Ana-Lee Gerdes, Julia Hyun, Alexander Kreuter, Jörg Schaller, Uwe Hillen, Alena-Lioba Michalowitz, Valentina Müller
{"title":"[Bullous mycosis fungoides-clinical indicator for an aggressive course of disease].","authors":"Ana-Lee Gerdes, Julia Hyun, Alexander Kreuter, Jörg Schaller, Uwe Hillen, Alena-Lioba Michalowitz, Valentina Müller","doi":"10.1007/s00105-024-05399-4","DOIUrl":"10.1007/s00105-024-05399-4","url":null,"abstract":"<p><p>Mycosis fungoides (MF) is defined as the most common cutaneous T‑cell lymphoma (CTCL). The bullous form is considered one of its numerous variants. Only a few cases of this rare entity have been described. We report the case of a man with an aggressive course of bullous MF, which led to lethal outcome within a few weeks due to a fulminant sepsis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"884-888"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Vorbeck, Kristin Technau-Hafsi, Franziska Schauer
{"title":"[Abscessing swelling of the chin in a young woman].","authors":"Julia Vorbeck, Kristin Technau-Hafsi, Franziska Schauer","doi":"10.1007/s00105-024-05366-z","DOIUrl":"10.1007/s00105-024-05366-z","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"831-833"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Update in the diagnosis and treatment of actinic keratosis].","authors":"Markus V Heppt","doi":"10.1007/s00105-024-05376-x","DOIUrl":"10.1007/s00105-024-05376-x","url":null,"abstract":"<p><p>Actinic keratosis (AK) is among the most common conditions in dermatology in an increasingly aging population. However, the presence of severe field cancerization with large treatment fields showing multiple lesions with distinct features often poses a therapeutic challenge. The most accurate possible characterization of the treatment field, risk assessment concerning the occurrence of cutaneous squamous cell carcinoma, and knowledge of the efficacy and local side effects of the available interventions are of paramount importance for effective management and preventive efforts. This article summarizes current developments in the diagnosis and treatment of AK and discusses their application in everyday clinical practice. In particular, the focus is on the increasing value of non-invasive diagnostic techniques like \"line-field\" confocal optical coherence tomography, and the recently approved topical agents tirbanibulin 1% ointment and 5‑fluorouracil 4% cream, as well as current developments of photodynamic therapy and prevention.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"815-822"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Holtorf, Miriam Mengoni, Thomas Tüting, Andreas Wienke, Jan Borggrefe, Alexey Surov, Mareike Alter
{"title":"[Sarcopenia and immune-related toxicity in patients with malignant melanoma undergoing immune checkpoint inhibition].","authors":"Christian Holtorf, Miriam Mengoni, Thomas Tüting, Andreas Wienke, Jan Borggrefe, Alexey Surov, Mareike Alter","doi":"10.1007/s00105-024-05405-9","DOIUrl":"10.1007/s00105-024-05405-9","url":null,"abstract":"<p><strong>Background and objectives: </strong>Sarcopenia is the generalized loss of muscle strength, mass, and function. The aim was to investigate whether pretherapeutic sarcopenia, as determined by the psoas muscles, affects therapy-mediated toxicity in patients with malignant melanoma undergoing immunotherapy.</p><p><strong>Patients and methods: </strong>Measurement of psoas musculature was performed pretherapeutically using computed tomography at the level of the third lumbar vertebra in the axial plane in 75 patients between January 2011 and December 2020. Sarcopenia was defined using the psoas muscle index (PMI). Immune-related toxicity was retrospectively assessed.</p><p><strong>Results: </strong>Treatment-related toxicity was recorded in 33 of the 75 patients (44%). Of these, 16 patients (36.2%) experienced dose-limiting severe events (DLT). Pretherapeutic sarcopenia was identified in 25 patients (33.3%). Comparative analysis showed that the patients with a DLT had lower PMI values compared with the patient group without a DLT (4.65 ± 1.33 vs. 5.79 ± 1.67 cm<sup>2</sup>m<sup>-2</sup>, p = 0.015) (odds ratio = 0.60, 95% confidence interval 0.40-0.92, p = 0.02).</p><p><strong>Conclusions: </strong>Pretherapeutic sarcopenia measured based on the psoas muscle is not a significant predictor of immune-mediated toxicity in patients with malignant melanoma treated with immune checkpoint inhibitors. Patients with DLT have lower values for the psoas muscle parameters PMI compared to the group of patients without DLT.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"798-803"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Bullet ant-more than just a painful sting].","authors":"Sarah Zierold, Mattis Bertlich, Eva Maria Oppel","doi":"10.1007/s00105-024-05343-6","DOIUrl":"https://doi.org/10.1007/s00105-024-05343-6","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":"75 Suppl 1","pages":"15-16"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Recommendations for the management of oral candidiasis during treatment with biologicals-results from an expert meeting of dermatologists].","authors":"Katharina Meier, Stefan Beissert, Kamran Ghoreschi, Sandra Philipp, Beate Schwarz, Hans-Jürgen Tietz, Khusru Asadullah","doi":"10.1007/s00105-024-05410-y","DOIUrl":"10.1007/s00105-024-05410-y","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"823-826"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}