Jazmin Lorena Serna Ortiz, Uwe Paasch, Sonja Grunewald, Focke Ziemssen, Andreas Dietz, Joseph Claßen, Rima Nuwayhid, Stefan Langer, Dirk Halama, Jan-Christoph Simon, Anna-Theresa Seitz
{"title":"[Management of side effects following hyaluronic acid filler injections].","authors":"Jazmin Lorena Serna Ortiz, Uwe Paasch, Sonja Grunewald, Focke Ziemssen, Andreas Dietz, Joseph Claßen, Rima Nuwayhid, Stefan Langer, Dirk Halama, Jan-Christoph Simon, Anna-Theresa Seitz","doi":"10.1007/s00105-024-05464-y","DOIUrl":"10.1007/s00105-024-05464-y","url":null,"abstract":"<p><p>With the increase of esthetic procedures using hyaluronic acid injections, the risk of complications also increases. Due to their complexity, interdisciplinary treatment is often necessary. In recent months, three cases have been treated on an interdisciplinary basis at Leipzig University Medical Center. This motivated us to develop a joint recommendation for action in co-operation with the departments of dermatology, plastic surgery, oral and maxillofacial surgery, ENT (ear, nose and throat), ophthalmology, and neurology.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Differential diagnosis of epidermotropic neoplasia].","authors":"Rose K C Moritz, Franziska C Ghoreschi","doi":"10.1007/s00105-025-05470-8","DOIUrl":"10.1007/s00105-025-05470-8","url":null,"abstract":"<p><p>Many benign and malignant neoplasms may involve the epidermis, a phenomenon which is commonly referred to as epidermotropism. Intraepidermal localization is an important diagnostic clue. However, differentiation of neoplastic cells can be challenging, especially when the cells are completely confined to the epidermis. Besides the large group of lymphoid and melanocytic neoplasms, several rare entities may show epidermotropism. Typical examples are mammary and extramammary Paget's disease and Langerhans cell histiocytosis. Other rare differential diagnoses include Merkel cell carcinoma, granular cell tumor, adnexal tumors, and epidermotropic metastases. The Borst-Jadassohn phenomenon describes the mimicry of epidermotropic neoplasia in Bowen's disease, Bowenoid actinic keratosis, clonal seborrheic keratosis, and hidroacanthoma simplex. Inflammatory dermatoses with increased intraepidermal localization of immune cells may mimic intraepidermal neoplasia. We review the different entities and summarize the key morphologic and immunohistochemical features for diagnosis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"140-151"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Vitiligo-update on pathogenesis, diagnostics and therapy].","authors":"Paloma Seidel, Markus Böhm","doi":"10.1007/s00105-024-05467-9","DOIUrl":"10.1007/s00105-024-05467-9","url":null,"abstract":"<p><p>Vitiligo is a common skin disease leading to depigmentation that is associated with progressive destruction of melanocytes. The main subtype, nonsegmental vitiligo (NSV), is considered a chronic autoimmune disease leading to activation of melanocyte-specific CD8+ lymphocytes and development of a cutaneous immune memory. Vitiligo can result in significant impairment of quality of life and is associated with a number of comorbidities. Despite the existence of national guidelines and international treatment recommendations, there is a strong need for improved health care for patients with vitiligo. The options in the treatment algorithm for vitiligo are similar and consisted until recently of only topical and systemic corticosteroids, topical calcineurin inhibitors, phototherapy, and surgical interventions. New insights into the pathobiological role of the interferon signature in vitiligo have most recently contributed to the approval of the first vitiligo-specific therapy with the topical Janus kinase 1/2 inhibitor ruxolitinib for patients with NSV.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"168-178"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A case of atopic dermatitis-the biopsychosocial view].","authors":"Eva Milena Johanne Peters","doi":"10.1007/s00105-024-05465-x","DOIUrl":"10.1007/s00105-024-05465-x","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis is perhaps the most comprehensively studied skin disease in psychosomatic medicine and psychoneuroimmunology. Its biopsychosocial conceptualization incorporates psychodynamic as well as behavioral and systemic considerations. At the same time, there is also extensive biological knowledge of the neuroendocrine-immune control of barrier and immune function, characterized through animal experiments and translational clinical studies. Integrating this knowledge into clinical routine, however, represents a challenge.</p><p><strong>Objectives: </strong>The biopsychosocial implications of atopic dermatitis are discussed using a concrete case as an example.</p><p><strong>Materials and methods: </strong>Case presentation and narrative review of relevant psychopathogenetic models and psychoneuroimmunological pathomechanisms.</p><p><strong>Results and conclusion: </strong>Using a case of stress-exacerbated atopic dermatitis, the contribution of acute and chronic stressors to the development and worsening of skin inflammation is discussed. Particular attention is paid to the role of the pituitary hypothalamic adrenal axis and neurogenic inflammation as central drivers of barrier disruption and immune imbalance in atopic dermatitis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"76-80"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Selection of the biopsy procedure-critical for dermatopathological diagnostics].","authors":"Almut Böer-Auer, Christian Rose","doi":"10.1007/s00105-024-05461-1","DOIUrl":"10.1007/s00105-024-05461-1","url":null,"abstract":"<p><p>Skin biopsy is one of the most frequently performed diagnostic measures in dermatological practice. Depending on the diagnostic question, the selection of the type of biopsy procedure and the biopsy location can have a considerable influence on histological assessment. Depending on the disease, different aspects must be taken into account for a precise diagnosis. This article summarizes these for exanthema, erythematosquamous dermatoses, blistering diseases, subcutaneous inflammatory processes, and alopecia with examples. Advantages and disadvantages of different biopsy types are also addressed for neoplastic diseases. The aim is to draw attention to difficulties in histopathologic differential diagnosis caused by the biopsy procedure and, thus, to improve the quality of biopsy and diagnosis.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"102-114"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Trefzer, Katrin Kerl-French, Andreas Benedikt Weins, Christina Schnopp
{"title":"[Retrospective analysis in children with vaccination granuloma].","authors":"Laura Trefzer, Katrin Kerl-French, Andreas Benedikt Weins, Christina Schnopp","doi":"10.1007/s00105-024-05457-x","DOIUrl":"10.1007/s00105-024-05457-x","url":null,"abstract":"<p><strong>Background: </strong>Vaccine granulomas are a common (0.3-1%) adverse event (AE) of (accidentally) subcutaneously administered vaccines and specific immunotherapies containing aluminum conjugates. The clinical symptoms with persistent itching subcutaneous nodules, predominantly affect infants and young children on the lateral thigh.</p><p><strong>Aim: </strong>To sensitize dermatologists to recognize this common and harmless vaccination AE, in order to prevent invasive diagnostics and confusion among parents and physicians.</p><p><strong>Materials and methods: </strong>Retrospective analysis of 13 children consulting pediatric dermatology between 2019 and 2023. Identification of diagnostic criteria and guidelines for action, based on the literature.</p><p><strong>Results and conclusion: </strong>In all, 13 children (9 boys, 4 girls) with subcutaneous indolent but itching nodules at the vaccination sites (11 on the thighs, 2 on the upper arms) with a latency of weeks to months were retrospectively evaluated. The children were vaccinated according to German STIKO (\"Ständige Impfkommission\") recommendations. Only inactivated vaccines contain aluminum. The documented occurrence of the first vaccination granulomas was between the 12th and 36th month of life. Regarding the STIKO vaccination calendar, the third immunization with the hexavalent inactivated vaccine coincides with the first administration of the live measles, mumps and rubella (MMR) vaccine (varicella (V)). This may incorrectly lead to the assumption that the live vaccine was the cause of granuloma development. Aluminum conjugation appears to be a central trigger of the granulomas; further susceptibility factors are largely unknown. Diagnosis of sensitization to aluminum through epicutaneous testing has no practical impact and is, therefore, not routinely recommended. After weeks to years, granulomas spontaneously regress.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Comprehensive training in psychodermatology: the diploma course of the European Society for Dermatology and Psychiatry].","authors":"Sandra Hanneken, Francoise Poot","doi":"10.1007/s00105-024-05452-2","DOIUrl":"10.1007/s00105-024-05452-2","url":null,"abstract":"<p><strong>Background: </strong>Psychodermatological conditions play an important role in dermatological practice. The biopsychosocial disease model is of central significance.</p><p><strong>Objective: </strong>Psychodermatological knowledge is underrepresented in specialist training and medical care. There is a need for continuing education offers for primary psychodermatological disorders as well as for skin diseases related to psychological stress.</p><p><strong>Materials and methods: </strong>The work comprises a description of the structure, organization, and content of the diploma course offered by the European Society for Dermatology and Psychiatry (ESDaP), along with a personal conclusion after completing the course.</p><p><strong>Results: </strong>Continuing education in the diagnosis and treatment of psychodermatological disorders should be an integral part of dermatology training. The ESDaP diploma course conveys knowledge regarding psychosomatic dermatology and dermatopsychiatry. The target audience includes dermatologists, psychologists, psychiatrists, and psychotherapists in training and practice. The two-level course offers foundational knowledge for those working with psychodermatological patients in level 1, while level 2 allows for advanced specialization. Additional requirements for obtaining the diploma include case presentations, lectures, and multiple-choice examinations.</p><p><strong>Conclusion: </strong>Psychological factors are common in dermatological patients and require effective and holistic management. The ESDaP diploma course provides in-depth knowledge and fosters skills in patient care and physician-patient communication.</p>","PeriodicalId":72786,"journal":{"name":"Dermatologie (Heidelberg, Germany)","volume":" ","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}