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[In vivo reflectance confocal microscopy and keratinocyte skin cancer : Reflectance confocal microscopy and artificial intelligence]. [体内反射共聚焦显微镜和角质细胞皮肤癌：反射共聚焦显微镜和人工智能]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-16 DOI: 10.1007/s00105-025-05586-x
Cristel Ruini
{"title":"[In vivo reflectance confocal microscopy and keratinocyte skin cancer : Reflectance confocal microscopy and artificial intelligence].","authors":"Cristel Ruini","doi":"10.1007/s00105-025-05586-x","DOIUrl":"https://doi.org/10.1007/s00105-025-05586-x","url":null,"abstract":"<p><strong>Background: </strong>Keratinocyte skin cancers (KC), including basal cell carcinoma (BCC) and the spectrum of squamous cell carcinoma (SCC), represent the most common malignancies worldwide. Accurate diagnosis and margin assessment are critical for optimal treatment but remain challenging when relying solely on clinical and dermoscopic evaluation. Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive imaging of skin architecture at near-histological levels, potentially improving diagnostic precision and reducing the need for (re)biopsies.</p><p><strong>Objective: </strong>To evaluate the current diagnostic criteria, diagnostic utility, advantages, and limitations of confocal microscopy in the assessment of nonmelanoma skin cancer (NMSC).</p><p><strong>Methods: </strong>A narrative review of recent literature and current guidelines was conducted, focusing on RCM for the detection, characterization, and monitoring of BCC and KC. Key diagnostic criteria, imaging protocols, and clinical applications were analyzed, including preoperative mapping, differentiation from benign lesions, and follow-up after treatment.</p><p><strong>Results: </strong>RCM provides real-time visualization of tumor architecture, cellular morphology, and vascular patterns, facilitating the identification of hallmark features such as basaloid tumor islands in BCC and keratinocyte atypia in SCC. Studies report improved diagnostic accuracy and reduced rates of unnecessary excisions. Limitations include restricted imaging depth and the requirement for operator expertise.</p><p><strong>Conclusion: </strong>RCM represents a powerful adjunct to conventional diagnostic methods for NMSC. Its ability to deliver high-resolution, noninvasive imaging enhances diagnostic confidence, supports surgical planning, and aids in treatment monitoring, ultimately improving patient care. Combining multiple noninvasive techniques with proper training is key to enhancing this approach and promoting its routine clinical use.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Brooke-Spiegler syndrome: dermatosurgical management of extensive tumors on the external auditory canal]. [brook - spiegler综合征：外耳道广泛肿瘤的皮肤外科治疗]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-16 DOI: 10.1007/s00105-025-05589-8
Lea Braun, Edgar Dippel, Christoph Löser
{"title":"[Brooke-Spiegler syndrome: dermatosurgical management of extensive tumors on the external auditory canal].","authors":"Lea Braun, Edgar Dippel, Christoph Löser","doi":"10.1007/s00105-025-05589-8","DOIUrl":"https://doi.org/10.1007/s00105-025-05589-8","url":null,"abstract":"<p><p>Brooke-Spiegler syndrome is a rare autosomal dominant disorder leading to the development of multiple benign adnexal tumors. A 65-year-old patient with a positive family history and multiple trichoepitheliomas and cylindromas has been receiving intermittent dermatological care at our department. In February 2025, tumors on the right ear were excised due to near-complete occlusion of the external auditory canal. This case highlights the importance of individualized dermatosurgical management in Brooke-Spiegler syndrome to achieve functional restoration and esthetic improvement.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Painful, cicatricial inflammation of the penile shaft-paraffinoma]. [疼痛，阴茎轴的瘢痕性炎症-石蜡瘤]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-15 DOI: 10.1007/s00105-025-05600-2
Diana Kohn, Udo Bilkenroth, Juliane Reinsch, Andre Schumann, Tino Wetzig
{"title":"[Painful, cicatricial inflammation of the penile shaft-paraffinoma].","authors":"Diana Kohn, Udo Bilkenroth, Juliane Reinsch, Andre Schumann, Tino Wetzig","doi":"10.1007/s00105-025-05600-2","DOIUrl":"https://doi.org/10.1007/s00105-025-05600-2","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Physical tests in urticaria]. [荨麻疹的体格检查]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-10 DOI: 10.1007/s00105-025-05591-0
Carolin Constanze Albers, Mathias Sulk
{"title":"[Physical tests in urticaria].","authors":"Carolin Constanze Albers, Mathias Sulk","doi":"10.1007/s00105-025-05591-0","DOIUrl":"https://doi.org/10.1007/s00105-025-05591-0","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Porokeratosis ptychotropica with mycotic superinfection in a 68-year-old man]. [68岁男性恙螨性角化症伴真菌性重复感染]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-10 DOI: 10.1007/s00105-025-05594-x
Jana Roßner, Alexander Enk, Ferdinand Toberer
{"title":"[Porokeratosis ptychotropica with mycotic superinfection in a 68-year-old man].","authors":"Jana Roßner, Alexander Enk, Ferdinand Toberer","doi":"10.1007/s00105-025-05594-x","DOIUrl":"https://doi.org/10.1007/s00105-025-05594-x","url":null,"abstract":"<p><p>Porokeratosis ptychotropica is a very rare subtype of porokeratosis, which is a heterogeneous group of inherited keratinization disorders. It is associated with verrucous, extensive hyperkeratotic plaques in the perigenital, gluteal, and inguinal regions. Histologically, porokeratosis exhibits the pathognomonic hallmark known as cornoid lamellae. Treatment results are generally disappointing and recurrence rates are high.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cutaneous metastasis of pleural mesothelioma]. [胸膜间皮瘤的皮肤转移]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-08 DOI: 10.1007/s00105-025-05575-0
Antigona Aliu, Katja Hohaus, Ulrich Peter Wehry, Zain Deeb, Frank Oellig, Thilo Gambichler, Sven-Niklas Burmann, Alexander Kreuter
{"title":"[Cutaneous metastasis of pleural mesothelioma].","authors":"Antigona Aliu, Katja Hohaus, Ulrich Peter Wehry, Zain Deeb, Frank Oellig, Thilo Gambichler, Sven-Niklas Burmann, Alexander Kreuter","doi":"10.1007/s00105-025-05575-0","DOIUrl":"https://doi.org/10.1007/s00105-025-05575-0","url":null,"abstract":"<p><p>Cutaneous metastasis of pleural mesothelioma is a rare manifestation and poses a diagnostic challenge due to its histopathological heterogeneity. We present a clinical case in which cutaneous metastasis of a known pleural mesothelioma was initially misdiagnosed. The correct diagnosis of cutaneous metastasis of a pleural mesothelioma was only confirmed through detailed immunohistochemical analysis. Precise histological classification is of high clinical relevance, as the therapeutic approach particularly depends on the histological subtype and the patient's Eastern Cooperative Oncology Group (ECOG) performance status. Early and accurate diagnosis, as well as timely initiation of appropriate therapy, are prognostically important.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Combined flaps for defect reconstruction in the nasal region]. [联合皮瓣修复鼻区缺损]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-07 DOI: 10.1007/s00105-025-05595-w
Anna Duswald, Thomas Volz
{"title":"[Combined flaps for defect reconstruction in the nasal region].","authors":"Anna Duswald, Thomas Volz","doi":"10.1007/s00105-025-05595-w","DOIUrl":"https://doi.org/10.1007/s00105-025-05595-w","url":null,"abstract":"<p><p>The steady increase in UV-related nonmelanocytic skin cancer is leading to a rising number of patients requiring surgery for multiple and/or extensive tumours. Reconstructions in the nasal area pose particular challenges due to the complex anatomy and functional constraints of the nose. The use of combined local flaps makes it possible to cover even multiple or large defects in an aesthetically optimal manner. Several approaches to this are presented in this review.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Targetoid maculae with vesicle formation and erosions]. 靶样斑疹伴囊泡形成和侵蚀。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-06 DOI: 10.1007/s00105-025-05593-y
Valentina Bieneck, Kristin Technau-Hafsi, Maja Mockenhaupt, Kilian Eyerich, Christoph Mathis Schempp
{"title":"[Targetoid maculae with vesicle formation and erosions].","authors":"Valentina Bieneck, Kristin Technau-Hafsi, Maja Mockenhaupt, Kilian Eyerich, Christoph Mathis Schempp","doi":"10.1007/s00105-025-05593-y","DOIUrl":"https://doi.org/10.1007/s00105-025-05593-y","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Use of modern imaging in dermatosurgery]. 现代影像学在皮肤外科中的应用。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-06 DOI: 10.1007/s00105-025-05596-9
Lukas Kofler, Katrin Kofler, Maximilian Deußing
{"title":"[Use of modern imaging in dermatosurgery].","authors":"Lukas Kofler, Katrin Kofler, Maximilian Deußing","doi":"10.1007/s00105-025-05596-9","DOIUrl":"https://doi.org/10.1007/s00105-025-05596-9","url":null,"abstract":"<p><p>Dermatosurgery plays a pivotal role in the management of cutaneous neoplasms, aiming not only at complete tumor removal but also at preserving functional and esthetic integrity. While conventional histopathology ensures high diagnostic accuracy, it is limited by processing time, artifacts, and restricted intraoperative availability. Novel imaging techniques such as confocal laser microscopy (CLM), optical coherence tomography (OCT), and line-field confocal OCT (LC-OCT) provide new opportunities for preoperative mapping, intraoperative margin assessment, and postoperative surveillance. Ex vivo confocal microscopy further allows rapid tissue analysis with minimal specimen loss. The synergistic use of multiple imaging modalities, together with artificial intelligence-assisted image interpretation, holds significant potential to refine dermatosurgical practice. These advances may contribute to more precise, patient-centered surgical care and reduce unnecessary re-operations.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hypersensitivity to tumescent local anesthesia in dermatosurgical procedures]. [皮肤外科手术中对肿胀局部麻醉的过敏]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-10-06 DOI: 10.1007/s00105-025-05598-7
S Aurich, R Treudler, S Grunewald
{"title":"[Hypersensitivity to tumescent local anesthesia in dermatosurgical procedures].","authors":"S Aurich, R Treudler, S Grunewald","doi":"10.1007/s00105-025-05598-7","DOIUrl":"https://doi.org/10.1007/s00105-025-05598-7","url":null,"abstract":"<p><p>Tumescent local anesthesia (TLA) offers many advantages in major and minor dermatosurgical procedures, especially in elderly and multimorbid patients in whom general anesthesia is sometimes associated with major risks. LA intolerances are rare. In our experience, TLA is a safe method despite the mixture of different LA. Monitoring of the patient during TLA is necessary. Clarification of a history of LA intolerance prior to surgical treatment is useful; however, a negative test does not reliably rule out an allergic reaction.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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