{"title":"[Treatment algorithm based on S1 guideline for the management of pincer nails (involuted nails)].","authors":"Antonia Pennitz, Christoph R Löser","doi":"10.1007/s00105-026-05674-6","DOIUrl":"https://doi.org/10.1007/s00105-026-05674-6","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":"77 5","pages":"349-351"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lara Maria Prien, Carolin Mitschang, Tobias Goerge
{"title":"[Acute venous disorders: deep vein thrombosis and superficial vein thrombosis of the lower extremity : Diagnosis and treatment in dermatology practice].","authors":"Lara Maria Prien, Carolin Mitschang, Tobias Goerge","doi":"10.1007/s00105-026-05655-9","DOIUrl":"10.1007/s00105-026-05655-9","url":null,"abstract":"<p><strong>Background: </strong>Deep vein thrombosis (DVT) is associated with potentially serious complications such as pulmonary embolism (PE) and postthrombotic syndrome. Superficial vein thrombosis (SVT) is also clinically relevant, as concomitant DVT and/or PE may already be present at initial diagnosis or may develop during follow-up.</p><p><strong>Objective: </strong>Which diagnostic and therapeutic steps are most relevant for dermatologists in clinical practice?</p><p><strong>Methods: </strong>Overview of the German S2k guideline and selected literature, supplemented by two case vignettes.</p><p><strong>Results: </strong>DVT diagnostics are guided by clinical pretest probability (Wells score). In patients with low probability, a negative D‑dimer test can rule out DVT. In patients with high probability or a positive D‑dimer test, duplex compression ultrasonography is indicated. In confirmed DVT, prompt therapeutic anticoagulation is required, preferably with direct oral anticoagulants, usually for ≥ 3 months depending on provocation status and risk of recurrence. In SVT, thrombus length and proximity to the deep venous junction determine management. SVT ≥ 5 cm, marked symptoms, or relevant risk factors warrant 45 days of anticoagulation (e.g., fondaparinux 2.5 mg s.c. once daily). SVT < 3 cm from the junction or with progression into the deep venous system requires therapeutic-dose anticoagulation analogous to DVT. Short-segment distal SVT can often be managed symptomatically.</p><p><strong>Conclusion: </strong>Structured risk stratification, focused diagnostic work-up, and guideline-concordant therapy are essential to prevent thromboembolic complications.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"308-314"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sohrab Elahwiesy, Jan-Christoph Simon, Manfred Kunz, Regina Treudler
{"title":"[Generalized pustulosis after leflunomide].","authors":"Sohrab Elahwiesy, Jan-Christoph Simon, Manfred Kunz, Regina Treudler","doi":"10.1007/s00105-025-05623-9","DOIUrl":"10.1007/s00105-025-05623-9","url":null,"abstract":"<p><p>Leflunomide is a an isoxazole derivative used as an immunosuppressive drug in rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that has an inhibiting effect of tumor necrosis factor alpha (TNF α) signaling. We present a case of with generalized pustular skin lesions after intake of leflunomide, which resemble a pustular exacerbation of a pre-existing psoriasis as well as a generalized pustular psoriasis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"331-334"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Differential diagnoses: skin changes on the leg and their significance].","authors":"Katrin Kofler, Lukas Kofler, Anke Strölin","doi":"10.1007/s00105-026-05656-8","DOIUrl":"10.1007/s00105-026-05656-8","url":null,"abstract":"<p><p>Cutaneous lesions of the lower extremities represent a frequent diagnostic challenge in daily clinical practice, as a wide range of infectious, inflammatory, vascular, neoplastic, and metabolic disorders may present with similar clinical features. Hypodermitis as a manifestation of chronic venous insufficiency, for example, is often misdiagnosed as erysipelas, which may result in delayed or inadequate treatment and potentially irreversible fibrotic changes. This article addresses this issue by presenting an illustrative case and provides a structured overview of relevant differential diagnoses of skin lesions affecting the lower legs. In addition to acute and chronic infectious dermatoses, inflammatory and immune-mediated diseases, vascular-related skin changes, neoplastic entities, and metabolically associated dermatoses are discussed. The aim is to facilitate early and targeted diagnostic evaluation by comparing clinical and anamnestic features. Accurate classification is essential, as treatment strategies, prognosis, and disease course vary considerably among these conditions. This article is intended to help avoid misdiagnosis and initiate early, etiologically based treatment.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"294-299"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thilo Gambichler, Sera Salina Weyer-Fahlbusch, Wolfgang Kemptner, Linda Kühn, Laura Susok
{"title":"[Generalized idiopathic eruptive macular pigmentation in a 9-year-old Romni].","authors":"Thilo Gambichler, Sera Salina Weyer-Fahlbusch, Wolfgang Kemptner, Linda Kühn, Laura Susok","doi":"10.1007/s00105-025-05613-x","DOIUrl":"10.1007/s00105-025-05613-x","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"325-326"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Diagnosis and treatment of varicose veins].","authors":"Felizitas Pannier, Laura Fischer","doi":"10.1007/s00105-026-05666-6","DOIUrl":"10.1007/s00105-026-05666-6","url":null,"abstract":"<p><p>Varicose veins are a common chronic disease in our population. They may frequently cause symptoms like pain, feeling of heaviness and tension in the legs. Untreated progression is frequent with complications like edema, skin changes, and venous ulcers but also deep or superficial thrombosis, pulmonary embolism as well as venous bleeding. The reasons for varicose veins are multigenetic changes with positive family history for varicose veins and degenerative tissue changes, increasing with age. For diagnosis, duplex ultrasound is key alongside the patient's medical history and clinical findings. In addition to symptomatic treatment with compression, ablation of varicose veins is available with less invasive endovenous thermal and nonthermal options and with open surgery.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"300-307"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Biologics and infections: understand and recognize].","authors":"Galina Balakirski, Pietro Nenoff","doi":"10.1007/s00105-026-05683-5","DOIUrl":"https://doi.org/10.1007/s00105-026-05683-5","url":null,"abstract":"<p><p>It is now impossible to imagine dermatology without the use of biologics. The numerous substances approved for the treatment of chronic inflammatory skin diseases in recent decades have become an integral part of dermatological treatment plans. Severe chronic inflammatory dermatoses such as psoriasis vulgaris, atopic dermatitis, and hidradenitis suppurativa can be significantly relieved using these therapeutics. The specific inhibition of important immunological pathways leads to a decrease in disease activity, but the reduction of particular proinflammatory cytokines may also impair the immune response and increase susceptibility to infections. For example, systemic therapy with tumor necrosis factor-alpha (TNF-α) inhibitors can lead to the reactivation of latent tuberculosis infection, and the use of interleukin (IL)-17 blockers has been associated with an increase in candida infections of the skin and mucous membranes. This article presents an overview of possible infection complications during systemic therapy with biologics.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Hand eczema and occupational counseling in adolescents].","authors":"Sonja Molin","doi":"10.1007/s00105-026-05685-3","DOIUrl":"https://doi.org/10.1007/s00105-026-05685-3","url":null,"abstract":"<p><strong>Background: </strong>Many adult patients with hand eczema report having noticed the first signs of their skin condition at a young age. The pathogenesis of hand eczema is multifactorial. In children or teenagers, atopic predisposition as well as skin irritation or contact sensitization play a major role in hand eczema development. To provide effective counseling to adolescents with hand eczema who are about to choose a career, it is helpful to know the current state of knowledge regarding hand eczema in this special group of patients.</p><p><strong>Objectives: </strong>Overview on the factors that are important for hand eczema in teenage patients, as well as possible approaches to career counseling.</p><p><strong>Materials and methods: </strong>Evaluation of the current literature on hand eczema in childhood and adolescence and the recommendations for career counseling.</p><p><strong>Results: </strong>The average age of onset for hand eczema is about 12 years. The 1‑year and lifetime prevalence in childhood are described as 5.2-10% and 6.5-13.3%, respectively, and 12.1% and 18.3% in adolescents and young adults. Trigger factors differ within the young patient groups: while among children they are often found in the context of leisure activities and hobbies, in adolescents they sometimes relate to an occupational context. The choice of profession does not necessarily have to be restricted even in the context of a previous history of eczema or an atopic preposition. It is crucial to counsel the young patients in detail, educating them about the special needs of their skin as well as on consistent moisturizing and skin protection.</p><p><strong>Conclusion: </strong>Early identification of trigger factors as well as good counseling and treatment optimization are essential for adolescent hand eczema patients in order to keep the influence of hand eczema on their development, thriving, and career choices as low as possible.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}