{"title":"[New diagnostic possibilities in hand eczema].","authors":"Philipp Bentz, Kilian Eyerich","doi":"10.1007/s00105-026-05689-z","DOIUrl":"https://doi.org/10.1007/s00105-026-05689-z","url":null,"abstract":"<p><strong>Background: </strong>Hand eczema is one of the most common inflammatory skin conditions and is of great significance both clinically and in terms of health economics. With a lifetime prevalence of up to 15%, it affects a significant portion of the population, particularly in occupational settings, where it is the most common work-related skin condition. The condition leads to a significant reduction in quality of life as well as considerable economic burdens. Diagnosis is complex due to its multifactorial etiology and variable clinical presentation.</p><p><strong>Methods: </strong>A structured literature search was conducted for publications on the diagnosis of hand eczema within the last 5 years.</p><p><strong>Results: </strong>A total of 32 publications were classified as relevant in terms of content: 7 guidelines or expert recommendations, 13 on biomarkers, 6 publications on dermoscopy and histological analyses, and 7 general descriptions of the current state of knowledge.</p><p><strong>Conclusion: </strong>Current research shows significant progress: Molecular and immunological analyses enable more precise differentiation between subtypes and differential diagnoses such as psoriasis. Biomarkers, transcriptome analyses, and noninvasive methods such as tape stripping open up new diagnostic possibilities. Additionally, data-based approaches show potential for improved histological classification. Overall, there is a growing trend toward precision medicine diagnostics that go beyond purely clinical and morphological approaches. In the long term, these developments could enable more personalized treatment and better disease management.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karoline Lukaschek, Maurice Waitek, Elke Weisshaar
{"title":"[Mental health in occupational dermatology].","authors":"Karoline Lukaschek, Maurice Waitek, Elke Weisshaar","doi":"10.1007/s00105-026-05688-0","DOIUrl":"https://doi.org/10.1007/s00105-026-05688-0","url":null,"abstract":"<p><strong>Background: </strong>Occupational skin diseases, particularly hand eczema and contact dermatitis (of the hands), are among the most common occupational diseases and can be associated with substantial psychosocial burden. They can impair quality of life, work ability, and mental health.</p><p><strong>Objective: </strong>To present the current state of knowledge on mental health in patients with occupational dermatoses, including relevant psychosocial stressors, comorbidities, and perspectives for care.</p><p><strong>Materials and methods: </strong>Review of the literature on psychological comorbidities, quality of life, stress, and interventions in occupational skin diseases, as well as rehabilitation programs such as tertiary individual prevention (TIP).</p><p><strong>Results: </strong>Symptoms of anxiety and depression are common in patients with occupational skin diseases. In one study of occupational hand eczema, 20% of patients reported anxiety symptoms and 14% depressive symptoms. Overall, approximately 7.5-24% of dermatoses are associated with obsessive-compulsive symptoms. Psychological comorbidities are linked to reduced quality of life, poorer disease outcomes, and impaired work ability. Stress acts both as a risk factor and a consequence of the disease and is associated with delayed healing and reduced work performance.</p><p><strong>Conclusion: </strong>Psychological factors play an important role in occupational skin diseases and should be considered in diagnosis and treatment. Interdisciplinary and psychoeducational interventions may improve mental health, disease coping, and occupational participation.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Damian Kostner, Caroline Possanner, Johanna Strobl
{"title":"Erratum zu: Genitale Dermatosen im Fokus: Nicht jede Hautveränderung ist eine Geschlechtskrankheit.","authors":"Damian Kostner, Caroline Possanner, Johanna Strobl","doi":"10.1007/s00105-026-05698-y","DOIUrl":"https://doi.org/10.1007/s00105-026-05698-y","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nawa Arif, Annika Vogt, Kamran Ghoreschi, Alexander Nast
{"title":"[Lichen nitidus in a young man on antiepileptic therapy].","authors":"Nawa Arif, Annika Vogt, Kamran Ghoreschi, Alexander Nast","doi":"10.1007/s00105-025-05612-y","DOIUrl":"10.1007/s00105-025-05612-y","url":null,"abstract":"<p><p>We report the case of a 22-year-old man who developed multiple flesh-colored papules during antiepileptic treatment with lamotrigine. Histopathological examination confirmed the diagnosis of lichen nitidus, showing a sharply demarcated lymphohistiocytic infiltrate in a typical \"ball-and-claw\" configuration. Despite discontinuation of lamotrigine, the lesions persisted, while topical corticosteroid therapy resulted in moderate improvement. This case highlights a rare possible association between lamotrigine and lichen nitidus and contributes to the discussion of drug-induced lichenoid dermatoses.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"328-330"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathalie-Christin Kaul, Ines Bertlich, Ferdinand Toberer
{"title":"[Treatment-refractory ulcer of the right lower leg].","authors":"Nathalie-Christin Kaul, Ines Bertlich, Ferdinand Toberer","doi":"10.1007/s00105-026-05663-9","DOIUrl":"10.1007/s00105-026-05663-9","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"352-355"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Postthrombotic syndrome: an update].","authors":"Stefanie Reich-Schupke","doi":"10.1007/s00105-026-05662-w","DOIUrl":"10.1007/s00105-026-05662-w","url":null,"abstract":"<p><p>Postthrombotic syndrome (PTS) is the most common chronic late complication after deep vein thrombosis (DVT): approximately 20-50% develop symptoms and a severe disease course with venous ulceration occurs in roughly 5-10%. The trigger is persistent venous hypertension caused by residual obstruction from incomplete recanalization and/or valve destruction leading to reflux; inflammatory processes further damage the vein wall and valves. Clinically, patients report heaviness, pain, tightness, edema, cramps and skin changes (hyperpigmentation, eczema, lipodermatosclerosis), potentially progressing to venous ulcers. The diagnosis is primarily clinical (typically within 18-24 months after DVT) and should be assessed with the Villalta score; duplex ultrasound is the standard imaging method to evaluate obstruction and reflux, although ultrasound findings do not always correlate with symptom severity. Major risk factors include proximal/iliofemoral DVT, recurrent thrombosis, obesity and delayed or inadequate initial treatment. Prevention and first-line management focus on early and adequate anticoagulation, mobilization and consistent compression therapy (often compression classes II-III) combined with regular exercise or training; for persistent edema, adjustable compression devices or intermittent pneumatic compression can be used. In severe, refractory PTS with pelvic vein obstruction, recanalization and stenting can be considered; venous ulcers require structured wound treatment.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"315-319"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Infantile hemangiomas: diagnosis and modern therapeutic approaches].","authors":"Friedrich G Kapp, Hagen Ott","doi":"10.1007/s00105-026-05679-1","DOIUrl":"10.1007/s00105-026-05679-1","url":null,"abstract":"<p><p>Infantile hemangiomas are benign vascular tumors that occur exclusively in infants and display a characteristic growth pattern. They usually become noticeable shortly after birth, proliferate over a period of 4-6 months, remain stable in size for a variable duration, and then gradually involute, although residual changes may persist. Diagnosis is typically made clinically, with careful attention to potential complications, functional impairments, and rare associated malformations such as those seen in PHACES and LUMBAR syndromes. A thorough understanding of the different types of hemangiomas, their clinical presentations, and the indications for further diagnostic evaluation is essential for optimal patient care. Therapeutically, propranolol has become established as an effective and safe first-line treatment for complicated infantile hemangiomas.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"335-345"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Skin alterations and tissue reactions in lymphedema].","authors":"Anya Miller","doi":"10.1007/s00105-026-05661-x","DOIUrl":"10.1007/s00105-026-05661-x","url":null,"abstract":"<p><p>Chronic lymphedema is an inflammatory disease that in addition to a typical volume increase, also leads to changes in the skin and tissues. Cysts and fistulas are a direct consequence of the increased pressure in the lymphatic vessels, while pachydermia and papillomatosis are signs of the inflammatory process in the tissues. This inflammation causes, among other things, the release of various interleukins through the activation of hypoxia-inducible factor (HIF) from lymph endothelial cells, macrophages, Th1, Th2 and Th17 cells, leading to fibroadipose tissue transformation and a resulting reduction in immune function. To avoid these consequences, treatment of the inflammatory response should be considered in addition to complex decongestive therapy (CDT), as is the case with other fibrosing skin diseases.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"320-324"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}