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[Nevus-associated melanoma or nevus on nevus?] 痣相关黑色素瘤还是痣上痣？］
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-08-01 Epub Date: 2025-07-10 DOI: 10.1007/s00105-025-05534-9
Julia Resch, Isabella Fried, Rainer Hofmann-Wellenhof
{"title":"[Nevus-associated melanoma or nevus on nevus?]","authors":"Julia Resch, Isabella Fried, Rainer Hofmann-Wellenhof","doi":"10.1007/s00105-025-05534-9","DOIUrl":"10.1007/s00105-025-05534-9","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"519-520"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Treatment of oral lichen planus-a review]. 口腔扁平苔藓的治疗综述
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-08-01 Epub Date: 2025-07-15 DOI: 10.1007/s00105-025-05540-x
Khava Abdusalamova, Farzan Solimani, Margitta Worm
{"title":"[Treatment of oral lichen planus-a review].","authors":"Khava Abdusalamova, Farzan Solimani, Margitta Worm","doi":"10.1007/s00105-025-05540-x","DOIUrl":"10.1007/s00105-025-05540-x","url":null,"abstract":"<p><p>Mucosal lichen planus (MLP) is a chronic, recurrent, inflammatory T‑cell disorder that can affect mucous membranes and, together with cutaneous lichen planus (CLP) and lichen planopilaris (LPP), belongs to the variants of lichen planus (LP) diseases. MLP can affect both the oral mucosa (oral lichen planus, OLP) and the genital mucosa. Patients with OLP can have varying degrees of severity. In particular, patients affected by an erosive/ulcerative form usually pose a therapeutic challenge because 1) there are currently no US Food and Drug Administration(FDA)/European Medicines Agency (EMA)-approved drugs and 2) the disease is often treatment resistant. Recently published studies on immunopathogenesis describe a predominant role of interferon-γ-induced inflammation, but many aspects of the disease are still unknown. Accordingly, primarily symptomatic therapies are currently available. In addition to topical glucocorticoids, retinoids in topical and systemic form and systemic glucocorticoids are established first-line therapies. A wide range of second- and third-line therapies show that no standard treatment that there is still o standard treatment. Among the new therapies, Janus kinase inhibitors and monoclonal antibodies should be emphasized, as they could expand the therapeutic spectrum for OLP in the future. However, prospective, placebo-controlled studies are needed for this in the future. Alternative and complementary treatments such as herbal therapies, phototherapy, platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) are also described in the literature. In this article, we discuss the current therapeutic options for this difficult-to-treat disease.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"491-498"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Noninvasive imaging of cutaneous melanoma metastases : Microenvironment and vascular insights in therapy]. [皮肤黑色素瘤转移的无创成像：治疗中的微环境和血管观察]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-29 DOI: 10.1007/s00105-025-05550-9
Oliver Mayer, Rebecca Schönherr, Julia Welzel, Sandra Schuh
{"title":"[Noninvasive imaging of cutaneous melanoma metastases : Microenvironment and vascular insights in therapy].","authors":"Oliver Mayer, Rebecca Schönherr, Julia Welzel, Sandra Schuh","doi":"10.1007/s00105-025-05550-9","DOIUrl":"https://doi.org/10.1007/s00105-025-05550-9","url":null,"abstract":"<p><p>A 63-year-old man with cutaneous melanoma metastases showed a strong therapeutic response to combined immunotherapy with ipilimumab and nivolumab. Using dynamic optical coherence tomography (D-OCT) and line-field confocal optical coherence tomography (LC-OCT), a significant reduction in vessel density and diameter was noninvasively observed. These vascular changes reflect the tumor microenvironment's response to therapy and highlight the potential of noninvasive imaging in treatment monitoring.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Divided bullae: half-half blisters in IgA pemphigus]. [分裂的大疱：IgA天疱疮的一半一半的水泡]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-29 DOI: 10.1007/s00105-025-05548-3
Daniel Craus, Alexander Kreuter, Valentina Laura Müller
{"title":"[Divided bullae: half-half blisters in IgA pemphigus].","authors":"Daniel Craus, Alexander Kreuter, Valentina Laura Müller","doi":"10.1007/s00105-025-05548-3","DOIUrl":"https://doi.org/10.1007/s00105-025-05548-3","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronic actinic dermatitis in a patient with darker skin]. [深色皮肤患者的慢性光化性皮炎]。
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-15 DOI: 10.1007/s00105-025-05549-2
Lisa Gabriele Zieringer, Stefan Schliep, Markus V Heppt
{"title":"[Chronic actinic dermatitis in a patient with darker skin].","authors":"Lisa Gabriele Zieringer, Stefan Schliep, Markus V Heppt","doi":"10.1007/s00105-025-05549-2","DOIUrl":"https://doi.org/10.1007/s00105-025-05549-2","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Suspected histamine intolerance-how to proceed?] 疑似组胺不耐受-如何处理？］
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-03-10 DOI: 10.1007/s00105-025-05482-4
Imke Reese
{"title":"[Suspected histamine intolerance-how to proceed?]","authors":"Imke Reese","doi":"10.1007/s00105-025-05482-4","DOIUrl":"10.1007/s00105-025-05482-4","url":null,"abstract":"<p><p>\"Histamine intolerance\" is often based on a self-diagnosis. Due to the known range of reactions that can be mediated by the messenger substance histamine, it is postulated that food histamine can trigger the same reactions. Results of studies with double-blind, placebo-controlled oral provocation tests do not confirm this, but rather show that orally administered histamine does not trigger reproducible reactions and that symptoms often occur after placebo, indicating a strong nocebo effect. Without reproducibility, however, the definition for an adverse reaction to food is not fulfilled. As many sufferers are severely affected by their self-diagnosis due to a massive restriction of their food choice, quality of life, and social interaction, allergy societies in German-speaking countries have published a guideline which describes a pragmatic diagnostic and therapeutic approach. The primary aim is to alleviate symptoms by improving digestive function and to expand the choice of foods, rather than to exclude the suspected diagnosis. Collaboration with a dietician/nutritionist with allergological expertise is therefore strongly recommended.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"422-427"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vegan beware! Allergenic potential of legumes]. (素食者小心!豆类的致敏潜力]。
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-04-30 DOI: 10.1007/s00105-025-05505-0
Jil Marie Jubel, Natalija Novak
{"title":"[Vegan beware! Allergenic potential of legumes].","authors":"Jil Marie Jubel, Natalija Novak","doi":"10.1007/s00105-025-05505-0","DOIUrl":"10.1007/s00105-025-05505-0","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of a vegan diet has increased worldwide in recent years. The relinquishing of animal products requires adequate protein, vitamin and mineral substitutes from plant-based foods. Legumes play an important role in this context. At the same time there are an increasing number of case reports of allergic reactions after consumption of legumes.</p><p><strong>Aim: </strong>The aim of this study was to summarize the current state of knowledge regarding the allergenic potential and the relevant allergens of legumes in the context of a vegan diet.</p><p><strong>Material/methods: </strong>A comprehensive literature search from the last 25 years on vegan diets and the allergens in legumes was conducted.</p><p><strong>Results: </strong>Peanuts and soybeans are among the well-known legumes with a high allergenic potential; however, there are also other legumes, such as lupins, lentils and peas, which can trigger severe allergic reactions. Exercise-induced anaphylaxis has also been described following the consumption of legumes.</p><p><strong>Conclusion: </strong>The increased consumption of legumes in the context of a vegan diet is bringing a wider range of plant-based foods into focus, which may have potentially allergenic properties. An increase in allergic reactions to legumes is to be expected. Precise molecular IgE diagnostics are crucial to be able to assess the risk of severe reactions.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"403-408"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New nutritional trends-new problems?] 新的营养趋势——新的问题？］
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-07-03 DOI: 10.1007/s00105-025-05519-8
Regina Treudler, Nicola Wagner
{"title":"[New nutritional trends-new problems?]","authors":"Regina Treudler, Nicola Wagner","doi":"10.1007/s00105-025-05519-8","DOIUrl":"https://doi.org/10.1007/s00105-025-05519-8","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":"76 7","pages":"401-402"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Miliary palmoplantar gout tophi in a patient with hyperuricemia and chronic renal insufficiency]. [高尿酸血症合并慢性肾功能不全患者的军事掌跖痛风痛风]。
IF 0.7
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-05-13 DOI: 10.1007/s00105-025-05499-9
Yousef Arafat, Stefanie Boms, Ocko Kautz, Andrea von Stemm, Thilo Gambichler
{"title":"[Miliary palmoplantar gout tophi in a patient with hyperuricemia and chronic renal insufficiency].","authors":"Yousef Arafat, Stefanie Boms, Ocko Kautz, Andrea von Stemm, Thilo Gambichler","doi":"10.1007/s00105-025-05499-9","DOIUrl":"10.1007/s00105-025-05499-9","url":null,"abstract":"<p><p>We report on a woman with palmoplantar whitish-yellowish aggregated, partly ulcerated papules on a slightly erythematous base. Histological examination showed pale amorphous nodular deposits in the dermis. On radiological examination, calcifications could be ruled out. Laboratory tests showed marked hyperuricemia and chronic renal insufficiency. We diagnosed miliary gout (MG) and initiated uric acid-reducing therapy with allopurinol 100 mg/day. First described in 2007, MG presenting with multiple whitish-yellowish papules is a rare intradermal variant of classic gout that is characterized by subcutaneous deposits. Clinically, MG can be confused with other dermatoses, for example, cutaneous calcification or pustular palmoplantar psoriasis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"442-444"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Atypical slowly growing node in the bend of the elbow]. [不典型的肘部缓慢生长的淋巴结]。
Dermatologie (Heidelberg, Germany) Pub Date : 2025-07-01 Epub Date: 2025-06-11 DOI: 10.1007/s00105-025-05520-1
Christina Naoum, Ferdinand Toberer
{"title":"[Atypical slowly growing node in the bend of the elbow].","authors":"Christina Naoum, Ferdinand Toberer","doi":"10.1007/s00105-025-05520-1","DOIUrl":"10.1007/s00105-025-05520-1","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"459-462"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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