Dermatologie (Heidelberg, Germany)最新文献

OMW: Strukturierte Antimikrobial- Stewardship(AMS)-Visiten. “结构化抗菌素管理（AMS）访问”。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-15 DOI: 10.1007/s00105-025-05541-w

Jannik Sonnenberg, Julia Fischer

引用次数: 0

[Chronic actinic dermatitis in a patient with darker skin]. [深色皮肤患者的慢性光化性皮炎]。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-15 DOI: 10.1007/s00105-025-05549-2

Lisa Gabriele Zieringer, Stefan Schliep, Markus V Heppt

引用次数: 0

[Treatment of oral lichen planus-a review]. 口腔扁平苔藓的治疗综述

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-15 DOI: 10.1007/s00105-025-05540-x

Khava Abdusalamova, Farzan Solimani, Margitta Worm

{"title":"[Treatment of oral lichen planus-a review].","authors":"Khava Abdusalamova, Farzan Solimani, Margitta Worm","doi":"10.1007/s00105-025-05540-x","DOIUrl":"https://doi.org/10.1007/s00105-025-05540-x","url":null,"abstract":"Mucosal lichen planus (MLP) is a chronic, recurrent, inflammatory T‑cell disorder that can affect mucous membranes and, together with cutaneous lichen planus (CLP) and lichen planopilaris (LPP), belongs to the variants of lichen planus (LP) diseases. MLP can affect both the oral mucosa (oral lichen planus, OLP) and the genital mucosa. Patients with OLP can have varying degrees of severity. In particular, patients affected by an erosive/ulcerative form usually pose a therapeutic challenge because 1) there are currently no US Food and Drug Administration(FDA)/European Medicines Agency (EMA)-approved drugs and 2) the disease is often treatment resistant. Recently published studies on immunopathogenesis describe a predominant role of interferon-γ-induced inflammation, but many aspects of the disease are still unknown. Accordingly, primarily symptomatic therapies are currently available. In addition to topical glucocorticoids, retinoids in topical and systemic form and systemic glucocorticoids are established first-line therapies. A wide range of second- and third-line therapies show that no standard treatment that there is still o standard treatment. Among the new therapies, Janus kinase inhibitors and monoclonal antibodies should be emphasized, as they could expand the therapeutic spectrum for OLP in the future. However, prospective, placebo-controlled studies are needed for this in the future. Alternative and complementary treatments such as herbal therapies, phototherapy, platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) are also described in the literature. In this article, we discuss the current therapeutic options for this difficult-to-treat disease.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Histological and clinical overlap of hidradenitis suppurativa and Crohn disease under IL-17 inhibition]. [IL-17抑制下化脓性汗腺炎和克罗恩病的组织学和临床重叠]。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-14 DOI: 10.1007/s00105-025-05545-6

Lennart Ocker, Christina Scheel, Nessr Abu Rached, Martin Dörler, Markus Stücker, Falk Bechara

引用次数: 0

[Bowenoid actinic keratosis presenting as unilateral chronic eczema of the eyelid]. [鲍温样光化性角化病表现为单侧眼睑慢性湿疹]。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-11 DOI: 10.1007/s00105-025-05539-4

Lisa Gabriele Zieringer, Michael Erdmann

引用次数: 0

[Nevus-associated melanoma or nevus on nevus?] 痣相关黑色素瘤还是痣上痣？］

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-10 DOI: 10.1007/s00105-025-05534-9

Julia Resch, Isabella Fried, Rainer Hofmann-Wellenhof

引用次数: 0

[Principles of antimicrobial stewardship]. [抗菌药物管理原则]。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-09 DOI: 10.1007/s00105-025-05530-z

Jannik Sonnenberg, Anna Simone Keimburg, Frederike Krus, Philipp Wöhler, Richard Vollenberg, Jonel Trebicka, Phil-Robin Tepasse, Julia Fischer

{"title":"[Principles of antimicrobial stewardship].","authors":"Jannik Sonnenberg, Anna Simone Keimburg, Frederike Krus, Philipp Wöhler, Richard Vollenberg, Jonel Trebicka, Phil-Robin Tepasse, Julia Fischer","doi":"10.1007/s00105-025-05530-z","DOIUrl":"https://doi.org/10.1007/s00105-025-05530-z","url":null,"abstract":"The global emergence of multiresistant pathogens threatens the effectiveness of antimicrobial therapies and calls for a rational use of antibiotics, antivirals, and antifungals. The main reason for the development of resistance is the inappropriate use of these substances in human and veterinary medicine and agriculture. Antimicrobial stewardship (AMS) combines strategies for optimizing prescribing practices in order to prevent the development of resistance, ensure successful treatment, and minimize side effects. Central elements are evidence-based guidelines, interdisciplinary visits, infectious disease consults, targeted training, feedback systems, and digital support. AMS is becoming increasingly established in Germany, but many antibiotics are still not prescribed in line with guidelines. Correct diagnosis, guideline-based empirical therapy, regular re-evaluation, dose adjustment, early oral administration, and outpatient parenteral anti-infective therapy (OPAT) are essential. Short, individually adapted treatment durations improve tolerability and reduce resistance pressure. AMS links epidemiological data with patient-specific factors and is key in personalized infection medicine. Only the consistent integration of AMS measures into everyday clinical practice can ensure the sustained efficacy of antimicrobial substances and improve the quality of patient care in the long term.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Spectrum of zoophilic dermatophytes]. [嗜兽性皮肤真菌的光谱]。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-09 DOI: 10.1007/s00105-025-05524-x

Katharina Antonia Langen, Jochen Brasch

引用次数: 0

[Relevant aspects of Candida species in dermatology : An overview]. 【念珠菌在皮肤病学中的相关方面：综述】。

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-09 DOI: 10.1007/s00105-025-05538-5

Valentina Laura Müller, Alexander Kreuter, Silke Uhrlaß, Pietro Nenoff

{"title":"[Relevant aspects of Candida species in dermatology : An overview].","authors":"Valentina Laura Müller, Alexander Kreuter, Silke Uhrlaß, Pietro Nenoff","doi":"10.1007/s00105-025-05538-5","DOIUrl":"https://doi.org/10.1007/s00105-025-05538-5","url":null,"abstract":"Candida species are opportunistic yeasts that form part of the normal human microbiota. Under certain conditions, such as immunosuppression, alterations in the microbiota, or disruption of the skin barrier, these commensals may become pathogenic and lead to clinically relevant infection. Candida (C.) albicans plays a central role in skin and mucosal infections, while other species, such as Nakaseomyces (N.) glabratus (formerly known as Candida glabratus) and C. auris, are increasingly gaining clinical significance. The most common Candida infections affect the skin and mucosal membranes; however, under predisposing factors, the pathogen can enter the bloodstream, leading to septicemia with organ involvement. In this context, multidrug-resistant pathogens, particularly C. auris, pose an escalating threat to public health. Diagnosis of Candida species is generally performed using conventional microbiological techniques, including cultures and microscopy, as well as advanced molecular methods such as polymerase chain reaction (PCR) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Given the rising rates of resistance and the associated therapeutic challenges, accurate species identification and resistance profiling prior to antifungal treatment are critical. Preventive measures, especially for high-risk populations, are crucial to reduce the incidence of Candida infections. While many superficial Candida infections can be managed with hygiene practices and topical antifungal treatments, invasive candidiasis necessitates close collaboration between microbiology, pharmacology, and infectious disease specialists to ensure optimal patient care.","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Suspected histamine intolerance-how to proceed?] 疑似组胺不耐受-如何处理？］

Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-03-10 DOI: 10.1007/s00105-025-05482-4

Imke Reese

引用次数: 0