{"title":"[Vegan beware! Allergenic potential of legumes].","authors":"Jil Marie Jubel, Natalija Novak","doi":"10.1007/s00105-025-05505-0","DOIUrl":"10.1007/s00105-025-05505-0","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of a vegan diet has increased worldwide in recent years. The relinquishing of animal products requires adequate protein, vitamin and mineral substitutes from plant-based foods. Legumes play an important role in this context. At the same time there are an increasing number of case reports of allergic reactions after consumption of legumes.</p><p><strong>Aim: </strong>The aim of this study was to summarize the current state of knowledge regarding the allergenic potential and the relevant allergens of legumes in the context of a vegan diet.</p><p><strong>Material/methods: </strong>A comprehensive literature search from the last 25 years on vegan diets and the allergens in legumes was conducted.</p><p><strong>Results: </strong>Peanuts and soybeans are among the well-known legumes with a high allergenic potential; however, there are also other legumes, such as lupins, lentils and peas, which can trigger severe allergic reactions. Exercise-induced anaphylaxis has also been described following the consumption of legumes.</p><p><strong>Conclusion: </strong>The increased consumption of legumes in the context of a vegan diet is bringing a wider range of plant-based foods into focus, which may have potentially allergenic properties. An increase in allergic reactions to legumes is to be expected. Precise molecular IgE diagnostics are crucial to be able to assess the risk of severe reactions.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"403-408"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yousef Arafat, Stefanie Boms, Ocko Kautz, Andrea von Stemm, Thilo Gambichler
{"title":"[Miliary palmoplantar gout tophi in a patient with hyperuricemia and chronic renal insufficiency].","authors":"Yousef Arafat, Stefanie Boms, Ocko Kautz, Andrea von Stemm, Thilo Gambichler","doi":"10.1007/s00105-025-05499-9","DOIUrl":"10.1007/s00105-025-05499-9","url":null,"abstract":"<p><p>We report on a woman with palmoplantar whitish-yellowish aggregated, partly ulcerated papules on a slightly erythematous base. Histological examination showed pale amorphous nodular deposits in the dermis. On radiological examination, calcifications could be ruled out. Laboratory tests showed marked hyperuricemia and chronic renal insufficiency. We diagnosed miliary gout (MG) and initiated uric acid-reducing therapy with allopurinol 100 mg/day. First described in 2007, MG presenting with multiple whitish-yellowish papules is a rare intradermal variant of classic gout that is characterized by subcutaneous deposits. Clinically, MG can be confused with other dermatoses, for example, cutaneous calcification or pustular palmoplantar psoriasis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"442-444"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Atypical slowly growing node in the bend of the elbow].","authors":"Christina Naoum, Ferdinand Toberer","doi":"10.1007/s00105-025-05520-1","DOIUrl":"10.1007/s00105-025-05520-1","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"459-462"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joachim Dissemond, Maurice Moelleken, Alpaslan Tasdogan
{"title":"[Pyoderma gangrenosum: pathogenesis, diagnosis, and treatment].","authors":"Joachim Dissemond, Maurice Moelleken, Alpaslan Tasdogan","doi":"10.1007/s00105-025-05522-z","DOIUrl":"10.1007/s00105-025-05522-z","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) is a skin disease that rapidly develops from papules or primarily sterile pustules. It is characterized by the formation of extremely painful wounds with a reddish-livid edge and surrounding areas. It can be triggered by trauma, bacteria or drugs in genetically predisposed people. In 70% of cases, the predilection sites manifest at the extensor sides of the lower extremities. Although the exact pathophysiology of this rare neutrophilic dermatosis has not yet been fully elucidated, an autoinflammatory genesis with increased neutrophil granulocyte activity is currently being discussed. Patients often have inflammatory comorbidities such as chronic inflammatory bowel disease or cancer. To confirm the diagnosis, the validated PARACELSUS score, which summarizes the nonspecific criteria, should be used. In addition to the administration of immunosuppressive drugs such as prednisolone and/or ciclosporin, patients with proven PG are treated systemically with biologics, small molecules, or intravenous immunoglobulins. Utilization of these pharmaceutical agents has seen a marked increase in recent cases of PG. This should be accompanied by topical pharmacological treatment of the wound surroundings as well as modern wound and pain therapy.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"449-458"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Genital herpes, paronychia, and lymphangitis of the arm-HSV 1 as the missing link].","authors":"Rika Kluck, Ulrike Raap, Maike Marleen Holtsche","doi":"10.1007/s00105-025-05490-4","DOIUrl":"10.1007/s00105-025-05490-4","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"441"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Novel foods-What must be considered?]","authors":"Frédéric Toussaint, Nicola Wagner","doi":"10.1007/s00105-025-05504-1","DOIUrl":"10.1007/s00105-025-05504-1","url":null,"abstract":"<p><p>Novel foods are food products that were not in circulation for consumption to any significant extent in the European Union before 1997. The introduction of novel foods harbors the risk of allergic reactions to new allergens or new cross-reactions that need to be taken into account. The aim of the study is to highlight the allergenic potential of selected novel foods. Allergens in edible insects in particular harbor the risk of anaphylactic reactions. In western industrial nations cross-sensitivity to crustaceans and shellfish are likely to play an important role in the future. Chia seeds, which are rich in fiber and omega-3-fatty acids, are also embraced in the term novel foods. Cross-reactions to sesame seeds or to other labiates (mustard, thyme, rosemary, sage) are possible. Consumption of natto, a Japanese dish containing fermented soy beans, can lead to delayed anaphylaxis. Nattokinase as well as polyglutamic acid (PGA) are well-known triggering allergens. It is postulated that sensitization to PGA may be acquired from skin contact to jellyfish and potentially by cosmetics containing PGA.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"409-413"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Eosinophilic esophagitis-an underestimated food allergy?]","authors":"A Hörning, A Madisch","doi":"10.1007/s00105-025-05513-0","DOIUrl":"10.1007/s00105-025-05513-0","url":null,"abstract":"<p><p>Eosinophilic oesophagitis (EoE) is a chronic T2-inflammatory disease and can be figuratively referred to as atopic dermatitis of the oesophagus. It is an immune-mediated disease caused by food allergens and is histologically defined by eosinophilic infiltration and clinically characterised by symptoms of oesophageal dysfunction. In addition to reducing the currently still considerable diagnostic latency, the focus is on prioritising existing and new treatment options with the aim of ensuring effective patient care with improved quality of life in the long term.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"428-433"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Food allergy as occupational disease].","authors":"Julia Zarnowski, R Treudler","doi":"10.1007/s00105-025-05509-w","DOIUrl":"10.1007/s00105-025-05509-w","url":null,"abstract":"<p><strong>Background: </strong>Food-induced allergic reactions not only occur in private settings but also in occupational context. In these cases, the presence of an occupational disease should be investigated. We provide an overview of selected food-associated occupational diseases.</p><p><strong>Methods: </strong>A literature search was conducted on food-associated occupational dermatoses (contact urticaria, protein contact dermatitis) and occupational food anaphylaxis.</p><p><strong>Results: </strong>Food allergy as an occupational disease is usually manifested as respiratory or cutaneous symptoms, while food anaphylaxis is rarely reported. Employees in food processing industries, in particular cooks and workers in the fishing and meat industry as well as employees in the bakery and pastry industries, represent a highly exposed group for food-associated occupational dermatoses, occupational asthma and food anaphylaxis.</p><p><strong>Conclusion: </strong>The possible triggers for occupational food allergies are diverse and can range from foods of animal origin (meat, fish, dairy products) to various plant-derived allergens and food additives (e.g. carmine E120, enzymes). A precise exposure history and allergological diagnostics are crucial in cases of suspected occupational food allergy.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"414-421"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thilo Gambichler, Kathrin Noldes, Andrea von Stemm, Ocko Kautz, Stefanie Boms
{"title":"[Disseminated atrophoderma of Pasini and Pierini with blaschkoid appearance].","authors":"Thilo Gambichler, Kathrin Noldes, Andrea von Stemm, Ocko Kautz, Stefanie Boms","doi":"10.1007/s00105-025-05503-2","DOIUrl":"10.1007/s00105-025-05503-2","url":null,"abstract":"<p><p>The rare atrophoderma of Pasini and Pierini (APP) is most commonly attributed to the disease spectrum of morphea, alongside atrophoderma Moulin. We report the case of a young woman with an unusually extensive presentation of APP, which partially exhibited a blaschkoid pattern. The clinically unobservable atrophy of the corium could be confirmed using an additive diagnostic procedure with 12 MHz ultrasound.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"445-448"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}