Christian Möllenhoff, Max Quoss, Eva Salzmann, Marie-Luise Schiffmann, Seila Steger, Stefanie Hübner
{"title":"[DGDC (German Society for Dermatologic Surgery) observation day with live nail surgery by Dr. Christoph Löser at the Ludwigshafen Dermatology Clinic : Insights and inspiration].","authors":"Christian Möllenhoff, Max Quoss, Eva Salzmann, Marie-Luise Schiffmann, Seila Steger, Stefanie Hübner","doi":"10.1007/s00105-025-05475-3","DOIUrl":"https://doi.org/10.1007/s00105-025-05475-3","url":null,"abstract":"<p><p>Comprehensive training in nail surgery is usually difficult to provide as part of clinical training and continuing education due to a lack of sufficient case numbers. The Dermatology Clinic and Skin Tumor Center at Ludwigshafen Hospital has been a surgical observation and training center of the German Society for Dermatologic surgery (DGDC) since 2014 and, under the direction of Dr. Christoph Löser, is counteracting this deficiency with observation seminars, including the topic of nail surgery. As part of this one-day work shadowing program, six participants from German-speaking countries were given the opportunity to develop theoretical principles and practical skills of nail surgery in a structured manner. A total of 8 patients with various nail pathologies were treated, providing a representative cross-section of nail diseases. Immediately after each surgery, the individual surgical steps were discussed in detail and, where appropriate, analyzed using photo documentation. Key information covered in the seminar included techniques of systematic nail surgery, which can be implemented in the participants' home clinics and practices in the sense of maximizing their impact. In addition, the participants learned which previously common surgical procedures on the nail unit are now obsolete. The in-depth learning format itself is informative and should continue to be offered in this form.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana-Lee Gerdes, Alexander Kreuter, Uwe Hillen, Jörg Schaller, Frank Oellig, Julia Hyun, Valentina Laura Müller
{"title":"[Cutaneous leishmaniasis misdiagnosed as epithelial skin cancer].","authors":"Ana-Lee Gerdes, Alexander Kreuter, Uwe Hillen, Jörg Schaller, Frank Oellig, Julia Hyun, Valentina Laura Müller","doi":"10.1007/s00105-025-05473-5","DOIUrl":"https://doi.org/10.1007/s00105-025-05473-5","url":null,"abstract":"<p><p>Cutaneous leishmaniasis, transmitted by sand flies of the genus Phlebotomus, is one of the most important traveler's dermatoses in Germany. In recent years, an increased incidence of the disease has been observed in travelers returning from endemic areas, including the Mediterranean region of Spain and Italy. In these regions, Leishmania infantum belonging to the Leishmania donovani complex is characteristically the most frequently detected pathogen. We herein report two cases of cutaneous leishmaniasis caused by Leishmania infantum with solitary or multilocular lesions, initially misdiagnosed as actinic keratosis and cutaneous squamous cell carcinoma.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Vitiligo-update on pathogenesis, diagnostics and therapy].","authors":"Paloma Seidel, Markus Böhm","doi":"10.1007/s00105-024-05467-9","DOIUrl":"https://doi.org/10.1007/s00105-024-05467-9","url":null,"abstract":"<p><p>Vitiligo is a common skin disease leading to depigmentation that is associated with progressive destruction of melanocytes. The main subtype, nonsegmental vitiligo (NSV), is considered a chronic autoimmune disease leading to activation of melanocyte-specific CD8+ lymphocytes and development of a cutaneous immune memory. Vitiligo can result in significant impairment of quality of life and is associated with a number of comorbidities. Despite the existence of national guidelines and international treatment recommendations, there is a strong need for improved health care for patients with vitiligo. The options in the treatment algorithm for vitiligo are similar and consisted until recently of only topical and systemic corticosteroids, topical calcineurin inhibitors, phototherapy, and surgical interventions. New insights into the pathobiological role of the interferon signature in vitiligo have most recently contributed to the approval of the first vitiligo-specific therapy with the topical Janus kinase 1/2 inhibitor ruxolitinib for patients with NSV.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lea Braun, Christoph Löser, Mindaugas Andrulis, Matthias Uhl, Manfred Wolter, Edgar Dippel
{"title":"[Intralesional rituximab for refractory granuloma faciale].","authors":"Lea Braun, Christoph Löser, Mindaugas Andrulis, Matthias Uhl, Manfred Wolter, Edgar Dippel","doi":"10.1007/s00105-025-05476-2","DOIUrl":"https://doi.org/10.1007/s00105-025-05476-2","url":null,"abstract":"<p><p>A 60-year-old man presented with refractory granuloma faciale. After unsuccessful treatment with dapsone, hydroxychloroquine, and radiotherapy, treatment with intralesional rituximab was initiated. This led to a steady improvement in the lesions without serious side effects. The case shows that rituximab can be a treatment option for refractory cases of granuloma faciale, especially in the context of IgG 4-related autoimmune disease.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A case of atopic dermatitis-the biopsychosocial view].","authors":"Eva Milena Johanne Peters","doi":"10.1007/s00105-024-05465-x","DOIUrl":"10.1007/s00105-024-05465-x","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis is perhaps the most comprehensively studied skin disease in psychosomatic medicine and psychoneuroimmunology. Its biopsychosocial conceptualization incorporates psychodynamic as well as behavioral and systemic considerations. At the same time, there is also extensive biological knowledge of the neuroendocrine-immune control of barrier and immune function, characterized through animal experiments and translational clinical studies. Integrating this knowledge into clinical routine, however, represents a challenge.</p><p><strong>Objectives: </strong>The biopsychosocial implications of atopic dermatitis are discussed using a concrete case as an example.</p><p><strong>Materials and methods: </strong>Case presentation and narrative review of relevant psychopathogenetic models and psychoneuroimmunological pathomechanisms.</p><p><strong>Results and conclusion: </strong>Using a case of stress-exacerbated atopic dermatitis, the contribution of acute and chronic stressors to the development and worsening of skin inflammation is discussed. Particular attention is paid to the role of the pituitary hypothalamic adrenal axis and neurogenic inflammation as central drivers of barrier disruption and immune imbalance in atopic dermatitis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"76-80"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Selection of the biopsy procedure-critical for dermatopathological diagnostics].","authors":"Almut Böer-Auer, Christian Rose","doi":"10.1007/s00105-024-05461-1","DOIUrl":"10.1007/s00105-024-05461-1","url":null,"abstract":"<p><p>Skin biopsy is one of the most frequently performed diagnostic measures in dermatological practice. Depending on the diagnostic question, the selection of the type of biopsy procedure and the biopsy location can have a considerable influence on histological assessment. Depending on the disease, different aspects must be taken into account for a precise diagnosis. This article summarizes these for exanthema, erythematosquamous dermatoses, blistering diseases, subcutaneous inflammatory processes, and alopecia with examples. Advantages and disadvantages of different biopsy types are also addressed for neoplastic diseases. The aim is to draw attention to difficulties in histopathologic differential diagnosis caused by the biopsy procedure and, thus, to improve the quality of biopsy and diagnosis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"102-114"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Comprehensive training in psychodermatology: the diploma course of the European Society for Dermatology and Psychiatry].","authors":"Sandra Hanneken, Francoise Poot","doi":"10.1007/s00105-024-05452-2","DOIUrl":"10.1007/s00105-024-05452-2","url":null,"abstract":"<p><strong>Background: </strong>Psychodermatological conditions play an important role in dermatological practice. The biopsychosocial disease model is of central significance.</p><p><strong>Objective: </strong>Psychodermatological knowledge is underrepresented in specialist training and medical care. There is a need for continuing education offers for primary psychodermatological disorders as well as for skin diseases related to psychological stress.</p><p><strong>Materials and methods: </strong>The work comprises a description of the structure, organization, and content of the diploma course offered by the European Society for Dermatology and Psychiatry (ESDaP), along with a personal conclusion after completing the course.</p><p><strong>Results: </strong>Continuing education in the diagnosis and treatment of psychodermatological disorders should be an integral part of dermatology training. The ESDaP diploma course conveys knowledge regarding psychosomatic dermatology and dermatopsychiatry. The target audience includes dermatologists, psychologists, psychiatrists, and psychotherapists in training and practice. The two-level course offers foundational knowledge for those working with psychodermatological patients in level 1, while level 2 allows for advanced specialization. Additional requirements for obtaining the diploma include case presentations, lectures, and multiple-choice examinations.</p><p><strong>Conclusion: </strong>Psychological factors are common in dermatological patients and require effective and holistic management. The ESDaP diploma course provides in-depth knowledge and fosters skills in patient care and physician-patient communication.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Trefzer, Katrin Kerl-French, Andreas Benedikt Weins, Christina Schnopp
{"title":"[Retrospective analysis in children with vaccination granuloma].","authors":"Laura Trefzer, Katrin Kerl-French, Andreas Benedikt Weins, Christina Schnopp","doi":"10.1007/s00105-024-05457-x","DOIUrl":"10.1007/s00105-024-05457-x","url":null,"abstract":"<p><strong>Background: </strong>Vaccine granulomas are a common (0.3-1%) adverse event (AE) of (accidentally) subcutaneously administered vaccines and specific immunotherapies containing aluminum conjugates. The clinical symptoms with persistent itching subcutaneous nodules, predominantly affect infants and young children on the lateral thigh.</p><p><strong>Aim: </strong>To sensitize dermatologists to recognize this common and harmless vaccination AE, in order to prevent invasive diagnostics and confusion among parents and physicians.</p><p><strong>Materials and methods: </strong>Retrospective analysis of 13 children consulting pediatric dermatology between 2019 and 2023. Identification of diagnostic criteria and guidelines for action, based on the literature.</p><p><strong>Results and conclusion: </strong>In all, 13 children (9 boys, 4 girls) with subcutaneous indolent but itching nodules at the vaccination sites (11 on the thighs, 2 on the upper arms) with a latency of weeks to months were retrospectively evaluated. The children were vaccinated according to German STIKO (\"Ständige Impfkommission\") recommendations. Only inactivated vaccines contain aluminum. The documented occurrence of the first vaccination granulomas was between the 12th and 36th month of life. Regarding the STIKO vaccination calendar, the third immunization with the hexavalent inactivated vaccine coincides with the first administration of the live measles, mumps and rubella (MMR) vaccine (varicella (V)). This may incorrectly lead to the assumption that the live vaccine was the cause of granuloma development. Aluminum conjugation appears to be a central trigger of the granulomas; further susceptibility factors are largely unknown. Diagnosis of sensitization to aluminum through epicutaneous testing has no practical impact and is, therefore, not routinely recommended. After weeks to years, granulomas spontaneously regress.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}