chronic obstructive pulmonary disease), and crisaborole (treatment of atopic dermatitis) are currently approved in Europe.Psoriasis: Apremilast is used for second-line treatment of plaque psoriasis and psoriatic arthritis and has a favorable side effect profile. Topical PDE4 inhibitors are currently being researched and have not yet been approved by the European Medicines Agency (EMA).Atopic dermatitis: The topical PDE4 inhibitor crisaborole was approved by the EMA in 2020 as a topical treatment alternative to glucocorticoids and calcineurin inhibitors. Although the substance has shown good tolerability in studies and also alleviates the accompanying itching, it did not find its way onto the German market. BEHçET'S DISEASE: Apremilast is approved for the treatment of Behçet's disease in adults with refractory, severe oral ulcers.Outlook: Case studies have also demonstrated the efficacy of systemic PDE4 inhibition in other skin diseases (including blistering autoimmune dermatoses, lichen planus, and acantholytic genodermatoses). The substances are also being researched and used to treat extracutaneous inflammatory diseases.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"791-797"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Nail problem]. [指甲问题]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-06-07 DOI: 10.1007/s00105-024-05341-8

Laurie Eicher, Mattis Bertlich, Lars E French, Michael Flaig, Eva Oppel

引用次数: 0

[Variants of biotechnological drugs in dermatology : Status quo and future]. [皮肤病学中的生物技术药物变体：现状与未来]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI: 10.1007/s00105-024-05403-x

Johannes Wohlrab, Adina Eichner

引用次数: 0

[Janus kinase inhibitors for skin disorders]. [治疗皮肤病的 Janus 激酶抑制剂]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-08-30 DOI: 10.1007/s00105-024-05406-8

Farzan Solimani, Kamran Ghoreschi

{"title":"[Janus kinase inhibitors for skin disorders].","authors":"Farzan Solimani, Kamran Ghoreschi","doi":"10.1007/s00105-024-05406-8","DOIUrl":"10.1007/s00105-024-05406-8","url":null,"abstract":"Immune factors such as interferon‑ɣ and interleukin 4 belong to the group of cytokines that are dependent on type I/II receptors for their signal transmission. Upon activation, these receptors transmit their signal to the cell nucleus and, thus, modulate gene transcription via a signaling cascade consisting of Janus kinases (JAK). This family of four kinases (JAK 1, JAK 2, JAK 3, and tyrosine kinase 2 (TYK2)) subsequently activate members of the signal transducer and activator of transcription (STAT). This finding turned the JAK/STAT signaling pathway into a pharmacological target for the treatment of inflammatory diseases in which cytokines using type I/II receptors play a pathogenic role. In 2018, the European Medicines Agency (EMA) approved tofacitinib for the treatment of psoriatic arthritis. This was the first approval of a JAK/STAT pathway inhibitor for patients treated by dermatologists and rheumatologists. Since then, several new JAK inhibitors have been approved for dermatologic diseases such as atopic dermatitis, alopecia areata, vitiligo, and plaque-type psoriasis. In addition, JAK inhibitors are being investigated for the treatment of many other skin diseases. Thus, systemic JAK inhibitors complete the spectrum of immunotherapeutics with a broader immunological approach compared to monoclonal antibodies. The low molecular weight of JAK inhibitors enables the preparation of these drugs for both systemic and topical administration. Their utilization could represent a valuable alternative to topical steroids. The safety profile of JAK inhibitors must be taken into account. Possible long-term effects may become apparent in the next few years. This article describes both approved JAK inhibitors and relevant new JAK inhibitors that are promising candidates for approval as therapeutics in dermatology.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"781-790"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Late-onset hydroa vacciniforme-like lymphoproliferative disorder]. [晚发性水瘤疫苗样淋巴细胞增生症]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-10-01 Epub Date: 2024-06-07 DOI: 10.1007/s00105-024-05362-3

Surina Frey, Anne-Charlotte Kuna, Michael J Flaig, Lars E French

引用次数: 0

[Mental disorders from climate and environmental changes using the example of dermatology]. [以皮肤病学为例，说明气候和环境变化引起的精神障碍]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI: 10.1007/s00105-024-05396-7

Lea Dohm, Susanne Saha, Kristina Fronhoffs, Uwe Gieler

{"title":"[Mental disorders from climate and environmental changes using the example of dermatology].","authors":"Lea Dohm, Susanne Saha, Kristina Fronhoffs, Uwe Gieler","doi":"10.1007/s00105-024-05396-7","DOIUrl":"10.1007/s00105-024-05396-7","url":null,"abstract":"Background: Global climate and environmental changes impose a significant impact on human health by increasing prevalences of chronic and acute skin diseases. Climate-associated environmental changes can also trigger or intensify mental illnesses independently of a skin disease.Aim: Discussion of the effects of the climate and environmental changes on dermatological diseases applying the biopsychosocial model.Materials and methods: A selective literature search in the PubMed database and other sources was conducted.Results: The biopsychosocial model considers complex interactions between biological, psychological, and social factors. In view of the consequences of climate and environmental changes, an extension of the model is proposed for the first time in order to address new challenges. The modified presentation supports the understanding of the dynamics and underscores that in dermatological care not only direct health effects of climate and environmental changes have to be dealt with, but also with an increasing number of mental illnesses, which in turn are to be regarded as direct and indirect health effects.Conclusion: Coping with the predicted increase in the burden of disease and the decline in the available labor force associated with demographic change poses a major challenge. In order to maintain the functionality of the healthcare system, the prompt implementation of resource-efficient, sustainable measures in all areas of society is essential. The integrative consideration of dermatological and psychological complaints in the context of climate and environmental changes requires the adaptation of content for the education, training, and continuing education of specialists.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"704-710"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Patient survey on the use of video consultation in the outpatient treatment of chronic pruritus]. [关于在慢性瘙痒症门诊治疗中使用视频咨询的患者调查]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.1007/s00105-024-05377-w

P Petzinka, S Ständer, C Juhra, C Zeidler

{"title":"[Patient survey on the use of video consultation in the outpatient treatment of chronic pruritus].","authors":"P Petzinka, S Ständer, C Juhra, C Zeidler","doi":"10.1007/s00105-024-05377-w","DOIUrl":"10.1007/s00105-024-05377-w","url":null,"abstract":"Background: Analyses of patient evaluations and barriers to the implementation of teledermatology procedures are still rare. The aim of this study was to determine whether administrative processes have an influence on the patient evaluation of telephone and video consultations.Methods: With the help of a patient survey, assessments of the processes and organisation surrounding the outpatient appointment were asked. These were then compared to the assessment of whether the telephone or video consultation is an alternative to on-site consultation.Results: In all, 1538 patients took part in the survey. Significant correlations were found between the evaluation of the telephone or video consultation and the distance between the place of residence and the outpatient clinic, whether the patient had already been seen several times or for the first time, as well as the evaluation of the waiting time for the appointment, the organisation before the appointment and the waiting time in the outpatient clinic.Conclusions: The study shows that even after the Coronavirus pandemic, telephone and video consultations remain an important tool for patients to contact their physician. However, patients' perceptions of the processes around the outpatient appointment have an influence on their willingness to participate in a digital consultation.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"721-726"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Simultaneous presentation of two skin lesions suspected of being malignant]. [同时出现两种疑似恶性皮肤病变]。

Dermatologie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-06-03 DOI: 10.1007/s00105-024-05365-0

Matthias D Kaufmann, Michael Erdmann, Stefan Schliep, Caroline Voskens, Carola Berking, Jürgen P Bauerschmitz

引用次数: 0