Pia-Charlotte Stadler, Charlotte Gust, Stefan Weißinger, Lars E French, Eva M Oppel
{"title":"[Overview of clinical manifestations, diagnosis and management of acute allergic disorders].","authors":"Pia-Charlotte Stadler, Charlotte Gust, Stefan Weißinger, Lars E French, Eva M Oppel","doi":"10.1007/s00105-025-05535-8","DOIUrl":"10.1007/s00105-025-05535-8","url":null,"abstract":"<p><p>Allergological emergencies represent a particular challenge in clinical practice, as they require rapid identification and appropriate treatment to prevent serious complications and life-threatening courses. These emergencies primarily include life-threatening systemic hypersensitivity reactions-anaphylaxis-which can manifest on the skin as generalized urticaria and the development of angioedema, as well as severe cutaneous adverse drug reactions (SCADR). Among these, toxic epidermal necrolysis (TEN) represents the most severe one with a mortality rate of up to 30%. In the following article, we will discuss the current state-of-the-art diagnostics and treatment strategies for these dermatological emergencies and highlight new and promising therapeutic approaches.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"507-515"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Spontaneous appearance of dewdrop-like rash].","authors":"Léonie A N Staats, Jürgen P Bauerschmitz","doi":"10.1007/s00105-025-05521-0","DOIUrl":"10.1007/s00105-025-05521-0","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"516-518"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Antibiotic treatment for sexually transmitted infections].","authors":"M Krekels, A Potthoff","doi":"10.1007/s00105-025-05531-y","DOIUrl":"10.1007/s00105-025-05531-y","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) remain a significant global public health concern. Bacterial STIs such as Treponema pallidum (syphilis), Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium require targeted antibiotic therapy to prevent complications and transmission. However, increasing antibiotic resistance poses a growing challenge in clinical management.</p><p><strong>Methods: </strong>This article summarizes current antibiotic treatment strategies for bacterial STIs, considering recent clinical guidelines and emerging resistance patterns. It also discusses the role of post-exposure prophylaxis with doxycycline (Doxy-PEP) as a preventive measure in high-risk populations.</p><p><strong>Results: </strong>Penicillin remains the first-line treatment for syphilis, with alternative regimens required for penicillin-allergic individuals. Chlamydia trachomatis is primarily treated with doxycycline, while azithromycin remains an option for specific populations, including pregnant women. Resistance to third-generation cephalosporins and macrolides increasingly complicates the management of gonorrhea. Mycoplasma genitalium infections demonstrate high resistance to macrolides, often requiring alternative regimens with fluoroquinolones such as moxifloxacin. The emerging use of Doxy-PEP has shown promise in reducing bacterial STI incidence but requires ongoing evaluation regarding its long-term effects on antibiotic resistance.</p><p><strong>Conclusion: </strong>Effective management of bacterial STI relies on evidence-based antibiotic selection, surveillance of resistance trends, and novel prevention strategies such as Doxy-PEP. Continuous adaptation of treatment guidelines is crucial to counteract the rising threat of antimicrobial resistance in STI pathogens.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"483-488"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lea Victoria Goerdt, Giulnara Grygorian, Michael P Schön, Rotraut Mössner
{"title":"[Drug-induced lichen planus responsive to upadacitinib treatment].","authors":"Lea Victoria Goerdt, Giulnara Grygorian, Michael P Schön, Rotraut Mössner","doi":"10.1007/s00105-025-05517-w","DOIUrl":"10.1007/s00105-025-05517-w","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"499-503"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can Raul Alpagut, António Manuel Sequeira Santos, Michael Hertl, Martin Gschnell
{"title":"[Bullous pemphigoid in skin of color-clinical picture of perifollicular melanocyte regeneration during re-epithelialization].","authors":"Can Raul Alpagut, António Manuel Sequeira Santos, Michael Hertl, Martin Gschnell","doi":"10.1007/s00105-025-05518-9","DOIUrl":"10.1007/s00105-025-05518-9","url":null,"abstract":"","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"504-506"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jannik Sonnenberg, Anna Simone Keimburg, Frederike Krus, Philipp Wöhler, Richard Vollenberg, Jonel Trebicka, Phil-Robin Tepasse, Julia Fischer
{"title":"[Principles of antimicrobial stewardship].","authors":"Jannik Sonnenberg, Anna Simone Keimburg, Frederike Krus, Philipp Wöhler, Richard Vollenberg, Jonel Trebicka, Phil-Robin Tepasse, Julia Fischer","doi":"10.1007/s00105-025-05530-z","DOIUrl":"10.1007/s00105-025-05530-z","url":null,"abstract":"<p><p>The global emergence of multiresistant pathogens threatens the effectiveness of antimicrobial therapies and calls for a rational use of antibiotics, antivirals, and antifungals. The main reason for the development of resistance is the inappropriate use of these substances in human and veterinary medicine and agriculture. Antimicrobial stewardship (AMS) combines strategies for optimizing prescribing practices in order to prevent the development of resistance, ensure successful treatment, and minimize side effects. Central elements are evidence-based guidelines, interdisciplinary visits, infectious disease consults, targeted training, feedback systems, and digital support. AMS is becoming increasingly established in Germany, but many antibiotics are still not prescribed in line with guidelines. Correct diagnosis, guideline-based empirical therapy, regular re-evaluation, dose adjustment, early oral administration, and outpatient parenteral anti-infective therapy (OPAT) are essential. Short, individually adapted treatment durations improve tolerability and reduce resistance pressure. AMS links epidemiological data with patient-specific factors and is key in personalized infection medicine. Only the consistent integration of AMS measures into everyday clinical practice can ensure the sustained efficacy of antimicrobial substances and improve the quality of patient care in the long term.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"465-469"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valerie Glatzel, Caroline Glatzel, Benjamin Kendziora, Justin Gabriel Schlager, Daniela Hartmann
{"title":"[Antibiotics and dermatologic procedures].","authors":"Valerie Glatzel, Caroline Glatzel, Benjamin Kendziora, Justin Gabriel Schlager, Daniela Hartmann","doi":"10.1007/s00105-025-05532-x","DOIUrl":"10.1007/s00105-025-05532-x","url":null,"abstract":"<p><p>Surgical site infections can occur after any dermatosurgical procedure and lead to increased morbidity and mortality. To minimize the risk, perioperative administration of antibiotics may be advisable if correctly indicated. The German Society for Dermatosurgery has issued current recommendations for this. Criteria such as the type of procedure, location, contamination of the surgical site, and patient-specific risk factors all play a role. Perioperative antibiotic prophylaxis should ideally be administered 30-60 min before the surgical procedure and can be administered orally or intravenously.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"480-482"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}